Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Dinamisia: Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR)
Forestrania, Roshamur Cahyan
Fakultas Farmasi, Universitas Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Inhibitory and Anti-Biofilm Effects of Orthoshipon aristatus Against Candida albicans Rahmasari, Ratika; Chairunissa, Ananda Hanny; Irianti, Marina Ika; Forestrania, Roshamur Cahyan; Arifianti, Ayun Erwina; Suryadi, Herman; Makau, Juliann Nzembi; Jantan, Ibrahim; Elya, Berna
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

There are increasing number of reports on Candida albicans developing resistance to available anti-fungal drugs. Thus, there is an urgent need to discover new agents for treatment of candidiasis. The alcoholic extracts of Orthoshipon aristatus have been shown to exhibit antifungal activity against C. albicans by using the agar diffusion and broth microdilution methods. However, the underlying mechanisms of anti-C. albicans effect of O. aristatus have not been well understood. This study was aimed to evaluate the cytotoxic and anti-biofilm effects of the n-hexane and ethanol extracts of purple and white varieties of O. aristatus leaves and branches against C. albicans. The effect of n-hexane and ethanol extract against C. albicans growth was carried out by crystal violet viability assay. IC50 values of the most active extract, and nystatin and fluconazole as positive controls were also determined by the crystal violet assay. Evaluation of the anti-biofilm effect was performed by treating C. albicans with the extracts at adhesion, development, and biofilm maturation stages using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The n-hexane extract of the purple variety of O. aristatus leaves demonstrated the strongest cytotoxic activity against C. albicans amongst the tested extracts, with an IC50 value of 0.67 µg/mL. The extract also showed strong anti-biofilm effect as fluconazole, with pronounced inhibition at the adhesion stage and less activity at the biofilm development and maturation stages. These results suggested that the n-hexane extract of the purple variety of O. aristatus leaves could be explored for discovery and development of anti-C. albicans agent.
Hanjeli, Rosela and Stevia Cultivation Training in Sasak Panjang Village, Bogor Regency: Pelatihan Budidaya Hanjeli, Rosela dan Stevia di Desa Sasak Panjang Kabupaten Bogor Roshamur Cahyan Forestrania; Febrina Amelia Saputri; Kartika Citra Dewi Permata Sari; Nisa Maria; Taufiq Indra Rukmana; Hindun Wilda Risni; Donna Maretta Ariestanti; Berna Elya
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2023): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v7i1.12947

Abstract

The community service program in Sasak Panjang Village, Bogor Regency, started with an assessment of the problems and potency of the village. These problems are the lack of close access to health care services and the failure to cultivate Family Medicinal Plants (FMP). According to The Ministry of Education and Culture program focus in 2022, it is necessary to carry out community service activities to increase the independence of public health efforts. Therefore, a community service program was performed through education, training, and mentoring for FMP cultivation to solve these problems. The success indicator of this activity was that the communities in Sasak Panjang were trained to cultivate the FMP (adlay, roselle, and stevia), and all crops could grow well. The outcome of this program is likely to encourage the independence of local community health initiatives in Sasak Panjang Village, Bogor Regency.
Aktivitas Anti-elastase dan Antioksidan dari Ekstrak Etanol Kayu Bangkal (Nauclea subdita) Korth. Steud. dengan Variasi Metode Ekstraksi Sintiami Ramadhani; Berna Elya; Roshamur Cahyan Forestrania
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.347

Abstract

Kayu Bangkal (Nauclea subdita) (Korth.) Steud. telah digunakan secara tradisional oleh penduduk asli Kalimantan Selatan, sebagai produk perawatan kulit berupa masker wajah, yang diyakini dapat melindungi kulit dari pengaruh buruk sinar matahari. Penelitian ini bertujuan untuk membandingkan rendemen, aktivitas anti-elastase, efek proliferasi sel, total polifenol, dan total flavonoid dan aktivitas antioksidan dari berbagai metode ekstraksi. Ekstraksi dilakukan dengan metode UAE (Ultrasound Assisted Extraction), MAE (Microwave Assisted Extraction), dan Soxhlet. Aktivitas anti-elastase dilakukan secara enzimatis menggunakan Porcine Pancreatic Elastase (PPE). Ekstrak teraktif dilanjutkan dengan pengujian proliferasi sel menggunakan HDFa. Pengujian kadar total polifenol dan flavonoid dilakukan dengan metode kolorimetri dan aktivitas antioksidan dengan metode DPPH, ABTS, dan FRAP. Hasil penelitian menunjukkan bahwa rendemen metode ekstraksi UAE (Ultrasound Assisted Extraction) kayu bangkal menghasilkan rendemen tertinggi, dengan nilai 7,12% lebih tinggi dibandingkan metode MAE (Microwave Assisted Extraction) dan Soxhlet, aktivitas anti-elastase tertinggi diperoleh pada ekstrak metode UAE (361,22 ?g/mL). Ekstrak teraktif memiliki efek proliferasi terhadap sel HDFa dependent dose, total fenol dan flavonoid tertinggi pada metode MAE dengan kadar berturut-turut 124.96±0.42 mg EAG/g ekstrak dan 16.62±0.23 mg EK/g ekstrak. Pengujian antioksidan dari masing-masing ekstrak umumnya menunjukkan aktivitas yang kuat dalam meredam radikal ABTS, DPPH dan reduksi besi. Hasil penelitian ini menunjukkan bahwa metode ekstraksi UAE dalam menarik senyawa aktif N. subdita berpotensi sebagai anti elastase, antiaging, dan antioksidan dibandingkan dengan metode ekstraksi lainnya. Penelitian ini diharapkan dapat memberikan informasi kepada masyarakat untuk dapat dikembangkan pada penelitian lebih lanjut.
Characterization of Phytocomponents of Mindi Leaf Extract and Chinese Petai Seeds by LC-HRMS and In Silico Activity Against Alpha-glucosidase Maharani, Maharani; Elya, Berna; Forestrania, Roshamur Cahyan
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Agustus 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i2.1007

Abstract

Melia azedarach L. and Leucaena leucocephala L. were two plant species that had attracted attention in phytochemical research due to their bioactive potential. However, research on the phytochemical characterization using Liquid Chromatography – High-Resolution Mass Spectrometry (LC-HRMS) of these two plants was still limited. This study was to identify and characterize the phytochemical properties of Mindi leaves (Melia azedarach L.) and Chinese Petai seeds (Leucaena leucocephala L.), as well as to conduct an in silico study. The research method involved reflux extraction using 70% ethanol as the solvent, qualitative phytochemical identification, and characterization using LC-HRMS. The compounds from LC-HRMS from each extract were analyzed for their bioactivity in silico. The results showed that Mindi leaves (M. azedarach L.) and  Petai cina seeds (L. leucochepala L.) contain alkaloids, saponins, phenolics, flavonoids, and tannins. The results of LC-HRMS analysis showed that 10 compounds were identified in each extract, and 3 of them were Prolylleucine, (3beta, 24R, 24'R)-fucosterol epoxide, and 2,3-Dihydro-1-benzofuran-2-carboxylic acid that is a compound found in both extracts. In silico results show that there is 1 compound in mindi leaf extract, namely Methyl isonicotinic, and 3 compounds from petai cina seed extract, namely trans-p-Coumaraldehyde, L-alanine, and 3-Buten-1-amine, which show pretty strong alpha-glucosidase inhibitory activity inhibits the target protein 3A4A. This research can be a reference for developing mini leaf extract and petai cina seeds as anti-diabetic candidates.
Co-Authors Arifianti, Ayun Erwina Berna Elya Chairunissa, Ananda Hanny Donna Maretta Ariestanti Febrina Amelia Saputri Herman Suryadi Hindun Wilda Risni Irianti, Marina Ika Jantan, Ibrahim Kartika Citra Dewi Permata Sari Maharani Maharani, Maharani Makau, Juliann Nzembi Nisa Maria Rahmasari, Ratika Sintiami Ramadhani Taufiq Indra Rukmana