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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Mulawarman Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Acta Chimica Asiana Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Ilmiah Berkala Sains dan Terapan Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal of Pharmascience
Tjitjik Srie Tjahjandarie
Department Of Chemistry, Faculty Of Science And Technology, Airlangga University, Jl. Mulyorejo Kampus C UNAIR Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Aktivitas Antioksidan Senyawa Kumarin Ter-O-Geranilasi dari Akar Limonia acidissima L. Tjitjik Srie Tjahjandarie; Ratih Dewi Saputri; Mulyadi Tanjung
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.143

Abstract

Five O-geranylated coumarins namely as auraptene (1), 7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2), 7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3), 6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated from the roots of Limonia accidissima L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210 and 234 µg/ml, respectively. Keywords: Limonia accidissima L., O-geranylated coumarins, antioxidant activity, DPPH
Melicope moluccana Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana Ryan Ayub Wahjoedi; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.260

Abstract

Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.
Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 1 No. 9 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i9.61

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii. Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 1–2 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat
Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 1 (2019): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i1.93

Abstract

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from the stem bark of Melicope hookeri. The structures of both compounds were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.
Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia Abror Rahman; Ifana Mahardika; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Two quercetin derivatives, pachypodol (1) and ayanin (2) were isolated from the stem bark of Melicope quercifolia (B.S. William) Ridl. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antioxidant against DPPH radical showing their IC50 were 254 ± 10 and 38.55 ± 0.02 µg/mL, respectively.
Pelatihan Simulasi Berbasis Kimia Komputasi Untuk Pengembangan Modul Pembelajaran Interaktif Haq, Kautsar Ul; Kristanti, Alfinda Novi; Suwito, Hery; Aminah, Nanik Siti; Windah, Axl Laurens Lukas; Nurrohman, Ardiana Ilham; Tjahjandarie, Tjitjik Srie; Octana Kurniawan, Gede Partha
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 1 (2026): Edisi Januari - April
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i1.8636

Abstract

Pemodelan kimia berbasis komputer merupakan topik penting dalam kimia komputasi. Meskipun belum termasuk dalam kurikulum Sekolah Menengah Atas, pendekatan komputasional dapat mendukung pembelajaran yang lebih interaktif dan berfungsi sebagai alat virtual untuk menjelaskan serta memprediksi reaktivitas kimia. Program pengabdian kepada masyarakat ini bertujuan meningkatkan pemahaman guru mengenai konsep dan praktik kimia komputasi, serta relevansinya dengan kurikulum. Pelatihan dilakukan melalui ceramah dan sesi praktikum menggunakan Avogadro 1.2.0 dan MOPAC2016. Efektivitas program dievaluasi secara kuantitatif dan kualitatif, sedangkan keberlanjutan dianalisis melalui penugasan di mana para guru merancang rencana integrasi materi ke dalam pembelajaran mereka. Analisis pre-test dan post-test menunjukkan peningkatan signifikan pada nilai peserta, dari rata-rata 44,9 menjadi 62,5 (P < 0,01). Umpan balik kualitatif menunjukkan bahwa para guru mengembangkan ide konkret untuk menerapkan kimia komputasi dalam kegiatan pembelajaran di kelas. Peserta menilai pelatihan ini relevan dengan kebutuhan pengajaran mereka. Program ini meningkatkan kesiapan dan motivasi mereka untuk mengintegrasikan kimia komputasi dalam praktik pembelajaran.
Aktivitas Antimalaria Senyawa Flavanon Terisoprenilasi Dari Kulit Batang Erythrina fusca L Novi Fatmawati; Novi Anggreini; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Journal of Pharmascience Vol. 5 No. 1 (2018): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i1.5786

Abstract

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial
The larvicidal activity of auraptene: oxygeranylated coumarin from Limonia acidissima L. Siti Mariyatul Ulfah; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung; Ratih Dewi Saputri; Eva Marliana
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.288

Abstract

Limonia acidissima  L. (Rutaceae) is a plant rich in coumarin compounds and has been used in traditional medicine. One of the main coumarin compounds reported from the roots of this plant is auraptene (7-oxygeranylcoumarin), which has previously been reported to have antioxidant activity. With increasing cases of vector-borne diseases, especially dengue fever transmitted by Aedes aegypti, the development of effective and environmentally friendly natural larvicides is needed. This study aimed to evaluate the larvicide activity of auraptene, building on previous research. The larvicide test was carried out using the WHO larval bioassay method on third-instar A. aegypti larvae at concentrations of 25–500 ppm within an exposure time of 24 h. Mortality data were analyzed using probit analysis to determine the Lethal Concentration 50% (LC50) value. The results showed that auraptene increased larval mortality with an LC50 of 145.29 ± 0.02 ppm after 24 h of exposure. This value indicates that auraptene is classified as an active natural larvicide. In conclusion, auraptene has the potential to be developed as a natural larvicidal candidate against A. aegypti and may expand the spectrum of biological activity of coumarin compounds from L. acidissima L.
Co-Authors Abdul Wafi Abdul Wafi Abror Rahman Aldin, Muhammad Fajar Alfinda Novi Kristanti Devina Oktari Rahayu Dewi, Bella Kurniawati Eva Marliana Eva Marliana, Eva Ganden Supriyanto Haq, Kautsar Ul Hery Suwito Ifana Mahardika Indatul Fitriyah Muhammad Fadjar Aldin Mulyadi Tanjung Nanik Siti Aminah Novi Anggreini Novi Fatmawati Nurrohman, Ardiana Ilham Octana Kurniawan, Gede Partha Putri, Nathasa Aquila Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Rino Wanandri Salam Rewa Ryan Ayub Wahjoedi Saputri, Ratih Dewi Saputri, Ratih Dewi Siti Mariyatul Ulfah Windah, Axl Laurens Lukas