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All Journal Althea Medical Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Surya Medika Sumatera Medical Journal Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat Multidisiplin Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia Indonesian Journal of Medical Sciences and Public Health Medical Sains : Jurnal Ilmiah Kefarmasian International Journal of Civil Engineering and Infrastructure (IJCEI) Jurnal Indonesia Sosial Sains Journal of Innovative and Creativity Medical Sains : Jurnal Ilmiah Kefarmasian International Journal of Psychology and Health Science Indonesian Journal of Innovation Multidisipliner Research
Himmi Marsiati
Graduate School, Doctoral Program In Biomedical Sciences, YARSI University, Jakarta, Indonesia
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PENINGKATAN KESADARAN MASYARAKAT TERHADAP PRODUK HALAL DAN THAYYIB Himmi Marsiati; Anna P. Roswiem; Triayu Septiani; Dedy Suseno
Jurnal Pengabdian Masyarakat Multidisiplin Vol 6 No 1 (2022): Oktober
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jpm.v6i1.2655

Abstract

Halal products generally can be seen from the Halal Certificate and or Halal Label on the product packaging. However, halal products often are sold with products that have not been guaranteed to the Halal in one place of display such as in supermarkets or the market, so it can’t be known the halalness of the product. To know halal and thayyib products, knowledge of foodstuffs are classified as halal and thayyib is needed. The purpose of this Community Service (PKM) activity is to socialize and educate related halal and thayyib products, the ingredients used in the product manufacturing process, and the halal critical point of each ingredient and or product. This form of activity is in the form of education and socialization about halal and thayyib materials and or products that enter, circulate, and be traded in the territory of Indonesia. To see the success rate and satisfaction of participants in this PKM activity are done through pretest, posttest, and questionnaire. The result of this PKM is that the participants can understand that the products that enter, circulate, and are traded in the territory of Indonesia are syubhat, so they must be halal certified. In addition, the participants of the PKM program can know and or distinguish what ingredients or products are halal or haram, as well as which are thayyib and which are not thayyib.
Molecular Biomarkers in Pneumonia: Therapeutic Potential of Traditional Plant Medicine Tirsa Persila Awairaro; Diniwati Mukhtar; Dicky Budiman; Himmi Marsiati
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6671

Abstract

Pneumonia causes 2.56 million global deaths annually, with current therapies limited by antimicrobial resistance and adverse effects. Traditional medicinal plants offer multi-target potential through anti-inflammatory, antioxidant, and immunomodulatory mechanisms. This review synthesizes knowledge on molecular biomarkers in pneumonia pathogenesis and evaluates therapeutic potential of medicinal plants, particularly Coleus amboinicus. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science covering publications from January 2000 to June 2025. Inclusion criteria encompassed studies investigating molecular biomarkers, pneumonia therapeutic pathways, or medicinal plants with respiratory therapeutic properties. Narrative synthesis was employed due to study heterogeneity. Of 1,247 articles identified, 10 studies met inclusion criteria and were utilized in the analysis. Key inflammatory biomarkers included IL-6, TNF-α, and IL-1β, increasing from 5.05 mg/dL (controls) to 25.30 mg/dL in bacterial pneumonia. Neutrophil extracellular trap (NET) formation emerged as a central mechanism (47.36% of protein targets). Coleus amboinicus demonstrated 139 bioactive compounds with broad-spectrum antimicrobial activity and antioxidant properties (DPPH EC₅₀ 32.67-152.8 µg/mL). Traditional medicinal plants, particularly Coleus amboinicus, modulate key molecular pathways in pneumonia through sophisticated multi-target mechanisms, supporting integration of biomarker-guided approaches in contemporary respiratory care.
An Integrative Approach to Autophagy and Oxidative Stress Pathways for Clinical Prediction in Colorectal Cancer: A Narrative Review Welly Hartono Ruslim; Himmi Marsiati; Nunung Ainur Rahmah; Wifanto Saditya Jeo
International Journal of Psychology and Health Science Vol. 4 No. 3 (2026): International Journal of Psychology and Health Science (July - September 2026)
Publisher : Greenation Publisher & Yayasan Global Research National

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/ijphs.v4i3.2264

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Increasing evidence suggests that oxidative stress and autophagy are interconnected biological processes involved in tumor initiation, progression, therapeutic resistance, and patient survival. However, their combined role as an integrated prognostic biomarker panel has not been comprehensively reviewed. This narrative review aimed to summarize current evidence on the interaction between oxidative stress and autophagy pathways and to evaluate the clinical potential of their biomarkers for prognostic prediction in CRC. This review was based on peer-reviewed open access publications from major scientific databases between 2019 and 2025. Studies that have assessed oxidative stress biomarkers, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), nuclear factor erythroid 2-related factor 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1), and autophagy-related biomarkers, including microtubule-associated protein 1 light chain 3 beta (LC3B) and sequestosome 1 (p62/SQSTM1) were critically synthesized. Current evidence suggests a role for oxidative stress and autophagy dysregulation in the development of CRC. Increased expression of LC3B, p62/SQSTM1, NRF2, and 8-OHdG is always associated with advanced disease, treatment resistance, tumor recurrence, and poor overall survival. Integrating biomarkers from both pathways appears to improve prognostic accuracy compared with individual biomarkers. Combined assessment of oxidative stress and autophagy biomarkers represents a promising prognostic approach for CRC. Nevertheless, large prospective studies are required to validate their clinical utility before routine implementation in precision oncology.
Status Nutrisi Vitamin D, Regulasi Jalur Metabolik, dan Ekspresi Vitamin D Receptor terhadap Profil Sitokin serta Stres Oksidatif pada Ibu Hamil dengan Risiko Preeklampsia: Sebuah Tinjauan Sistematis dan Meta-Analisis Raden Roro Pratiwi Madya Putri; Himmi Marsiati; Dicky Budiman; Sri Wuryanti
Indonesian Journal of Innovation Multidisipliner Research Vol. 4 No. 3 (2026): Juli - September
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v4i3.1665

Abstract

Latar Belakang: Defisiensi Vitamin D merupakan masalah malnutrisi mikronutrien global pada ibu hamil yang berkaitan erat dengan tingginya risiko komplikasi multiorgan seperti preeklampsia. Intervensi preventif di fasilitas kesehatan primer sering kali mengabaikan aspek bioavailabilitas seluler, di mana kecukupan asupan pangan atau suplemen tidak selalu menjamin pemulihan status gizi akibat adanya faktor genetik (polimorfisme) yang membatasi penyerapan tubuh. Secara gizi-endokrinologi, gangguan regulasi jalur metabolik dan rendahnya ikatan reseptor memicu iskemia plasenta yang memanifestasikan peningkatan sitokin pro-inflamasi serta akumulasi stres oksidatif sistemik. Tujuan: Penelitian ini bertujuan untuk mengevaluasi korelasi status gizi Vitamin D, aktivitas regulasi metabolik, dan ekspresi Vitamin D Receptor terhadap profil sitokin serta marker stres oksidatif pada ibu hamil dengan risiko preeklampsia. Metode: Tinjauan sistematis dan meta-analisis ini dirancang secara terstruktur menggunakan metodologi Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Penjaringan artikel ilmiah difokuskan pada database PubMed, Scopus, dan Cochrane Library dengan objek studi berupa intervensi pangan kaya kalsiferol, paparan matahari, serta regimen suplemen. Validitas data diuji menggunakan instrumen Cochrane dan Skala Newcastle-Ottawa sebelum dianalisis secara statistik. Hasil: Hasil analisis menunjukkan bahwa asupan gizi pangan hewani (ikan berlemak, kuning telur) dan minuman fortifikasi yang dikombinasikan dengan paparan sinar matahari efektif menyediakan prekursor nutrisi. Prekursor tersebut harus dipecah melalui sistem regulasi metabolik tubuh menjadi bentuk aktif Vitamin D3 (kalsitriol) agar dapat diutilisasi oleh jaringan plasenta. Proses biokimia zat gizi ini terbukti meningkatkan ekspresi Vitamin D Receptor secara signifikan guna menekan transkripsi sitokin pro-inflamasi Tumor Necrosis Factor-Alpha dan Interleukin-6. Sebaliknya, ikatan kompleks reseptor tersebut mendorong peningkatan kadar sitokin anti-inflamasi Interleukin-10 di sirkulasi maternal. Aktivitas pemecahan Vitamin D3 aktif yang optimal juga terbukti menurunkan kadar malondialdehida selaku marker peroksidasi lipid. Pada saat yang sama, mekanisme seluler ini memicu upregulasi enzim antioksidan endogen superoksida dismutase untuk memitigasi disfungsi endotel. Analisis dosis mengonfirmasi bahwa regimen intervensi klinis 1.000 hingga 2.000 IU/hari serta dosis koreksi defisiensi hingga 4.000 IU/hari efektif mempercepat pencapaian status sufisiensi serum (>30 ng/mL). Hasil akhir klinis memperlihatkan perbaikan parameter vaskular pada ultrasonografi Doppler arteri uterina dan penurunan insidensi preeklampsia yang signifikan. Kesimpulan: Pemenuhan target nutrisi Vitamin D yang diimbangi kelancaran konversi bentuk aktif dan optimalnya fungsi ikatan Vitamin D Receptor efektif meregulasi homeostasis imunologis maternal. Ahli gizi dan klinisi disarankan untuk menyusun panduan terapi nutrisi terstandarisasi dengan mempertimbangkan variabilitas genetik penyerapan pasien. Pemantauan status metabolik mikronutrien ini sangat direkomendasikan sebagai algoritma preventif tambahan di faskes primer. Implikasi: Secara nyata, optimalisasi pemecahan bentuk aktif Vitamin D pada ibu hamil mampu melancarkan sirkulasi aliran darah dan transfer nutrisi uteroplasenta, mencegah komplikasi kejang eklampsia, serta menekan angka morbiditas multiorgan pasien.
UTILIZATION OF ARTIFICIAL AQUIFERS BY ADDING ZEOLITE AND CARBON TO IMPROVE WATER QUALITY Mohammad Imamuddin; budiman budiman; Himmi Marsiati; Firda Rachma Dewi; Nila Sekar Mahdiani
International Journal of Civil Engineering and Infrastructure Vol. 5 No. 1 (2025): IJCEI Volume 5 No. 1
Publisher : University Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/ijcei.5.1.13-22

Abstract

Water is the most important component of life. The function of water for living beings cannot be replaced by any other substance. One of the main issues currently faced regarding waterresources is the declining quality of water for both domestic and non-domestic purposes.According to the Regulation of the Minister of Health of the Republic of Indonesia No.492/Menkes/PER/IV/2010 concerning drinking water requirements, it states that safe andhealthy drinking water for consumption must meet requirements that include physical,chemical, and bacteriological criteria. Strict requirements are imposed on drinking waterbecause they are directly related to the biological processes of the body that determine humanquality of life. The consumption rate of drinking water is very high in tropical regions. This isdue to the high humidity, and people in tropical areas require a large amount of drinkingwater to quench their thirst. Therefore, high-quality drinking water is necessary to maintainhealth. The dangers or health risks resulting from the decline in the physical quality of watercan have negative impacts on health. The utilization of groundwater remains a mainstay forcommunities in meeting their domestic and non-domestic water needs. The increasingpopulation has led to a decline in the quality of clean water due to human activities that causeenvironmental pollution. Sources of groundwater pollution include industrial activities, wastedisposal sites, mining areas, residential areas, salt industries, agricultural activities, andlivestock farming.
Co-Authors Andrea Ivana Allicia Hutabarat Anna P. Roswiem Bistamy Muhammad Nursabur Budiman Budiman Carolin Aprilia Baslani Desi Ariyani Haddad Desi Aryani Dicky Budiman Dicky Budiman Dicky Budiman Diniwati Mukhtar Diniwati Mukhtar Edy Parwanto Firda Rachma Dewi Hadiati Fitri Hasna Luthfiah Inas Hasna Azizah Kamal Anas Karina A Ridwan Linda Weni Linda Weni Mohammad Imamuddin Muhammad Andre Niljon Munfaati Nila Sekar Mahdiani Nunung Ainur Rahmah Nunung Ainur Rahmah Putri Arifa Izzati Q Qomariyah Raden Roro Pratiwi Madya Putri Raden Roro Pratiwi Madya Putri Restu Syamsul Hadi Reza Aditya Digambiro Sabarina Elfrida Manik Sabarina Elfrida Manik Sri Hastuti Andayani Sri Wuryanti Suseno, Dedy Susi Endrini Switania Putri Puspita Tirsa Persila Awairaro Tri Panjiasih Susmiarsih Triayu Septiani Welly Hartono Ruslim Wening Sari Wifanto Saditya Jeo Yazid Zainur Isnen