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All Journal Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) E-Jurnal Medika Udayana Universa Medicina Cermin Dunia Kedokteran
I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi
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Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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GAMBARAN SEDENTARY LIFESTYLE PADA MAHASISWA PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA SELAMA MASA TRANSISI PANDEMI COVID-19 Santoso, Ayu Meylianawati; Dinata, I Made Krisna; Adiatmika, I Putu Gede; Primayanti, I Dewa Ayu Inten Dwi
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P09

Abstract

Sedentary lifestyle adalah perilaku yang terjadi pada saat kita duduk, berbaring, ataupun melakukan aktivitas yang membutuhkan energi sangat rendah. Sedentary lifestyle dapat dibedakan menjadi tiga tingkatan yaitu rendah, sedang, dan tinggi. Aktivitas fisik yang rendah pada mahasiswa Pendidikan Dokter Universitas Udayana menjadi salah satu faktor risiko dari Sedentary Lifestyle. Pembelajaran yang dilakukan dengan dua metode yaitu offline dan online menimbulkan perubahan pada aktivitas fisik mahasiswa. Penelitian ini bertujuan untuk mengetahui gambaran sedentary lifestyle pada mahasiswa Pendidikan Dokter Universitas Udayana selama masa transisi pandemi COVID-19. Penelitian ini merupakan penelitian deskriptif dengan metode cross-sectional. Penelitian ini dilakukan di Universitas Udayana dengan sampel mahasiswa Pendidikan Dokter angkatan 2019-2021. Besaran sampel yang diambil setelah menggunakan rumus Slovin adalah 98 sampel menggunakan simple random sampling. Terdapat 10 aktivitas sedentari yang didata durasi waktunya selama satu minggu. Bermain musik merupakan aktivitas sedentari yang jarang dilakukan mahasiswa Pendidikan Dokter dengan rata-rata dalam seminggu sebanyak 15 menit. Menggunakan handphone/mengobrol merupakan aktivitas sedentari yang sering dilakukan mahasiswa Pendidikan Dokter dengan rata-rata dalam seminggu sebanyak 4 jam. Sebanyak 95% mahasiswa Pendidikan Dokter Universitas Udayana dalam tingkat kegiatan sedentari yang tinggi. Sedentary Lifestyle pada mahasiswa Pendidikan Dokter beragam dengan kegiatan yang paling dominan adalah menggunakan handphone/mengobrol. Penelitian lebih lanjut perlu untuk menilai hubungan antar variabel dengan jumlah yang lebih besar dan desain kuisioner yang lebih menarik. Kata kunci : Gambaran, Kegiatan Sedentari, Sedentary Lifestyle
Beban Tas Siswa di Sekolah Dasar Saraswati 5 Denpasar Harkitasari, Saktivi; Dewi Manuaba, Ida Ayu Laxmi Ananda; Primayanti, I Dewa Ayu Inten Dwi; Purnamasidhi, Cokorda Agung Wahyu
Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) Vol 6 No 2 (2020): Volume 6 No 2 Desember 2020
Publisher : Program Studi Magister Ergonomi Fisiologi Kerja Pascasarjana Universitas Udayana Denpasar Bekerjasama dengan Perhimpunan Ergonomi Indonesia (PEI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JEI.2020.v06.i02.p09

Abstract

The use of school bags without ergonomics design, miscarriage school bag, excessive bag load and carrying bags with long duration could be risk of disrupting the musculoskeletal system. The aim of this research is to know the frequency of bag load category of elementary students at SD Saraswati 5 Denpasar according to class, age, gender and weight of respondent. This research method was a descriptive cross-sectional study conducted at SD Saraswati 5 Denpasar. The sample in this study was selected by systematic random sampling. There were 86 respondents who carried load of bag of medium category amounted to 40 (46.5%) student, heavy bag category tend to carried by grade 3 student amounted to 12 (54.5%), male and female students carried the same bag load that is the moderate category 40 (46.5%) and the group with the mildest weight among other groups tend to carried heavy bag category amounted to 16 (55.2%). The conclusion is Students of Elementary School Saraswati 5 Denpasar more often carry the bag burden of the medium category. More heavy bag load categories are carried by students aged 7 years - 9 years. Groups of students with the lightest weight tend to carry heavy bag loads.
Antimalarial flavonoid glycoside from Carica papaya with inhibitory potential against Plasmodium falciparum dihydrofolate reductase thymidylate synthase: an in-silico study Sri Laksemi, Dewa Ayu Agus; Primayanti, I Dewa Ayu Inten Dwi; Surudarma, I Wayan; Damayanti, Putu Ayu Asri; Susanti, Ni Made Pitri
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.26-33

Abstract

BACKGROUNDCarica papaya is traditionally used to treat malaria. The mechanism of action of the active constituents may be determined by molecular docking. This study therefore examined the in silico antimalarial activity of selected compounds from Carica papaya using Plasmodium falciparum dihydrofolate reductase thymidylate synthase (PfDHFR-TS) as target protein. METHODSAntimalarial activity screening of Carica papaya compounds was done in silico using AutoDock 4.2 software which was equipped with Autodock tools 1.5.6 for preparation. Five compounds contained in Carica papaya leaves, i.e. quercitrin, isoquercitrin, carpaine, caricaxanthin, and violaxanthin were successfully docked with the target protein. The molecular docking method is declared valid if the RMSD obtained is not more than 2 Å. In vitro evaluation of the test compounds as antimalarials was accomplished by determining their inhibitory activity against dihydrofolate reductase thymidylate synthase (PfDHFR-TS) which plays a role in the synthesis of nucleotides needed by Plasmodium falciparum. RESULTSValidation of Plasmodium falciparum DHFR-TS with PDB ID 1J3I showed an RMSD value of 1.58 Å. The docking results showed that quercitrin, isoquercitrin, carpaine, and caricaxanthin showed negative energy values similar to the native ligand. Therefore the four compounds have good affinity for the target protein, while violaxanthin shows a positive energy value, indicating no affinity for the target protein. CONCLUSIONBased on binding affinity values and molecular interactions, isoquercitrin and quercitrin have inhibitory activity against dihydrofolate reductase thymidylate synthase (PfDHFR-TS), such that they have potential as natural antimalarial candidates.
Potensi Ekstrak Akar Manis (Glycyrrhiza glabra L.) untuk Pengobatan Hiperpigmentasi: Tinjauan Pustaka Sianturi, Ester Yulyana; Primayanti, I Dewa Ayu Inten Dwi
Cermin Dunia Kedokteran Vol 52 No 12 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i12.2043

Abstract

Hyperpigmentation is a dermatological condition characterized by increased melanin production which is the pigment responsible for skin color. Melanin is synthesized by melanocytes through an enzymatic pathway regulated by the enzyme tyrosinase. This process can be triggered by various factors such as ultraviolet (UV) radiation, hormonal changes, skin inflammation, aging, and the use of certain medications. One therapeutic approach is the use of natural ingredients, including herbal plant extracts. Glycyrrhiza glabra L., commonly known as licorice root, has long been used in both traditional and modern medicine due to its active compounds such as glabridin, which possesses antioxidant and tyrosinase-inhibiting properties. This review aims to evaluate the potential of licorice root extract as a natural depigmenting agent in the treatment of hyperpigmentation. A literature review was conductedusing databases PubMed, Google Scholar, NCBI, and ResearchGate. The findings indicate that glabridin selectively inhibits tyrosinase activity without causing skin irritation and also exhibits anti-inflammatory and photoprotective effects. Licorice root extract showspromise as a safe and effective natural therapeutic option for managing hyperpigmentation.
Co-Authors Cokorda Agung Wahyu Purnamasidhi Dewi Manuaba, Ida Ayu Laxmi Ananda I Made Krisna Dinata I Putu Gede Adiatmika Ni Made Pitri Susanti Putu Ayu Asri Damayanti Saktivi Harkitasari, Saktivi Santoso, Ayu Meylianawati Sianturi, Ester Yulyana Sri Laksemi, Dewa Ayu Agus Surudarma, I Wayan