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All Journal Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Community Health and Preventive Medicine (JOCHAPM)
Holipah Holipah
Department Of Public Health Faculty Of Medicine Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Validitas Estimasi Tinggi Badan berdasarkan Tinggi Lutut pada Lansia di Kota Malang (Validity of Height Estimation based on Knee Height in the Elderly in Malang) Nur Azkiyah, Wulan Sari; Handayani, Dian; -, Holipah
Indonesian Journal of Human Nutrition Vol 3, No 2 (2016)
Publisher : Jurusan Gizi, Fakultas Kedokteran, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.759 KB) | DOI: 10.21776/ub.ijhn.2016.003.02.5

Abstract

AbstrakPengukuran antropometri lansia pada dasarnya sama dengan usia lainnya, tetapi terkadang memerlukan cara yang berbeda untuk memberikan hasil yang lebih tepat karena perubahan fisiologi. WHO menekankan pentingnya persamaan yang tepat pada setiap negara dalam memprediksi tinggi badan lansia. Di Indonesia, beberapa studi mengenai persamaan tinggi lutut telah dilakukan, namun belum banyak dilakukan penerapannya untuk keakuratan pada suatu daerah. Analisis dari persamaan Chumlea I, Oktavianus, dan Fatmah kemungkinan akan menimbulkan hasil yang berbeda jika diterapkan di Kota Malang. Penelitian ini bertujuan untuk menganalisis validitas prediksi tinggi badan berdasarkan tinggi lutut menggunakan persamaan Chumlea I, Oktavianus, dan Fatmah serta merumuskan suatu model persamaan prediksi tinggi badan berdasarkan tinggi lutut pada lansia di Kota Malang. Penelitian cross sectional ini menggunakan 123 responden (69 laki-laki dan 54 perempuan) dengan usia 60-80 tahun yang dipilih dengan teknik purposive sampling. Kemudian peneliti melakukan perhitungan tinggi badan estimasi berdasarkan tinggi lutut menggunakan persamaan Chumlea I, Oktavianus, dan Fatmah. Hasil menunjukkan terdapat perbedaan antara rata-rata tinggi badan aktual dengan persamaan Chumlea I (p<0,05), Oktavianus (p<0,05), dan Fatmah (p<0,05), dengan korelasi yang sangat kuat (r>0,8). Ada perbedaan pada empat kelompok data, yaitu tinggi badan aktual, persamaan Chumlea I, Oktavianus, dan Fatmah pada laki-laki dan perempuan. Kesimpulan dari penelitian ini adalah ketiga persamaan tersebut cenderung bersifat overestimate. Dan persamaan baru yang dihasilkan dari penelitian ini tidak ada perbedaan rata-rata tinggi badan aktual dengan rata-rata estimasi tinggi badan menggunakan persamaan baru.Kata kunci: lansia, Persamaan Chumlea I,  Oktavianus,  Fatmah  AbstractAnthropometric measurement on elderly is principally the same as any other age measurements, but sometimes needs a different way to give more accurate results due to physiological changes. WHO emphasizes the importance of exact equation in each country in predicting the height of the elderly. In Indonesia, several studies on knee height equations have been conducted, but the accuracy of its application on a particular area has not been done much. The analysis of Chumlea I, Oktavianus, and Fatmah equations will likely lead to different results if applied in Malang. This study aimed to analyze the height predictive validity of knee height using the equations of Chumlea I, Oktavianus, and Fatmah and to formulate an equation model on height prediction based on knee height of the elderly in Malang. This cross-sectional study used 123 respondents (69 males and 54 females) aged 60-80 years old selected by purposive sampling. Then, the researchers conducted height estimation calculations based on knee height using Chumlea I, Oktavianus, and Fatmah equations. The results showed that there were differences between the average height of the actual equation of Chumlea I (p <0.05), Octavian (p <0.05), and Fatmah (p <0.05), with very strong correlations (r> 0.8). There were differences in the four groups of data, i.e. the actual height, equations of Chumlea I, Oktavianus, and Fatmah in men and women. This study concludes that those three equations tend to be overestimate. The new equation resulting from this study does not show differences in the actual average height and estimated average height.Keywords: elderly, Equation, Chumlea I, Oktavianus, Fatmah
Asupan Kolesterol dan Tekanan Darah pada WUS Hipertensi Suku Madura di Kota Malang (Cholesterol Intake and Blood Pressure in WRA’s Hypertension of Madurese Ethnic Group in Malang) Rahima, Dwira; Rahmawati, Widya; -, Holipah; Wirawan, Nia N.
Indonesian Journal of Human Nutrition Vol 3, No 2 (2016)
Publisher : Jurusan Gizi, Fakultas Kedokteran, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (437.356 KB) | DOI: 10.21776/ub.ijhn.2016.003.02.3

Abstract

AbstrakTekanan darah tinggi atau hipertensi diprediksikan akan meningkat sebesar 60% pada tahun 2025. Wanita Usia Subur (WUS) mempunyai risiko lebih tinggi mengalami hipertensi yang da-pat disebabkan oleh pola makan tinggi energi, protein dan lemak tetapi minim serat. Masyarakat Indonesia yang terdiri dari beragam suku mempunyai pola makan yang berbeda, salah satunya pada suku madura yang pola makannya tinggi sumber kolesterol dan rendah serat. Penelitian ini bertujuan untuk mengetahui hubungan asupan kolesterol dengan tekanan darah pada WUS. Penelitian ini menggunakan pendekatan cross sectional study dengan teknik pengambilan subjek menggunakan purpossive sampling (n=48). Hasil penelitian menunjukkan 93,8% asupan kolesterol sesuai dengan rekomendasi WHO yaitu ≤300 mg. Berdasarkan uji statistik, asupan kolesterol tidak berhubungan dengan tekanan darah responden (p=1,000).  Kesimpulan dari penelitian ini tidak menunjukkan adanya hubungan antara asupan kolesterol dengan tekanan darah pada WUS tekanan darah tinggi. Perlu dilakukan penelitian lanjutan mengenai hal serupa dengan jumlah responden yang lebih banyak dan jika memungkinkan dilakukan uji laborato-rium untuk mengetahui jangka waktu asupan kolesterol dapat meningkatkan kadar kolesterol darah.Kata kunci: asupan kolesterol, tekanan darah, WUS AbstractHigh blood pressure or hypertension is predicted to increase by 60% in 2025. Women of Reproductive Age (WRA) have a higher risk of hypertension caused by a diet of high energy, high protein, and high fat, but low in fiber. Indonesian is composed of various ethnics that have different diets, one of them is Madurese ethnic whose diets are high in cholesterol but low in fiber. This study aims to determine the relationship of cholesterol intake with blood pressure in WRA. This study used a cross sectional study and purposive sampling technique (n=48). The result showed 93.8% of cholesterol intake is in accordance with the WHO recommendation that is ≤300 mg. Based on statistic test, cholesterol intake was not related with  respondents blood pressure (p=1.000). This research concludes that there is no relationship between cholesterol intake and blood pressure in WRA with high blood pressure. Further research is needed on the same subjects with more of respondents and laboratory test, if possible, to find out the duration of cholesterol intake that can increase blood cholesterol level.Keywords: cholesterol intake, blood pressure, women of reproductive age
Differences in p53 Expression in High-Grade Conventional Osteosarcoma and Giant Cell Tumor of Bone Teguh Prihantoro; Eviana Norahmawati; Rose Khasana Dewi; Holipah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.680

Abstract

Background: Osteosarcoma is the most common primary tumor of bone. Generally, patients with osteosarcoma have a poor prognosis. So it is very important to be able to diagnose as early as possible. Histopathologically, osteosarcoma has a variety of types similar to non-malignant lesions, such as giant cell tumor of bone. Therefore, caution is needed in diagnosing because if it is misdiagnosed, it will result in different management. This study aims to look at differences in p53 protein expression in high-grade conventional osteosarcoma and giant cell tumor of bone. Methods: This observational analytic study used 30 samples from tissue biopsies/surgeries diagnosed with conventional high-grade osteosarcoma and 30 samples of giant cell tumor of bone at the Anatomical Pathology Installation of Dr. Saiful Anwar General Hospital Malang, Indonesia, between 2018-2022. p53 expression was examined using the immunohistochemical staining method. Positive if stained with brown on the nucleus of the cell, the percentage of 500 malignant cells was calculated in the large field of view of the objective lens (x40) randomly. Univariate and bivariate data analysis was performed using SPSS. Results: The average p53 protein expression in conventional high-grade osteosarcoma was 80.0% ± 26.2, with the lowest value being 19% and the highest value being 100%. Whereas in giant cell tumor of bone, the average p53 expression was 1.7% ± 4.3, with the lowest value being 0% and the highest value being 17.6%. Statistical analysis using the Mann-Whitney test showed that p53 expression in conventional high-grade osteosarcoma and giant cell tumor of bone showed a significant difference (p=0.000). Conclusion: There is a significant difference between p53 expression in high-grade conventional osteosarcoma and giant cell tumor of bone.
Differences in p53 Expression in High-Grade Conventional Osteosarcoma and Giant Cell Tumor of Bone Teguh Prihantoro; Eviana Norahmawati; Rose Khasana Dewi; Holipah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.680

Abstract

Background: Osteosarcoma is the most common primary tumor of bone. Generally, patients with osteosarcoma have a poor prognosis. So it is very important to be able to diagnose as early as possible. Histopathologically, osteosarcoma has a variety of types similar to non-malignant lesions, such as giant cell tumor of bone. Therefore, caution is needed in diagnosing because if it is misdiagnosed, it will result in different management. This study aims to look at differences in p53 protein expression in high-grade conventional osteosarcoma and giant cell tumor of bone. Methods: This observational analytic study used 30 samples from tissue biopsies/surgeries diagnosed with conventional high-grade osteosarcoma and 30 samples of giant cell tumor of bone at the Anatomical Pathology Installation of Dr. Saiful Anwar General Hospital Malang, Indonesia, between 2018-2022. p53 expression was examined using the immunohistochemical staining method. Positive if stained with brown on the nucleus of the cell, the percentage of 500 malignant cells was calculated in the large field of view of the objective lens (x40) randomly. Univariate and bivariate data analysis was performed using SPSS. Results: The average p53 protein expression in conventional high-grade osteosarcoma was 80.0% ± 26.2, with the lowest value being 19% and the highest value being 100%. Whereas in giant cell tumor of bone, the average p53 expression was 1.7% ± 4.3, with the lowest value being 0% and the highest value being 17.6%. Statistical analysis using the Mann-Whitney test showed that p53 expression in conventional high-grade osteosarcoma and giant cell tumor of bone showed a significant difference (p=0.000). Conclusion: There is a significant difference between p53 expression in high-grade conventional osteosarcoma and giant cell tumor of bone.
HUBUNGAN ANTARA EKSPRESI CYCLIN D1 DAN SMOOTH MUSCLE ACTIN DENGAN KARSINOMA SEL BASAL KELOMPOK RISIKO REKURENSI RENDAH DAN TINGGI Berlian Anggraeni Putri; Diah Prabawati Retnani; Hendy Setyo Yudhanto; Holipah; Rose Khasana Dewi; Hery Susilo
Majalah Kesehatan FKUB Vol. 9 No. 2 (2022): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2022.009.02.1

Abstract

Kanker kulit yang tersering dikelompokkan menjadi kanker kulit melanositik dan nonmelanositik. Kanker kulit nonmelanositik menempati urutan kelima terbanyak dari seluruh jenis kanker di dunia dengan jenis yang paling sering adalah karsinoma sel basal. Secara histopatologis karsinoma sel basal dibagi menjadi dua kelompok, yaitu kelompok risiko rekurensi rendah dan tinggi. Sifat Karsinoma sel basal yang proliferatif dan invasif membutuhkan marker yang dapat memprediksi keduanya, di antaranya adalah cyclin D1 dan smooth muscle actin (SMA). Penelitian ini untuk membuktikan adanya hubungan antara ekspresi cyclin D1 dengan karsinoma sel basal kelompok risiko rendah dan tinggi. Desain penelitian adalah observasional analitik dengan metode cross-sectional, sampel penelitian karsinoma sel basal ditetapkan sebanyak 30 sampel, terdiri dari 15 sampel kelompok risiko rekurensi rendah dan 15 sampel kelompok risiko rekurensi tinggi. Ekspresi cyclin D1 dan SMA pada sediaan imunohistokimia dinilai secara semi kuantitatif pada masing-masing kelompok kemudian akan dilakukan uji chi-square. Hasil penelitian ini menunjukkan bahwa ekspresi cyclin D1 memiliki hubungan dengan karsinoma sel basal kelompok risiko rekurensi rendah dan tinggi (p = 0,008 < 0,05), namun tidak berhubungan dengan ekspresi SMA (p = 0,389 > 0,05). Ekspresi cyclin D1 pada karsinoma sel basal kelompok risiko rendah memiliki skor yang lebih rendah dibandingkan dengan kelompok risiko rekurensi tinggi. Sementara pada SMA tidak didapatkan perbedaan yang bermakna. Kesimpulan penelitian ini, ekspresi cyclin D1 memiliki hubungan dengan karsinoma sel basal kelompok risiko rekurensi rendah dan tinggi, sedangkan SMA tidak berhubungan.  
THE EFFECT OF PROVIDING EDUCATIONAL VIDEOS TOWARDS KNOWLEDGE, ATTITUDE, AND BEHAVIOURS RELATED TO REPRODUCTIVE HEALTH, STIs, AND HIV/AIDS IN NON-MEDICAL COMMUNITIES Nik Ahmad Rashdan; Theakirana Firdaus; Asy Syifa Karima; Nur Nadia; Holipah Holipah
Journal of Community Health and Preventive Medicine Vol. 1 No. 2 (2021): JOCHAPM Vol. 1 No. 2 2021
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.015 KB) | DOI: 10.21776/ub.jochapm.2021.001.02.1

Abstract

Reproductive Health is important to prevent Sexually Transmitted Diseases (STDs). The previous study showed that the young people have a low knowledge, and low attitude and behavior regarding reproductive health especially for non-medical community. Video education is known as one of the effective health promotion media. This research aims to know the factor that influences knowledge and attitude towards reproductive health and improving their knowledge, attitude and behavior about reproductive health. This study used a pre-experimental method with a one-group pretest-posttest design. The population in this study infinite population. The population in the reproductive age around 20-30 who did not work in the medical field randomly chosen online. The data were analyzed by descriptive analysis and analytical statistics (Wilcoxon test). The knowledge of respondents towards the health of reproduction and diseases related has increased in the value of the average of pre-intervention as much as 64.48 to 84.43. Respondents' attitudes also improved from the value of 79.51 to 89.55 after watching the educational video. Educational video can increase knowledge related to the health of reproduction, STDs, and HIV/AIDS, and improve the attitude of the respondents to the diseases and screening before marriage.
Co-Authors Asy Syifa Karima Berlian Anggraeni Putri Dewi, Rose Khasana Dian Handayani Eviana Norahmawati Hendy Setyo Yudhanto Hery Susilo Nik Ahmad Rashdan Nur Azkiyah, Wulan Sari Nur Nadia Rahima, Dwira Retnani, Diah Prabawati Teguh Prihantoro Theakirana Firdaus Widya Rahmawati Wirawan, Nia N.