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All Journal JBIO: jurnal biosains (the journal of biosciences) Biology, Medicine, & Natural Product Chemistry
Erlintan Sinaga
Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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THE EFFECT OF ETHANOL EXTRACT OF PIRDOT (Saurauria vulcani) ON HEMATOLOGICAL PROFILE AND KEAP1-NRF2 INHIBITION OF WHITE RATS INDUCED RHODAMINE B Adriana Yulinda Dumaria Lumban Gaol; Erlintan Sinaga; Rosinta Febryanti Simamora; Feimmy Ruth Pratiwi Sipahutar; Hudson Sidabutar
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 1 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i1.44136

Abstract

The study was designed to evaluate the hematological effect of ethanol extract of Pirdot (Saurauia vulcani) (EES) in white rats induce rhodamine B and predict interaction of bioactive compound Pirdot to bind active site Keap1-Nrf2. Twenty- four Male Wistar rats (100-200 g) divided into four groups. Group P1 served as group control is administered with CMC 0.5%; group P2 is treated with Rhodamine B 750 mg/kg BW, Group KP1 administered EES 500 mg/kg BW; and Group KP2 is treated with EES 500 mg/kg BW+ Rhodamine B 750 mg/kg BW. Hematological parameters were assessed. The results revealed that red blood cell (RBC), white blood cell (WBC), thrombocyte count, and hemoglobin concentration (Hb) in rats induced Rhodamine B significantly lower than the control group. However, EES could improve the value of hematological profile. Our finding demonstrated that EES normalizes the value of hematological parameters in rats induce Rhodamine B. Moreover, beta-amyrin, pomolic acid and maslinic acid from Pirdot had good binding affinity to Keap1-Nrf2
IDENTIFYING THE POTENTIAL OF Saurauia vulcani Korth. LEAVES ON BLOOD GLUCOSE LEVEL, HISTOPATHOLOGY OF PANCREATIC AND SPLEEN IN RATS (Rattus norvegicus) INDUCED ALLOXAN – IN VIVO AND IN SILICO APPROACH Erlintan Sinaga; Uswatun Hasanah; Feimmy Ruth Pratiwi Sipahutar; Hudson Sidabutar; Melati Nugrahalia Sipahutar
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 2 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i2.53242

Abstract

Insulin resistance related to pancreatic islet and spleen was one of incidence for diabetes mellitus disease. Our study determined the potential antidiabetic of Pirdot leaves (Saurauia vulcani, Korth.) (EEP) through in vivo and in silico approach. The effect of Pirdot on blood glucose level and histopathological pancreatic and spleen was analyzed by in vivo. Thirty male Wistar rats were divided into five groups as follows. Group KN served as negative control and was orally given distilled water; group KP were only 5.04 mg/ kg alloxan administered; group P1 were administered 16.5 mg/kg EEP and 5.04 mg/kg alloxan; group P2 were administered 33 mg/kg EEP and 5.04 mg/kg alloxan; group P3 rats 66 mg/kg EEP and 5.04 mg/kg alloxan. A single dose of alloxan was given in rats diabetic at KP, P1, P2, and P3 group treatment. Furthermore, the protein-protein interaction (PPI) and molecular docking were used to predict the interaction between the crossed genes in diabetes mellitus (DM) with 6 active compounds of Pirdot through in silico approach. The results indicated that Saurauia vulcani significantly decreased blood glucose and improved the histopathological alteration of pancreatic islet and spleen in alloxan induced treated diabetic rats. Moreover, the network pharmacology demonstrated ten hub genes and three genes target such as GANC (α-glucosidase), DPP4, and PTPN1 (tyrosine phosphatase protein) contributed in DM signaling pathway. Finally, the molecular docking study showed that the bioactive compounds Pirdot have a good binding affinity to the active site of PTP1B and α-glucosidase protein when compared to acarbose as a control compound
The Ameliorative Effect of Apigenin in Plectranthus amboinicus Lour Spreng in the Treatment of Hepato-renal Carcinogenesis Induced Benzo(a)pyrene Melva Silitonga; Hendro Pranoto; Erlintan Sinaga; Feimmy Ruth Pratiwi Sipahutar; Adriana Yulinda Dumaria LumbanGaol; Fajar Apollo Sinaga
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1483-1490

Abstract

Benzo(a)pyrene (B(a)P) is the major cause of hepato-renal carcinogenesis. Apigenin in Plectranthus amboinicus (EPA), has indicated some biological activities such as antioxidant and antimutagenic activity. The aim of this study is to investigate the potential of apigenin in EPA as anti-cancer against chronic hepatorenal damage exposed to B(a)P. The rats of 4 groups (n=6) were divided as follows: Group I (P0) was given food and water ad-libitum; Group II (PB) was administered orally B(a)P 2 mg/kg BW; Group III (PB+E) received orally B(a)P 2 mg/kg BW and EPA 500 mg/kg; Group IV (PE) was administered orally EPA 500 mg/kg BW. The therapeutic effect of EPA was explored using network pharmacology and molecular docking. The results showed that Group III could significantly improve (P < 0.05) the hepatorenal function parameter, including DNA concentration. SGPT, SGOT, blood urea nitrogen, and creatinine compared to those treated with B(a)P. The outcome data pharmacology revealed 6 targets could be the main core target. The good binding affinity indicated Apigenin docked to AKT1 protein with -10.00 kcal/mol relevant to Doxorubicin as control drug. Our results provide a new insight of apigenin in EPA potentially suppressing the regulation of chemical carcinogenesis by B(a)P.
The Effect of Torch Ginger (Etlingera elatior) Flower Extract on Creatinine Levels and Kidney Histophatology in Alloxan-Induced White Rats (Rattus norvegicus) Nofri Megariang Hura; Erlintan Sinaga
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.771-776

Abstract

Kidney function impairment is a common complication of hyperglycemia, characterized by increased creatinine levels and structural damage to renal tissue. Alloxan is frequently used to induce kidney injury through oxidative stress mechanisms. Torch ginger (Etlingera elatior) flower contains antioxidant compounds with potential nephroprotective effects. This study aims to determine the effect of torch ginger (Etlingera elatior) flower extract on creatinine levels and kidney histopathology in alloxan-induced white rats (Rattus norvegicus). The study used a Completely Randomized Design (CRD) with an experimental approach. The negative control group received destilled water, while the positive control group was induced with alloxan (120 mg/kgBW) intraperitoneally and treated with glibenclamide (0.45 mg/kgBW). The treatments groups (P1, P2, and P3) were given alloxan (120 mg/kgBW) and torch ginger (Etlingera elatior) flower extract orally at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively. This study showed that torch ginger (Etlingera elatior) flower extract significantly reduced creatinine levels and improved kidney histopathology (renal tubular necrosis). The 400 mg/kgBW dose was the most effective in lowering creatinine levels and repairing kidney tissue damage.
Co-Authors Adriana Yulinda Dumaria Lumban Gaol Adriana Yulinda Dumaria LumbanGaol Feimmy Ruth Pratiwi Sipahutar Feimmy Ruth Pratiwi Sipahutar Hudson Sidabutar Melati Nugrahalia Sipahutar Melva Silitonga Nofri Megariang Hura Pranoto, Hendro Rosinta Febryanti Simamora Uswatun Hasanah