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All Journal Microbiology Indonesia Jurnal Pendidikan dan Pembelajaran Kimia (JPPK) JURNAL PENGABDIAN KEPADA MASYARAKAT Chimica et Natura Acta JURNAL SAINS INDONESIA Jurnal Pendidikan Kimia (JPKim) Efektor Gagasan Pendidikan Indonesia Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Teknologi Pendidikan : Jurnal Penelitian dan Pengembangan Pembelajaran JGK (Jurnal Guru Kita) Abdimas Mandalika Jurnal Bioteknologi & Biosains Indonesia (JBBI)
SARONOM SILABAN
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Aktivitas Antikanker Ekstrak Etanolbuah Ranti Hitam (Solanum blumei Nees ex Blume) Terhadap Sel Leukimia L1210 Simorangkir, Murniaty; Silaban, Saronom; Surbakti, Ribu; Barus, Tonel; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 5, No 1 (2017)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.107 KB) | DOI: 10.24198/cna.v5.n1.12819

Abstract

Tanaman ranti hitam (Solanum blumei Nees ex Blumei), famili Solanaceae, ditemukan di daerah Dairi dan Karo, secara tradisional digunakan sebagai tanaman obat. Pengujian aktivitas antikanker dari ekstrak etanol buah ranti hitam terhadap sel leukemia L1210 telah dilakukan dengan metode hemositometri setelah diinkubasi 48 jam pada suhu 37°C di dalam inkubator 5% CO2. Hasil penelitian menunjukkan ekstrak etanol buah ranti hitam berpotensi sebagai antikanker terhadap sel leukemia L1210 dengan nilai IC50 sebesar 14,88 µg/mL (aktif).
Pengaruh Suhu pada Ekspresi Pretrombin-2 Manusia Rekombinan di Escherichia coli ER2566 Silaban, Saronom; Simorangkir, Murniaty; Maksum, Iman Permana; Subroto, Toto; Hasan, Khomaini
Jurnal Sains Indonesia Vol 42, No 1 (2018): Jurnal Sains Indonesia
Publisher : Universitas Negeri Medan

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Abstract

Human recombinant prethrombin-2 (rhPT-2) was expressed in Escherichia coli. Previous studies reported that the expression of rhPT-2 in E. coli tends to formed inclusion body. This study aims to determine the effect of temperature on the expression of rhPT-2 in E. coli ER2566. This study begins with the isolation of recombinant plasmids, competent cell preparation and transformation of competent cells of E. coli ER2566 strain, and rhPT-2 gene expression with various induction temperatures 12, 18, 22 and 30°C. Characterization results showed that the induction temperature of 22°C was the optimum temperature of rhPT-2 gene expression as a soluble fraction in E. coli ER2566 with IPTG concentration 0.1 mM. These results prove that the temperature affects the expression of rhPT-2 in E. coli ER2566.
Pengaruh Suhu pada Ekspresi Pretrombin-2 Manusia Rekombinan di Escherichia coli ER2566 Silaban, Saronom; Simorangkir, Murniaty; Maksum, Iman Permana; Hasan, Khomaini
Jurnal Sains Indonesia Vol 42, No 2 (2018): Edisi Juli - Desember
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jsi.v42i2.12245

Abstract

Human recombinant prethrombin-2 (rhPT-2) was expressed in Escherichia coli. Previous studies reported that the expression of rhPT-2 in E. coli tends to formed inclusion body. This study aims to determine the effect of temperature on the expression of rhPT-2 in E. coli ER2566. This study begins with the isolation of recombinant plasmids, competent cell preparation and transformation of competent cells of E. coli ER2566 strain, and rhPT-2 gene expression with various induction temperatures 12, 18, 22 and 30°C. Characterization results showed that the induction temperature of 22°C was the optimum temperature of rhPT-2 gene expression as a soluble fraction in E. coli ER2566 with IPTG concentration 0.1 mM. These results prove that the temperature affects the expression of rhPT-2 in E. coli ER2566. [EFFECT OF TEMPERATURE ON RECOMBINANT HUMAN PRETROMBIN-2 EXPRESSION IN ESCHERICHIA COLI ER2566] (J. Sains Indon., 42(2): 25-30, 2018)Keywords:Induction Temperature, Soluble Fraction, Prethrombin-2, E. coli ER2566
Analysis Effectiveness of the Online Learning through the Use of Google Classroom during the COVID-19 Pandemic Putri Novira; Albinus Silalahi; Saronom Silaban
Jurnal Pendidikan dan Pembelajaran Kimia Vol 10, No 1 (2021): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

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Abstract

The purpose of this study was to analyze the effectiveness of online learning asynchronously through the use of google classroom media at Medan State University, Chemistry Education Departement, batch 2018 in the chemical separation course during the COVID-19 pandemic. This study used descriptive qualitative method. The sample of this research was 29 students of the fifth semester class A chemistry education study program in 2018. The data collection technique used was filling out a questionnaire via google form as many as 24 statements. The results obtained indicate that the benefits of google classroom are good with a percentage of 76.9%, ease, quality of user use, use of google classroom and effectiveness are 86.3%, 80.3%, 81.9%, and success respectively. 88.6% in very good category. In general, the effectiveness of online learning through the use of google classrooms at Medan State University, Chemistry Education Study Program class of 2018 is very good, students find it easy to use google classroom, have very good quality of use of learning, and have good enough use for students.Keywords: online learning, COVID-19, google classroom, effectiveness. 
PENDAMPINGAN KELOMPOK PENGRAJIN PANDAI BESI DESA DURIN SIMBELANG KECAMATAN PANCUR BATU DALAM MEMANFAATKAN TUNGKU LEBUR Juniastel Rajagukguk; Hariono Hariono; Saronom Silaban; Hesti Fibriasasi
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 28, No 1 (2022): JANUARI-MARET
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v28i1.33542

Abstract

Industri kecil menempati posisi strategis dalam kebijaksanaan pembangunan nasional karena industri kecil mempunyai karakteristik yang lebih banyak menggunakan tenaga kerja dibandingkan modal dan peralatan. Pembangunan sektor industri sangat penting untuk meningkatkan kesempatan kerja bagi angkatan kerja, laju serta kualitas pertumbuhan ekonomi. Salah satu peluang yang dapat dikembangkan untuk memperkuat perekonomian adalah industri Kerajinan Pandai Besi. Tujuan program kemitraan masyarakat ini adalah melakukan pendampingan terhadap mitra dalam memanfaatkan limbah besi dan dapat menginovasi untuk meningkatkan kualitas produk dari pengrajin pandai besi. Pelaksanaan kegiatan pendampingan dilakukan dengan tahapan perencanaan, pelatihan dan pendampingan. Dampak dari pelaksanaan Program Kemitraan Masyarakat ini adalah pertambahan produksi dari mitra dengan menghasilkan berbagai jenis produk baru dari limbah besi. Dimana perbandingan hasil produksi tungku bakar terbarukan dengan tungku bakar kayu/arang yakni 95 berbanding 50 dan dapat mempercepat produksi besiKata Kunci: Pandai Besi; Tungku Lebur.
Implementasi Pembelajaran Kontekstual untuk Aktivitas dan Hasil Belajar Kimia Siswa Marudut Sinaga; Saronom Silaban
Gagasan Pendidikan Indonesia Vol 1, No 1 (2020)
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/gpi.v1i1.8051

Abstract

Hasil belajar yang optimal dalam pembelajaran kimia akan dicapai jika ada penekanan aktivitas siswa baik secara fisik, mental, intelektual, maupun emosional. Salah satu metode yang dapat memberdayakan peserta didik adalah pendekatan kontekstual. Penelitian ini bertujuan untuk melihat keefektifan pembelajaran kontekstual dalam merangsang keaktifan belajar siswa dan melihat keefektifan pembelajaran kontekstual terhadap hasil belajar siswa. Rancangan penelitian yang digunakan adalah Pretes-Postest Control Group Design. Dua kelas digunakan sampel penelitian yang diambil dari 5 kelas populasi (kelas XI SMA Swasta Methodist-1 Medan) secara acak sederhana (Simple Random Sampling). Lembar observasi digunakan untuk memperoleh data aktivitas belajar siswa. Sementara itu, tes hasil belajar digunakan untuk mengukur keefektifan pembelajaran kontekstual ditinjau dari hasil belajar siswa. Semua instrumen telah divalidasi sebelumnya. Hasil analisis data aktivitas belajar siswa diperoleh skor rata-rata aktivitas belajar siswa pada kelas eksperimen sebesar 76,14 dan 56,53 pada kelas kontrol. Sementara itu, rata-rata postes untuk kelas eksperimen lebih tinggi (88,04) lebih tinggi dari kelas kontrol sebesar 81,79 dengan selisih 6,25. Hasil ini menunjukkan bahwa pembelajaran kontekstual efektif dalam merangsang keaktifan belajar dan hasil belajar siswa. 
Implementation of Contextual-Based Chemistry Electronic Textbook Class X SMA/MA Semester II on Learning Outcomes and Student’s Learning Motivation Khairani Islamiyah; Tita Juwitaningsih; Saronom Silaban
Jurnal Pendidikan dan Pembelajaran Kimia Vol 11, No 2 (2022): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

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Abstract

Low results study students and motivation student in learning chemistry during the Covid-19 pandemic at Baitul Aziz Private High School Deli Serdang. This research aim for knowing outcomes learning students who are taught with contextual-based chemistry electronic textbook more high from score criteria minimum completeness (KKM = 75); knowing student’s learning motivation who are taught with contextual-based chemistry electronic textbook. This research using the ADDIE model (Analysis; Design; Development; Implementation; Evaluation) in the article this will discussed at the implementation. Population in study this is is student class X MIPA Baitul Aziz Private Senior High School Deli Serdang 2021/2022 as many as 50 students, sample study this student class X MIPA2 Baitul Aziz Deli Serdang Private High School as many as 24 people were selected with using purposive sampling technique. Instruments used in research including: instruments test as many as 10 essay questions and questionnaires motivation study students. Research results show that results study student higher from KKM value (test one sample t-test obtained result value sig. α = 0.002 0.05; score tcount ttable = 8.087 1.714) and students motivated (81.7%) to study chemical with use contextual-based chemistry electronic textbook very effective used in learning chemistry at school to improve learning outcomes and student’s learning motivation.
Codon Optimization and Chaperone Assisted Solubilization of Recombinant Human Prethrombin-2 Expressed in Escherichia coli SARONOM SILABAN; IMAN PERMANA MAKSUM; SHABARNI GHAFFAR; KHOMAINI HASAN; SUTARYA ENUS; TOTO SUBROTO; SOETIJOSO SOEMITRO
Microbiology Indonesia Vol. 8 No. 4 (2014): December 2014
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (692.802 KB) | DOI: 10.5454/mi.8.4.5

Abstract

Prethrombin-2 (PT2) is a thrombin precursor, which plays a role in the conversion of fibrinogen into fibrin during blood clotting process. Previous study reported that the expression of human prothrombin-2 (rhPT2) in Escherichia coli formed inclusion bodies. The aim of this study was to establish a strategy to express a soluble rhPT2 in E. coli. This study was animed to design and codon optimize human prethrombin-2 gene as well as to optimize the expression condition using four strains of E. coli. The codon adaptation index (CAI) of the unoptimized hpt2 gene was 0.336, with 56.8% GC content. After optimization, the CAI of optimized hpt2 became 1.000 with 53.1% GC content. The optimized gene was successfully cloned into pTWIN1 expression vector. Expression analysis indicated that only E. coli ArcticExpress strain could successfully express a soluble recombinant rhPT2 protein, with only part of rhPT2 being expressed in insoluble form. However, the rest of the E. coli strains used in the experiments failed to express the rhPT2 in soluble form. We are deducing that the success in achieving soluble expression was not only due to the availability of chaperonins Cpn60/Cpn10, which played a crucial role in the protein folding in E. coli ArcticExpress strain, but also due to the codon optimization of hpt2 gene.
Analisis Kebutuhan Pengembangan Bahan Ajar Kimia Berbasis Elektronik Terintegrasi Model Pembelajaran Problem Based Learning Pada Siswa SMA Kelas X Kota Medan Asmi, Andalia; Silaban, Saronom; Silaban, Ramlan
Efektor Vol 11 No 1 (2024): Efektor Vol.11 No.1 Tahun 2024
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/e.v11i1.21594

Abstract

This study aims to fulfill the requirement for improving chemistry instruction materials for SMA classes, and the study's findings will be consulted for further information in the development of electronic chemistry teaching materials. A qualitative descriptive method was employed in the study. Four secondary schools participated in this study in Medan City by interviewing four teachers from each school and observing the IPA-X class with 80 students. It has been done. As the Study shows, teachers still use traditional teaching methods and only use school-published textbooks. The teaching materials must be revised, as students still use electronic media in 48.9% of the survey results. I found that they made use of the training materials provided. The required percentage is 53.6%. These results demonstrate the need to develop electronic materials that help students comprehend the subject matter and facilitate learning and exploring the learning process.
Development and Implementation of Chemistry STEM-Based Module on Buffer Solution Material in Senior High School Siregar, Litani; Silaban, Saronom
Jurnal Teknologi Pendidikan : Jurnal Penelitian dan Pengembangan Pembelajaran Vol 8, No 4 (2023): Oktober
Publisher : UNDIKMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jtp.v8i4.8572

Abstract

One of the issues class XI SMA Negeri 1 Purba students encounter is that the teaching materials still used aren't very diverse; they mostly consist of textbooks, which makes it difficult for students to comprehend the material in the textbook. The goal of this study is to create a STEM-based chemistry module that will enhance student learning outcomes and activities. Research and development (R&D) using the ADDIE development model is the research methodology applied. This STEM-based chemistry module scored on average 89.47% for content feasibility, 90.17% for presentation feasibility, 95.31% for STEM assessment, 82.69% for language feasibility, and 95.16% for graphics, placing it in the category of being "very feasible to use in learning." With average student pretest and posttest scores of 43.57 and 86.43 in small groups and 39.67 and 84.67 with an N-Gain score of 0.75 for student learning outcomes in large groups, the STEM-based chemistry module developed was deemed effective for improving student learning outcomes and student learning activities. The average value of all student learning activities was 77.4% with high criteria.
Co-Authors Adillah, Rani Albinus Silalahi Arfika, Nurul Asmi, Andalia Boangmanalu, Eka Putra Dairi Dede Ruslan Dodi Pramana Ginting, Susanna Gurning, Biworo Frida Hariono Hariono Hesti Fibriasasi IMAN PERMANA MAKSUM IMAN PERMANA MAKSUM Juniastel Rajagukguk Khairani Islamiyah KHOMAINI HASAN Lukman, Mena Fadillia Marudut Sinaga Murniaty Simorangkir Partomuan Simanjuntak Pohan, Ade Hermansyah Putri Novira Rajagukguk, Suryana Ramlan Silaban Ribu Surbakti, Ribu Saragih, Lenti Susanna Setiawan, Mhd Arif SHABARNI GHAFFAR Siahaan, Sabda Dian Nurani Sibarani, Choms Gary Ganda Tua Siregar, Litani SOETIJOSO SOEMITRO Sriadhi Sriadhi, Sriadhi SUTARYA ENUS Tita Juwitaningsih Tonel Barus, Tonel Toto Subroto Ulgari, Siti Wirda Hayatina Lubis, Wirda Hayatina Yeni Purba, Fince Putri