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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Medical Chemistry and Bioinformatics
Sri Suryo Adiyanti, Sri Suryo
Department of Clinical Pathology, Faculty of Medicine, University of Indonesia Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health

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Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen, and D-dimer in Coronavirus Disease 2019 Outcome Atmaja, Fredy Wirya; Adiyanti, Sri Suryo; Kristanty, Diyah; Dwira, Surya; Kusmardi, Kusmardi
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 3, No. 1
Publisher : UI Scholars Hub

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COVID-19, caused by SARS-CoV-2 has been reported to be associated with coagulopathy and DIC. This study aimed to investigate the profiles and differences of PT, APTT, fibrinogen, and D-dimer in COVID- 19 outcome. This retrospective cohort was conducted at Central Laboratory Clinical Pathology Department of dr. Cipto Mangunkusumo Hospital from July – December 2020. Demographic, clinical, and laboratory data were extracted from EHR and compared between poor and good outcome. Ninety-seven subjects were confirmed positive COVID-19, 45 of whom (46.4%) were in poor outcome group, while 52 subjects (53.6%) were in good outcome group. Median of PT 11.0” (9.7-28.3), APTT 38.4” (23.9-121), fibrinogen 484.8 mg/dL (51.2-940.9), and D-dimer 1,800 µg/L (190-35,200). Longer PT, APTT, and higher D-dimer (p < 0.05), while lower fibrinogen (p > 0.05) was found in poor outcome group. There were significant differences of PT, APTT and D-dimer in COVID-19 outcome.
Sindrom Raynaud: Laporan Kasus Sary, Sanny Kusuma; Adiyanti, Sri Suryo
Majalah Kedokteran Indonesia Vol 74 No 1 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.1-2024-554

Abstract

Introduction: Raynaud’s phenomenon is a condition characterized by sudden discoloration of the skin on the fingers caused by vasospasm. It can occur either as a primary condition or secondary to other diseases, such as Sjogren’s syndrome. Laboratory tests play an essential role in diagnosing and treating Raynaud’s syndrome. Case Report: A 38-year-old woman with clinical Raynaud’s syndrome underwent Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) examinations, which resulted in prolonged values. The patient complained of pain and a black wound on the tips of the 2nd and 3rd fingers of the left hand. The patient was checked for PT, APTT, lupus anticoagulant (LA), antinuclear antibody (ANA), anticardiolipin antibody (ACA) IgG and IgM, Beta 2 GP IgG and IgM, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and ANA profile with fluctuating PT and APTT results, weak positive LA, indeterminate ACA IgG, fast ESR, increased CRP, ANA profile (++) Ro-52 recombinant.Discussion: Raynaud’s syndrome is a group of symptoms caused by vasospasm and is often associated with autoimmune diseases. The patient presented with typical complaints of Raynaud’s phenomenon and laboratory results of the ANA profile that support a diagnosis of Sjogren’s syndrome. Fluctuations in PT and APTT may be due to intravenous heparin therapy, warfarin, inflammatory conditions, or antiphospholipid antibodies.Conclusion: ANA profile results in patients corresponding to Sjogren’s syndrome, which underlies Raynaud’s syndrome. It is advisable to check mixing studies, liver synthesis function, and antiphospholipid antibodies with an interval of 12 weeks to look for other causes of prolonged PT and APTT.
Co-Authors Atmaja, Fredy Wirya Dwira, Surya Giantini, Astuti Indrasari, Nuri Dyah Kristanty, Diyah Kusmardi Kusmardi Nafisah Nafisah Nurhardini, Tammy Rustadi Sosrosumihardjo Sary, Sanny Kusuma Yudhistira Yudhistira Yusra, Yusra