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Prabudi, Muhammad O.
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women Siregar, M. Fidel G.; Jabbar, Feisal; Effendi, Iman H.; Alhair, Tanzil; Prabudi, Muhammad O.; Faradina, Dwi
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.452

Abstract

Osteoporosis is a common condition associated with an increased risk of bone fractures due to fragility. Bone mineral density (BMD) is lower in menopausal women due to estrogen deficiency, age-related decline in osteoblast function, decreased calcium absorption, and reduced synthesis of vitamin D, which lead to osteoporosis. The aim of this study was to determine the correlation between serum vitamin D levels and BMD assessed using radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. A cross-sectional study was conducted at Prof. Dr. Chairuddin P. Lubis Hospital of Universitas Sumatera Utara, Medan, Indonesia, from May 2023 to August 2023. Consecutive sampling method was employed to sample menopausal women with no history of hysterectomy or oophorectomy (unilateral or bilateral), and no history of hormone replacement therapy or vitamin D supplementation. Interviews and physical examinations were conducted to obtain the characteristics of the subjects (age, duration of menopause, and body mass index). The 25(OH)D level was measured using immunoassay and REMS examination was conducted to assess BMD. The Spearman correlation test was used to assess the correlation between serum vitamin D levels and BMD. A total of 32 menopausal women were included in this study with the average vitamin D level was 18.05±5.81 ng/mL, and the mean BMD level was -2.13±1.23. The data showed a significant positive correlation between serum vitamin D levels and BMD in menopausal women (r=0.710; p=0.020). This study highlights that REMS could be useful as an alternative to dual-energy x-ray absorptiometry (DXA) to assess DMD in postmenopausal women.
Comparison of leptin and estrone levels between normal body mass index and obese menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Sari, Rizka A.; Adella, Cut A.; Prabudi, Muhammad O.; Barus, Melvin NG.; Rivany, Riza; Tobing, Immanuel DL.; Azmeila, Selly
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.745

Abstract

Postmenopausal women often experience hormonal changes and shifts in fat composition, affecting weight gain and obesity. Understanding the link between hormones, especially estrogen and leptin, is key to managing weight and lowering disease risk in menopausal women. The aim of this study was to compare the levels of leptin and estrone in menopausal women with normal weight and obesity. A cross-sectional study was conducted on menopausal women, either normal body mass index (BMI) or obese, at H. Adam Malik General Hospital, Medan, Indonesia. Blood samples were collected to measure leptin and estrone levels using the enzyme-linked immunosorbent assay (ELISA) method. The differences in leptin levels between groups were analyzed using the Wilcoxon test, while the correlation between BMI and leptin was examined using the Pearson correlation test. The disparity in estrone levels in both groups was analyzed using the Mann-Whitney test and the correlations between variables were assessed using the Spearman or Pearson correlation tests as appropriate. The mean leptin levels in normal BMI and obesity groups were 17.73±4.96 and 25.46±12.95 ng/mL, respectively, and were statistically different (p=0.006). The mean estrone levels in menopausal women with normal BMI and obesity were 943.23±391.79 and 851.38±282.23 ng/mol, respectively and were not statistically different (p=0.564). A significant positive correlation was found between BMI and leptin level (r=0.59; p<0.001), while  BMI and estrone were not significantly correlated (r=0.083; p=0.559). In conclusion, leptin level was significantly different between BMI groups and had a strong positive correlation with BMI. This finding could be an important insight in body weight management and disease risk prevention in menopausal women.
Role of serum estradiol and C-telopeptide on musculoskeletal pain in menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Lumbantobing, Jonathan T.; Pasaribu, Hotma P.; Prabudi, Muhammad O.; Ardiansyah, Edy; Effendi, Iman H.; Tobing, Immanuel DL.; Azmeila, Selly; Nabila, Nabila
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.747

Abstract

Musculoskeletal pain is one of the common symptoms of menopause syndrome throughout the world. Estradiol is the most potent and abundant derivative of estrogen and is associated with musculoskeletal pain, stiffness, and depressed mood during the menopausal transition. C-telopeptide is a molecule released during osteoclastic bone resorption and degradation of type I collagen, which is reported to have higher levels in individuals with musculoskeletal pain. An observational analytical study with a cross-sectional design was used in this research. Estradiol and C-telopeptide levels were measured in this study using enzyme-linked immunosorbent assay (ELISA). Musculoskeletal pain was assessed using the Nordic Musculoskeletal Questionnaire (NMQ) and the Menopause Quality of Life Questionnaire (MENQOL). Musculoskeletal pain was determined if the participant answered “yes” on questions number 12, 14 and 25 on the MENQOL. Data analysis was performed using the independent Student t-test for normally distributed data and the Mann-Whitney test for non-normally distributed data. A correlation test was performed using the Pearson correlation test for normally distributed data and the Spearman correlation test for non-normally distributed data. The results showed a non-significant relationship between estradiol and C-telopeptide levels with musculoskeletal pain assessed using the NMQ or MENQOL questionnaires. The correlation test also showed no correlation between estradiol and C-telopeptide levels in women with and without musculoskeletal pain.
Effects of vitamin D supplementation on salivary cortisol and psychological health among postmenopausal women: A pilot quasi-experimental study Syahdema, Muhammad F.; Siregar, Muhammad FG.; Nasution, Hiro HD.; Prabudi, Muhammad O.; Marpaung, Johny; Sukatendel, Khairani
Narra X Vol. 3 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i2.224

Abstract

Menopause is a significant life transition often accompanied by mood disturbances, many of which are linked to cortisol levels and hypothalamic–pituitary–adrenal (HPA) axis dysregulation. Vitamin D deficiency is highly prevalent in postmenopausal women and shares overlapping adverse outcomes with menopausal symptoms. This study aimed to investigate the effect of vitamin D supplementation on salivary cortisol levels and psychological symptoms in postmenopausal women. This pilot study employed a quasi-experimental design, recruiting 32 postmenopausal women via consecutive sampling from the study population in Kwala Bekala Village, Medan Johor District. Participants were consecutively added into two groups, receiving either 1000 IU or 2000 IU of vitamin D daily for one month. Salivary cortisol levels and Depression, Anxiety, and Stress Scale (DASS) scores were measured before and after the intervention.  The findings revealed that serum 25(OH)D levels increased significantly in both groups, with higher post-supplementation levels in the 2000 IU group than in the 1000 IU group (28.94±5.86 ng/mL vs 24.13±5.28 ng/mL, p=0.021). Salivary cortisol decreased in both groups, with a greater reduction observed in the 2000 IU group (median Δ=9.55 ng/mL vs mean Δ=4.92±4.29 ng/mL, p=0.032). Psychological symptoms measured by DASS scores also improved significantly, with the 2000 IU group showing a larger reduction (mean Δ=11.31±6.65 vs median Δ=3.5, p=0.022). Vitamin D supplementation at both 1000 IU and 2000 IU effectively reduced salivary cortisol and improved psychological symptoms in postmenopausal women. Due to differences in baseline characteristics, caution is warranted when inferring clear dose superiority.
Co-Authors Adella, Cut A. Alhair, Tanzil Ardiansyah, Edy Azmeila, Selly Barus, Melvin NG. Dwi Faradina Effendi, Iman H. Jabbar, Feisal Lumbantobing, Jonathan T. Marpaung, Johny Nabila, Nabila Nasution, Hiro HD. Pasaribu, Hotma P. RIZA RIVANY, RIZA Sari, Rizka A. Siregar, M. Fidel G. Siregar, Muhammad FG. Sukatendel, Khairani Syahdema, Muhammad F. Terauchi, Masakazu Tobing, Immanuel DL.