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All Journal Jambura Journal of Health Sciences and Research Jurnal Kesehatan Amanah Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Asyrun Alkhairi Lubis
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Jurnal Indah Sains dan Klinis

 1 
Efek Pemberian Ekstrak Daun Gelagah (Saccharum spontaneum L.) terhadap Diabetes Induksi Aloksan pada Tikus Putih (Rattus Norvegicus) Tiara Salsabilla Mendrofa; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.05

Abstract

Saccharum spontaneum L. (Family: Poaceae) is a tall perennial grass with deep roots and rhizomes, capable of growing up to 3-4 meters in height, and is commonly found along water bodies or roadsides. This plant is widely distributed throughout the tropical regions of Asia, Africa, America, and Australia. Saccharum spontaneum L. is a tall, erect, perennial grass with feathery inflorescences, often growing in swampy areas. Its leaves and stems contain lignin, carbohydrates, proteins, and amino acids, while its roots and lower stems contain starch and polyphenolic compounds. This study aims to evaluate the effect of Saccharum spontaneum L. leaves extract on blood glucose levels in male white rats (Rattus norvegicus) induced with alloxan. The leaves extract was obtained through maceration using 96% ethanol solvent. Phytochemical screening results indicated that the leaves of Saccharum spontaneum L. contain alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The antidiabetic test was conducted using male Wistar rats. In this study, the Saccharum spontaneum L. leaves extract was administered in three different doses: group 4 received a dose of 100 mg/KgBW, group 5 received a dose of 200 mg/KgBW, and group 6 received a dose of 400 mg/KgBW. Additionally, there were control groups consisting of group 1 (normal), group 2 (negative control), and group 3 (positive control) which were given the drug glibenclamide 5 mg/60 kg. All doses were administered orally. Diabetes induction in the rats was performed using alloxan monohydrate at a dose of 100 mg/KgBW administered intraperitoneally. The results of the study showed that the greatest reduction in blood glucose levels occurred in group 6 with a dose of 400 mg/KgBW, which decreased blood glucose levels by 71.78% at the 180th minute. Group 5 showed a reduction of 55.80% and group 4 showed a reduction of 51.91% at the 180th minute. Group 3, which was given glibenclamide, showed a reduction in blood glucose levels of 71.14% at the 180th minute. These results indicate that the highest dose of Saccharum spontaneum L. leaves extract (400 mg/KgBW) had the most significant effect in lowering blood glucose levels in male Wistar rats induced with alloxan monohydrate
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Co-Authors AA Sudharmawan, AA Adinda Silvani Ginting Akmalul Habib Damanik Angelia Vega Astriani Natalia Astriani Natalia Br Ginting Elfia Neswita Erida Novriani Ermi Girsang Farren Farren Gerhart Frengki Hardian Harefa Henny Yolanda Ardilla Melnihati Laia Muhammad Yunus Nabilah Khairunnisa Nasution, Ali Napiah Novitaria Br Sembiring nurasni nurasni Rena Meutia Rizkya Adinda Nasution Siti Nurkholifah Sri Devi Alfitriani Sylvia Winata Tiara Salsabilla Mendrofa