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FORMULASI NANOEMULGEL KOMBINASI EKSTRAK N-BUTANOL PEGAGAN, EKSTRAK N-BUTANOL LERAK DAN MINYAK BIJI MIMBA MENGGUNAKAN DESAIN FULL FACTORIAL: NANOEMULGEL FORMULATION COMBINATION OF N-BUTANOL EXTRACT OF PEGAGAN, N-BUTANOL LERAK EXTRACT AND MIMBA SEED OIL USING A FULL FACTORIAL DESIGN Sukarjati; Pungky Slamet Wisnu Kusuma; Asti Rahayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.656

Gel spermisida yang mengandung bahan aktif nonoxynol-9 merupakan salah satu kontrasepsi non hormonal berbentuk gel yang banyak digunakan di kalangan masyarakat, namun, senyawa nonoxynol-9 dapat menyebabkan iritasi dan gatal-gatal pada vagina. Pada penelitian ini dibuat alternatif herbal spermisida dari tanaman pegagan, lerak dan mimba yang diformulasikan dalam sistem penghantaran nanoemulgel. Pada penelitian ini dilakukan optimasi dan formulasi nanoemulgel berbahan kombinasi dari ekstrak n-butanol Pegagan, ekstrak n-butanol Lerak dan minyak biji Mimba menggunakan model full factorial design (23). Pada penelitian ini didapatkan hasil bahwa ukuran partikel nanoemulgel memiliki rentang 477,5 ± 0,2 hingga 781,2 ± 0,6 nm. Daya sebar dari Nanoemulgel memiliki rentang 5,8 ± 0,2 sampai 6,6 ± 0,1 cm. Zeta Potensial dari nanoemulgel memiliki rentang -37,1 ± 0,7 sampai -37,1 ± 0,7 mV. Rentang pH yang dihasilkan adalah 5,9 ± 0,1 hingga 6,6 ± 0,1, viskositas yang dihasilkan adalah 768 ± 0,8 hingga 833 ± 0,8 cps.Variabel konsentrasi ekstrak n-butanol lerak dan interaksi antara ekstrak n-butanol pegagan dan minyak biji mimba berpengaruh signifikan terhadap respon ukuran partikel dilihat dari nilai p-value < 0,05 dengan nilai masing-masing p-value 0,04 dan 0,036. Pada respon zeta potential dan respon daya sebar, semua variabel konsentrasi ekstrak n-butanol lerak, ekstrak n-butanol pegagan, minyak biji mimba, interaksi ekstrak n-butanol lerak dan ekstrak n-butanol pegagan, interaksi antara ekstrak n-butanol pegagan dan minyak biji mimba dan interaksi ekstrak n-butanol lerak dan minyak biji mimba memiliki nilai p-value > 0,05, sehingga dapat disimpulkan tidak ada berpengaruh signifikan terhadap respon zeta potential dan daya sebar.

PKM BUDIDAYA IKAN LELE (Clarias gariepinus) MENGGUNAKAN SISTEM BIOFLOK PADA GURU SMA SE-JAWA TIMUR Pungky SWK; Vivin Andriani; Diah Karunia Binawati; Sukarjati; Arif Yachya; Dyah Hariani; Susie Amilah
Jurnal Penamas Adi Buana Vol 6 No 02 (2023): Jurnal Penamas Adi Buana
Publisher : LPPM Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/penamas.vol6.no02.a6427

The Cultivation of high-density fish requires artificial feed with high protein content for growth. The higher the protein contained in the feed, the more expensive the feed price, while the feed is the largest cost reaching 60-70% of the production cost. In addition to the problem of feed in high-stocking density fish farming, of course, the waste disposal is also getting higher, which causes failure in the cultivation business. To overcome these problems, it is necessary to make a breakthrough in the cultivation system, one of which is catfish farming using a biofloc system by utilizing heterotrophic bacteria proven to reduce ammonia waste discharge in ponds. The results of this study need to be immediately socialized through training activities for high school teachers. The pretest and post-test results of trainees based on the percentage of activity objectives showed an increase with an average of 55%. It is hoped that the results of the training for high school biology teachers will not only get new knowledge about the application of biofloc to catfish farming. The knowledge gained can be disseminated to students in their schools to support better biology learning

FORMULASI NANOEMULGEL KOMBINASI EKSTRAK N-BUTANOL PEGAGAN, EKSTRAK N-BUTANOL LERAK DAN MINYAK BIJI MIMBA MENGGUNAKAN DESAIN FULL FACTORIAL: NANOEMULGEL FORMULATION COMBINATION OF N-BUTANOL EXTRACT OF PEGAGAN, N-BUTANOL LERAK EXTRACT AND MIMBA SEED OIL USING A FULL FACTORIAL DESIGN Sukarjati; Pungky Slamet Wisnu Kusuma; Asti Rahayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.656

Gel spermisida yang mengandung bahan aktif nonoxynol-9 merupakan salah satu kontrasepsi non hormonal berbentuk gel yang banyak digunakan di kalangan masyarakat, namun, senyawa nonoxynol-9 dapat menyebabkan iritasi dan gatal-gatal pada vagina. Pada penelitian ini dibuat alternatif herbal spermisida dari tanaman pegagan, lerak dan mimba yang diformulasikan dalam sistem penghantaran nanoemulgel. Pada penelitian ini dilakukan optimasi dan formulasi nanoemulgel berbahan kombinasi dari ekstrak n-butanol Pegagan, ekstrak n-butanol Lerak dan minyak biji Mimba menggunakan model full factorial design (23). Pada penelitian ini didapatkan hasil bahwa ukuran partikel nanoemulgel memiliki rentang 477,5 ± 0,2 hingga 781,2 ± 0,6 nm. Daya sebar dari Nanoemulgel memiliki rentang 5,8 ± 0,2 sampai 6,6 ± 0,1 cm. Zeta Potensial dari nanoemulgel memiliki rentang -37,1 ± 0,7 sampai -37,1 ± 0,7 mV. Rentang pH yang dihasilkan adalah 5,9 ± 0,1 hingga 6,6 ± 0,1, viskositas yang dihasilkan adalah 768 ± 0,8 hingga 833 ± 0,8 cps.Variabel konsentrasi ekstrak n-butanol lerak dan interaksi antara ekstrak n-butanol pegagan dan minyak biji mimba berpengaruh signifikan terhadap respon ukuran partikel dilihat dari nilai p-value < 0,05 dengan nilai masing-masing p-value 0,04 dan 0,036. Pada respon zeta potential dan respon daya sebar, semua variabel konsentrasi ekstrak n-butanol lerak, ekstrak n-butanol pegagan, minyak biji mimba, interaksi ekstrak n-butanol lerak dan ekstrak n-butanol pegagan, interaksi antara ekstrak n-butanol pegagan dan minyak biji mimba dan interaksi ekstrak n-butanol lerak dan minyak biji mimba memiliki nilai p-value > 0,05, sehingga dapat disimpulkan tidak ada berpengaruh signifikan terhadap respon zeta potential dan daya sebar.

Potential of Combined Insulin Leaf (Smallanthus sonchifolius) and Noni Fruit (Morinda citrifolia L.) Extracts in Reducing Blood Glucose Level and Spermatogenic Cells Improvement in Diabetic Mice Sukarjati; Aldi Syahputra
Jurnal Penelitian Pendidikan IPA Vol 11 No 5 (2025): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i5.11174

Elevated blood glucose levels are a hallmark of diabetes mellitus, which can lead to reproductive disorders, particularly affecting spermatogenic cells. This study aimed to evaluate the effectiveness of insulin leaf extract, noni fruit extract, and their combinations in reducing blood glucose levels and their impact on the number of spermatogenic cells in diabetic mice. A total of 36 male mice were divided into 12 treatment groups, including a normal control group, a negative control group (induced with alloxan 120 mg/KgBW), a positive control group (alloxan + metformin), and nine treatment groups with various doses of individual and combined extracts. Blood glucose levels were measured using Accu-Chek, and testicular histology was prepared following laboratory standards. Data were analyzed using the ANOVA test followed by the Duncan post hoc test. Results showed that the combination of insulin leaf extract at 150 mg/KgBW/day and noni fruit extract at 62.5 mg/KgBW/day was the most effective in reducing blood glucose levels. Additionally, the combination of 125 mg/KgBW insulin leaf extract and 50 mg/KgBW noni fruit extract significantly increased the number of spermatogenic cells. Thus, the combination of insulin leaf and noni fruit extracts shows potential as a natural antidiabetic therapy and for restoring spermatogenic cell function in diabetic conditions.

Potential of Combined Curcuma zedoaria and Piper crocatum Leaf Extracts as Natural Male Antifertility Agents: an Experimental Study in Mice Sukarjati; Mitha Novia Sari
Jurnal Penelitian Pendidikan IPA Vol 11 No 10 (2025): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i10.12380

Curcuma zedoaria and Piper crocatum are indigenous Indonesian herbal plants containing various bioactive compounds. C. zedoaria is known to contain curcumin, tannins, saponins, and flavonoids, while P. crocatum contains piperine, tannins, saponins, flavonoids, alkaloids, and triterpenoids. This study aimed to investigate the effects of white turmeric extract, red betel leaf extract, and their combination on the spermatogenic cells of male mice. Extracts were obtained using the maceration method. A total of 30 male mice, aged 3 months and weighing 25–30 grams, were randomly divided into four treatment groups with three replications each: control, white turmeric extract, red betel extract, and a combination of both extracts. The extracts were administered orally at doses of 50, 100, and 150 mg/kg BW for individual extracts, and 25:25, 50:50, and 75:75 mg/kg BW for the combined treatment, over 35 days. Histological sections of the testis were prepared following standard laboratory protocols. One-way ANOVA showed a significant decrease (p < 0.05) in all cell types in treated groups, with the most substantial reduction observed at the 75:75 mg/kg BW combination dose. The conclusion of this study is that the combined extract of C. zedoaria and P. crocatum has the potential as an antifertility

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