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All Journal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Jurnal EduHealth Jurnal Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Adi Susanto
STIKes Ibnu Sina Ajibarang
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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FORMULASI TABLET PARASETAMOL DENGAN KOMBINASI PVP DAN AMILUM UMBI PORANG (Amorphopallus onchopyllus) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET Arinda Nur Cahyani; Adi Susanto; Iva Rinia Dewi; Iswatun Nurhikmah
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 4 No. 02 (2023): Februari
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v4i02.886

Abstract

Tablets are the most widely used preparations, this is because tablets have advantages that other pharmaceutical preparations do not have, both in terms of production, storage, distribution, and use. This study aims to determine the concentration of PVP and starch from porang tubers which can be used as a binder in the preparation of paracetamol tablets and to determine the combination of PVP and starch from porang tubers as a binder to the physical properties of paracetamol tablets. In this study, 4 paracetamol tablet formulas with PVP binder were made combined with porang tuber starch with a weight of 650 mg per tablet. The binder used was PVP in each formula, namely F1 0%, F2 1%, F3 3%, and F4 5%, and porang tuber starch in each formula was F1 5%, F2 0%, F3 6%, and F4 7%. Tablets were made using wet granulation, the granules obtained were tested for their physical properties. including moisture content, flow time, angle of repose, and compressibility. After the powder mixture was compressed with a hardness between 4-8 kg, the resulting tablets were then tested for their physical properties including weight uniformity, size uniformity, friability, hardness, and disintegration time. The tablets produced from all formulas met the uniformity of weight, uniformity of size, and friability, the hardness that met the physical properties of the tablets was only found in formula I, which was 7.30 kg, and the fastest disintegration time in formula I was 9.6 minutes.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK SEFTRIAKSON DAN SEFTAZIDIM PADA PASIEN PNEUMONIA DEWASA DI RAWAT INAP RSUD AJIBARANG PERIODE JANUARI – DESEMBER 2021 Adi Susanto; Eko Hidayaturohman Khumaeni; Lina Septiana
Jurnal Kesehatan Vol. 10 No. 1 (2022): April : Health Journal “Love That Renewed”
Publisher : Sekolah Tinggi Ilmu Kesehatan Santo Borromeus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55912/jks.v10i1.40

Abstract

Pneumonia is a world health problem with the highest mortality rate, both in developed and developing countries such as Indonesia. Pneumonia is an acute infectious disease that affects the lung parenchyma (alveoli) so that the lung tissue becomes inflamed. To treat pneumonia, appropriate antibiotics are needed, minimal side effects and affordable costs. So it is necessary to study the cost-effectiveness analysis in order to make it easier to choose a more cost-effective treatment in pneumonia patients. The purpose of this study was to determine the cost-effectiveness of the use of antibiotics ceftriaxone and ceftazidime in adult pneumonia patients in Ajibarang Hospital inpatient period January – December 2021. This study was a descriptive study with retrospective data collection. Sampling using total sampling method and data collection using patient medical records. The results showed that the ACER value of the antibiotic ceftriaxone was Rp. 17,468 with an effectiveness of 87%, while the ACER value of ceftazidim is Rp. 15,375 with 100% effectiveness. In the quadrant placement the cost-effectiveness of ceftazidime occupies the dominant column in quadrant II (higher effectiveness with lower cost). Based on the ACER value and cost-effectiveness quadrant, ceftazidime is a more cost-effective therapy than ceftriaxone because it has a lower ACER value and occupies the dominant column.
Anti-inflammatory Activity of Taro Stem Ethanol Extract (Colocasia esculenta (L.) Schott) In Vitro Arinda Nur Cahyani; Adi Susanto; Eko Hidayaturrohman Khumaeni; Indira Pipit Miranti; Febia Citraeni; Ratih Widiyanti
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.391 KB)

Abstract

Inflammation is a complex response of vascular tissue to hazards such as pathogens, irritants, and damaged cells/tissues. Inflammation is caused by the release of chemical mediators from damaged tissue and cell migration. The purpose of this study was to determine the efficacy of ethanol extract of taro stem (Colocasia esculenta (L.) Schott) which is used as an anti-inflammatory agent and to determine the concentration of ethanol extract of taro stem (Colocasia esculenta (L.) Schott) which can provide anti-inflammatory activity. The method used in this research is the stability of the red blood cell membrane. The concentrations used were 0 ppm, 25 ppm, 75 ppm, 150 ppm and 100 ppm. The results of the percentage inhibition of hemolysis stability of the red blood cell membrane of taro stem extract concentrations of 0 ppm (00.00%), 25 ppm (82.58%), 75 ppm (83.47%), 150 ppm (47.17%), 100 ppm (24.23%). Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%. Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%. Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%.
Analisis Kualitatif Formalin Dan Boraks Pada Kikil Sapi Yang Dijual Di Pasar Ajibarang Ana Cahyani Hari Safitri; Adi Susanto
An-Najat Vol. 1 No. 2 (2023): MEI : An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v1i2.28

Abstract

Kikil adalah kulit sapi bagian dalam yang dapat dimakan dan merupakan bahan makanan yang mudah membusuk sehingga membutuhkan pengawetan baik secara fisik maupun kimia. Hal tersebut menyebabkan para produsen kikil sapi untuk menambahkan pengawet seperti formalin dan boraks yang penggunaanya dilarang yang tercantum dalam Permenkes RI No. 033 tahun 2012. Tujuan dari penelitian ini untuk mengetahui ada atau tidaknya kandungan formalin dan boraks pada kikil sapi yang dijual di Pasar Ajibarang. Tempat penelitian dilakukan di Pasar Ajibarang dan Laboratorium STIKes Ibnu Sina Ajibarang. Jenis penelitian ini adalah penelitian deskriptif. Pengambilan sampel dengan metode total sampling. Jumlah sampel sebanyak 5 sampel kikil sapi dari pasar Ajibarang. Metode pemeriksaan yang digunakan yaitu untuk analisis formalin menggunakan metode reaksi warna larutan KMnO4 0,1 N dan untuk analisis boraks menggunakan metode kertas turmerik. Hasil penelitian didapatkan dari kelima sampel kikil sapi untuk uji formalin 4 diantaranya positif mengandung formalin dan 1 sampel negatif formalin, sedangkan untuk uji boraks 5 sampel negatif mengandung boraks.
Co-Authors Alfi Umayah Ana Cahyani Hari Safitri Arinda Nur Cahyani Ary Nahdiyani Amalia Eko Hidayaturahman Khumaeni Eko Hidayaturrohman Khumaeni Febia Citraeni Iswatun Nurhikmah Iva Rinia Dewi Lina Septiana Miranti, Indira Pipit Ratih Widiyanti