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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) E-Jurnal Medika Udayana Media Kesehatan Masyarakat Indonesia Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Bali Anatomy Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Biomedika
Cokorda Agung Wahyu Purnamasidhi
Tropical And Infectious Diseases Division, Internal Medicine Department, Universitas Udayana, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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High Interleukin-6 Level Increases Depression Risk on Geriatric Population in Denpasar, Bali-Indonesia Purnamasidhi, Cokorda Agung Wahyu; Kuswardhani, R.A. Tuty
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.439 KB)

Abstract

Background: High interleukin-6 (IL-6) serum level was responsible in inflammatory regulation through the interaction within macrophage, glial melatonin production and regulation of methyl CpG- binding protein 2 (MeCP2) and influenced neuro-inflammation process, thus, it increased the risk of depression. The aim of this study was to determine whether high interleukin-6 serum level increased the risk of depression in geriatrics. Methods: A case control was performed as the design of this study. Geriatric populations with depression enrolled as the case group and without depression as control group. Assessment of IL-6 serum level was conducted by the patient’s venous blood. The IL-6 serum> 10 pg/ml was categorized as high. Results: In this study, 30 cases and 30 controls who met the criteria included as samples. There were 20 males (66.7%) and 10 females (33.3%). Factors associated with an increased risk of depression in geriatric were a high level of serum interleukin-6 (OR=3.60; CI95%: 1.22-10.64, p=0.018) and a marital status (OR=3.50; CI95%: 1.11- 1.02, p=0.028). High level of interleukin-6 was a significant and an independent risk factor of depression in geriatric (OR=3.60; CI95%: 1.22-10.64, p=0.021) in multivariate analysis. Conclusion: This study concluded that high IL- 6 serum level increased the risk of depression in geriatric.
The effect of online learning on burnout conditions of students in Medical Faculty, Udayana University I Nyoman Gede Narendra Yanakusuma; I Gde Haryo Ganesha; Cokorda Agung Wahyu Purnamasidhi
Bali Anatomy Journal Vol 4 No 2 (2021): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/baj.v4i2.61

Abstract

Background: Learning in the network (online) is learning by using the internet to access material and interact with teachers and students presented through electronic devices, making it easier to access information anytime, anywhere. Implementing online learning can provide stressful conditions for students, resulting in burnout conditions. Aim: To determine the effect of online learning on the burnout condition of medical faculty students. Methods: This study was an observational study with a cross-sectional study design. The total sample was 325 respondents, and the sampling method used a consecutive sampling technique. Result: The results showed that burnout ratings obtained from 325 subjects received low burnout as many as 118 people (36.3%), moderate burnout as many as 197 people (60.6%), and severe burnout as many as ten people (3.1%). Conclusion: Burnout can occur during the implementation of online learning. There is a sense of saturation, fatigue, and limitations in doing practicum or lab skills so that the lectures that are run will not be optimal.
High Incidence of Hepatitis B Virus Infection in Hemodialysis Patients at Sanglah General Hospital and It’s Risk Factors Cokorda Agung Wahyu Purnamasidhi; I Ketut Mariadi; I Dewa Nyoman Wibawa; Yenny Kandarini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.387 KB) | DOI: 10.24871/1732016155-161

Abstract

Background: Patients receiving maintenance hemodialysis (HD) are at higher risk for Hepatitis B Virus (HBV) infections than in general population. Strict infection control is essential to prevent nosocomial transmission. We aimed to investigate the incidence of HBV infection in the HD population in Sanglah General Hospital as well as risk factors acquired HBV infection.Method: All adult patients receiving maintenance HD (n=267) in 3 dialysis units at Sanglah Hospital were studied between March to June 2016. In this study, medical record of patients on maintenance hemodialysis were reviewed and the patients were interviewed by the researchers to collect data regarding the serology status of these patients before and during HD, and potential risk factors which could be associated with HBV acquisition.Results: Participant mean age was 54.07 ± 0.80 years and 154 (57.7%) were male.We found 21 patients (7.8%) were sero-positive for HBV (HBsAg positive) with mean titer was 9.26±1.85. Of the sero-positive patients,1 patient (4.8%) were known to be infected before the initiation of HD and 20 patients (95.2%) were infected during HD. Incidence of HBV infection during  HD was 7.5% (20/266). Sero-positive patients were younger with mean age was 51.81±2.76 years, had longer time on dialysis and had previous blood transfusions. Risk factors, which significant associated with hepatitis B infection were history of transfusion (p0.01; OR: 2.49; 95%CI: 1.29-8.18) and duration of hemodialysis (p 0.01; OR: 1.07; 95% CI: 1.03-3.74).Conclusion: Patients on maintenance HD in Sanglah General Hospital have a high incidence of HBV infection. The factors associated with HBV infection are highly suggestive of nosocomial transmission within HD units. History of transfusion and duration of hemodialysis were significant risk factors for HBV infection in patients receiving maintenance HD.
Clinical Features of COVID-19 Patients at Udayana University Hospital During First Three Months of the COVID-19 Pandemic Cokorda Agung Wahyu Purnamasidhi; Ni Made Dewi Dian Sukmawati; Anak Agung Ayu Yuli Gayatri; I Made Susila Utama; I Ketut Agus Somia; Ketut Tuti Parwati Merati; Haruko Akatsu
Media Kesehatan Masyarakat Indonesia Vol. 18 No. 4: DECEMBER 2022
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30597/mkmi.v18i4.20235

Abstract

COVID-19 exhibits a wide variety of symptoms, ranging from mild, moderate, severe, and critical respiratory dysfunctions up to death. Therefore, this study aimed to examine the demographic, clinical, and laboratory profile of COVID-19 patients admitted to Udayana University Hospital, Bali, during the first three months of the pandemic. Data were collected from the electronic medical records of 236 patients hospitalized from April to June 2020. The samples had a mean age of 40 years old, and they consisted of 58.50% male. Based on the records, the common clinical characteristics included fever (52.5%) and cough (47.5%), followed by less common traits, such as sore throat (18.2%), dyspnea (10.2%), flu (8.9%), and headache (3.8%). Laboratory results during admission showed an average lymphocyte count of 2.16 ± 2.19 × 109 cells/L and a neutrophil- lymphocyte ratio of 3.02 ± 3.41. The majority of patients were private corporation employees (30.51%), followed by migrant workers (21.19%). Furthermore, a fatality rate of 1.69% was recorded in the study hospital. These results were expected to provide epidemiological knowledge of COVID-19 patients, which can help clinicians to anticipate possible outcomes during treatment.
UNDERSTANDING LEVEL OF PKK BANJAR PURWA SANTHI BENOA ON MEDICAL MASK WASTE MANAGEMENT AND STRENGTHENING HEALTH PROTOCOLS IN CONTROLLING COVID-19 INFECTION I Komang Hotra Adiputra; Kadek Diana Harmayani; Ni Made Susilawathi; Cokorda Agung Wahyu Purnamasidhi; Komang Ayu Witarini; I Wayan Arya Biantara; I Dewa Made Sukrama; I Gede Purna Weisnawa; Jerry; Putu Kintan Wulandari; Darren Junior; Dewa Ayu Fony Prema Shanti; I Dewa Ayu Agung Warmadewanthi
INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY VOLUME 6, NUMBER 1, APRIL 2023
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/urbanenvirotech.v6i1.15335

Abstract

The increase in mask waste and a lack of understanding about the management of single-use mask waste raises the potential for environmental pollution and COVID-19 transmission. Aim: This study aimed to assess the level of understanding of medical mask waste management and strengthening health protocols in controlling COVID-19 infection in Banjar Purwa Santhi, Benoa, Badung Regency. Methodology and Results: A cross-sectional method and descriptive study design were used with a sample of 100 respondents selected via stratified sampling. The research and service activities at Banjar Purwa Santhi Benoa include public campaign and assessment of the level understanding of medical mask waste management. Based on univariate analysis, 91% of respondents know that mask waste contains hazardous and toxic substances. If mask waste is disposed carelessly, 98% of respondents stated that it can pollute the environment, and 98% of respondents also stated that it has the potential to become a means of transmitting COVID-19. However, 85% of respondents disposed of the masks in the household trash. Conclusion, significance and impact study: Respondents had a good level of knowledge about health protocols and mask waste management but have not separated masks from household waste. By holding the community service activity, it is hoped that changes in community behavior will occur.
HUBUNGAN KOMPONEN DALAM PEMERIKSAAN DARAH LENGKAP TERHADAP TINGKAT KEPARAHAN KLINIS PASIEN COVID-19 DI RUMAH SAKIT UNIVERSITAS UDAYANA Suteja, Richard Christian; Purnamasidhi, Cokorda Agung Wahyu; Krisnawardani K, Cokorde Istri Yuliandari; Suastika, Luh Oliva Saraswati
E-Jurnal Medika Udayana Vol 12 No 10 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i10.P08

Abstract

COVID-19 merupakan suatu wabah yang memiliki tingkat penularan yang cukup tinggi. Oleh karena ketersediaan yang sangat tinggi, pemeriksaan darah lengkap berpotensi digunakan sebagai skrining awal terjadinya tingkat keparahan klinis yang berat pada pasien COVID-19. Penelitian ini bertujuan untuk mengetahui hubungan komponen pemeriksaan darah lengkap terhadap tingkat keparahan klinis pasien pada COVID-19. Sebuah studi potong lintang dilakukan di Rumah Sakit Universitas Udayana pada pasien COVID-19 berusia 18-59 tahun yang terkonfirmasi via RT-PCR dan dirawat inap pada Maret 2020 hingga Maret 2021. Pasien dengan rekam medisnya tidak lengkap, tidak menjalani pemeriksaan darah lengkap pada hari pertama, menderita keganasan hematologis, terinfeksi HIV, atau menderita komorbid autoimun dieksklusi dari subyek yang akan dianalisis. Subyek yang telah dibagi menjadi kelompok kritis dan non-kritis berdasarkan kriteria kementerian kesehatan RI kemudian dianalisis hubungannya terhadap komponen dalam pemeriksaan darah lengkap pada hari pertama rawat inap berupa hemoglobin, leukosit, eosinofil, basofil, neutrofil, limfosit, monosit, trombosit, dan komponen turunannya. Variabel usia, jenis kelamin, dan komorbid juga dianalisis untuk menyingkirkan pengaruh variabel perancu. Analisis menemukan bahwa leukosit, eosinofil, basofil, neutrofil, limfosit, monosit, trombosit, NLR, PLR, dan MLR berhubungan secara signifikan terhadap tingkat keparahan klinis pada pasien COVID-19 di Rumah Sakit Universitas Udayana. Hemoglobin tidak berhubungan secara signifikan tingkat keparahan klinis pada pasien COVID-19 di Rumah Sakit Universitas Udayana. Temuan ini dapat membantu klinisi untuk menilai potensi terjadinya perburukan tingkat keparahan klinis menjadi tingkatan berat hingga kritis pada pasien COVID-19.
The Incidence and Characteristics of Misdiagnosed Covid-19 Patients with Dengue Fever Infections at Udayana University Hospital in 2020-2021 Adiputra, I Komang Hotra; Swastika, I Kadek; Diarthini, Ni Luh Putu Eka; Sudarmaja, I Made; Purnamasidhi, Cokorda Agung Wahyu
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.42119

Abstract

The rise in dengue fever in recent decades combined with the emergence of COVID-19 at the end of 2019, has created new challenges in the healthcare sector. This research is a descriptive study with a cross-sectional research design and using medical record data at Udayana University Hospital in 2020–2021. According to the study, 1.22% cases of misdiagnosis out of a total of 2365 suspected cases of COVID-19 were found at Udayana University. The majority of cases of misdiagnosis involved people older than 60 years, namely 7 people (24.1%) and were dominated by men, namely 17 people (58.6%). The most common symptoms found are fever, cough, shortness of breath, headache, and malaise, According to laboratory results, dominant patients have thrombocytopenia, followed by high alanine transaminase (ALT), high aspartate transaminase (AST), and leukopenia. The appearance of thrombocytopenia in cases of COVID-19 with dengue fever is the result of suppressed platelet synthesis due to virus induction which causes bone marrow suppression and platelet clearance. Leukopenia and leukocytosis may coexist with lymphopenia as an indicator of disease severity. The similarity of symptoms and laboratory results between COVID-19 and dengue fever allows for misdiagnosis that will affect the patient's management. Therefore, the aim of this study is to determine the misdiagnosis rate of COVID-19 with dengue fever at Udayana University Hospital in 2020–2021, so that it can reduce misdiagnosis of the disease.
Epidemiological and Clinical Features of Critical and Non-Critical Elderly COVID-19 Patients in Udayana University Academic Hospital: A Retrospective Study Purnamasidhi, Cokorda Agung Wahyu; Somia, I Ketut Agus; Junior, Darren; Suteja, Richard Christian; Adiputra, I Komang Hotra; Purnama, Giovanca Verentzia; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Shanti, Dewa Ayu Fony Prema; Diksha, I Gusti Ngurah Ariestha Satya
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.43097

Abstract

Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.
Epidemiological, Clinical, And Occupational Characteristics of Migrant Workers Confirmed with COVID-19 At Udayana University Hospital Paramita, Ni Putu Pradnya; Wirawan, I Made Ady; Purnamasidhi, Cokorda Agung Wahyu; Florensia, Maria; Akatsu, Haruko
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.44596

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has prompted Indonesian expatriates to return home. Travel history, including migrant repatriation, was thought to spread COVID-19. These factors increased COVID-19 transmission. This study examined the epidemiological, clinical, and occupational characteristics of migrant workers with COVID-19 at Udayana University Hospital. This descriptive study utilized a cross-sectional methodology. The research samples consisted of 97 migrant workers diagnosed with COVID-19 who had been treated at Udayana University Hospital between March to August of 2020, using the total sampling technique. The median age (IQR) of migrant workers is 30, and 84.53% are male. Before returning to Indonesia, many worked and visited the US (20.6%). 87.63% of respondents worked in hospitality sector, and mostly worked in 8–12-hour shifts. All respondents have insurance; most employers are provided with PPE and information regarding COVID-19 prevention. At the airport, COVID-19 screening revealed fever (70.6%) and cough (76.3%) as the most common symptoms. A 94.8% of migrant workers had no comorbidities, and 87.6% had normal chest X-rays. From this research, we discovered that amongst migrant workers, positive-COVID-19 results were mostly found in young, mobile men. Most of them worked for 8–12 hours per day, and majority worked in hospitality sector. Almost all of them did not have any comorbidities and the most common symptoms found were fever and cough. The findings suggest that male workers in their productive age with high mobility and working in the hospitality sector are at higher risk of infection. 
Occupational and Return-To-Work Characteristics of Covid-19 Patients After Treated in Udayana University Hospital Karya, I Kadek Jony Dwi; Wirawan, I Made Ady; Purnamasidhi, Cokorda Agung Wahyu; Florensia, Maria; Akatsu, Haruko
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.45414

Abstract

Corona virus disease 2019 (COVID-19) is a new disease caused by severe acute respiratory syndrome corona virus 2 (SARS-COV-2). The COVID-19's symptoms are fatigue, muscle pain, and psychological disorders. The purpose of this study was to describe the occupational characteristics and health conditions of COVID-19 patients who had recovered after being treated at Udayana University Hospital. This study is a descriptive study with a quantitative method and cross-sectional design. The research samples were 110 COVID-19 patients treated at Udayana University Hospital from June to August 2020 and taken using random sampling. The results showed that the highest proportion of respondents were aged between 24-44 years (44.5%), with almost equal proportions of women (50.1%) and men (49.09%). Most of them lived in Denpasar (46.36%). Most respondents work as private sector employees (24.55%), and 70% of them were using personal protective equipment (PPE) while working. Most respondents needed less than seven days to return to work after being declared "in recovery state” (60%), with the remaining 55.5% having a decreased work duration to be less than 8 hours per day. The proportion of respondents with comorbidities was 30.91%. As many as 27.27% were experiencing previously similar symptoms (fever, fatigue, cough) 4 to 5 months after being declared "cured.” COVID-19 patients who have recovered should be monitored for a longer period of time to evaluate the symptom reoccurrence and its impact on their occupational and health conditions.
Co-Authors Adiputra, I Komang Hotra Agus Eka Darwinata Akatsu, Haruko Anak Agung Ayu Yuli Gayatri Anom Suardika Darren Junior Dewa Ayu Fony Prema Shanti Dewi Manuaba, Ida Ayu Laxmi Ananda Dian, Ni Made Dewi Diksha, I Gusti Ngurah Ariestha Satya Divasta, I G Mahapraja Florensia, Maria Gayatri, Anak Agung Ayu Yuli Giovanca Verentzia Purnama Guptha, I Dewa Gede Agung Siwa Haruko Akatsu Hiranandini Prawista, I Gusti Ayu Maha I Dewa Ayu Agung Warmadewanthi I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Dewa Made Sukrama I Dewa Nyoman Wibawa I Gde Haryo Ganesha I Gede Purna Weisnawa I Kadek Swastika I Ketut Agus Somia I Ketut Mariadi I Komang Hotra Adiputra I Komang Hotra Adiputra I Made Ady Wirawan I Made Jawi I Made Sudarmaja I Made Susila Utama I Nyoman Gede Narendra Yanakusuma I Wayan Arya Biantara I Wayan Putu Sutirta Yasa Indratmo, Novea Jerry Jerry Junior, Darren Kadek Diana Harmayani Karya, I Kadek Jony Dwi Ketut Tuti Parwati Merati Komang Ayu Witarini Krisnawardani K, Cokorde Istri Yuliandari Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Made Dewi Dian Sukmawati Ni Made Susilawathi Paramita, Ni Putu Pradnya Pratiwi, Cokorda Agung Pratyaksa, I Gusti Ngurah Dinda Pujawan, I Made Naris Purnama, Giovanca Verentzia Putu Kintan Wulandari R. A.T. Kuswardhani Richard Christian Suteja Saktivi Harkitasari, Saktivi Satya Diksha, I Gusti Ngurah Ariestha Shanti, Dewa Ayu Fony Prema Siahaan, Katrin Wilentina Suastika, Luh Oliva Saraswati Suteja, Richard Christian Tirtha Yasa, I Nyoman Wawan Utama, I Made Susila Weisnawa, I Gede Purna Wulandari, Putu Kintan Yenny Kandarini