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All Journal Research Journal of Life Science Journal of Pain, Vertigo and Headache
Rodhiyan Rakhmatiar
Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience

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 1 
Effect of Centella asiatica Extract on Locomotor Activity and Hsp60 Expression in Zebrafish models of Parkinsons Rodhiyan Rakhmatiar; Mulyohadi Ali; M. Dalhar
Research Journal of Life Science Vol 7, No 3 (2020)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2020.007.03.1

Abstract

Parkinson's disease characterized by a decrease in motor activity is a progressive neurodegenerative disorder caused by the degeneration of dopaminergic neurons. Centella asiatica is suspected of having a neuroprotectant effect and is not yet known how Centella asiatica role in the prevention of Parkinson's disease. The study was conducted to prove the effect of Centella asiatica extract on the expression of Hsp60 and locomotor activity zebrafish models of Parkinson's with rotenone exposure. The study was conducted using 25 zebrafish divided into various groups. Centella asiatica extract and rotenone exposure have given for 28 days, observed locomotor activity on days 0, 7, 14, 21 and 28. The expression of Hsp60 measured using immunohistochemical techniques. There is a significant difference between locomotor activity at various doses of Centella asiatica (p<0.05) with a very strong correlation (r=0.929; p<0.01) where the higher doses of Centella asiatica, the higher locomotor activity. Found a significant difference between the reduced expression of Hsp60 to various Centella asiatica dose group (p<0.05) but no correlation between the expression of Hsp60 with Centella asiatica dose groups and locomotor activity. Centella asiatica extract is able to increase locomotor activity and decrease the expression of Hsp60 in zebrafish models of Parkinson's.
STROKE AFTER ELECTRICAL INJURY : CASE REPORT Eko Arisetijono; Catur Ari Setianto; Sri Budi Rianawati; Masruroh Rahayu; Rodhiyan Rakhmatiar
Journal of Pain, Headache and Vertigo Vol. 1 No. 2 (2020): September
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.884 KB) | DOI: 10.21776/ub.jphv.2020.001.02.2

Abstract

Electrical injury ranging widely reported caused variety of clinical manifestations including brain. Cerebral infarction is one of the manifestation either after low or high voltage electrical injury. We report the case of 49 – year old male who suffered a household electrical injury (110 – 220 Volt) while he was installing the light bulb. He found unconsciousness with left hemiparesis and also central paresis of the left facial nerve (Cranial Nerve VII). The Head Computed Tomography Scan (CT scan) showed wide infarction at right hemisphere which the territory of right cerebral media artery which can be caused by electrical injury.     
DIABETIC NEUROPATHIC PAIN Reza Rachmantoko; Zamroni Afif; Dessika Rahmawati; Rodhiyan Rakhmatiar; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 2 No. 1 (2021): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.154 KB) | DOI: 10.21776/ub.jphv.2021.002.01.3

Abstract

Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain is one of the most common symptoms of diabetic neuropathic, but the pathophysiology mechanism of pain is not clearly known. The hyptosesis of toxicity of hyperglycemia on development of pain complication has been widely accepted globally, but there is other proposed hypothesis. Basic concept in management of painful diabetic neuropathic is exclusion of the other cause of painful peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use for alleviating pain. The first choice drug of therapy for alleviating pain are anticonvulsant, like pregabalin and gabapentin, and antidepressant, mainly that work on inhibiting serotonine and noradrenaline reuptake. In conclusion, the better understanding of painful diabetic neuropathic underlying mechanism can help to find a better management that improving the guideline quality in optimalizing pain control.
STROKE AFTER ELECTRICAL INJURY : CASE REPORT Eko Arisetijono; Catur Ari Setianto; Sri Budi Rianawati; Masruroh Rahayu; Rodhiyan Rakhmatiar
Journal of Pain, Headache and Vertigo Vol. 1 No. 2 (2020): September
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2020.001.02.2

Abstract

Electrical injury ranging widely reported caused variety of clinical manifestations including brain. Cerebral infarction is one of the manifestation either after low or high voltage electrical injury. We report the case of 49 – year old male who suffered a household electrical injury (110 – 220 Volt) while he was installing the light bulb. He found unconsciousness with left hemiparesis and also central paresis of the left facial nerve (Cranial Nerve VII). The Head Computed Tomography Scan (CT scan) showed wide infarction at right hemisphere which the territory of right cerebral media artery which can be caused by electrical injury.     
DIABETIC NEUROPATHIC PAIN Reza Rachmantoko; Zamroni Afif; Dessika Rahmawati; Rodhiyan Rakhmatiar; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 2 No. 1 (2021): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2021.002.01.3

Abstract

Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain is one of the most common symptoms of diabetic neuropathic, but the pathophysiology mechanism of pain is not clearly known. The hyptosesis of toxicity of hyperglycemia on development of pain complication has been widely accepted globally, but there is other proposed hypothesis. Basic concept in management of painful diabetic neuropathic is exclusion of the other cause of painful peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use for alleviating pain. The first choice drug of therapy for alleviating pain are anticonvulsant, like pregabalin and gabapentin, and antidepressant, mainly that work on inhibiting serotonine and noradrenaline reuptake. In conclusion, the better understanding of painful diabetic neuropathic underlying mechanism can help to find a better management that improving the guideline quality in optimalizing pain control.
Co-Authors Catur Ari Setianto Dessika Rahmawati Eko Arisetijono M. Dalhar Masruroh Rahayu Mulyohadi Ali Reza Rachmantoko Shahdevi Nandar Kurniawan, Shahdevi Nandar Sri Budi Rianawati Zamroni Afif