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All Journal Indonesian Food Science and TechnologyJournal Jurnal Kreativitas PKM Pharmaceutical Sciences and Research (PSR)
Renesteen, Editha
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Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Nursing Public Health

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Chemical Properties, Biological Activities and Poisoning Treatment of Novichok: A Review Rahmania, Tesia Aisyah; Wardhani, Bantari Wisynu Kusuma; Renesteen, Editha; Harahap, Yahdiana
Pharmaceutical Sciences and Research Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Novichok is an organophosphate compound found as a nerve agent chemical weapon. However, the information about its chemical properties, biological activities, and molecular interactions in the body are still protected under the “top secret” security clearance. Novichok, with the codes A230, A232 and A234, is a compound whose structure has been successfully determined. The compound is synthesized from a precursor through a nucleophilic substitution reaction. Novichok agents are considered more potent than VX gas and can be applied in unitary and binary forms. This compound has ability for the binding with acetylcholinesterase (AChE) due to inability of acetylcholine metabolism. AChE catalyzes the rapid hydrolysis of acetylcholine to acetate and choline. The treatment of Novichok agent poisoning is similar to management of other nerve agents, such as atropine and pralidoxime administered intravenously. In this paper, we reviewed the Novichok component from chemical and biological perspective. Moreover, we discussed the potential molecular interaction and treatment of this compound.
CRISPR/Cas9 Genome Editing: Future Treatment of Duane Retraction Syndrome Zulfikar, Muhammad Raihan; Renesteen, Editha; Wardhani, Bantari W.K.
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Duane Retraction Syndrome (DRS) is characterized by limited eye movement. One of its causes is a mutation in the CHN1, MAFB, or SALL4 gene. Nowadays, the treatment for DRS is limited to glasses, occlusion, and surgery. However, this treatment has not been able to cure the disease’s hereditary issue. Another strategy to be considered for the treatment is CRISPR/Cas9, a tool for performing gene editing with a wide range of applications, including treating genetic diseases. We made sgRNA as a first step in using CRISPR/Cas9 as a treatment for DRS in silico using the CCTop website. By computing sgRNA, conducting tests, and analyzing the results, CRISPR/Cas9 may repair genetic mutations. Currently, there are no reports on the use of CRISPR/Cas9 in DRS. Hence, this study would be very useful as a starting point for using CRISPR/Cas9 as a DRS treatment. However, it needs to be further proven through in vivo, in vitro, and clinical trials study.
Encapsulation Properties of Red Chili Powder (Capsicum Annum L.) Using Gelatin As a Coating Agent Renate, Dharia; Rahmi, Silvi Leila; Maryani, Anis Tatik; Amelia, Tri Lola; Renesteen, Editha
Indonesian Food Science and Technology Journal Vol. 7 No. 2 (2024): Volume 7. Number 2, July 2024 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v7i2.35630

Abstract

Penguatan Program Promotif dan Preventif melalui Skrining Tekanan Darah, Gula Darah Sewaktu, dan Saturasi Oksigen Permana, Yandi; Wardhani, Bantari Wisynu Kusuma; Azhar, Muhammad; Khalisa, Andi Thafida; Renesteen, Editha; Subiyakto, Yuli
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 1 (2025): Volume 8 No 1 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i1.18311

Abstract

ABSTRAK Penyakit tidak menular seperti obesitas, hipertensi, dan diabetes mellitus menjadi masalah kesehatan utama di Indonesia, yang memerlukan deteksi dini dan intervensi tepat waktu. Kegiatan pengabdian masyarakat ini bertujuan untuk mendapatkan gambaran indeks massa tubuh (IMT), saturasi oksigen, tekanan darah, dan kadar gula darah sewaktu (GDS) di Desa C. Penelitian menggunakan metode deskriptif kuantitatif dengan melibatkan 50 responden. Pengukuran IMT, saturasi oksigen, tekanan darah sistolik dan diastolik, serta GDS dilakukan untuk mengidentifikasi risiko penyakit tidak menular. Hasil analisis menunjukkan bahwa 56% responden berada dalam kategori obesitas, 26% tergolong overweight, dan 18% memiliki IMT normal. Tekanan darah sistolik mencatat bahwa 30% responden berada diatas normal, sementara kadar GDS yang melebihi 200 mg/dL ditemukan pada 12% responden. Hasil ini mendorong adanya pemeriksaan lebih lanjut untuk menegakkan diagnosa dan intervensi melalui edukasi kesehatan serta pentingnya gaya hidup sehat.   Kata kunci: Pengabdian Masyarakat, Deteksi Dini, Indeks Masa Tubuh, Tekanan Gula Darah, Gula Darah Sewaktu. ABSTRACT Non-communicable diseases (NCDs) such as obesity, hypertension, and diabetes mellitus are major health issues in Indonesia, requiring early detection and timely intervention. This community service activity aims to provide an overview of body mass index (BMI), oxygen saturation, blood pressure, and random blood glucose (RBG) levels in C Village, Gunung Putri District. The study employed a descriptive quantitative method involving 50 respondents. Measurements of BMI, oxygen saturation, systolic and diastolic blood pressure, and RBG were conducted to identify the risk of non-communicable diseases. The analysis revealed that 56% of respondents were classified as obese, 26% were overweight, and 18% had normal BMI. Systolic blood pressure indicated that 30% of respondents had value above normal, while random blood glucose levels exceeding 200 mg/dL were found in 12% of respondents. These findings suggest the need for further examinations to confirm diagnosis and emphasize interventions through health education and the importance of a healthy lifestyle. Keywords: Community Service, Early Detection, Body Mass Index, Blood Pressure, Random Blood Glucose.
Co-Authors Amelia, Tri Lola Anis Tatik Maryani Dharia Renate Khalisa, Andi Thafida Muhammad Azhar Permana, Yandi Rahmania, Tesia Aisyah Silvi Leila Rahmi Subiyakto, Yuli Wardhani, Bantari W.K. Wardhani, Bantari Wisynu Kusuma Yahdiana Harahap Zulfikar, Muhammad Raihan