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All Journal Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Bakti Farmasi Duta Pharma Journal Jurnal Ilmiah Kesehatan Delima Jurnal Medika: Medika Journal of Pharmascience
Eva Kholifah
Sekolah Tinggi Ilmu Kesehatan Salsabila Serang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Analisis Profil Fisika Kimia dan Farmakokinetik Senyawa Pentagamavunon-1 Secara Komputasi Eva Kholifah; Endah
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.053 KB)

Abstract

Pentagamavunon-1 (PGV-1) is a curcumin analog which is known to inhibit the growth of cancer cells, bacteria and inhibit free radicals as an antioxidant agent. The purpose of this study was analyzed the pharmacokinetic profile and physicochemical properties of PGV-1 computationally. The predicted parameters were Lipinski rule of five, bioavailability, Blood Brain Barrier (BBB) ​​absorption, GI absorption, P-gp substrate, and prediction of metabolic enzymes involved in drug ADME processes. The results of this study indicate that the compound PGV-1 complies with the Lipinski rule of five with the characteristics of a molecular weight of 348.43 g/mol, hydrogen donor 2, hydrogen acceptor 3, Log P 4.71 and molar refractory 40-130. PGV-1 could absorb through the GI and can pass the blood brain barrier passively without P-gp protein. Several enzymes involved in the metabolism of PGV-1 are CYP2C19, CYP2C9, CYP 3A4. Thus, our finding suggest that PGV-1 can be developed as a drug target compound for active oral drugs.
Peran Apoteker dalam Kepatuhan Penggunaan Tablet Tambah Darah untuk Pencegahan Stunting pada Siswi Pelita Cibitung Yusransyah Yusransyah; Asep Salman Alfarizqi; Teguh Sudarto; Eva Kholifah; Sofi Nurmay Stiani; Baha Udin
Jurnal IPTEK Bagi Masyarakat Vol 4 No 3 (2025)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/j-ibm.v4i3.1114

Abstract

Anemia pada remaja putri merupakan masalah kesehatan signifikan di Indonesia, dengan prevalensi tinggi yang berdampak jangka panjang pada kesehatan reproduksi serta meningkatkan risiko stunting pada keturunannya. Program pemberian Tablet Tambah Darah (TTD) telah diinisiasi oleh pemerintah sebagai upaya pencegahan stunting, namun tingkat kepatuhan konsumsi TTD di kalangan remaja putri masih rendah. Peran apoteker sebagai edukator dan fasilitator dalam program kesehatan masyarakat menjadi sangat krusial untuk meningkatkan kepatuhan konsumsi TTD. Pengabdian masyarakat ini bertujuan untuk meningkatkan kepatuhan konsumsi TTD sebagai langkah pencegahan stunting pada siswi SMK melalui Program Gerakan Anti Stunting di SMK Pelita Cibitung tahun 2024. Kegiatan yang dilakukan meliputi edukasi interaktif mengenai stunting, anemia, dan pentingnya konsumsi TTD, serta monitoring dan evaluasi tingkat kepatuhan konsumsi TTD. Evaluasi dilakukan menggunakan kuesioner MARS (Medication Adherence Report Scale). Hasil evaluasi menunjukkan adanya peningkatan kepatuhan konsumsi TTD setelah diberikan edukasi dan dilakukan monitoring melalui WhatsApp Group. Hal ini menunjukkan bahwa keterlibatan aktif apoteker dalam edukasi dan monitoring dapat meningkatkan kepatuhan konsumsi TTD pada remaja putri.
Penetapan Kadar Total Flavonoid Dan Alkaloid Ekstrak Etanol Herba Jotang (Acmella uliginosa (Sw.) Cass) Fajrin Noviyanto; Siti Alfiyah; Eva Kholifah
Journal of Pharmascience Vol. 11 No. 1 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.16840

Abstract

Jotang (Acmella uliginosa (Sw.) Cass) merupakan salah satu tanaman yang secara tradisional digunakan untuk pengobatan sakit gigi, sariawan, dan sakit tenggorokan. Pada tumbuhan jotang terdapat metabolit sekunder yaitu flavonoid yang dapat digunakan sebagai pengobatan antiinflamasi, antioksidan, antidiabetes, antibakteri, dan alkaloid dapat digunakan untuk pengobatan antibakteri, antidiare dan antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui senyawa kimia ekstrak jotang, kadar total flavonoid dan kadar alkaloid yang ada dalam ekstrak jotang. Tahapan yang dilakukan pada penelitian ini yaitu pengambilan jotang, determinasi jotang, preparasi jotang, ekstraksi dengan metode maserasi, remaserasi, skrining fitokimia, analisis kadar flavonoid dan analisis kadar alkaloid total. Hasil penelitian menunjukan bahwa ekstrak etanol herba jotang  mengandung senyawa tanin, alkaloid, flavonoid dan saponin. Hasil kadar flavonoid ekstrak etanol herba jotang didapat sebesar 0,269% dan hasil kadar alkaloid total didapat sebesar 15,34%. Dapat disimpulkan bahwa pada penelitian ini mengandung senyawa flavonoid, alkaloid, saponin dan tanin. Kadar flavonoid total yang dimiliki sebesar 0,269% dan kadar alkaloid total sebesar 15,34%. Kata Kunci: Metabolit Sekunder, Maserasi, Kadar, Spektrofotometer UV-Vis, Tanin Jotang (Acmella uliginosa (Sw.) Cass) is a plant that is traditionally used to treat toothache, canker sores and sore throats. In the jotang plant there are secondary metabolites, namely flavonoids which can be used as antiinflammatory, antioxidant, antidiabetic, antibacterial, and alkaloids can be used for antibacterial, antidiarrheal and anti-inflammatory treatment. Rhe purpose of this study was to determine the chemical compounds of the jotang extract, the total levels of flavonoid, and the levels of alkaloids present in the jotang extract. The stages carried out in this study were jotang taking, jotang determination, sample preparation, extraction by maceration method, remaceration, phytochemical screening, analysis of flavonoid content, and analysis of total alkaloid content. The research results show that tannins, alkaloids, flavonoids and saponins are compound contained in the ethanol extract of jotang herbs. The flavonoid content result were 0.269% and the total alkaloid content result were 15.34%. it can be concluded that the ethanol extract of jotang herb contains flavonoids, alkaloid, saponins, and tannins. Jotang herb ethanol extract has a total flavonoid content of 0,269% and a total alkaloid content of 15.34%.
Tingkat Pengetahuan Karang Taruna Cahaya Mandala dalam Pembuatan Kombucha Bunga Kecombrang di Desa Mandalawangi Eva Kholifah; Deya Adiby Nabillah; Muhamad Suhaemi; Endah Endah; Renditya Ismiyati; Anton Anton; Asep Asep; Balqis Maulana; Surya Ahmaddhani; Syala Nabilah
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/gena5b10

Abstract

This community service activity was motivated by the potential of local natural resources in the form of Torch Ginger flowers (Etlingera elatior) in Mandalawangi Village, Pandeglang Regency, which have not been optimally utilized despite their high antioxidant activity and potential to be processed into probiotic kombucha beverages that are beneficial for health and possess economic value. The purpose of this activity was to improve the knowledge and skills of members of the Karang Taruna Cahaya Mandala in producing Torch Ginger flower kombucha as an effort to enhance public health and welfare. The activity was carried out through interactive lectures, hands-on training, and counseling using leaflet media, involving 30 respondents selected based on their active participation in the community. Knowledge evaluation was conducted through pretest and posttest assessments using the Wilcoxon test to analyze significant differences in knowledge levels before and after the activity. The results showed an increase in the knowledge level categorized as “good” from 63% before the training to 90% after the training, with a significance value of p = 0.000 (p<0.05), indicating that the activity was effective in improving participants’ understanding of Torch Gingerflower kombucha production. In addition to increasing health awareness, this activity also contributed positively to community economic empowerment through the development of local value-added products. In conclusion, the training and counseling on Torch Ginger flower kombucha production proved effective in enhancing community knowledge and skills; however, further activities are recommended, including business mentoring and product certification, to ensure the sustainability and broader impact of the program.
Peningkatan Kesiapan Wirausaha Karang Taruna Desa Mandalawangi melalui Pelatihan Kombucha Bunga Kecombrang dan Pendampingan Pengajuan P-IRT Eva Kholifah; Renditya Ismiyati; Deya Adiby Nabillah; Endah Endah
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/kx0pqw42

Abstract

This community service activity was motivated by the potential of local natural resources in the form of kecombrang flowers (Etlingera elatior) in Mandalawangi Village, Pandeglang Regency, which have not been optimally utilized despite their high antioxidant activity and potential to be processed into probiotic kombucha beverages that are beneficial for health and possess economic value. The purpose of this activity was to improve the knowledge and skills of members of the Karang Taruna Cahaya Mandala in producing kecombrang flower kombucha as an effort to enhance public health and welfare. The activity was carried out through interactive lectures, hands-on training, and counseling using leaflet media, involving 30 respondents selected based on their active participation in the community. Knowledge evaluation was conducted through pretest and posttest assessments using the Wilcoxon test to analyze significant differences in knowledge levels before and after the activity. The results showed an increase in the knowledge level categorized as “good” from 63% before the training to 90% after the training, with a significance value of p = 0.000 (p<0.05), indicating that the activity was effective in improving participants’ understanding of kecombrang kombucha production. In addition to increasing health awareness, this activity also contributed positively to community economic empowerment through the development of local value-added products. In conclusion, the training and counseling on kecombrang flower kombucha production proved effective in enhancing community knowledge and skills; however, further activities are recommended, including business mentoring and product certification, to ensure the sustainability and broader impact of the program.
Identifikasi Flavonoid total dan Vitamin C pada Ekstrak buah Alkesa (Pouteria campechiana (Kunth) Baehni) menggunakan Spektrofotometri UV-VIS Eva Kholifah; Lolo Agustian; Fajrin Noviyanto
Jurnal Ilmiah Kesehatan Delima Vol. 6 No. 2 (2024): Jurnal Ilmiah Kesehatan Delima
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60010/jikd.v6i2.120

Abstract

Buah Alkesa (Pouteria campechiana (Kunth) Baehni) adalah buah yang mengandung antioksidan yang sangat tinggi buah alkesa ini menjadi sumber karbohidrat, vitamin, mineral, serat dan mengandung senyawa flavonoid, saponin, dan vitamin C. Tujuan penelitian ini adalah untuk mengetahui kadar vitamin C dan flavonoid total pada ekstrak buah alkesa dengan menggunakan metode spektrofotometer UV-Vis. Hasil penelitian ini menunjukan kandungan metabolit sekunder buah alkesa adalah flavonoid dan saponin, kadar vitamin C yang diperoleh pada ekstrak buah alkesa sebesar 1,2816% sedangkan kadar flavonoid total sebesar 0,2533%. Pada penelitian ini menunjukan buah alkesah mengandung flavonoid dan vitamin c yang bisa dikembangkan dalam produk farmasi.
Formulasi dan Optimasi Serum Kombucha Bunga Kecombrang (Etlingera elatior) Dengan Variasi Gelling agent Karbopol dan Xanthan Gum Eva Kholifah; Aufalya Wibirezkina; Sofi Nurmay Stiani; Endah
Jurnal Ilmiah Bakti Farmasi Vol 11 No 2 (2026): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v11i2.178

Abstract

Kulit merupakan organ terluar tubuh yang rentan terhadap paparan radikal bebas, yang dapat menyebabkan penuaan dini, hiperpigmentasi, hingga kanker kulit. Untuk mengatasi hal tersebut, antioksidan topikal menjadi salah satu solusi efektif. Kombucha bunga kecombrang (Etlingera elatior) diketahui memiliki aktivitas antioksidan yang tinggi dan berpotensi digunakan sebagai bahan aktif dalam sediaan kosmetik, seperti serum. Penelitian ini bertujuan untuk mengoptimalkan formula serum berbasis kombucha bunga kecombrang dengan variasi gelling agent Karbopol dan Xanthan Gum, serta mengevaluasi stabilitas fisiknya. Metode penelitian menggunakan pendekatan eksperimental dengan enam formula (F1–F6) yang dievaluasi berdasarkan uji organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat, dan uji stabilitas melalui cycling test. Hasil menunjukkan bahwa seluruh formula memenuhi syarat mutu fisik serum sebelum cycling, namun hanya F1, F4, dan F6 yang tetap stabil setelah uji cycling. Formula 6 (kombinasi Karbopol 1% dan Xanthan Gum 1%) sebagai formula optimum karena menunjukkan pH ideal (4,55), viskositas stabil (3483 mPas), daya sebar baik (6,04 cm), daya lekat sesuai standar (2,90 detik), dan stabilitas fisik yang baik. Dengan demikian, Formula 6 dapat dikembangkan menjadi sediaan serum antioksidan yang aman, stabil, dan efektif.
Co-Authors Anton Anton Asep Asep Asep Salman Alfarizqi Aufalya Wibirezkina Baha Udin Balqis Maulana Deya Adiby Nabillah Deya Adiby Nabillah Endah Endah Endah Endah Endah Endah Fajrin Noviyanto Fajrin Noviyanto Lolo Agustian Muhamad Suhaemi Renditya Ismiyati Renditya Ismiyati Siti Alfiyah Sofi Nurmay Stiani Stiani, Sofi Nurmay Surya Ahmaddhani Syala Nabilah Teguh Sudarto Yusransyah, Yusransyah