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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya International Journal of Islamic Education, Research and Multiculturalism (IJIERM)
Livia Virgoh
Universitas Prima Indonesia
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Medicine & Pharmacology Neuroscience Public Health Other

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UJI TOKSISITAS AKUT EKSTRAK KUNYIT PUTIH TERHADAP KADAR GULA DARAH DAN KOLESTEROL Fiska Maya Wardhani; Gabriella Fransisca Ong; Livia Virgoh; Adhayani Lubis; Marah Halim Nasution
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.19028

Abstract

Kunyit putih memiliki kandungan zat utama kurkumin yang  mengandung diferuloylmethan sebagai antioksidan alami. Kurkumin memiliki manfaat sebagai antiinflamasi, antikanker, antifungal, antidiabetes dan antikolesterol. Kunyit putih banyak dibudidayakan di daerah Jawa, khususnya di Jawa Barat, Jawa Timur, terutama di hutan jati Jawa Tengah karena  obat tradisional dipercaya warga setempat mempunyai efek samping yang ringan daripada  obat modern, tetapi belum banyak penelitian mengenai toksisitas dan dosis aman dari kunyit putih. Tujuan penelitian ini untuk mengetahui dosis toksisitas akut  ekstrak kunyit putih (Curcuma zedoaria) terhadap kadar gula darah dan kolesterol. Penelitian eksperimental ini melibatkan 6 kelompok tikus dengan perlakuan yang berbeda, 2 kelompok kontrol yaitu : kelompok normal dan kelompok NaCMC 1%, dan 4 kelompok perlakuan dengan dosis 250 mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000 mg/KgBB. Kadar gula darah dan kolesterol diukur dengan spektrofotometri, setelah tikus diberi perlakuan selama 14 hari. Berdasarkan hasil uji yang telah dilakukan, dosis paling efektif untuk menurunkan kadar gula darah adalah 500mg/kgBB. Berdasarkan uji One Way Anova terdapat perbedaan KGD yang signifikan antara Kelompok Normal dan Na CMC 1% dengan EKP250, EKP500, EKP750, dan EKP2000 serta tidak terdapat perbedaan kolestrol yang signifikan antara Kelompok Normal dan Na CMC 1% dengan EKP250, EKP500, EKP750, dan EKP2000. 
Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin Livia Virgoh; Tan Suyono; Linda Chiuman; Lia Nurlaela; Michaela Kosasih; Clarissa lister
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024): International Journal of Islamic Education, Research and Multiculturalism (IJIERM
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.430

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage.
Co-Authors Adhayani Lubis Clarissa Lister Fiska Maya Wardhani Gabriella Fransisca Ong Lia Nurlaela Linda Chiuman Marah Halim Nasution Michaela Kosasih Tan Suyono