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All Journal Indonesian Journal of Cancer Sumatera Medical Journal SCRIPTA SCORE Scientific Medical Journal Narra J
RIZA RIVANY, RIZA
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Korelasi Hypoxia Inducible Factor- 1A (HIF-1A) dan Vascular Endothelial Growth Factor (VEGF) Dengan Hasil Operasi pada Kanker Ovarium Jenis Epitel RIVANY, RIZA
Indonesian Journal of Cancer Vol 8, No 3 (2014): Jul - Sep 2014
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.257 KB)

Abstract

Hypoxia inducible factor 1α (HIF-1α) regulates gene involved inresponse to hypoxia and promotes angiogenesis. HIF-1α is atranscriptional factor to induce vascular endothelial growth factor(VEGF). The objective of this study was to examine the correlation ofHIF-1α and VEGF expression with surgical outcome in epithelialovarian cancer, therefore could predict optimality of debulking inovarian cancer.Thirty patients with epithelial ovarian cancer who underwent primarysurgery were included in this study. Tumor tissues were obtainedfrom surgery and examined with q reverse transcriptase polymerasechain reaction (qRT-PCR) for HIF-1α and VEGF expression analysis.Evaluation of surgical outcome was based on volume of residualtumor. Correlation between HIF-1α and VEGF was analyzed by usingSpearman correlation test while the correlation between HIF-1α andVEGF and surgical outcome was analyzed by ANOVA.Results: The mean age of the study subjects was 47.53±10.41 years.Eleven patients (36.7%) were diagnosed with stage I ovarian cancer,9 patients (30%) with stage II, 8 patients (26.7%) stage III and 2patients (6.7%) with stage IV. Out of 30 patients, 22 patients (73.3%)successfully underwent optimal debulking and 8 patients (26.7%)with suboptimal debulking. There was a correlation between HIF-1αand VEGF expression (r=0.582) but no correlation between HIF-1αand VEGF expression with surgical outcome in patients withepithelial ovarian cancer.Conclusion: There was a significant correlation between HIF-1α andVEGF expression but no significant correlation between HIF-1α andVEGF expression with surgical outcomes.
IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies Rusda, Muhammad; Rivany, Riza; Hasibuan, Citra Lestari; Lutan, Delfi; Aldiansyah, Dudy; Adella, Cut Adeya
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.865 KB) | DOI: 10.32734/sumej.v2i1.719

Abstract

To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.
Cervical Cancer Risk Factors at Haji Adam Malik General Hospital Medan 2016-2018 Fikar Siregar, Muhammad Khairi Akbar; Rivany, Riza
Sumatera Medical Journal Vol. 4 No. 1 (2021): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v4i1.3305

Abstract

The incidence of cervical cancer is still quite high. It is never separated from the risk factors that influence it. Some of them are sexually active, relatively young marital age, have high parity, use of contraception, and smoking can increase a woman's potential for cervical cancer. The aim of this study was to determine the characteristics of patients about the risk factors for cervical cancer in Haji Adam Malik General Hospital, Medan in 2016-2018. This research method uses descriptive observational design with cross sectional using medical record data. The results of this study using consecutive sampling techniques, took 100 samples and obtained several characteristics are age of patients, age of marriage, marriage history, number of parities, use of contraception, and smoking history. From this study it can be concluded that the characteristics of the incidence of cervical cancer in the General Hospital of Haji Adam Malik Medan in 2016-2018 are 50-59 years old, marital age ≤ 20 years old, married once, multigravida, uses injection type of hormonal contraception , and not smoking .
Comparison of leptin and estrone levels between normal body mass index and obese menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Sari, Rizka A.; Adella, Cut A.; Prabudi, Muhammad O.; Barus, Melvin NG.; Rivany, Riza; Tobing, Immanuel DL.; Azmeila, Selly
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.745

Abstract

Postmenopausal women often experience hormonal changes and shifts in fat composition, affecting weight gain and obesity. Understanding the link between hormones, especially estrogen and leptin, is key to managing weight and lowering disease risk in menopausal women. The aim of this study was to compare the levels of leptin and estrone in menopausal women with normal weight and obesity. A cross-sectional study was conducted on menopausal women, either normal body mass index (BMI) or obese, at H. Adam Malik General Hospital, Medan, Indonesia. Blood samples were collected to measure leptin and estrone levels using the enzyme-linked immunosorbent assay (ELISA) method. The differences in leptin levels between groups were analyzed using the Wilcoxon test, while the correlation between BMI and leptin was examined using the Pearson correlation test. The disparity in estrone levels in both groups was analyzed using the Mann-Whitney test and the correlations between variables were assessed using the Spearman or Pearson correlation tests as appropriate. The mean leptin levels in normal BMI and obesity groups were 17.73±4.96 and 25.46±12.95 ng/mL, respectively, and were statistically different (p=0.006). The mean estrone levels in menopausal women with normal BMI and obesity were 943.23±391.79 and 851.38±282.23 ng/mol, respectively and were not statistically different (p=0.564). A significant positive correlation was found between BMI and leptin level (r=0.59; p<0.001), while  BMI and estrone were not significantly correlated (r=0.083; p=0.559). In conclusion, leptin level was significantly different between BMI groups and had a strong positive correlation with BMI. This finding could be an important insight in body weight management and disease risk prevention in menopausal women.
Gambaran Pengetahuan Ibu Hamil Tentang Hiperemesis Gravidarum pada Trimester I Kehamilan Marpaung, Ayesha Nazira; Rivany, Riza; Tobing, Tina Christina L.; Ketaren, Andre Pasha
SCRIPTA SCORE Scientific Medical Journal Vol. 5 No. 2 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v5i2.14896

Abstract

Background: Nausea and vomit are problems that often occur in the first trimester of pregnancy, and this can cause problems for pregnant women. Many people still have the perception that this is a normal occurrence, leading pregnant women to avoid medical examinations, resulting in potential side effects. This relates to the knowledge. Pregnant women with poor knowledge can lead to complications during pregnancy, while those with good knowledge will prevent complications. Objective: To describe pregnant women’s knowledge about hyperemesis gravidarum in the first trimester of pregnancy based on age, gravida, and academic. Methods: This research is an observational descriptive study with a cross-sectional research design, employing consecutive sampling method. Data were collected using primary data sources derived from questionnaire responses. Results: Based on data from 100 respondents, 28 people (28%) have good knowledge. 27 people (27%) have moderate knowledge. 45 people (45%) have poor knowledge. Conclusion: Most of pregnant women in this research belonged to the age group of 19-34 years, with primigravida and majority have poor knowledge. Keyword: Hyperemesis gravidarum, knowledge, pregnant women   Latar Belakang: Mual dan muntah merupakan masalah yang sering terjadi pada trimester pertama kehamilan dan hal ini dapat menimbulkan masalah pada ibu hamil. Masih banyak masyarakat yang memiliki pandangan bahwa hal tersebut normal terjadi, sehingga ibu hamil tidak melakukan pemeriksaan dan akan menimbulkan efek samping. Hal ini berkaitan dengan pengetahuan yang dimiliki oleh ibu hamil. Ibu hamil yang memiliki pengetahuan yang kurang terhadap hiperemesis gravidarum menyebabkan terjadinya komplikasi pada ibu hamil, sedangkan ibu hamil dengan pengetahuan yang baik akan mencegah terjadinya komplikasi. Tujuan: Untuk mengetahui tingkat pengetahuan ibu hamil terhadap hiperemesis gravidarum pada trimester I kehamilan berdasarkan usia, pendidikan terakhir dan gravida. Metode: Penelitian ini adalah penelitian deskriptif observasional dengan desain penelitian cross sectional. Pengambilan sampel dengan consecutive sampling. Data yang diambil menggunakan sumber data primer yang berasal dari pengisian kuesioner. Hasil: Berdasarkan data yang diperoleh dari 100 responden terdapat 28 orang (28%) memiliki pengetahuan baik. 27 orang (27%) memiliki pengetahuan cukup. 45 orang (45%) memiliki pengetahuan kurang. Kesimpulan: Mayoritas ibu hamil pada penelitian ini merupakan kelompok usia 19-34 tahun, dengan primigravida, dan mayoritas memiliki pengetahuan yang kurang. Kata Kunci: Hiperemesis gravidarum, ibu hamil, pengetahuan
Review Article: Characteristics of Ovarian Cancer Across Age, Epithelial Histopathology, and Stages Laksmi, Subhika; Rivany, Riza; Edianto, Deri; Rifsal Siregar, Denny
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.5651

Abstract

Background: Ovarian cancer is a disease that has a high mortality rate, it has 185 thousand deaths in 2018. In Indonesia, it is estimated that there are 100 cancer patients per 100 thousand people. Ovarian cancer is a malignancy with no specific symptoms, as a result advanced stage is commonly found at diagnosis and there is no effective screening test to date. However, genetic factors have been found to play a role in this disease. Aims: The aim of this study is to find out the characteristics of ovarian cancer patients. Methods: This research uses a review article research design, with a narrative type. Data collection was taken from a collection of journals sourced from Pubmed and met the inclusion and exclusion criteria set by the author and then summarized. Six journals that included the characteristics of  ovarian cancer patients are included in this review article. Results: According to the six journals, the mean age is 54 years old, the most stage found is stage 3, and the most epithelial histopathology found is serous. Conclusion: According to the six journals that were reviewed, the characteristics of ovarian cancer patients based on age, stage, and epithelial histopathology were found to be consistent with the theory that has been established.
Co-Authors Adella, Cut A. Aldiansyah, Dudy Azmeila, Selly Barus, Melvin NG. CUT ADEYA ADELLA, CUT ADEYA Delfi Lutan Deri Edianto Fikar Siregar, Muhammad Khairi Akbar Hasibuan, Citra Lestari Ketaren, Andre Pasha Laksmi, Subhika Marpaung, Ayesha Nazira Prabudi, Muhammad O. Rifsal Siregar, Denny Rusda, Muhammad Sari, Rizka A. Siregar, Muhammad FG. Terauchi, Masakazu Tina Christina L. Tobing, Tina Christina L. Tobing, Immanuel DL.