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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Mulawarman Pharmascience Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Tjitjik Srie Tjahjandarie
Department Of Chemistry, Faculty Of Science And Technology, Airlangga University, Jl. Mulyorejo Kampus C UNAIR Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI KULIT BATANG AKA KALESI (Spatholobus ferrugineus) Ratih Dewi Saputri; Muhammad Fadjar Aldin; Tjitjik Srie Tjahjandarie; Eva Marliana; Mulyadi Tanjung
JURNAL KIMIA MULAWARMAN Vol 20 No 2 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v20i2.920

Abstract

Tujuan dari penelitian ini adalah untuk mengisolasi dan menguji aktivitas antikanker senyawa pterokarpan dari kulit batang Spatholobus ferrugineus (Zoll. & Moritzi) Benth terhadap MCF-7 yaitu sel kanker payudara. Terdapat dua senyawa turunan pterokarpan yang berhasil diisolasi yaitu senyawa variabilin (1) and medikarpin (2). Kedua senyawa tersebut dikarakterisasi dengan instrument 1D dan 2D NMR yang menyatakan bahwa kedua senyawa yang berhasil diisolasi adalah senyawa 1 dan 2. Senyawa 1 dan 2 menunjukkan aktivitas antikanker dengan nilai IC50 2,73 dan 14,36 μg/mL. Kata kunci : pterokarpan, antikanker, Spatholobus ferrugineus, MCF-7.
Aktivitas Antioksidan Senyawa Kumarin Ter-O-Geranilasi dari Akar Limonia acidissima L. Tjitjik Srie Tjahjandarie; Ratih Dewi Saputri; Mulyadi Tanjung
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.143

Abstract

Five O-geranylated coumarins namely as auraptene (1), 7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2), 7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3), 6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated from the roots of Limonia accidissima L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210 and 234 µg/ml, respectively. Keywords: Limonia accidissima L., O-geranylated coumarins, antioxidant activity, DPPH
Melicope moluccana Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana Ryan Ayub Wahjoedi; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.260

Abstract

Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.
Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 1 No. 9 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i9.61

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii. Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 1–2 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat
Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 1 (2019): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i1.93

Abstract

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from the stem bark of Melicope hookeri. The structures of both compounds were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.
Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia Abror Rahman; Ifana Mahardika; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Two quercetin derivatives, pachypodol (1) and ayanin (2) were isolated from the stem bark of Melicope quercifolia (B.S. William) Ridl. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antioxidant against DPPH radical showing their IC50 were 254 ± 10 and 38.55 ± 0.02 µg/mL, respectively.
Co-Authors Abdul Wafi Abdul Wafi Abror Rahman Aldin, Muhammad Fajar Devina Oktari Rahayu Dewi, Bella Kurniawati Eva Marliana Eva Marliana, Eva Ganden Supriyanto Ifana Mahardika Indatul Fitriyah Muhammad Fadjar Aldin Mulyadi Tanjung Novi Anggreini Novi Fatmawati Putri, Nathasa Aquila Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Rino Wanandri Salam Rewa Ryan Ayub Wahjoedi Saputri, Ratih Dewi Saputri, Ratih Dewi