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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Mulawarman Pharmascience Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Tjitjik Srie Tjahjandarie
Department Of Chemistry, Faculty Of Science And Technology, Airlangga University, Jl. Mulyorejo Kampus C UNAIR Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Pharmascience

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Aktivitas Antimalaria Senyawa Flavanon Terisoprenilasi Dari Kulit Batang Erythrina fusca L Novi Fatmawati; Novi Anggreini; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Pharmascience Vol 5, No 1 (2018): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i1.5786

Abstract

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial
Co-Authors Abdul Wafi Abdul Wafi Abror Rahman Aldin, Muhammad Fajar Devina Oktari Rahayu Dewi, Bella Kurniawati Eva Marliana Eva Marliana, Eva Ganden Supriyanto Ifana Mahardika Indatul Fitriyah Muhammad Fadjar Aldin Mulyadi Tanjung Novi Anggreini Novi Fatmawati Putri, Nathasa Aquila Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Rino Wanandri Salam Rewa Ryan Ayub Wahjoedi Saputri, Ratih Dewi Saputri, Ratih Dewi