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All Journal Chimica et Natura Acta
Tonel Barus, Tonel
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sumatera Utara Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology

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Aktivitas Antikanker Ekstrak Etanolbuah Ranti Hitam (Solanum blumei Nees ex Blume) Terhadap Sel Leukimia L1210 Simorangkir, Murniaty; Silaban, Saronom; Surbakti, Ribu; Barus, Tonel; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 5, No 1 (2017)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.107 KB) | DOI: 10.24198/cna.v5.n1.12819

Abstract

Tanaman ranti hitam (Solanum blumei Nees ex Blumei), famili Solanaceae, ditemukan di daerah Dairi dan Karo, secara tradisional digunakan sebagai tanaman obat. Pengujian aktivitas antikanker dari ekstrak etanol buah ranti hitam terhadap sel leukemia L1210 telah dilakukan dengan metode hemositometri setelah diinkubasi 48 jam pada suhu 37°C di dalam inkubator 5% CO2. Hasil penelitian menunjukkan ekstrak etanol buah ranti hitam berpotensi sebagai antikanker terhadap sel leukemia L1210 dengan nilai IC50 sebesar 14,88 µg/mL (aktif).
Characterization and Antidiabetic Potential of Durian Leaf (Durio zibethinus Linn.) Ethyl Acetate Extract Aruan, Dyna Grace Romatua; Barus, Tonel; Haro, Gindo; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 12, No 2 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n2.47817

Abstract

Durian leaves (Duiro zibethinus Linn.) are one of the plants whose leaves are used as a fever reducer (antipyretic). The aim of this research is to isolate natural ingredients using natural ingredient extraction techniques by maceration and identify steroid compounds from durian leaves that have anti-diabetic potential. Isolation was carried out through several stages, namely maceration, fractionation, subfractionation using column chromatography, purification using preparative TLC, and testing the purity of the isolate using TLC and determining the melting point of the isolate. The antidiabetic potential of the isolation was carried out using the α-glucosidase enzyme inhibition method. The chemical structure of the isolate was characterized using IR and UV-Vis spectroscopy. Based on IR spectroscopy analysis, the isolation has C=C, OH, O-C functional groups, C-H aromatic functional groups. UV-Vis spectroscopy data shows that there are maximum peaks at 207 nm and 247 nm, meaning that the isolated steroid compound has unconjugated double bonds. Based on spectroscopic data and comparison with reference compounds, it could be identified that the isolate obtained was β-sitosterol.
Co-Authors Dyna Grace Romatua Aruan Haro, Gindo Lamek Marpaung, Lamek Mastura, Mastura Murniaty Simorangkir Partomuan Simanjuntak Ribu Surbakti, Ribu SARONOM SILABAN