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All Journal BALI MEDICAL JOURNAL (BMJ) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Svāsthya: Trends in General Medicine and Public Health
Alvin Hartanto Kurniawan, Alvin Hartanto
Faculty of Medicine, Airlangga University, Surabaya-Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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SUSCEPTIBILITY OF RIFAMPICIN-ISONIAZID RESISTANT MYCOBACTERIUM TUBERCULOSIS ISOLATES AGAINST LEVOFLOXACIN Kurniawan, Alvin Hartanto; Mertaniasih, Ni Made; Soedarsono, S.
BALI MEDICAL JOURNAL Vol 5 No 1 (2016)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.946 KB)

Abstract

Background: Tuberculosis (TB) is a high burden disease in Indonesia with multidrug-resistant (MDR) TB incidence started to increase. Treatment success of MDR-TB globally was low in number than it was targeted which was especially caused by fluoroquinolone resistance. One of the fluoroquinolone is levofloxacin, an antibiotic that has been widely used irrationally as antimicrobial treatment. Therefore, this study investigated the sensitivity and MBC of MDR Mycobacterium tuberculosis isolates against Levofloxacin. Method: The susceptibility test for MDR -Mycobacterium tuberculosis on levofloxacin by standard method with levofloxacin were on concentrations 0,5 ?g/ml, 1 ?g/ml, and 2 ?g/ml. Sample of 8 strains MDR-Mycobacterium tuberculosis were cultured with each concentrations on Middlebrook 7H9 for 1 week incubation. Next, each of the incubated concentration was subcultured on solid media Middlebrook 7H10 for 3 weeks incubation. Colonized agar plates after 3 weeks incubation were confirmed with acid-fast stain. Results: On MB 7H10 with levofloxacin concentration 2 ?g/ml showed bactericidal effect 100% by no MDR Mycobacterium tuberculosis colony grew (0/8) while the MB 7H10 with levofloxacin concentration 1 ?g/ml and 0,5 ?g/ml showed the bactericidal effect 37,5% and 25% respectively. The colonized agar plate implied that the MDR Mycobacterium tuberculosis with levofloxacin concentration 1 ?g/ml (5/8) and 0,5 ?g/ml (6/8) grew well. Conclusion: Levofloxacin concentration 2 ?g/ml was susceptible on MDR Mycobacterium tuberculosis. The concentration 2 ?g/ml of levofloxacin could be considered as MBC.
Correlation between Body Mass Index to Hypertension in A Rural Area in East Java Kurniawan, Alvin Hartanto; Suwandi, Benedictus Hanjaya; Prakoso, Dicky Teguh; Moksidy, Reynaldy Cliftianto; Talitha, Irma; Anggraeni, Maharani Kartika; Zulkifli, Danang
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.7385

Abstract

Hypertension is one of the most commonly encountered problems in primary health care and a major risk factor for other lethal diseases. Obesity, another arising problem in developing and developed countries, is another major risk factor for metabolic disease. However, studies about both diseases and their intercorrelation in rural areas are still limited. Therefore, we conducted this study to investigate the correlation between body mass index (BMI) and blood pressure in a rural area. This study was an observational, cross-sectional study performed in outpatients at Community Health Care of Ngronggot, a rural area in East Java for one month with inclusion criteria aged 18 years old, systole blood pressure (SBP) ≥140 and/or diastole blood pressure (DBP) ≥90, or a history of anti-hypertensive treatment. Information including age, gender, SBP, DBP, mean arterial pressure (MAP), body weight, and height was collected and calculated for its distribution and correlation using the Spearman rank-order correlation test. There were 201 subjects in this study, 65.7% of which were female, while 34.3% of which are male, and the median age was 59 years old. We also found that more than 60% of our participants were overweight and obese. The results of the Spearman test showed that BMI significantly correlated with SBP (p=0.029), DBP (p=0.016), and MAP (p=0.008). In conclusion, BMI had a positive correlation with blood pressure, and obesity was prevalent in our rural area population.
Nephritic syndrome and acute kidney injury following poststreptococcal glomerulonephritis in pediatric patients: A case report Indriastuti, Endah; Rangkuti, Rahmah Yasinta; Kurniawan, Alvin Hartanto
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 1 (2024): July 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i1.14

Abstract

Acute kidney injury (AKI) is characterized by an abrupt decrease in glomerular filtration rate, manifesting as an increase in serum creatinine or oliguria. Nephritic syndrome, a manifestation of glomerulonephritis, presents with hematuria, hypertension, decreased urine output, and edema. This case report discusses an 11-year-old Asian boy who presented with decreased urination, shortness of breath, hypertension, and bilateral leg edema. Urinalysis revealed hematuria, proteinuria, and dysmorphic erythrocytes, while serum creatinine was elevated with a decreased estimated glomerular filtration rate (eGFR). The patient had a positive ASTO test, indicating poststreptococcal glomerulonephritis as the underlying cause of nephritic syndrome and AKI. Although most cases of poststreptococcal glomerulonephritis in children have a favorable outcome, some cases can develop into a serious, life-threatening condition that requires careful attention. This case highlights the importance of early detection and management of poststreptococcal glomerulonephritis to prevent progression to nephritic syndrome and AKI, especially in resource-limited settings. Modest examination modalities can facilitate early detection and faster patient management, particularly in developing countries, to reduce the risk of mortality associated with severe AKI in pediatric patients.
Co-Authors Anggraeni, Maharani Kartika Indriastuti, Endah Moksidy, Reynaldy Cliftianto Ni Made Mertaniasih Prakoso, Dicky Teguh Rangkuti, Rahmah Yasinta S. Soedarsono Suwandi, Benedictus Hanjaya Talitha, Irma Zulkifli, Danang