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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Mulawarman Pharmascience Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Tjitjik Srie Tjahjandarie

Department Of Chemistry, Faculty Of Science And Technology, Airlangga University, Jl. Mulyorejo Kampus C UNAIR Surabaya

Author-ID : 552912

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides Aldin, Muhammad Fajar; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 1 (2019)
Publisher : Sam Ratulangi University

AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides Â Muhammad Fajar Aldin1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabayamulyadi-t@fst.unair.ac.idÂ ABSTRACTÂ Â Â Â Â Â Â Â Â Â Â Macaranga aleuritoides is one of species belongs to Euphorbiaceae family. Macapruinosin A (1) is one stilben derivatives with an irregular sesuiterpenyl side chain was isolated from the leaves of Macaranga aleuritoides. The structure of the isolated compound were determined by spectroscopic methods, including UV, IR, 1D and 2D NMR. The anticancer activity of macapruinosin A towards murin P-388 cells showed IC50 value of 1.65 Î¼g/mL and showed high activity.Keywords : Macaranga aleuritoides, macapruinosin A, stilbenoid, anticancer.Â ABSTRAKÂ Â Â Â Â Â Â Â Â Â Â Macaranga aleuritoides merupakan salah satu spesies tumbuhan dari famili Euphorbiaceae. Makapruinosin A, senyawa turunan stilben dengan rantai samping seskuiterpen tak teratur telah diisolasi dari daun M. aleuritoides Struktur senyawa tersebut ditetapkan berdasarkan analisis spektroskopi,meliputi UV, IR, 1D dan 2D NMR. Uji aktivitas antikanker senyawa makapruinosin A terhadap sel murin P-388 memperlihatkan nilai IC50 sebesar 1,65 Î¼g/mL dan dikategorikan sangat aktif.Â Kata kunci : Macaranga aleuritoides, makapruinosin A, stilbenoid, antikanker.Â Â Â Â Â

DUA ISOMER SENYAWA FLAVONOID DARI BATANG Sesbania grandiflora Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Putri, Nathasa Aquila; Dewi, Bella Kurniawati; Tanjung, Mulyadi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 1 (2020)
Publisher : Sam Ratulangi University

ABSTRACTTwo isomer flavonoids, 7,4Â´-dihydroxyflavanon (1) and 7,4Â´-dihydroxyisoflavanon (2) were isolatedfrom the bark of Sesbania grandiflora L. Their structures were determined based on spectroscopicdata such as UV, IR, MS, 1D and 2D NMR.Keywords : Sesbania grandiflora L., flavonoid, 7,4Â´-dihydroxyflavanon, 7,4Â´-dihydroxyisoflavanonABSTRAKDua isomer senyawa flavonoid, 7,4Â´-dihidroksiflavanon (1) dan 7,4Â´-dihidroksiisoflavanon(2) telah berhasil dipisahkan dari batang Sesbania grandiflora L. Kedua struktur senyawaisomer ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR.Kata kunci : Sesbania grandiflora L., flavonoid, 7,4Â´-dihidroksiflavanon, 7,4Â´-dihidroksiisoflavanon

Method Validation of Chloramphenicol Analysis in the Shrimp Based on Diazotization Reaction Abdul Wafi; Ganden Supriyanto; Tjitjik Srie Tjahjandarie
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.26520

A simple, rapid and precise spectrophotometric method has been developed and validated for the determination of Chloramphenicol (CAP) in the shrimp based on diazotization reaction at room temperature. The CAP was reduced by zinc powder and the diazotization reaction was carried out in the presence of NaNO2, bismuth nitrate pentahydrate as catalyst. The 2-napthol used as coupling agent to form a red-violet solution and the absorbance of azo dye solution was measured by UV-Vis spectrophotometer at 554 nm. The method validation parameters including linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) have been investigated. The correlation coefficient (R2) was 0.996 for concentration range 0.70 – 4.65 µg/mL. The LOD and LOQ were 0.36 µg/mL and 1.19 µg/mL. Accuracy and precision of the method were performed by spiking of CAP in the shrimp sample at concentration 1.16; 2.33; 3.49 µg/mL. Analysis result showed that the accuracy and precision of the method were 92.77-97.37 % and 0.21-2.39 % respectively.Keywords : Chloramphenicol, diazotization, shrimp, spectrophotometry, method validation.

AKTIVITAS ANTIOKSIDAN SENYAWA FLAVONOID DARI Macaranga pearsonii Merr. Eva Marliana; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
JURNAL KIMIA MULAWARMAN Vol 13 No 2 (2016)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tiga senyawa flavanon , 4’-O-metil-8-isoprenileriodiktiol (1), 4’-O-metil-8-isoprenilnaringenin (2) and Lonkokarpol A (3) , telah diisolasi dari ekstrak metanol daun Macaranga pearsonii Merr. Elusidasi struktur senyawa berdasarkan data spektroskopi UV, 1D and 2D NMR, and HREISMS. Senyawa 1 – 3 ditentukan aktivitas antioksidannya terhadap peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH), dengan nilai IC50 adalah 536,89 μM, 1226,11 μM dan 426,43 μM.

Flavanon Novi Fatmawati; Novi Anggreini; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
JURNAL KIMIA MULAWARMAN Vol 16 No 1 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v16i1.586

Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.

Aktivitas Antimalaria Senyawa Flavanon Terisoprenilasi Dari Kulit Batang Erythrina fusca L Novi Fatmawati; Novi Anggreini; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Pharmascience Vol 5, No 1 (2018): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i1.5786

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial

ISOLASI SENYAWA ALKALOID TURUNAN FUROKUINOLIN DARI RANTING Toddalia asiatica L. DAN UJI AKTIVITAS ANTIKANKER Mulyadi Tanjung; Devina Oktari Rahayu; Tjitjik Srie Tjahjandarie
Jurnal Kimia Riset Vol. 3 No. 2 (2018): Desember
Publisher : Universitas Airlangga

AbstrakToddalia asiatica merupakan tumbuhan perdu yang tersebar di Afrika, Asia, Madagascar, dan Australia (Hu et al., 2015). Senyawa metabolit sekunder yang ditemukan tumbuhan Toddalia asiatica L. adalah alkaloid. Ekstraksi senyawa alkaloid dari tumbuhan Toddalia asiatica L. dengan cara maserasi menggunakan pelarut metanol pada suhu kamar. Proses isolasi dilakukan melalui fraksinasi dan pemurnian menggunakan kromatografi kolom gravitasi, dan kromatografi radial. Hasil isolasi yang didapatkan merupakan senyawa alkaloid turunan furokuinolin yaitu skimmianin. Struktur senyawa alkaloid turunan furokuinolin yang diketahui melalui analisa hasil spektroskopi UV, IR, 1D NMR (1H-NMR dan 13C-NMR), serta 2D NMR (HMBC dan HMQC) dan uji aktivitas antikanker terhadap sel kanker murin leukemia P-388. Kata kunci : Alkaloid turunan furokuinolin, skimmianin, Toddalia asiatica L., antikanker AbstractToddalia asiatica L. is a bushy plant that spreads in Africa, Asia, Madagascar, and Australia (Hu et al., 2015). The secondary metabolite compound found in Toddalia asiatica L. is alkaloid. Extraction of alkaloid compounds from Toddalia asiatica L. by maceration using methanol at room temperature. The isolation process is diluted by fractionation and purification using column chromatography of gravity and radial chromatography. The result of isolation is an alkaloid compound derived furokuinolin, skimmianin. The structure of alkaloid compounds derived from furokuinolin known through spectroscopic analysis including UV, IR, 1D NMR (1H-NMR and 13C-NMR), and 2D NMR (HMBC and HMQC) and the anticancer activity test against the cancer cells murine P-388.Key word : Alkaloid compound derived furokuinolin, skimmianin, Toddalia asiatica L., anticancer

A Novel Spectrophotometric Method for Determination of Chloramphenicol Based On Diazotization Reaction at Room Temperature Abdul Wafi; Ganden Supriyanto; Tjitjik Srie Tjahjandarie
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

An analytical method for determination of chloramphenicol (CAP) based on the diazotization reaction at room temperature has been developed. The CAP was reduced using zinc powder (Zn) and diazotization reaction was carried out at room temperature in the presence of NaNO2, bismuth nitrate pentahydrate (Bi(NO3)3.5H2O) as catalyst. 2-napthol was used as coupling agent to form a red-violet solution and the absorbance was measured by UV-Vis spectrophotometer at 554 nm. The optimization of analytical parameters including reducing agent, catalyst, coupling agent and time response were 0.15 g, 0.15 g, 230.67 µg/mL and 8-9 min respectively.

Cytotoxic Activity of Flavonols from Macaranga gigantea (Rchb.f. & Zoll.) Müll.Arg. Rino Wanandri Salam Rewa; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7649

Two flavonols, glyasperin A (1), and meliternatin (2) has been isolated from the leaves of Macaranga gigantea (Rchb.f. & Zoll.) Müll.Arg. Extraction and isolation of flavonols were used methanol with the maceration method. The process of fractionation and purification used column chromatography and radial chromatography. The structure of both flavonols was determined by spectroscopic methods, including UV-Vis, IR, HRESIMS, 1D NMR (1H, and 13C-NMR) and 2D NMR (HMBC and HMQC). The cytotoxic activity of glyasperin A (1), and meliternatin (2) toward P-388 leukemia murine cells by MTT method, showing IC50 values 3.44 and 30.04 µg/mL, respectively.

AKTIVITAS ANTIKANKER SENYAWA KUMARIN TERISOPRENILASI DARI BUAH Melicope latifolia (DC.) T.G. Hartley Indatul Fitriyah; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Terapan Kimia Vol 15, No 1 (2021)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Melicope latifolia (DC.) T.G. Hartley merupakan salah satu spesies tumbuhan yang termasuk famili Rutaceae. Penelitian ini bertujuan untuk mengisolasi senyawa kumarin terisoprenilasi dari buah M. latifolia serta menentukan aktivitas antikanker terhadap sel murin leukemia P-388. Ekstraksi senyawa kumarin terisoprenilasi yang terdapat dalam buah M. latifolia menggunakan metanol. Pemisahan dan pemurnian menggunakan kromatografi kolom gravitasi dan kromatografi radial menghasilkan dua senyawa kumarin terisoprenilasi, yakni alosantoksiletin (1) dan isopimpinelin (2). Struktur kedua senyawa kumarin terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, HR-ESI-MS, 1D dan 2D NNMR. Aktivitas antikanker terhadap sel P-388 menggunakan metode MTT memperlihatkan nilai IC50 sebesar 3,41 ± 0,31 dan 23,70 ± 1,37 µg/mL.

Co-Authors Abdul Wafi Abdul Wafi Abror Rahman Aldin, Muhammad Fajar Devina Oktari Rahayu Dewi, Bella Kurniawati Eva Marliana Eva Marliana, Eva Ganden Supriyanto Ifana Mahardika Indatul Fitriyah Muhammad Fadjar Aldin Mulyadi Tanjung Novi Anggreini Novi Fatmawati Putri, Nathasa Aquila Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Rino Wanandri Salam Rewa Ryan Ayub Wahjoedi Saputri, Ratih Dewi Saputri, Ratih Dewi

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