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All Journal Jurnal Kreativitas PKM Narra J Pharmaceutical Sciences and Research (PSR)
Permana, Yandi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Grasp of dihydroartemisinin resistance in Indonesia: Focused on genetic polymorphisms and new antimalarial Wardhani, Bantari WK.; Permana, Yandi
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.336

Abstract

The eastern region of Indonesia is endemic to malaria, a tropical parasitic infection that causes significant mortality. The Sustainable Development Goals (SDGs) encompass the global commitment to prevent and eliminate malaria by the end of 2030. Nevertheless, the biggest issue lies in the antimalarial drug resistance in Indonesia. Genetic polymorphism has been a considerable factor in the mechanism of antimalarial drug resistance of which could lead to inadequate activity of antimalarial drugs to undertake Plasmodium infection by several molecular mechanisms. Hence, first-line therapy for malaria in Indonesia such as dihydroartemisinin, piperaquine, and primaquine, becomes ineffective. However, the resistance is unavoidable. This review aims to summarize the genetic polymorphism possible mechanisms contributing to antimalarial resistance in the Indonesian population and to discuss the potential new antimalarial drug candidates.
Penguatan Program Promotif dan Preventif melalui Skrining Tekanan Darah, Gula Darah Sewaktu, dan Saturasi Oksigen Permana, Yandi; Wardhani, Bantari Wisynu Kusuma; Azhar, Muhammad; Khalisa, Andi Thafida; Renesteen, Editha; Subiyakto, Yuli
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 1 (2025): Volume 8 No 1 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i1.18311

Abstract

ABSTRAK Penyakit tidak menular seperti obesitas, hipertensi, dan diabetes mellitus menjadi masalah kesehatan utama di Indonesia, yang memerlukan deteksi dini dan intervensi tepat waktu. Kegiatan pengabdian masyarakat ini bertujuan untuk mendapatkan gambaran indeks massa tubuh (IMT), saturasi oksigen, tekanan darah, dan kadar gula darah sewaktu (GDS) di Desa C. Penelitian menggunakan metode deskriptif kuantitatif dengan melibatkan 50 responden. Pengukuran IMT, saturasi oksigen, tekanan darah sistolik dan diastolik, serta GDS dilakukan untuk mengidentifikasi risiko penyakit tidak menular. Hasil analisis menunjukkan bahwa 56% responden berada dalam kategori obesitas, 26% tergolong overweight, dan 18% memiliki IMT normal. Tekanan darah sistolik mencatat bahwa 30% responden berada diatas normal, sementara kadar GDS yang melebihi 200 mg/dL ditemukan pada 12% responden. Hasil ini mendorong adanya pemeriksaan lebih lanjut untuk menegakkan diagnosa dan intervensi melalui edukasi kesehatan serta pentingnya gaya hidup sehat.   Kata kunci: Pengabdian Masyarakat, Deteksi Dini, Indeks Masa Tubuh, Tekanan Gula Darah, Gula Darah Sewaktu. ABSTRACT Non-communicable diseases (NCDs) such as obesity, hypertension, and diabetes mellitus are major health issues in Indonesia, requiring early detection and timely intervention. This community service activity aims to provide an overview of body mass index (BMI), oxygen saturation, blood pressure, and random blood glucose (RBG) levels in C Village, Gunung Putri District. The study employed a descriptive quantitative method involving 50 respondents. Measurements of BMI, oxygen saturation, systolic and diastolic blood pressure, and RBG were conducted to identify the risk of non-communicable diseases. The analysis revealed that 56% of respondents were classified as obese, 26% were overweight, and 18% had normal BMI. Systolic blood pressure indicated that 30% of respondents had value above normal, while random blood glucose levels exceeding 200 mg/dL were found in 12% of respondents. These findings suggest the need for further examinations to confirm diagnosis and emphasize interventions through health education and the importance of a healthy lifestyle. Keywords: Community Service, Early Detection, Body Mass Index, Blood Pressure, Random Blood Glucose.
Optimization of External Disintegrating Materials in Wet Granulation Formulation of Ondansetron Tablets Permana, Yandi; Tuba, Syahrul; Riyadi, Taufik; Sugindro, Sugindro
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Inadequate management of chemotherapy-induced side effects, including nausea and vomiting, can impact the healing response of cancer patients. Ondansetron, a preferred medication for the treatment, is classified as a biopharmaceutic classification system (BCS) class II drug, which limits its bioavailability. To enhance its solubility, sodium starch glycolate (SSG) and pregelatinized starch (PG) are used as super disintegrants. This study investigates the impact of these super disintegrants on ondansetron dissolution and identifies the optimal formulation. Ondansetron tablets were prepared using the wet granulation method, with nine formulations varying in SSG and PG concentrations (0%, 1%, 3%, 5%, and 7%). The tablets underwent physical and chemical quality evaluations. The results indicate that ondansetron dissolution improved with SSG and PG at concentrations of 1% and 3% but decreased at higher concentrations (5% and 7%). Statistical analysis revealed significant differences in dissolution fraction parameters and efficiency across varying SSG and PG concentrations (p < 0.05). The optimal formulation for enhancing ondansetron dissolution was found to be with 3% PG, achieving a dissolution efficiency value of 79.88% + 0.11%.
Co-Authors Khalisa, Andi Thafida Muhammad Azhar Renesteen, Editha Riyadi, Taufik Subiyakto, Yuli Sugindro, Sugindro Syahrul Tuba Wardhani, Bantari Wisynu Kusuma Wardhani, Bantari WK.