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All Journal Indonesian Journal of Chemistry
Hasnah Natsir
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl. Perintis Kemerdekaan Km 10 Tamalanrea, Makassar 90245, South Sulawesi, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes Rizal Irfandi; Indah Raya; Ahyar Ahmad; Ahmad Fudholi; Hasnah Natsir; Desy Kartina; Harningsih Karim; Santi Santi; Subakir Salnus
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73738

Abstract

The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.
A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract Subakir Salnus; Wahid Wahab; Rugaiyah Arfah; Firdaus Zenta; Hasnah Natsir; Muriyati Muriyati; Fatimah Fatimah; Arini Rajab; Zulfian Armah; Rizal Irfandi
Indonesian Journal of Chemistry Vol 22, No 4 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.71053

Abstract

Nanotechnology explores nanoscale materials that can be used in a wide range of industries such as biotechnology, cosmetics, drug delivery, nanomedicine, and biosensors. Nanoparticles in diverse shapes and sizes can be prepared through physical, chemical, and biological methods. The employment of reducing agents, which will change their form, size range, level of stability, and interaction, is a crucial part thus employing a biological approach is necessary. Chemically generated metal oxide nanoparticles raise considerable issues owing to the usage of hazardous and poisonous chemicals, as well as the potential for conservational impairment. In contrast, the production of silver nanoparticles using the principal method of green synthesis has found a special place in research that is considered more environmentally approachable requiring the use to produce non-toxic nanomaterials. Plants and polymer materials have received a lot of interest in the preparation of nanoparticles since they are renewable and affordable. In this review, we present a comprehensive overview of more ecologically friendly synthesis techniques that use plant extracts to make silver nanoparticles and their application as antibacterial agents, as well as toxicity features based on the shape, size range, and phytochemical mechanism of plants.
Co-Authors Ahmad Fudholi Ahyar Ahmad Arini Rajab Desy Kartina Fatimah Fatimah Firdaus Zenta Harningsih Karim Indah Raya Irfandi, Rizal Muriyati Rugaiyah Arfah Santi Santi Subakir Salnus Subakir Salnus Wahid Wahab Zulfian Armah