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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Cendekia Journal of Pharmacy Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JAFP (Jurnal Akademi Farmasi Prayoga) Jurnal Ilmu Multidisplin Journal of Clinical Pharmacy and Pharmaceutical Science Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Fef Rukminingsih
Politeknik Katolik Mangunwijaya, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Tekanan Darah Pasien Hipertensi Dengan Diabetes Melitus Tipe II Di Puskesmas Ngemplak Simongan Kota Semarang Rukminingsih, Fef; Octasari, Paulina Maya; Dewi, Restu Anita Sukma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p41-46

Abstract

Hypertension is often asymptomatic and if left untreated can cause complications. Hypertension is an increase in systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. The blood pressure target for hypertensive patients with type II diabetes melitus (HT-DMTII) is <130/80 mmHg. The risk of complications increases if blood pressure does not reach the therapeutic target. Ngemplak Simongan Health Center, Semarang City has quite a lot of HT-DMTII patients, who undergo routine check-ups every month. This study aims to determine the achievement of blood pressure targets for HT-DMTII patients at Ngemplak Simongan Health Center, Semarang City. This study is an observational descriptive study using purposive sampling technique. The data used is retrospective data obtained from medical record data of HT-DMTII patients for the period August - October 2023. The inclusion criteria used were patients aged ≥36 years, receiving the same treatment for 2 consecutive months and having blood pressure data for 2 consecutive months. The data taken included medical record number, age, gender, blood pressure data for 2 consecutive months in the period August - October 2023, antihypertensives given and duration of use. From 62 patients, it was known that the majority were female patients 72.58%, aged >60 years as many as 58.06% and those who used antihypertensives for more than 5 years as many as 61.29%. A total of 59 people (95.16%) received single antihypertensive therapy. The most widely used antihypertensive was amlodipin (90.32%). There were 20 patients (32.26%) whose blood pressure reached the target.
Kejadian Nyaris Cidera (KNC) Pada Pelayanan Resep Pasien Poli Penyakit Dalam di Instalasi Farmasi Rawat Jalan RS Roemani Muhammadiyah Semarang Octasari, Paulina Maya; Yulia, Rika; Rukminingsih, Fef
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p1-6

Abstract

The paradigm changing in health care form “quality” to “quality and safety” aims to improve the quality of life of patient. One of the efforts is to minimize the occurrence of incidents. The largest number of the patient safety incidence is Nearly Injury Incidence, which is 18.53%. The increased risk of NPC can be caused by their presence of polypharmacy. Polypharmacy is often experienced in patients at the Internal Medicine Polyclinic at Roemani Muhammadiyah Semarang Hospital. Therefore, it is necessary to conduct research to determine the number of KNCs in the prescription service of poly internal medicine patients in the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang. The study was a descriptive observational study with prospective data from prescription services for patients with internal medicine at the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang in March 2020. Evaluations were carried out at each stage of prescription service. Stages consist of prescribing, taking drugs, and preparing medicines etiquette, checking. Data were analyzed and grouped according to the type of KNC at each stage of prescription service for patients with internal medicine, the number and percentage of KNC on each prescription sheet. The results showed that there were 25 KNCs on 375 sheets of prescribed poly patients in internal medicine at Roemani Muhammadiyah Hospital Semarang. The percentage of KNC is the drug entry stage of 9 KNC (2.4%), the taking stage of 15 KNC (4%), the preparation stage of 1 KNC (0.27%).
Toksisitas Subkronis Ekstrak Biji Salak (Salacca Zalacca) Terhadap Fungsi Hati Mencit Putih Octasari, Paulina Maya; Rukminingsih, Fef; Vita, Cristin Yulia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p119-125

Abstract

Salak seeds (Salacca zalacca) contain several secondary metabolites like as 0.059% flavonoids, 0.082% tannins and 0.063% alkaloids. Salak is a potential plant as a medicinal ingredient, so it is necessary to conduct a drug safety study. Subchronic toxicity test needs to be done in traditional drug therapy because it is given continuously. This study objective was to examine the subchronic toxicity of salak seed extract on liver function in male Swiss strain mice. This type of research is an experimental study with a completely randomized design with a one-way pattern with one treatment factor. There are four treatment groups with a total of 7 mice replications. Variations in the dose of salak seed extract administration were 91 mg/20 gBW of mice, 114 mg/20 gBW of mice, and 137 mg/20 gBW of mice. The toxicity test were SGPT and SGOT values on days 0 and 14. The data tested with one-way ANOVA followed by a t-test. The Salak Seed Extract (EBS) is a viscous extract with a dark brown colour, a distinctive smell of salak, and a chelate taste. The amount of the extraction result was 12.26%. Positive EBS contains flavonoids with a reddish-orange colour. The treatment of Salak Seed Extract ( 91 mg/20 g BW and 137 mg/20 g BW) was not increased significantly the SGPT and SGOT levels for 14 days (p-value 0.896 and 0.072). Although the second dose (114 mg/20 g BW) was increased the SGPT and SGOT levels (p-value 0.002), this enhancement was less than twice
HIPERTENSI EMERGENSI DI INTENSIVE CARE UNIT (ICU) RUMAH SAKIT UMUM DAERAH (RSUD) TUGUREJO SEMARANG Setyoningrum Pujiastuti; Fef Rukminingsih
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.3

Abstract

A sudden increase in blood pressure reaching> 180/120 mmHg accompanied by involvement of organ damage is called hypertensive emergencies. Nationwide Emergency Department recorded visits of hypertensive emergency cases as much as 3309 million in 2006 and 6178 million in 2013. The Hospital data information system (SIMRS) in Tugurejo Regional Hospital Semarang in 2017 found that the number of patients diagnosed with hypertension reached 1,125 patients. The aim of this study was to evaluate the use of antihypertension in hypertensive emergency patients in the Intensive Care Unit (ICU) of Tugurejo Hospital Semarang in the period January - December 2018. This study is a descriptive observational study using retrospective data. Data retrieval was done by looking at the medical record data of patients with hypertensive emergencies who received hypertension therapy in the ICU Tugurejo Hospital in the period January - December 2018. Data were analyzed based on patient characteristics, antihypertensive use patterns and evaluation of antihypertensive use. The number of patients who fulfilled the inclusion and exclusion criteria were 58 patients. The results of this study indicate that the suitability of antihypertensive use in decreasing systolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours in a row is 81.03%; 24.14%; 20.93%. Whereas for a decrease in diastolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours respectively 77.59%; 43.10%; 74.42% according to the ACC / AHA guidelines (2018).     
Pengaruh Sistem Penyimpanan Sediaan Farmasi pada Karakteristik Fisik di Apotek Dataran Rendah dan Dataran Tinggi Bayu Kristianto, Yosua; Diyah Ikasari, Endang; Fef Rukminingsih
Jurnal Ilmu Multidisiplin Vol. 4 No. 1 (2025): Jurnal Ilmu Multidisplin (April–Mei 2025)
Publisher : Green Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jim.v4i1.824

Abstract

Penyimpanan persediaan farmasi harus mengikuti regulasi yang berlaku untuk menjaga kualitas dan mencegah kerusakan. Tujuannya menjaga kualitas, mencegah penyalahgunaan, dan mengelola persediaan secara efisien. Apotek berperan penting dalam pengelolaan ini, mengingat faktor lokasi dan kondisi geografis seperti suhu dan kelembaban dapat mempengaruhi karakteristik fisik dari sediaan farmasi tersebut. Pengamatan sistem penyimpanan dilakukan secara deskriptif observasional sesuai dengan Petunjuk Teknis Standar Pelayanan Kefarmasian. Tujuan penelitian ini adalah mengevaluasi kesesuaian proses penyimpanan obat di apotek dataran rendah dan dataran tinngi dengan pedoman standar, mengidentifikasi faktor-faktor yang mempengaruhi kerusakan mutu sediaan farmasi, menganalisis pengaruh suhu, kelembaban, dan kondisi penyimpanan terhadap stabilitas fisika sediaan farmasi, serta perubahan stabilitas sediaan farmasi pada kondisi dan waktu tertentu di kedua apotek tersebut. Pengujian karakteristik fisik sediaan farmasi untuk mengevaluasi pengaruh sistem penyimpanan sediaan farmasi di dua apotek dengan kondisi geografis berbeda, melibatkan sampel sediaan farmasi padat, semi padat dan cair dengan zat aktif vitamin C. Pengujian karakteristik fisik sediaan farmasi dilakukan pada bulan ke nol sampai bulan ke tiga dengan menganalisis data uji sediaan farmasi SPSS versi 24. Hasil penelitian diperoleh karakteristik fisik sediaan farmasi baik pada sediaan padat, semipadat dan cair yang dilakukan pada apotek dataran rendah dan dataran tinggi memiliki hasil berpengaruh signifikan pada pengujian kerapuhan, kekerasan dan waktu hancur pada sediaan padat. Berpengaruh signifikan pada pengujian daya lekat, daya sebar, uji pH pada sediaan semipadat. Berpengaruh signifikan pada pengujian bobot jenis, uji pH, uji viskositas pada sediaan cair. Berdasarkan hasil tersebut sediaan farmasi yang disimpan pada apotek pada kondisi geografis yang berbeda di apotek mengalami perbedaan karakteristik fisik yang signifikan (p<0.05).
Sand Granules Ekstrak Biji Alpukat (Persea Americana Seed Extract) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue : Sand Granules of Avocado Seed Extract (Persea Americana Seed Extract) as Natural Larvaside of Dengue Fever Rukminingsih, Fef; Pujiastuti, Anasthasia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.362 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13607

Abstract

Dengue hemorrhagic fever (DHF) threatens people in the rainy season. DHF is one of the major public health problems in Indonesia. These problems encourage an effort to eradicate Ae. aegypti larvae by using natural larvicide. One of the plants that can be used as natural larvicides is avocado seeds (Persea americana Seed) which contain saponin. This study aims to determine the larvacidal activity of avocado seed extract sandgranules with LC50 of 8.87 mg.mL-1 against Ae. aegypti larvae. This study is an experimental research with a complete random design in a unidirectional pattern. The independent variable in this study is the variation concentration of Explotab as a disintegrant agent ie 2, 3, and 4%. Sand granules of avocado seed extract are made by wet granulation method. Results of the larvacidal activity test of avocado seed extract sand granules were analyzed by calculating the percentage of larvae mortality and statistical analysis using SPSS. The results of this study is the larvacidal activity of pure avocado seed extract with LC50 8.87 mg. L-1 is greater than the avocado seed extract sand granules. The addition of Explotab did not affect the total larvae mortality, but there was a significant difference in larvae mortality at 5 hours of sand granules exposure with explotab concentration of 3% and 4% (a significance value <0.05).
EVALUASI KELENGKAPAN RESEP SECARA ADMINISTRATIF DAN FARMASETIS DI APOTEK MRANGGEN KABUPATEN DEMAK Silvi, Niken Hidayatus; Octasari, Paulina Maya; Rukminingsih, Fef
Cendekia Journal of Pharmacy Vol 8, No 2 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i2.241

Abstract

Prescription screening is one of the pharmaceutical services conducted by examining prescriptions according to administrative, pharmaceutical, and clinical requirements aimed at preventing medication errors. Administrative requirements ensure prescriptions legality while pharmaceutical requirements assure therapeutic success. The study aimto determine administrative and pharmaceutical completeness of prescriptions in Mranggen Pharmacy, Demak Regency.This study is a descriptive observational study using prospective data from prescriptions in Mranggen Pharmacy, Demak Regency, in February 2023. The study used forms to assess the completeness of administrative and pharmaceutical aspects. Complete administrative data includes prescription date, doctor's name, doctor's practice license number, doctor's signature, patient's name, gender, age, address, and weight. Complete pharmaceutical data includes drug name, dosage forms, drug strength, drug unit, drug quantity, and instructions for use. The data was analyzed quantitatively to determine the percentage of administrative completeness, pharmaceutical completeness, and both.This study involved 311 prescription sheets and 43 copies of prescriptions. The results indicate that 12.15% of prescriptions are complete administratively, 47.74% are complete pharmaceutically, and 9.32% are complete in both aspects. The name, quantity, and how or when to use the medication is 100% while the lowest completeness is the aspect of patient's weight, which is 14.2%
Co-Authors Apriliyani Apriliyani Aulia Putri, Fayza Azifatul Ula Bayu Kristianto, Yosua Daisy Ariani Dewi, Restu Anita Sukma Dian Safitri Diyah Ikasari, Endang Djoko Wahyono Hanik Utaminingrum I Dewa Putu Pramantara Kartika Widayati Taroeno Hariadi Kristi Nadila, Lilis Megi Pangestuningsih Nike Kusuma Dewi Oktavia Dwi Danira Paulina Maya Octasari Pujiastuti, Anasthasia Putri Sri Wahyuni Rahmawati, Fita Rika Yulia Setyoningrum Pujiastuti Silvi, Niken Hidayatus Susanto, Theresia Carolina Tri Mulyani Tri Murti Andayani Valentina Catur Nova Vita, Cristin Yulia Widiastuti, Mei