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All Journal Medicina Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Community Development Journal ABDI MOESTOPO: Jurnal Pengabdian pada Masyarakat Cermin Dunia Kedokteran Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Hang Tuah Medical Journal Abdi Widya: Jurnal Pengabdian Masyarakat

Saktivi Harkitasari, Saktivi

Universitas Warmadewa

Author-ID : 518815

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENURUNAN JUMLAH LEUKOSIT SEBAGAI PREDIKTOR PERBAIKAN KLINIS PENDERITA STROKE HEMORAGIK SELAMA PERAWATAN Harkitasari, Saktivi; Nuartha, Anak Agung Bagus Ngurah; Purwata, Thomas Eko
Medicina Vol 46 No 2 (2015): Mei 2015
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.154 KB)

Prognosis penderita stroke hemoragik dipengaruhi oleh banyak faktor, salah satunya adalah jumlahleukosit. Berbagai penelitian menyatakan bahwa peningkatan jumlah leukosit sebagai prediktorperburukan klinis dan kematian pada penderita stroke hemoragik, tetapi sampai saat ini masihbelum jelas apakah penurunan jumlah leukosit setelah terjadi leukositosis dapat sebagai prediktorperbaikan klinis penderita stroke hemoragik. Penelitian ini menggunakan rancangan kohort prospektif.Subjek penelitian adalah penderita stroke hemoragik dengan awitan datang d”24 jam denganleukositosis saat masuk rumah sakit yang dirawat di Sanglah Denpasar. Kelompok yang mengalamipenurunan jumlah leukosit dibandingkan dengan kelompok yang tidak mengalami peningkatan atautanpa perubahan jumlah leukosit. Penilaian luaran klinis menggunakan perubahan skor NIHSS yangdinilai pada hari ketujuh. Total sebanyak 44 subjek dimasukkan dalam penelitian, 19 subjekmeunjukkan perbaikan skor NIHSS. Penurunan jumlah leukosit memiliki hubungan yang signifikandengan perbaikan klinis (RR=5,33; IK95%: 1,81 sampai 15,74; P<0,0001). Hasil penelitianmenunjukkan hanya penurunan jumlah leukosit memiliki hubungan yang independent dengan perbaikanskor NIHSS. Disimpulkan bahwa pada penderita stroke hemorgaik dengan leukositosis, penurunanjumlah leukosit dapat menjadi prediktor perbaikan klinis selama perawatan yang diukur denganskala NIHSS. [MEDICINA 2015;46:92-8].The prognosis of hemorrhagic stroke patients is associated with many factors, leucocyte count is one ofthem. Many studies indicated that elevated leucocyte count is a predictor for bad clinical outcome anddeath in patients with hemorrhagic stroke, however, there is remain unclear whether leucocyte reductionafter leucocytosis could be a predictor for better clinical outcome of patients with hemorrhagic stroke.Thisis a prospective cohort study. Subject were hemorrhagic stroke patients who were arrival time d”24hours onset with leucocytosis admitted in Sanglah hospital Denpasar. Group with leucocyte countreduction were compared with group leucocyte count elevation or without changing. Clinical outcomewere measured with NIHSS score changing at day 7.A total of 44 subjects were recruited, 19 of themhad better NIHSS score. Leucocyte count reduction was significantly associated with better clinicaloutcome (RR=5,33; 95%CI: 1,81 to 15,74; P<0,0001). Leucocyte count reduction was the onlyindependently associated with better NIHSS score. It was concluded that in hemorrhagic stroke patientswith leucocytosis, leucocyte count reduction could be a predictor for better clinical outcome duringhospitalization measured with NIHSS.[MEDICINA 2015;46:92-8].

Diagnosis dan Terapi Miastenia Gravis pada Anak Harkitasari, Saktivi
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Miastenia gravis merupakan penyakit autoimun paut saraf otot yang didapat. Manifestasi klinis penyakit ini adalah gejala kelemahan yang berfluktuasi dan bervariasi pada otot-otot okuler, anggota gerak, pernafasan, dan bulbar. Miastenia gravis tipe okuler lebih banyak dijumpai dan memiliki usia awitan lebih awal. Pengobatan miastenia gravis menggunakan penghambat asetilkolinesterase, kortikosteroid, azathioprine, plasmaferesis, dan imunoglobulin intravena serta timektomi. Prognosis miastenia gravis pada anak-anak lebih baik daripada dewasa.Myasthenia gravis is an acquired autoimmune neuromuscular junction disease. The clinical manifestations are fluctuating weaknesses of ocular, limbs, respiratory, and bulbar muscles. Ocular myasthenia is the most frequent type with earlier age of onset. Treatment of myasthenia gravis uses acetylcholinesterase inhibitors, corticosteroids, azathioprine, plasmapheresis, intravenous immunoglobulin and thymectomy. Prognosis in children are better than in adults.Â

Diagnosis dan Terapi Miastenia Gravis pada Anak Saktivi Harkitasari
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i3.1030

Pemberdayaan Remaja sebagai Peer Educator “Cerdas Menggunakan Internet” di Bali Orphan Day Center Putu Asih Primatanti; Saktivi Harkitasari; Komang Trisna Sumadewi; Kadek Ayu Astuti
ABDI MOESTOPO: Jurnal Pengabdian Pada Masyarakat Vol 6, No 2 (2023): Juli 2023
Publisher : Universitas Prof. Dr. Moestopo (Beragama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32509/abdimoestopo.v6i2.2739

Pembatasan sosial menyebabkan individu terpaksa mengurangi interaksi sosial dan mencari aktivitas di rumah. Salah satu akibatnya adalah tingginya penggunaan internet dengan berbagai jenis motivasi penggunaan. Penggunaan internet yang berlebihan, khususnya penggunaan sosial media memberikan dampak negatif seperti problem mental dan perilaku berupa kecanduan atau adiksi. Anak yatim piatu berhak mendapatkan bimbingan tentang penggunaan internet ini untuk menghindari dampak yang kurang baik nantinya. Salah satu cara yang dilakukan adalah dengan kegiatan pengabdian dengan memberdayakan dan menyiapkan mereka agar mampu mandiri dalam mengelola penggunaan internet, bahkan mampu menjadi penyuluh sebaya (peer educator) bagi teman-temannya. Kegiatan PKM ini bertujuan untuk meningkatkan pengetahuan dan kemampuan mitra agar dapat cerdas menggunakan internet dan sosial media. Metode yang digunakan dalam pengabdian masyarakat ini adalah memberikan edukasi tentang dampak penggunaan internet dan sosial media, serta melatih untuk melakukan dan memanfaatkan fasilitas filter dan screen time saat menggunakan smartphone maupun perangkat lainnya. Seluruh kegiatan mulai dari pemberian materi dan pelatihan terbukti meningkatkan pengetahuan anak di Bali Orphan mengenai dampak penggunaan internet yaitu sebanyak 95%, dan meningkatkan kemampuan menggunakan filter serta aplikasi untuk membatasi penggunaan internet. Peningkatan pengetahuan dilihat dari meningkatnya hasil post-test dan sudah bisa menggunakan aplikasi filter maupun screen time secara mandiri tanpa bantuan.

Beban Tas Siswa di Sekolah Dasar Saraswati 5 Denpasar Harkitasari, Saktivi; Dewi Manuaba, Ida Ayu Laxmi Ananda; Primayanti, I Dewa Ayu Inten Dwi; Purnamasidhi, Cokorda Agung Wahyu
Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) Vol 6 No 2 (2020): Volume 6 No 2 Desember 2020
Publisher : Program Studi Magister Ergonomi Fisiologi Kerja Pascasarjana Universitas Udayana Denpasar Bekerjasama dengan Perhimpunan Ergonomi Indonesia (PEI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JEI.2020.v06.i02.p09

The use of school bags without ergonomics design, miscarriage school bag, excessive bag load and carrying bags with long duration could be risk of disrupting the musculoskeletal system. The aim of this research is to know the frequency of bag load category of elementary students at SD Saraswati 5 Denpasar according to class, age, gender and weight of respondent. This research method was a descriptive cross-sectional study conducted at SD Saraswati 5 Denpasar. The sample in this study was selected by systematic random sampling. There were 86 respondents who carried load of bag of medium category amounted to 40 (46.5%) student, heavy bag category tend to carried by grade 3 student amounted to 12 (54.5%), male and female students carried the same bag load that is the moderate category 40 (46.5%) and the group with the mildest weight among other groups tend to carried heavy bag category amounted to 16 (55.2%). The conclusion is Students of Elementary School Saraswati 5 Denpasar more often carry the bag burden of the medium category. More heavy bag load categories are carried by students aged 7 years - 9 years. Groups of students with the lightest weight tend to carry heavy bag loads.

IMPROVING CHILDREN'S VISUAL SPATIAL INTELLIGENCE THROUGH DRAWING AT BALI STREET MUMS AND KIDS PROJECT FOUNDATION, DENPASAR Sumadewi, Komang Trisna; Yupardhi, Toddy Hendrawan; Primatanti, Putu Asih; Harkitasari, Saktivi
Community Development Journal Vol 8 No 1 (2024): Community Development Journal
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/cdj.v8i1.5625

Presently, multiple educational options exist for both primary school and higher education. The entire education system is designed to assist students in cultivating a range of abilities or intelligences inherent in each individual, encompassing mental and physical aspects. This concept is usually referred to as "Multiple Intelligences." Spatial visual intelligence is a form of intelligence that can visualize objects and possesses cognitive benefits in processing information through mental imagery. The parenting style employed by parents also influences children's intellectual ability. Based on interviews with foundation managers, it has been seen that due to online learning, youngsters affiliated with the foundation end up reverting to life on the streets, resorting to begging. Before the COVID-19 outbreak, the charity organized various programs and training sessions to enhance street children's skills. Several measures are implemented to diminish the inclination of street children to return to the streets. Nevertheless, given the prevailing circumstances, these activities have significantly reduced, resulting in children reverting to the streets as beggars, often with the consent of their parents. The foundation management anticipates providing training programs to cultivate children's intelligence, encompassing cognitive and emotional aspects. Furthermore, the foundation management seeks to provide parental education to parents of these youngsters. A service program was implemented to address these issues. It involved providing parenting education and teaching children how to draw to enhance their visual-spatial intelligence. The practice yielded a 60.4% increase in parents' knowledge and improved children's drawing skills. All participants attended this activity without exception. Therefore, this service program action was successful.

The Effect of Pilocarpine Hydrochloride on The Occurrence of Temporal Lobe Epileptic Seizures in White Mice (Mus musculus L.) BALB/C Strain Audria, Intan Safira; Harkitasari, Saktivi; Diah Witari, Ni Putu; Ningrum, Rima Kusuma; Putra Parwati, Tjok Istri; Sumadewi, Komang Trisna; Wiranatha, I Gede; Pratiwi, Cokorda Agung
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.67-72

The objective of this research was to determine the effective dosage of pilocarpine hydrochloride to provoke epileptic seizures in animal models. In this study, a true-experimental method was utilized, employing a post-test only control group design. A total of 32 white mice (Mus musculus Linnaeus UICC 524) BALB/c strains were divided into four different groups for this study. The experimental groups were subjected to varying dosages of pilocarpine hydrochloride: 220 mg/kgBW as group I, 320 mg/kgBW as group II, and 350 mg/kgBW as group III. On the other hand, the control group was administered a saline solution (NaCl 0.9%) at a dosage of 0.16% ml/kgBW. Both pilocarpine hydrochloride and saline solution (NaCl 0.9%) were injected intraperitoneally (i.p) into mice. In group I, none of the mice experienced epileptic seizures, and they all survived. In contrast, in group III, all the mice experienced epileptic seizures, but none of them survived. The Man-Whitney Test showed significant differences in seizure occurrence across doses (p<0.01). The effective dose of pilocarpine hydrochloride for inducing epileptic seizures associated with temporal lobe epilepsy (TLE) in this study appears to be in the range of 320 mg/kgBW to 350 mg/kgBW.

Meningkatkan Kesiapsiagaan Karyawan Sektor Pariwisata Melalui Pelatihan Bantuan Hidup Dasar Sumadewi, Komang Trisna; Subrata, Tanjung; Yupardhi, Toddy Hendrawan; Harkitasari, Saktivi
Abdi Widya: Jurnal Pengabdian Masyarakat Vol 4 No 2 (2025): Abdi Widya: Jurnal Pengabdian Masyarakat
Publisher : Pusat Penerbitan LP2MPP ISI Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59997/awjpm.v4i2.5428

Program pengabdian masyarakat ini bertujuan untuk meningkatkan kesiapsiagaan karyawan sektor pariwisata, khususnya di Hotel Ibis Denpasar, dalam menghadapi situasi kegawatdaruratan, terutama yang berkaitan dengan risiko tenggelam. Masalah yang dihadapi mitra adalah pengetahuan mitra mengenai kegawatdaruratan medis masih terbatas khususnya yang berkaitan dengan henti nafas dan henti jantung, kurangnya pelatihan tentang Bantuan Hidup Dasar (BHD) di kalangan karyawan, dan mitra tidak memiliki keterampilan yang memadai untuk menangani keadaan darurat. Metode yang digunakan dalam pelatihan ini meliputi serangkaian tahapan, mulai dari koordinasi dengan manajemen hotel, pengadaan sarana dan prasarana, hingga pelaksanaan pelatihan. Perangkat yang digunakan dalam pelatihan ini termasuk manekin untuk latihan praktik serta alat presentasi dan video. Proses pengabdian melibatkan beberapa tahapan seperti persiapan, tahap pelaksanaan meliputi pretest, penyampaian materi, pelatihan praktik, dan post-test untuk mengevaluasi peningkatan pengetahuan peserta, serta tahap monitoring dan evaluasi. Indikator keberhasilan dievaluasi berdasarkan peningkatan pengetahuan peserta, kehadiran peserta, dan peningkatan keterampilan peserta. Implikasi dari kegiatan pengabdian ini adalah peningkatan pengetahuan sebesar 52,9% yang dilihat dari nilai pre-test dan post-test. Selain itu, juga didapatkan peningkatan keterampilan mitra dalam memberikan pertolongan pertama dan BHD, yang sangat penting untuk meningkatkan keselamatan tamu di hotel serta menciptakan lingkungan yang lebih aman di sektor pariwisata.

Mesial Temporal Lobe Epilepsy as a Common but Elusive Case: A Case Report Junior, Darren; Wulandari, Putu Kintan; Harkitasari, Saktivi; Sumardika, I Wayan; Sumadewi, Komang Trisna
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22259

Epilepsy is a common neuronal disorder that could include partial or generalized seizures due to abnormal brain electrical activity. A 32-year-old female patient was presented to the emergency room with a chief complaint of seizure. The seizure semiology started with epigastric pain, which then progressed into sudden speech arrest. Afterward, the patient experienced left-sided head movement followed by jerkings on the left hand. The patient then became unconscious and experienced full body rigidity. Physical examinations, vital signs, and laboratory results showed no abnormalities. Diagnostic assessments only showed unspecific signs of diffuse cerebral edema through a CT Scan and an atrophy of the right hippocampus with a slight increase in FLAIR signal intensity and dilatation of the right lateral ventricle pericornu through MRI. The patient was given phenytoin and folic acid twice daily. The presence of right mesial temporal sclerosis served as a possible cause of epilepsy in this patient despite having several obscurities. The patient showed atypical signs of generalized tonic seizure progression, adult-onset seizures, and increased MRI FLAIR signal intensity. More detailed examinations and constant reports of epilepsy cases are highly needed among physicians to provide more specific methods and tools to diagnose, classify, and treat epilepsy in the future.

Genetic Mutations and Polymorphisms Related to Severity, Mortality, and Antibody-Dependent Enhancement of Dengue Virus (DENV) Infection: A Literature Review Purnamasidhi, Cokorda Agung Wahyu; Junior, Darren; Satya Diksha, I Gusti Ngurah Ariestha; Hiranandini Prawista, I Gusti Ayu Maha; Guptha, I Dewa Gede Agung Siwa; Pratyaksa, I Gusti Ngurah Dinda; Indratmo, Novea; Suteja, Richard Christian; Harkitasari, Saktivi
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.70457

The dengue virus (DENV) is a blood-borne Flavivirus transmitted through vectors and ranks as the fastest-spreading tropical disease globally. Dengue infection could exhibit mild to severe symptoms depending on various factors. Antibody-dependent enhancement (ADE) is a cross-reactive phenomenon between different DENV strains that clinicians should be aware of, as it leads to a higher incidence of dengue with warning signs and severe dengue. On the molecular level, many genes contribute to the severity and pathophysiology of ADE. Mutations and polymorphisms in these genes could alter the course of dengue infection. This article aims to comprehensively review studies that measure the impact of dengue-related genetic mutations and polymorphisms on the severity, mortality, and ADE of DENV infection. We performed a literature review to identify relevant articles on PubMed, Science Direct, Europe PMC, and Google Scholar. The review examines polymorphisms across multiple gene families: Fcγ receptors, cytokines (TNF-α, TGF-β1, IL-10), immune regulatory genes (MICB, PLCE1, RIPK2), antigen-presenting machinery (DC-SIGN, TAP), and host defense mechanisms (VDR, CTLA-4, MBL, HPA). These genetic variations have population-specific effects and may confer both protection in some populations and increased susceptibility to severe outcomes of dengue in others. The effects of these polymorphisms are context-dependent and differ according to the phase of infection, ethnicity, and gene-gene interactions. Overall, it could be concluded that aside from external factors, polymorphisms on human genes regulating mechanisms and components related to dengue infection have been extensively discussed to play a role in the overall clinical outcome.

Co-Authors Aditya Yudistira Albert Salim Anak Agung Bagus Ngurah Nuartha Anak Agung Ngurah Agung Bayu Sutha Anak Agung Ngurah Agung Bayu Sutha Asri Lestarin Audria, Intan Safira Cokorda Agung Wahyu Purnamasidhi Desyanti Risky Putri Dewa Ayu Agung Alit Suka Astini Dewa Ayu Putri Sri Masyeni Dewa Ayu Sri Shita Meliani Dewi Manuaba, Ida Ayu Laxmi Ananda Giovanca Verentzia Purnama Guptha, I Dewa Gede Agung Siwa Hiranandini Prawista, I Gusti Ayu Maha I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gede Purna Weisnawa I Gusti Ngurah Agung Cahyadi Putra I Komang Hotra Adiputra I Made Wandia I Wayan Diki Wahyu Adinata I Wayan Sumardika Ida Bagus Giri Sena Putra Ida Bagus Giri Sena Putra Indratmo, Novea Jerry Junior, Darren Kadek Ayu Astuti Kadek Surya Atmaja Komang Trisna Sumadewi Komang Triyani Kartinawati Luh Gede Evayanti MADE BAGUS MANIK SATRIA MAHOTTAMA Made Ilora Hiranandasastri Ni Made Kharisma Praba Yuanika Ni Made Widya Apsari Cahyadewi Ni Putu Diah Witari, Ni Putu Ni Putu Dian Puspitha Maheswari Yasa Ni Putu Sukarini Ni Wayan Diana Ekayani Pratiwi, Cokorda Agung Pratyaksa, I Gusti Ngurah Dinda Primatanti, Putu Asih Putra Parwati, Tjok Istri Putu Asih Primatanti R. A.T. Kuswardhani Richard Christian Suteja Rima Kusuma Ningrum Satya Diksha, I Gusti Ngurah Ariestha Sri Masyeni Sri Masyeni, Dewa Ayu Putri Sumadewi, Komang Trisna Suteja, Richard Christian Suyasning Hastiko Indonesia Tanjung Subrata Thomas Eko Purwata Tjok Istri Putra Parwati Toddy Hendrawan Yupardhi, Toddy Hendrawan Wayan Sayang Yupardhi Wiranatha, I Gede Wulandari, Putu Kintan

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