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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Cendekia Journal of Pharmacy Jurnal Riset Kefarmasian Indonesia Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JAFP (Jurnal Akademi Farmasi Prayoga) Jurnal Ilmu Multidisplin Journal of Clinical Pharmacy and Pharmaceutical Science Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Fef Rukminingsih
Politeknik Katolik Mangunwijaya, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Uji Efek Hipoglikemia Ekstrak Daun Bandotan (Ageratum conyzoides L) pada Tikus Jantan (Rattus norvegicus) Galur Wistar Fef Rukminingsih; Paulina Maya Octasari; Oktavia Dwi Danira
Jurnal Akademi Farmasi Prayoga Vol 7 No 2 (2022): JURNAL AKADEMI FARMASI PRAYOGA
Publisher : Akademi Farmasi Prayoga Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56350/jafp.v7i2.83

Abstract

Abstrak Hipoglikemik adalah suatu keadaan yang menunjukkan kadar glukosa darah ≤ 70mg/dL. Daun bandotan (Ageratum conyzoidez L) mengandung senyawa flavonoid yang diduga memiliki aktivitas menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk menguji efek hipoglikemik ekstrak daun bandotan (EDB) dan pengaruh variasi dosis EDB terhadap efek hipoglikemik pada tikus jantan galur Wistar. Penelitian ini merupakan penelitian eksperimental dengan rancangan acak lengkap pola searah satu faktor. Variabel yang diukur adalah kadar glukosa darah berupa efek hipoglikemik EDB pada tikus jantan galur Wistar. Sebanyak 25 ekor tikus dibagi dalam 5 kelompok perlakuan. Kelompok I kontrol negative CMC-Na 0,5%, kelompok II kontrol postif glibenklamid 0,04 mg/mL, kelompok III, IV, V diberi EDB dengan variasi dosis 100, 200, 300 mg/kgBB. Pengukuran kadar glukosa darah dilakukan setelah 2 jam pemberian senyawa selama 5 hari berturut – turut. Analisis data menggunakan uji Shapiro wilk, dikatakan terdistribusi normal jika p > 0,05 dan uji levene dengan uji homogenitas nilai p > 0,05. Dilanjutkan uji One Way Anova dan uji post hoc dengan taraf kepercayaan 95%. Hasil penelitian menunjukan EDB positif mengandung flavonoid. Kelompok kontrol positif memiliki efek hipoglikemik (≤ 70mg/dl). Variasi dosis EDB yang memiliki kemampuan menurunkan kadar glukosa darah tetapi tidak memiliki efek hipoglikemik karena kadar glukosa darah setelah perlakuan >70 mg/dL pada pada tikus normal.
Peresepan Obat Dispepsia di Apotek Kharisma Semarang Pasca Gelombang Kedua Covid-19 Daisy Ariani; Fef Rukminingsih; Paulina Maya Octasari
Jurnal Akademi Farmasi Prayoga Vol 8 No 1 (2023): JURNAL AKADEMI FARMASI PRAYOGA
Publisher : Akademi Farmasi Prayoga Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Dispepsia dideskripsikan sebagai gejala gangguan pencernaan yang menyebabkan rasa tidak nyaman, mual dan muntah. Gejala umum yang juga muncul adalah rasa perih, kembung, dan panas di daerah perut bagian atas. Pasca pandemic Covid-19 gelombang kedua, terjadi peningkatan resep untuk pasien dyspepsia di Apotek Kharisma Semarang. Apotek Kharisma merupakan salah satu apotek besar di Kota Semarang. Tujuan penelitian ini untuk mengetahui pola peresepan obat dispepsia di Apotek Kharisma Semarang. Penelitian ini merupakan penelitian deskriptif observasional dengan menggunakan data retrospektif. Data yang digunakan adalah lembar resep pasien dispepsia yang berumur 18-65 tahun, periode Agustus - Desember 2021. Data yang diambil meliputi umur, jenis kelamin, nama obat dan pemakaiannya. Data kemudian di analisis secara kualitatif dan kuantitatif. Jumlah resep yang diperoleh sebanyak 495 lembar resep. Jumlah pasien perempuan sebanyak 322 (65,05%). Sebagian besar berumur lebih dari 36 tahun sebanyak 338 pasien (68,28%). Sebanyak 409 pasien (82,63%) mendapat terapi tunggal, sebanyak 26 pasien (5,25%) mendapat terapi kombinasi 2 obat dan sebanyak 60 pasien (12,12%) mendapat terapi kombinasi 3 obat. Ada 14 jenis obat dyspepsia yang diresepkan yang berasal dari 7 golongan obat. Jenis obat yang paling banyak diresepkan adalah antasida baik untuk pemakaian tunggal maupun kombinasi. Kombinasi 2 obat yang paling banyakdigunakan adalah antasida dan golongan prokinetik. Antasida juga dikombinasikan dengan penghambat pompa H+ dan H2 blocker sebagai jenis 3 kombinasi obat terbanyak digunakan. Abstract Dyspepsia is a set of clinical symptoms consisting of stinging, bloating, heat, nausea, vomiting, and discomfort in the upper abdomen. After the second wave of the Covid-19 pandemic, there was an increase in prescriptions for dyspeptic patients at the Kharisma Pharmacy Semarang. This study aims to determine the pattern of prescribing dyspepsia drugs at the Kharisma Pharmacy Semarang. This study is an observational descriptive study using retrospective data. The data used are prescription sheets for dyspepsia patients aged 18-65 years, the period August-December 2021.The data taken include age, gender, name of the drug and its use. The data is then analyzed qualitatively and quantitatively. The number of recipes obtained as many as 495 recipe sheets. The number of female patients was 322 (65.05%). Most of them were more than 36 years old as many as 338 patients (68.28%). A total of 409 patients (82.63%) received single therapy, as many as 26 patients (5.25%) received combination therapy with 2 drugs and as many as 60 patients (12.12%) received combination therapy with 3 drugs. There are 14 types of dyspepsia drugs that are prescribed from 7 drug classes. The type of drug that is most widely prescribed is antacid either for single use or in combination. The most widely used combination of 2 drugs are antacids and prokinetic groups. While the combination of the 3 drugs most widely used are antacids, proton pump inhibitors and H2 receptor antagonists.
POTENSI ANTIDIABETIK EKSTRAK ETANOLIK BIJI SALAK (Salacca zalacca) PADA MENCIT PUTIH JANTAN GALUR SWISS (Mus musculus) YANG DIINDUKSI ALOKSAN Rukminingsih, Fef; Maya Octasari, Paulina; Kristi Nadila, Lilis; Aulia Putri, Fayza
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1600

Abstract

Traditional medicine is an alternative treatment for diabetes mellitus. Flavonoids are compounds that have the activity of lowering blood glucose levels. Snake fruit (Salacca zalacca) contains flavonoids. This study aims to determine the antidiabetic potential of snake fruit ethanolic extract (SFEE) on male white Swiss mice. This research is an experimental study that consisted of 2 stages, namely testing the antidiabetic power and testing the hypoglycemia side effects of SFEE. Each stage was tested on 5 treatment groups. The various doses used were 91 mg, 114 mg, and 137 mg of 20g mice. In stage 1, fasting blood sugar checks are carried out on days 0, 3 and 17. Meanwhile, in stage 2, fasting blood sugar checks are carried out on days 1, 7 and 14. The positive control in the stage 1 test was metformin, while the stage 2 test used glibenclamide. The results showed that varying doses of SFEE  91 mg, 114 mg, and 137 mg of 20g mice had antidiabetic power of 62.87%, 68.07%, and 70.98%. The greater the dose of SFEE, the greater its antidiabetic power. However, the larger the dose of SFEE and the longer it is administered, the hypoglycemic effects will occur
Monitoring Tekanan Darah Pada Pasien Diabetes Melitus Tipe Dengan Hipertensi Di Puskesmas Tlogosari Kulon Kota Semarang Fef Rukminingsih; Putri Sri Wahyuni
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 2 No. 2 (2023): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v2i2.38

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both. DM is a risk factor for hypertension. Hypertension in DM increases the risk of complications so it is necessary to monitor whether blood pressure targets are achieved. This study aims to determine the achievement of blood pressure targets in type 2 DM patients with hypertension at the Tlogosari Kulon Health Center, Semarang City. This research is a descriptive observational study. Data collection uses purposive sampling technique. Data were obtained from medical records of type 2 DM patients with hypertension aged ≥ 45 years, who had blood pressure examination results on 2 consecutive visits in September 2022 – February 2023, use antihypertensives for at least 1 year. It was found 47 patients, consisting of 25 male patients and 22 female patients. A total of 26 patients were aged between 60-69 years. A total of 36 patients (76.59%) had taken antihypertensives for 1-5 years and 42 patients (89.40%) received single therapy, namely amlodipine. Only 1 patient received combination therapy of 2 drugs (amlodipine and candesartan). There were 14 patients who achieved the target blood pressure <140/90 mmHg (29.78%).
PENGUKURAN PERSEPSI TENAGA TEKNIS KEFARMASIAN DI KOTA DAN KABUPATEN SEMARANG TERHADAP APOTEK ONLINE Fef Rukminingsih; Azifatul Ula; Dian Safitri
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.636

Abstract

The development of online pharmacies in Indonesia will have an impact on the existence and role of Pharmaceutical Technicians. The number of pharmacies in Semarang City and Regency has reached almost 500 units. The number of Pharmaceutical Technicians who have practice permits in Semarang City is 477 people and in Semarang Regency is 115 people. Objective: This study aims to measure the perception of Pharmaceutical Technicians in Semarang City and Regency towards online pharmacies. Method: This research is a descriptive observational study using a cross sectional study design with using purposive sampling technique. The research data was obtained through a questionnaire in the form of a Likert scale which was distributed via google form in the Whatsapp group of Persatuan Ahli Farmasi Indonesia of Semarang City and Regency. Perceptions that are measured are drug guarantees, prices and consumer services. Pharmaceutical Technicians is said to have a positive perception of online pharmacies if the average score of the three parameters is in the range of 802.5 – 1284. Results: Respondents involved in this study were 321 respondents. Female respondents were 288 respondents (89.72%), 270 respondents (84.11%) aged less than 36 years and 177 respondents (55.14%) had Diploma III Pharmacy education. The drug guarantee parameter got a score of 1098, the drug price parameter got a score of 904 and the consumer service parameter got a score of 1035.5. The average score for the three parameters is 1012.5. Conclusion: Pharmaceutical Technicians in Semarang City and Regency have a positive perception toward online pharmacies.
Tekanan Darah Pasien Hipertensi Dengan Diabetes Melitus Tipe II Di Puskesmas Ngemplak Simongan Kota Semarang Rukminingsih, Fef; Octasari, Paulina Maya; Dewi, Restu Anita Sukma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p41-46

Abstract

Hypertension is often asymptomatic and if left untreated can cause complications. Hypertension is an increase in systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. The blood pressure target for hypertensive patients with type II diabetes melitus (HT-DMTII) is <130/80 mmHg. The risk of complications increases if blood pressure does not reach the therapeutic target. Ngemplak Simongan Health Center, Semarang City has quite a lot of HT-DMTII patients, who undergo routine check-ups every month. This study aims to determine the achievement of blood pressure targets for HT-DMTII patients at Ngemplak Simongan Health Center, Semarang City. This study is an observational descriptive study using purposive sampling technique. The data used is retrospective data obtained from medical record data of HT-DMTII patients for the period August - October 2023. The inclusion criteria used were patients aged ≥36 years, receiving the same treatment for 2 consecutive months and having blood pressure data for 2 consecutive months. The data taken included medical record number, age, gender, blood pressure data for 2 consecutive months in the period August - October 2023, antihypertensives given and duration of use. From 62 patients, it was known that the majority were female patients 72.58%, aged >60 years as many as 58.06% and those who used antihypertensives for more than 5 years as many as 61.29%. A total of 59 people (95.16%) received single antihypertensive therapy. The most widely used antihypertensive was amlodipin (90.32%). There were 20 patients (32.26%) whose blood pressure reached the target.
Kejadian Nyaris Cidera (KNC) Pada Pelayanan Resep Pasien Poli Penyakit Dalam di Instalasi Farmasi Rawat Jalan RS Roemani Muhammadiyah Semarang Octasari, Paulina Maya; Yulia, Rika; Rukminingsih, Fef
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p1-6

Abstract

The paradigm changing in health care form “quality” to “quality and safety” aims to improve the quality of life of patient. One of the efforts is to minimize the occurrence of incidents. The largest number of the patient safety incidence is Nearly Injury Incidence, which is 18.53%. The increased risk of NPC can be caused by their presence of polypharmacy. Polypharmacy is often experienced in patients at the Internal Medicine Polyclinic at Roemani Muhammadiyah Semarang Hospital. Therefore, it is necessary to conduct research to determine the number of KNCs in the prescription service of poly internal medicine patients in the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang. The study was a descriptive observational study with prospective data from prescription services for patients with internal medicine at the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang in March 2020. Evaluations were carried out at each stage of prescription service. Stages consist of prescribing, taking drugs, and preparing medicines etiquette, checking. Data were analyzed and grouped according to the type of KNC at each stage of prescription service for patients with internal medicine, the number and percentage of KNC on each prescription sheet. The results showed that there were 25 KNCs on 375 sheets of prescribed poly patients in internal medicine at Roemani Muhammadiyah Hospital Semarang. The percentage of KNC is the drug entry stage of 9 KNC (2.4%), the taking stage of 15 KNC (4%), the preparation stage of 1 KNC (0.27%).
Toksisitas Subkronis Ekstrak Biji Salak (Salacca Zalacca) Terhadap Fungsi Hati Mencit Putih Octasari, Paulina Maya; Rukminingsih, Fef; Vita, Cristin Yulia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p119-125

Abstract

Salak seeds (Salacca zalacca) contain several secondary metabolites like as 0.059% flavonoids, 0.082% tannins and 0.063% alkaloids. Salak is a potential plant as a medicinal ingredient, so it is necessary to conduct a drug safety study. Subchronic toxicity test needs to be done in traditional drug therapy because it is given continuously. This study objective was to examine the subchronic toxicity of salak seed extract on liver function in male Swiss strain mice. This type of research is an experimental study with a completely randomized design with a one-way pattern with one treatment factor. There are four treatment groups with a total of 7 mice replications. Variations in the dose of salak seed extract administration were 91 mg/20 gBW of mice, 114 mg/20 gBW of mice, and 137 mg/20 gBW of mice. The toxicity test were SGPT and SGOT values on days 0 and 14. The data tested with one-way ANOVA followed by a t-test. The Salak Seed Extract (EBS) is a viscous extract with a dark brown colour, a distinctive smell of salak, and a chelate taste. The amount of the extraction result was 12.26%. Positive EBS contains flavonoids with a reddish-orange colour. The treatment of Salak Seed Extract ( 91 mg/20 g BW and 137 mg/20 g BW) was not increased significantly the SGPT and SGOT levels for 14 days (p-value 0.896 and 0.072). Although the second dose (114 mg/20 g BW) was increased the SGPT and SGOT levels (p-value 0.002), this enhancement was less than twice
HIPERTENSI EMERGENSI DI INTENSIVE CARE UNIT (ICU) RUMAH SAKIT UMUM DAERAH (RSUD) TUGUREJO SEMARANG Setyoningrum Pujiastuti; Fef Rukminingsih
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.3

Abstract

A sudden increase in blood pressure reaching> 180/120 mmHg accompanied by involvement of organ damage is called hypertensive emergencies. Nationwide Emergency Department recorded visits of hypertensive emergency cases as much as 3309 million in 2006 and 6178 million in 2013. The Hospital data information system (SIMRS) in Tugurejo Regional Hospital Semarang in 2017 found that the number of patients diagnosed with hypertension reached 1,125 patients. The aim of this study was to evaluate the use of antihypertension in hypertensive emergency patients in the Intensive Care Unit (ICU) of Tugurejo Hospital Semarang in the period January - December 2018. This study is a descriptive observational study using retrospective data. Data retrieval was done by looking at the medical record data of patients with hypertensive emergencies who received hypertension therapy in the ICU Tugurejo Hospital in the period January - December 2018. Data were analyzed based on patient characteristics, antihypertensive use patterns and evaluation of antihypertensive use. The number of patients who fulfilled the inclusion and exclusion criteria were 58 patients. The results of this study indicate that the suitability of antihypertensive use in decreasing systolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours in a row is 81.03%; 24.14%; 20.93%. Whereas for a decrease in diastolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours respectively 77.59%; 43.10%; 74.42% according to the ACC / AHA guidelines (2018).     
Pengaruh Sistem Penyimpanan Sediaan Farmasi pada Karakteristik Fisik di Apotek Dataran Rendah dan Dataran Tinggi Bayu Kristianto, Yosua; Diyah Ikasari, Endang; Fef Rukminingsih
Jurnal Ilmu Multidisiplin Vol. 4 No. 1 (2025): Jurnal Ilmu Multidisplin (April–Mei 2025)
Publisher : Green Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jim.v4i1.824

Abstract

Penyimpanan persediaan farmasi harus mengikuti regulasi yang berlaku untuk menjaga kualitas dan mencegah kerusakan. Tujuannya menjaga kualitas, mencegah penyalahgunaan, dan mengelola persediaan secara efisien. Apotek berperan penting dalam pengelolaan ini, mengingat faktor lokasi dan kondisi geografis seperti suhu dan kelembaban dapat mempengaruhi karakteristik fisik dari sediaan farmasi tersebut. Pengamatan sistem penyimpanan dilakukan secara deskriptif observasional sesuai dengan Petunjuk Teknis Standar Pelayanan Kefarmasian. Tujuan penelitian ini adalah mengevaluasi kesesuaian proses penyimpanan obat di apotek dataran rendah dan dataran tinngi dengan pedoman standar, mengidentifikasi faktor-faktor yang mempengaruhi kerusakan mutu sediaan farmasi, menganalisis pengaruh suhu, kelembaban, dan kondisi penyimpanan terhadap stabilitas fisika sediaan farmasi, serta perubahan stabilitas sediaan farmasi pada kondisi dan waktu tertentu di kedua apotek tersebut. Pengujian karakteristik fisik sediaan farmasi untuk mengevaluasi pengaruh sistem penyimpanan sediaan farmasi di dua apotek dengan kondisi geografis berbeda, melibatkan sampel sediaan farmasi padat, semi padat dan cair dengan zat aktif vitamin C. Pengujian karakteristik fisik sediaan farmasi dilakukan pada bulan ke nol sampai bulan ke tiga dengan menganalisis data uji sediaan farmasi SPSS versi 24. Hasil penelitian diperoleh karakteristik fisik sediaan farmasi baik pada sediaan padat, semipadat dan cair yang dilakukan pada apotek dataran rendah dan dataran tinggi memiliki hasil berpengaruh signifikan pada pengujian kerapuhan, kekerasan dan waktu hancur pada sediaan padat. Berpengaruh signifikan pada pengujian daya lekat, daya sebar, uji pH pada sediaan semipadat. Berpengaruh signifikan pada pengujian bobot jenis, uji pH, uji viskositas pada sediaan cair. Berdasarkan hasil tersebut sediaan farmasi yang disimpan pada apotek pada kondisi geografis yang berbeda di apotek mengalami perbedaan karakteristik fisik yang signifikan (p<0.05).
Co-Authors Apriliyani Apriliyani Aulia Putri, Fayza Azifatul Ula Bayu Kristianto, Yosua Daisy Ariani Dewi, Restu Anita Sukma Dian Safitri Diyah Ikasari, Endang Djoko Wahyono Hanik Utaminingrum I Dewa Putu Pramantara Kartika Widayati Taroeno Hariadi Kristi Nadila, Lilis Megi Pangestuningsih Nike Kusuma Dewi Oktavia Dwi Danira Paulina Maya Octasari Pujiastuti, Anasthasia Putri Sri Wahyuni Rahmawati, Fita Rika Yulia Setyoningrum Pujiastuti Silvi, Niken Hidayatus Susanto, Theresia Carolina Tri Mulyani Tri Murti Andayani Valentina Catur Nova Vita, Cristin Yulia Widiastuti, Mei