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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Public Health of Indonesia Jurnal Info Kesehatan
Bia, Michael Bhadi
Poltekkes Kemenkes Kupang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Neuroscience Public Health

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Evaluation of artemisinin-based combination therapy (ACT) to uncomplicated falciparum malaria patients in Purworejo District, Central Java, Indonesia Michael Bhadi Bia; E. Elsa Herdiana Murhandarwati; Neil F Lobo; William A Hawley; . Supargiyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 1 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1401.807 KB) | DOI: 10.19106/JMedSci004801201605

Abstract

Artemisinin-based Combination Therapy (ACT) to treat uncomplicated Plasmodiumfalciparum malaria has been applied in Purworejo District, Central Java, Indonesia, since2004. However evaluation of the two ACT regimens used ie: Artesunate Amodiaquine(AAQ) and Dihydroartemisinin-Piperaquine (DHP) co-administered with Primaquine (PQ)has not been performed. This study aims to evaluate the efficacy and side effects ofAAQ+PQ and DHP+PQ treatment in uncomplicated falciparum malaria in Purworejo. Inthis descriptive and observational study, 46 Pf infected patients who fullfill the inclusionand exclusion criterias were recruited from December 2010 to August 2011. StandardACT treatment were given to the patients followed by WHO drug efficacy evaluation for28 days. The clinical symptoms and adverse events was also evaluated over the course ofthe treatment. From all recruited subjects, 37 patients received DHP+PQ and 9 patientsreceived AAQ+PQ. On the DHP+PQ treated patient, all subjects were free of asexualand sexual parasites by Day-3 while on AAQ+PQ treated patient, this parasite clearancewas achieved faster as early as on D-2 at the latest. On the otherhand, the disappearanceof fever was also last longer in DHP+PQ treated patient which in one patient last onD-14, while in AAQ+PQ treated patient, the symptom of fever dissappeared by D-2at the latest. No Early or Late Treatment Failures were found on either DHP+PQ orAAQ+PQ treatment as well as clinical and parasitological failures. However, the presenceof adverse events cause by both drugs should not be ignored to ensure drug compliance.
Serum total protein and albumin levels among malnourished elementary-aged children East Nusa Tenggara, Indonesia Tangkelangi, Marni; Djami, Supriati Wila; Bia, Michael Bhadi; Astuti, Aldiana
Public Health of Indonesia Vol. 8 No. 4 (2022): October - December
Publisher : YCAB Publisher & IAKMI SULTRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v8i4.643

Abstract

Background: School-aged children between 6-12 years are a vulnerable group that could be affected by malnutrition, which may cause growth failure and affect their school achievement. East Nusa Tenggara, Indonesia, is known as the province with the highest cases of malnutrition. Objective: This study aimed to determine serum total protein and albumin levels among malnourished elementary-aged children. Serum total protein and albumin are biochemical parameters that give valuable data due to malnutrition. Methods: This study employed a case-control design. Purposive sampling was used to select the samples with a total of 90 children aged 6 – 12 years, of which 45 were assigned to a case group and a control group. The children’s blood was collected and analyzed using Riele Photometer 5010. The Biuret method was applied for total protein and bromocresol green for albumin serum. Independent sample t-test with a significant value <0.05 was used to determine the difference between mean total protein and albumin levels. Results: The percentage of low total protein levels in malnourished children was 36%, and the percentage of low albumin levels was 27%. The mean level of total protein and albumin was found to be lower in malnourished than in well-nourished children, 6.324±1.1748 g/dL vs. 7.047±0.6330 g/dL (p = <0.001), and 3.927 g/dL±0.7779 g/dL vs. 4.242 g/dL±0.5272 (p = 0.016), respectively. Conclusion: There were significant differences in total protein and albumin serum among malnourished and well-nourished children. The results may serve as basic information for further studies or to create an intervention to reduce malnutrition.
Personal Hygiene and Soil Transmitted Helminth Incidence in Elementary School Students Amanuban Barat District, South Central Timor Michael Bhadi Bia; Ni Made Susilawati; Agnes Rantesalu; Karol Octrisdey; Winioliski L.O. Rohi Bire
JURNAL INFO KESEHATAN Vol 20 No 2 (2022): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol20.Iss2.932

Abstract

Soil-transmitted helminth infection remained a significant public health problem in many developing countries. Elementary school-age children dominated the cases in Indonesia due to poor personal hygiene. South Central Timor had the top three poverty and the highest stunting rates in East Nusa Tenggara. Research to examine the relationship between personal hygiene and the incidence of Soil-Transmitted Helminth infection had never been conducted in South Central Timor. The study population consisted of 279 elementary school students selected from Inpres Nulle Elementary School, Inpres Neonmat Elementary School, and GMIT Nulle Elementary School through the Multistage Random Sampling technique. It was obtained 160 children as the study samples. The study found that 46 children (29.0%) were positive for STH, and 114 (71.0%) were negative for STH. Furthermore, 30 (65.2%) were positive for hookworm, 14 (30.4%) were positive for Ascaris lumbricoides, and 2 (4.4%) children had mixed infections. Multiple Logistic Regression Tests showed a significant effect of washing hands with soap after defecating with p = 0.031 and OR = 7.158. Thus, if a child did not wash his hands with soap after defecating, he had a risk of STH infection by 7.158 times. Furthermore, the effect of eating habits obtained a p = 0.038 and an OR value = 0.133 with the possibility of eating habits that did not protect against STH infection. In addition, the effect of dirty nails obtained a p=0.064 and an OR=5.264, which indicated the risk of contracting STH by 5.264 times. The effect of snacking habit obtained a p = 0.005 and an OR=0.121. It can be concluded that the incidence of STH was simultaneously influenced by the habit of defecating on the ground, washing hands without soap after defecation, eating raw food, having dirty nails, and having poor snacking habits.
Co-Authors . Supargiyono Agnes Rantesalu Agnes Rantesalu Astuti, Aldiana Bire, Winioliski L.O. Rohi Djami, Supriati Wila E. Elsa Herdiana Murhandarwati Karol Octrisdey Marni Tangkelangi Neil F Lobo Ni Made Susilawati Ni Made Susilawati William A Hawley Winioliski L.O. Rohi Bire