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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Majalah Kedokteran Sriwijaya Universa Medicina Indonesian Journal of Rheumatology Indonesian Journal of Obstetrics & Gynecology Science Science Midwifery
Andri Reza Rahmadi
Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Most Frequent Musculoskeletal Manifestation of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin General Hospital Bandung Rahadian Nugi Sutrisno; Andri Reza Rahmadi; Nita Novita; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.627 KB) | DOI: 10.37275/ijr.v9i2.71

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with wide range of clinical symptoms. The patients frequently complain musculoskeletal involvement during the active state of the disease. Musculoskeletal manifestation in SLE patients is an important sign in making early diagnosis and monitoring treatment response. This study aims to determine the presentation of musculoskeletal involvement of SLE patients in Dr. Hasan Sadikin General Hospital Bandung.Methods: a descriptive cross-sectional quantitative study done by interviewing SLE patients concerning musculoskeletal manifestation as the primary data and tracking their medical record as the secondary data. Study was conducted between September to November 2016 in Rheumatology Clinic Dr. Hasan Sadikin General Hospital Bandung.Result: Ninety-seven SLE patients, 91 females (93,81%) and 6 males (6,19%), were enrolled in this study with mean age 35.12 (±10.91) years. The three highest proportions of muskuloskeltal manifestations were arthritis of the knee (84,5%), myalgia of upper back(40,2%), and muscle weakness (15,5%). We did not find any Jaccoud’s Arthropathy (JA) and tendinitis manifestation. Osteoporosis were occured in 4 patients (4,12%), whereas gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus wereonly occured in one patient (1,03%), respectively.Conclusion: The common musculoskeletal manifestation in SLE patients were arthritis of knee, myalgia of upper back, and muscle weakness. Only small portion of patients suffered from osteoporosis, gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus.Keyword: musculoskeletal manifestation, musculoskletal involment, SLE
Correlation between Serum Krebs von den Lungen-6 Levels with Forced Vital Capacity and Modified Rodnan Skin Score of Patients with Restrictive Lung Disease in Diffuse-Type Systemic Sclerosis Herlina Yani; Sumartini Dewi; Andri Reza Rahmadi
Indonesian Journal of Rheumatology Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i2.133

Abstract

Background Pulmonary fibrosis / intersitial lung disease (ILD) in systemic sclerosis (SSc) is a complicated restrictive pulmonary disease and the leading cause of disease-related mortality. Progressive skin fibrosis in diffuse-type SSc (dSSc) is associated with decreased forced vital capacity (FVC). Modified Rodnan Skin Score (mRSS) examination is used as a parameter to assess skin fibrosis, while high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) are used to assess pulmonary fibrosis. The HRCT test remains as the gold standard in diagnosing ILD. However, it costs a lot and is not available in all healthcare facilities. Krebs Von den Lungen-6 (KL-6) is a biomarker to evaluate pulmonary fibrosis. The aim of this study was to analyze the correlation of serum KL-6 levels with FVC and mRSS value of patients with restrictive lung disease in dSSc. Method This was a cross-sectional study that used primary data from dSSc patients who visited rheumatology outpatient clinic in Hasan Sadikin Hospital Bandung, Indonesia, during the period of June-July 2019. History taking, physical examination, mRSS, spirometry, and serum KL-6 levels were performed. Data were analyzed using the Rank Spearman correlation test. Result There were 27 subjects with the mean age of 42 ± 12 years. Based on FVC (%) restrictive lung disease criteria, the majority of subjects (74.1%) had severe restrictive lung disease and the rest of all subjects (25.9%) were non severe restrictive lung disease. Serum KL-6 levels ranged from 0.545 to 8.138 ng/ml. The results showed that there was no correlation between serum KL-6 levels and FVC values (r = -0.118, p = 0.279) and mRSS (r = 0.101, p = 0.312 ). Conclusion There is no correlation between serum KL-6 levels with FVC and mRSS value of patient with restritive lung disease in diffuse type systemic sclerosis. Keywords : diffuse type systemic sclerosis, Forced Vital Capacity, KL-6, mRSS, restrictive lung disease.
Correlation Between Cognitive Function with Disease Activity of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin Hospital Bandung: An Analytical Cross-Sectional Study Aep Saepudin; Paulus Anam Ong; Syarief Hidayat; Andri Reza Rahmadi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.142

Abstract

Background: Cognitive dysfunction was found in 55-80% Neuropsychiatry Systemic Lupus Erythematosus (NPSLE) patients. Serious concern from clinicans was needed as its impact to patient’s quality of life. Disease activity is expected to be affecting patient’s cognitive function. Previous studies regarding correlation between disease activity and cognitive dysfunction showed various results. This study aimed to evaluate the correlation between disease activity and cognitive function in SLE patients.Methods: This study is an analytical cross-sectional study. Subjects were SLE patients at the rheumatology clinic of Dr. Hasan Sadikin Hospital Bandung during June-August 2017. Subject’s evaluations included disease activity assessment using SLE disease activity index-2K (SLEDAI-2K) and cognitive function assessment using MoCA-Ina test. Data were analyzed by using Spearman Rank correlation test. Results: Mean age of the subjects was 31 ± 8 years old, most of them were senior high school graduates (65.8 %) and median length of study was 12 years. Subject’s median duration of illness was 44 months. Their MoCA-Ina median score was 25, while SLEDAI-2K median score was 6. Cognitive dysfunctions were found in more than half of subjects (52.63%), which memory domain (78.95%) was most frequently impaired. Most of subjects were patients with active SLE (63.2%). Correlation test showed there was no correlation between SLEDAI-2K score and MoCA-Ina score (rs=0.023, p=0.445).Conclusion: There was no correlation between disease activity (SLEDAI-2K score) and cognitive function (MoCA-Ina score). Keywords: Cognitive dysfunction, MoCA-Ina, Systemic lupus erythematosus, SLEDAI-2K
Difference between the Decrease in P1NP Concentration and MRSS Within 3 Months Treatment of Systemic Sclerosis Devy Priyantini Hanafi; Sumartini Dewi; Andri Reza Rahmadi
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v13i2.184

Abstract

Introduction: Systemic sclerosis is characterized by extensive and progressive organ fibrosis leads to organ failure and death. Progression of skin thickening is a predictor of morbidity and mortality. Due to the limitation of modified Rodnan skin score (MRSS) sensitivity in detecting small changes in skin fibrosis, thus we proposed Procollagen Type I N-Terminal Propeptide (P1NP) as potential biomarker. This study aimed to analyze the difference between the decrease in P1NP concentration and MRSS within 3 months treatment of systemic sclerosis. Methods: We conducted a retrospective cohort of paired numerical comparative analytic methods, as follow up of a study done by Vincent et al. and Dewi et al. Analyzis of MRSS changes and serum P1NP concentrations were done prior to treatment (baseline), and on week 4th, 8th and 12th treatment. Result: Fifty-nine subjects were enrolled in the study. We analyzed the results of P1NP and MRSS at 4th, 8th and 12th weeks of treatment, there was a significant decrease in mean rank of P1NP and MRSS (p=0.033 and <0.001). The effect of MRSS change was greater than P1NP. The highest decreasing effect of MRSS was obtained at week 8th (?2 = 0.424, 42.4% decrease effect), and the largest decrease effect of P1NP was obtained at week 12th (?2 = 0.120; 12% decrease effect). Conclusion: There was a difference in decreasing P1NP concentrations and MRSS in systemic sclerosis within 3 months of observation. MRSS showed a larger decrease in change than P1NP after treatment.
Differential Diagnosis of Fever of Unknown Origin in Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Kevin Fachri Muhammad; Ferdy Ferdian; Andri Reza Rahmadi
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2198

Abstract

Objective: To describe an unusual case of drug reaction with eosinophilia and systemic symptoms presenting as fever of unknown origin (FUO) and the diagnostic hurdles that come with the presence of differential diagnosis of FUO, which is tuberculous lymphadenitis.Methods: A 34-year-old female with a chief complaint of fever that has lasted for 3 weeks accompanied with jaundice and skin rashes for 2 weeks was admitted with an indication of FUO. She had a history of carbamazepine consumption for trigerminal neuralgia 2 months prior. Cervical lymphadenopathy was palpable bilaterally and hepatomegaly, elevated liver enzyme, as well as hyperbilirubinemia were observed. After excluding differentials for many causes of prolonged fever, patient was treated for Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and was given intravenous steroid injections. Fine needle aspiration biopsy was performed for her cervical lymphadenopathy.Results: Biopsy presented a mix of sialadenitis and tuberculous lymphadenopathy. Clinical improvement was observed on the second day after steroid administration. Patient was discharged on the seventh day after steroid administration.  Conclusion: FUO is one of the possible manifestations of DRESS; however, thorough investigation still needed to be done considering the possibility of more than one entity of disease that can cause FUO in patients, such as tuberculous lymphadenopathy seen in this case.
B-Cell Activating Factor Profile and Quality of Life in Systemic Lupus Erythematosus Patients Andri Reza Rahmadi; Habib Burahman; Nadia Gita Ghassani; Rachmat Gunadi Wachjudi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.204

Abstract

Background: B-Cell Activating Factor (BAFF) is a cytokine that plays a role in systemic lupus erythematosus (SLE) pathogenesis. BAFF increases B cell function, which will affect disease activity. In addition to decreasing disease activity, good quality of life (QoL) is one of the goals to be achieved in SLE therapy, which is also affected by disease activity. The purpose of this study is to know the correlation of the BAFF profile with the QoL of SLE patients. Methods: This was a cross-sectional study using secondary data from a previous study. The subjects of this study were SLE patients who had visited the rheumatology outpatient clinic or were hospitalized in Hasan Sadikin Hospital Bandung from September 2016 until February 2017. Subjects were asked to complete the Short Form-36 and measure their BAFF level in serum. Demographic data were collected, and disease activity data were assessed by Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The statistical analysis used in this study was the Spearman test. Results: There was a positive correlation between BAFF and MEX-SLEDAI (r 0.238, p-value 0.038). There was also a negative correlation between MEX-SLEDAI and PCS, as well as the MCS score (r -0.392 and -0.371, p-value <0.05). Conclusion: BAFF levels will increase in higher disease activity which will affect a poorer quality of life.
Cost effectiveness analysis of rheumatoid arthritis outpatient at a hospital in bandung Oskar Skarayadi; Wita Anggraeni; Pudjiastuti Kartidjo; Andri Reza Rahmadi; Suci Nar Vikasari
Science Midwifery Vol 10 No 6 (2023): February: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i6.1155

Abstract

Rheumatoid arthritis is a chronic systemic autoimmune disease of the joints with unknown etiology. treatment therapy is carried out to reduce the symptoms of inflammation, one of which is by using methylprednisolone and methotrexate. treatment is carried out in the long term. this study aims to analyze the cost-effectiveness of combined methylprednisolone in rheumatoid arthritis patients. the study used a retrospective descriptive analytic design. the data were taken from 31 outpatient medical records in hasan sadikin hospital from january 2017-december 2018. the research data included the das28 score, doctor visit fees, medical expenses, and laboratory fees. cost-effectiveness analysis is done by calculating the average cost effectiveness ratio (acer) and incremental cost effectiveness ratio (icer). the results showed 17 patients using methylprednisolone+methotrexate, 6 patients using methylprednisolone+sulfasalazine, 1 patient using methylprednisolone+cyclosporine, 2 patients using methylprednisolone+methotrexate+chloroquine, 3 patients using methylprednisolone+chloroquine+cyclosporine and 2 patients using methylprednisolone+chloroquine. the lowest acer value was obtainedwhen the combination of methylpredisolone+chloroquine was rp. 453,716 per effectiveness with an icer value of rp. 11,686 per effectiveness. this study concludes that the combination of methylprednisolone + chloroquine is the most effective therapy compared to other combinations of methylprednisolone.
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Osteoarthritis (Knee, Hand, Hip) Rakhma Yanti Helmi; Najirman; Ida Ayu Ratih Wulansari Manuaba; Andri Reza Rahmadi; Pande Ketut Kurniari; Malikul Chair; Ika Vemilia Warlisti; Eka Kurniawan; Harry Isbagio; Handono Kalim; Rudy Hidayat; Laniyati Hamijoyo; Cesarius Singgih Wahono; Sumariyono
Indonesian Journal of Rheumatology Vol. 15 No. 1 (2023): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v15i1.225

Abstract

Background: Osteoarthritis (OA) is the most common form arthritis in the world, and its prevalence is predicted to rise higher in the future due to increasing life expectancy and growing number of elderly population. With the emergence of new treatment options in the last several years, a better understanding of OA diagnosis and management is required by every physician in Indonesia. Methods: A panel of eight selected rheumatologists from the Indonesian Rheumatologist Association (IRA) developed recommendations based on key questions formulated by a steering committee from IRA. These recommendation materials were taken from several online databases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and each member of the panelist team will assign a score to express their level of agreement. Results: A total of 25 recommendations discussing the diagnosis, pharmacological and non-pharmacological therapies, as well as monitoring for OA were formulated. Conclusion: These recommendations can be used to help clinicians in accurately diagnosing OA and choosing the most suitable therapy for their patients. All recommendation statements were tailored to the clinical setting, facility, and drug availability in Indonesia.
Comparison of Pregnancy Outcomes with Autoimmune Rheumatic Disease and Without Autoimmune Rheumatic Disease Sulaiman, Aina Zakia; Pribadi, Adhi; Hamijoyo, Laniyati; Irianti, Setyorini; Rahmadi, Andri Reza
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.724

Abstract

Introduction: It is known that pregnancies with autoimmunity have a higher risk of complications in the mother and fetus compared to pregnancies without autoimmunity. The purpose of this study was to determine the comparison between pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease.Methods: This study is an observational analytic with a retrospective cross-sectional design. Data were obtained from all patients with pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease at Hasan Sadikin Hospital Bandung 1 January - 31 December 2021-2023.Results: During this period, 71 pregnant women were found to be accompanied by autoimmune rheumatic diseases and then data on pregnant women without autoimmune rheumatic diseases were randomly taken as controls. In this study, it was found that pregnant women with autoimmune diseases experienced more neonatal outcomes of stunted fetal growth, namely 11(15.5%) compared to pregnant women without autoimmune rheumatic diseases, namely 2(2.8%) with a p-value of 0.009.Conclusion: This study found that pregnant women with autoimmune rheumatic disease experienced more neonatal outcomes of FGR compared to pregnant women without autoimmune rheumatism.Perbandingan Antara Luaran Kehamilan Dengan Penyakit Rhematik Autoimun Dan Tanpa Penyakit Rematik AutoimunAbstrakPendahuluan: Diketahui bahwa kehamilan dengan autoimun memiliki risiko komplikasi pada ibu maupun janin lebih tinggi dibandingkan dengan kehamilan tanpa autoimun. Tujuan penelitian ini untuk mengetahui perbandingan antara luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimunMetode: Penelitian ini bersifat analitik observasional dengan desain potong lintang retrospektif. Data diperoleh dari seluruh pasien luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimun di Rumah Sakit Hasan Sadikin Bandung 1 Januari – 31 Desember 2021-2023Hasil: Dalam periode tersebut ditemukan 71 orang ibu hamil yang disertai dengan penyakit rematik autoimun kemudian diambil data ibu hamil tanpa penyakit rematik autoimun secara random sebagai kontrol. Pada penelitian ini didapatkan ibu hamil dengan penyakit autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat yaitu 11(15.5%) dibandingkan ibu hamil tanpa penyakit rematik autoimun yaitu 2(2.8%) dengan p- value0.009.Kesimpulan : Penelitian ini menemukan bahwa ibu hamil dengan penyakit rematik autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat dibandingkan dengan ibu hamil tanpa rematik autoimun.Kata kunci : Luaran Maternal, Luaran Neonatal, Autoimun 
Co-Authors A Nawawi Adhi Pribadi Adnyana, I K Amaylia Oehadian Amrullah, Al Hadi Annisa Dwi Khairina Aulia Abdillah Ramadhan Aulia Abdillah Ramadhan, Aulia Abdillah Dania Artriana Riswandi Devy Priyantini Hanafi Dewi, Sumartini Eka Kurniawan Ferdy Ferdian Habib Burahman Handono Kalim Harry Isbagio Henni Djuhaeni Henni Djuhaeni Herlina Yani I Ketut Adnyana Ika Vemilia Warlisti Kevin Fachri Muhammad Khairina, Annisa Dwi Laniyati Hamijoyo Laniyati Hamijoyo, Laniyati Malikul Chair Marina A. Moeliono Marina A. Moeliono, Marina A. Nadia Gita Ghassani Najirman Najirman Nawawi, A Nita Novita Nita Novita Nur Atik Oskar Skarayadi, Oskar Pande Ketut Kurniari Paulus Anam Ong Pudjiastuti Kartidjo Rachmat Gunadi Wachjudi Rahadian Nugi Sutrisno Rakhma Yanti Helmi Rudy Hidayat Setyorini Irianti Solly Aryza Suci Nar Vikasari, Suci Nar Sulaiman, Aina Zakia Sumariyono Sumartini Dewi Sutrisno, Rahadian Nugi Syarief Hidayat Wahono, Cesarius Singgih Wita Anggraeni Wulansari Manuaba, Ida Ayu Ratih Yeny Tanoyo