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All Journal Chimica et Natura Acta JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR)
Tonel Barus, Tonel
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sumatera Utara Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology

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Aktivitas Antikanker Ekstrak Etanolbuah Ranti Hitam (Solanum blumei Nees ex Blume) Terhadap Sel Leukimia L1210 Simorangkir, Murniaty; Silaban, Saronom; Surbakti, Ribu; Barus, Tonel; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 5, No 1 (2017)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.107 KB) | DOI: 10.24198/cna.v5.n1.12819

Abstract

Tanaman ranti hitam (Solanum blumei Nees ex Blumei), famili Solanaceae, ditemukan di daerah Dairi dan Karo, secara tradisional digunakan sebagai tanaman obat. Pengujian aktivitas antikanker dari ekstrak etanol buah ranti hitam terhadap sel leukemia L1210 telah dilakukan dengan metode hemositometri setelah diinkubasi 48 jam pada suhu 37°C di dalam inkubator 5% CO2. Hasil penelitian menunjukkan ekstrak etanol buah ranti hitam berpotensi sebagai antikanker terhadap sel leukemia L1210 dengan nilai IC50 sebesar 14,88 µg/mL (aktif).
Isolation and Identification of Flavonoid Compounds from Mangrove Leaves Burus (Bruguiera cylindrica (L.) Blume) Barus, Tonel; Sihombing , Jonathan
Journal of Chemical Natural Resources Vol. 6 No. 2 (2024): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jcnar.v6i2.18147

Abstract

Flavonoid compounds have been successfully isolated from the Mangrove leave burus (Bruguiera cylindrica (L.) Blume) through a series of extraction processes. The maceration procedure, which involved soaking the material to be extracted in methanol solvent to allow the desired chemicals to dissolve gradually, was used for the first extraction. Following the addition of ethyl acetate, the extract was concentrated once more. This ethyl acetate extract is subsequently dissolved in methanol and partitioned with n-hexane. The obtained methanol layer was evaporated until dry, then analyzed using thin layer chromatography (TLC), with silica gel as the stationary phase and chloroform as the mobile phase. The composition of the chloroform:methanol eluent used varied (90:10, 80:20, and 70:30 v/v), and the pure amorphous solid compound with an orange-yellow color was successfully obtained using a 70:30 v/v eluent, weighing 16.3 mg and having an Rf value of 0.73. Compound identification was carried out using UV-Visible, FT-IR, and ¹H-NMR. Spectroscopic data indicate that the extracted compound belongs to the flavonol group.
Isolation of Flavonoid Compounds Derived from Buni Leaves (Antidesma bunius (L) Spreng.) Barus, Tonel; Manalu, Ria Agnes Adelina; Marpaung, Lamek
Journal of Chemical Natural Resources Vol. 6 No. 2 (2024): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jcnar.v6i2.18379

Abstract

The flavonoid compounds from the leaves of buni (A. bunius (L) Spreng.) have been isolated through a process of maceration utilizing methanol as the solvent. The concentrated methanol extract was combined with ethyl acetate. The concentrated ethyl acetate extract was subsequently dissolved in methanol and subjected to partition extraction using n-hexane. The concentrated methanol extract was acidified with 6% HCl, followed by partition extraction using chloroform. The concentrated chloroform extract was isolated using column chromatography, employing an eluent mixture of n-hexane and ethyl acetate in the following ratios: 90:10, 80:20, 70:30, and 60:40 (v/v). The compounds underwent purification via TLC preparative, resulting in a tawny paste with a mass of 30 mg and an Rf value of 0.31. The compound underwent additional identification through the application of Ultraviolet Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared Spectroscopy (FT-IR), and Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), leading to the conclusion that the flavonoid in question is isoflavone.
Co-Authors Lamek Marpaung, Lamek Manalu, Ria Agnes Adelina Mastura, Mastura Murniaty Simorangkir Partomuan Simanjuntak Ribu Surbakti, Ribu SARONOM SILABAN Sihombing , Jonathan