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All Journal Journal of Food and Pharmaceutical Science Journal of Energy, Material, and Instrumentation Technology Duta Pharma Journal Journal of Food and Pharmaceutical Sciences Journal of Information Engineering and Technology Jurnal Ilmiah Ilmu Kesehatan
Endah
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Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Analisis Profil Fisika Kimia dan Farmakokinetik Senyawa Pentagamavunon-1 Secara Komputasi Eva Kholifah; Endah
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.053 KB)

Abstract

Pentagamavunon-1 (PGV-1) is a curcumin analog which is known to inhibit the growth of cancer cells, bacteria and inhibit free radicals as an antioxidant agent. The purpose of this study was analyzed the pharmacokinetic profile and physicochemical properties of PGV-1 computationally. The predicted parameters were Lipinski rule of five, bioavailability, Blood Brain Barrier (BBB) ​​absorption, GI absorption, P-gp substrate, and prediction of metabolic enzymes involved in drug ADME processes. The results of this study indicate that the compound PGV-1 complies with the Lipinski rule of five with the characteristics of a molecular weight of 348.43 g/mol, hydrogen donor 2, hydrogen acceptor 3, Log P 4.71 and molar refractory 40-130. PGV-1 could absorb through the GI and can pass the blood brain barrier passively without P-gp protein. Several enzymes involved in the metabolism of PGV-1 are CYP2C19, CYP2C9, CYP 3A4. Thus, our finding suggest that PGV-1 can be developed as a drug target compound for active oral drugs.
Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review Endah
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7100

Abstract

The possible uses of black pepper, a common spice used for cooking, have been expanded. Despite countless studies on its advantageous biological effects, it would be difficult to determine its effectiveness as an anti-aging and chemo-preventive medication. Piperine, chavicine, caryophyllene, and sabinene are a few examples of black pepper components that exhibit pharmacological characteristics. This article reviews black pepper's main ingredients and discusses how effective it is at preventing aging and cancer. Using Google Scholar, PubMed, and Medline for our electronic research, we screened pertinent papers from scientific journals. To help with the explanation in the narrative, all the data was compiled and summarized into tables and graphs. Overall, the anti-aging properties of black pepper and its constituents are exhibited through several pathways, including senescence prevention, antioxidant protection, control of ROS levels, and the inhibition of aging-related enzymes. Additionally, cell cycle regulation, antiangiogenic and anti-metastatic action, apoptosis induction, and the suppression of carcinogenesis are some of the mechanisms utilized in cancer prevention activities. It has been shown to have synergistic effects on several cancer cells when combined with doxorubicin. According to these studies, black pepper could be considered for development as an anti-aging and chemo-preventive agent.
Pengembangan Media Pembelajaran Interaktif Pengenalan Perangkat Keras Komputer di SDN Surokarsan 2 Yogyakarta Endah; Priyanto
Journal of Information Engineering and Technology Vol. 1 No. 1 (2023): March 2023
Publisher : Department of Electronics and Informatics Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jiety.v1i1.31

Abstract

Penelitian ini bertujuan untuk mengembangkan Media Pembelajaran Interaktif Pengenalan Perangkat Keras Komputer Di SDN Surokarsan 2 Yogyakarta, dan untuk mengetahui kelayakan dari Media Pembelajaran Interaktif Pengenalan Perangkat Keras Komputer Di SDN Surokarsan 2 Yogyakarta. Penelitian ini menggunakan model pengembangan ADDIE melalui lima tahapan. Teknik pengambilan data menggunakan metode angket instrumen validasi media, instrumen validasi materi dan angket responden. Hasil penelitian diketahui bahwa: (1) media pembelajaran interaktif pengenalan perangkat keras komputer dapat menjadi media belajar siswa. (2) media pembelajaran interaktif berisi materi disertai gambar dan suara untuk belajar mandiri siswa maupun bersama guru. (3) media pembelajaran interaktif pengenalan perangkat keras komputer memperoleh penilaian 94,13% dari ahli media, 88% dari ahli materi dan 85,13% dari responden. Sesuai hasil tersebut, disimpulkan bahwa media pembelajaran interaktif pengenalan perangkat keras komputer yang dikembangkan sangat layak digunakan untuk pembelajaran di SDN Surokarsan 2 Yogyakarta.
Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review Endah
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7100

Abstract

The possible uses of black pepper, a common spice used for cooking, have been expanded. Despite countless studies on its advantageous biological effects, it would be difficult to determine its effectiveness as an anti-aging and chemo-preventive medication. Piperine, chavicine, caryophyllene, and sabinene are a few examples of black pepper components that exhibit pharmacological characteristics. This article reviews black pepper's main ingredients and discusses how effective it is at preventing aging and cancer. Using Google Scholar, PubMed, and Medline for our electronic research, we screened pertinent papers from scientific journals. To help with the explanation in the narrative, all the data was compiled and summarized into tables and graphs. Overall, the anti-aging properties of black pepper and its constituents are exhibited through several pathways, including senescence prevention, antioxidant protection, control of ROS levels, and the inhibition of aging-related enzymes. Additionally, cell cycle regulation, antiangiogenic and anti-metastatic action, apoptosis induction, and the suppression of carcinogenesis are some of the mechanisms utilized in cancer prevention activities. It has been shown to have synergistic effects on several cancer cells when combined with doxorubicin. According to these studies, black pepper could be considered for development as an anti-aging and chemo-preventive agent.
Fabrication of Bioceramic Carbonated Hydroxyapatite–Chitosan Composite Scaffold Derived from River Snail Shells via Freeze-Drying for Bone Grafting Applications Wati, Rosita; Alnovera, Vayza Deva; Herbanu, Aldi; Endah; Tresnaningtyas, Sekar Asri; Gifari, Muhammad Wildan; Siburian, Marsudi
Journal of Energy, Material, and Instrumentation Technology Vol 6 No 4 (2025): Journal of Energy, Material, and Instrumentation Technology (In Press)
Publisher : Departement of Physics, Faculty of Mathematics and Natural Sciences, University of Lampung

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Abstract

KUALITAS TIDUR SEBAGAI PREDIKTOR FUNGSI KOGNITIF ANAK SEKOLAH DASAR: STUDI KORELASIONAL DI KABUPATEN LOMBOK TIMUR Endah; Lili Al Pizamara; Nurhayati; Robiatul Adawiyah
PrimA: Jurnal Ilmiah Ilmu Kesehatan Vol. 11 No. 2 (2025): PrimA: Jurnal Ilmiah Ilmu Kesehatan
Publisher : LPPM STIKES Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47506/trhsgs26

Abstract

Latar Belakang: Kualitas tidur merupakan faktor fisiologis krusial yang berperan sebagai prediktor terhadap performa kognitif anak. Di tengah tantangan era modernisasi, menjaga stabilitas fungsi kognitif siswa sekolah dasar menjadi kunci utama dalam mempersiapkan generasi unggul menuju Indonesia Emas 2045. Tujuan: Penelitian ini bertujuan untuk menganalisis peran kualitas tidur sebagai prediktor fungsi kognitif pada anak di SDN 1 Gereneng Timur, Kabupaten Lombok Timur. Metode: Jenis penelitian ini adalah kuantitatif dengan desain korelasional menggunakan pendekatan cross-sectional. Sampel berjumlah 34 siswa kelas 4 yang diambil melalui teknik accidental sampling. Instrumen penelitian menggunakan kuesioner kualitas tidur (PSQI) dan lembar observasi fungsi kognitif. Data dianalisis menggunakan uji korelasi Spearman Rank. Hasil: Hasil penelitian menunjukkan mayoritas siswa memiliki kualitas tidur baik (73,5%) dan fungsi kognitif baik (61,7%). Analisis bivariat menunjukkan adanya hubungan positif yang sangat kuat dan signifikan secara statistik (r = 0,942; p = 0,000). Kesimpulan: Kualitas tidur memiliki pengaruh yang signifikan dan searah terhadap fungsi kognitif; semakin baik kualitas tidur, semakin optimal kemampuan kognitif siswa.
Pengaruh Metode Bernyanyi Terhadap Kepatuhan Cuci Tangan Pakai Sabun Di PAUD KB Ingin Terampil  Kabupaten Lombok Timur Endah; Tia Puspa Pratiwi; Nurhayati; Ageng Abdi Putra
PrimA: Jurnal Ilmiah Ilmu Kesehatan Vol. 12 No. 1 (2026): PrimA: Jurnal Ilmiah Ilmu Kesehatan
Publisher : LPPM STIKES Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47506/e0vv7571

Abstract

Pendahuluan: Kesehatan anak usia prasekolah sangat penting karena rentan terhadap penyakit menular seperti ISPA, diare, dan kecacingan. Salah satu upaya pencegahannya adalah mencuci tangan pakai sabun (CTPS). Data menunjukkan mencuci tangan dengan sabun lebih efektif mengurangi risiko infeksi dibanding hanya dengan air, sehingga diperlukan pendekatan edukasi yang menyenangkan. Metode bernyanyi menjadi salah satu alternatif karena mampu meningkatkan motivasi, rasa senang, serta memudahkan anak mengingat langkah cuci tangan. PAUD KB Ingin Terampil Kabupaten Lombok Timur merupakan salah satu lokasi di mana sebagian besar anak belum menerapkan perilaku CTPS sebelum makan dan sesudah bermain. Tujuan:Penelitian ini bertujuan untuk mengetahui pengaruh metode bernyanyi terhadap kepatuhan cuci tangan pakai sabun pada anak usia prasekolah di PAUD KB Ingin Terampil Kabupaten Lombok Timur. Metode: Jenis penelitian ini adalah kuantitatif dengan desain pre-experimental one-group pretest-posttest. Jumlah populasi sebanyak 62 anak, dengan sampel sebanyak 32 responden yang didapatkan menggunakan teknik accidental sampling. Pengukuran kepatuhan dilakukan menggunakan lembar observasi sebelum dan sesudah intervensi metode bernyanyi beserta gerakannya. Data dianalisis menggunakan uji Wilcoxon Signed Ranks Test karena data tidak berdistribusi normal. Hasil: Kepatuhan anak sebelum diberikan intervensi metode bernyanyi sebagian besar berada pada kategori tidak patuh yaitu sebanyak 25 orang (78%), cukup patuh 7 orang (22%), dan tidak ada yang patuh (0%). Setelah diberikan intervensi metode bernyanyi, kategori tidak patuh menurun menjadi 7 orang (22%), cukup patuh meningkat menjadi 18 orang (56%), dan patuh meningkat menjadi 7 orang (22%). Hasil analisis statistik menggunakan uji Wilcoxon diperoleh nilai $p\text{-value} = 0{,}000$ ($p < 0{,}05$), yang menunjukkan bahwa ada pengaruh metode bernyanyi terhadap kepatuhan cuci tangan pakai sabun pada anak usia prasekolah di PAUD KB Ingin Terampil Kabupaten Lombok Timur. Kesimpulan: Edukasi melalui metode bernyanyi yang dilakukan bersama gerakan dapat meningkatkan kepatuhan anak usia prasekolah dalam mencuci tangan pakai sabun, sehingga anak yang semula tidak patuh menjadi cukup patuh hingga patuh sesuai dengan langkah-langkah kebersihan tangan yang benar.
Co-Authors Ageng Abdi Putra Alnovera, Vayza Deva Eva Kholifah Gifari, Muhammad Wildan Herbanu, Aldi Lili Al Pizamara Nurhayati Priyanto Robiatul Adawiyah Rosita Wati Siburian, Marsudi Tia Puspa Pratiwi Tresnaningtyas, Sekar Asri