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All Journal Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Sebatik Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Nabilah Nauli Jehan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Analisis Senyawa Asam Mefenamat dalam Sediaan Jamu Pegal Linu di PasarSumber Kabupaten Cirebon Indri Dwi Rahasasti; Nabilah Nauli Jehan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.27812

Abstract

Abstract: Indonesia is a country where people are still productive in consuming herbal medicine. The number of consumers of herbal medicine resulted in some herbal medicine manufacturers adding medicinal chemicals in it. In accordance with BPOM rules that apply a herbal medicine may not contain the slightest BKO. This study aim to analyze the content of mefenamic acid in herbs that circulate around the Sumber Regency market in Cirebon. Mefenamic acid is one of the drugs used to treat various kinds of pain, especially toothache, muscle aches, joint pains and aches when or before menstruation. The method used in this research is descriptive qualitative test using Thin Layer Chromatography (TLC) and quantitative tests using UV-Vis spectrophotometry. In TLC, the initial identification of a compound is based on a comparison of the value of Rf versus standard Rf. Rf values are generally not the same from laboratory to laboratory even at different analysis times in the same laboratory, so it is necessary to consider the use of relative Rf, ie the Rf value of compound stains compared to other compound stains on the same plate. Five of the eight samples found on the market contained mefenamic acid compounds. The samples containing mefenamic acid of found in the code numbers B, C, F, G and H. The highest levels of mefenamic acid were found in the B-1 sample of 0.14%. According to the One Way ANOVA statistical test results obtained a sig value of 0.001 <0.05. This shows the data on the levels of mefenamic acid in a sample of aching rheumatic / rheumatic herbs there are significant differences circulating in the Sumber Regency Cirebon market.  
Mangiferin Content in N-Hexane and Diethyl Ether Fractions of Mango (Mangifera indica L.) Leaves Var. Gedong Gincu : Luviriani, Eva; Calyptranti, Rosellynia; Jehan, Nabilah Nauli
Sebatik Vol. 28 No. 2 (2024): December 2024
Publisher : STMIK Widya Cipta Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46984/sebatik.v28i2.2513

Abstract

Mango (Mangifera indica L.) is a tropical fruit plant with high economic value and potential as a source of phytopharmaceuticals. One notable mango variety is Gedong Gincu, originating from Majalengka Regency, West Java, which contains active compounds such as mangiferin, flavonoids, saponins, and tannins with various therapeutic effects. This study aims to compare the mangiferin content in the n-hexane and diethyl ether fractions of Gedong Gincu mango leaf extract using the Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method. Mango leaves were extracted with ethanol, followed by fractionation using n-hexane and diethyl ether. The resulting fractions were then analyzed for mangiferin content using RP-HPLC. The weights of the n-hexane and diethyl ether fractions were 13.418 g and 8.21 g, respectively. Phytochemical screening revealed the presence of flavonoids, alkaloids, phenols, tannins, and saponins. RP-HPLC analysis showed differences in mangiferin content between the two fractions, with retention times (RT) of 1.430 minutes for the n-hexane fraction and 1.473 minutes for the diethyl ether fraction, indicating variations in solubility and interaction with the mobile phase. The RP-HPLC quantification revealed that the n-hexane fraction contained 339.5 mg/L of mangiferin, while the diethyl ether fraction contained 547.3 mg/L. This study provides valuable insights into the comparison of extraction solvents for mangiferin, which can be further utilized in the development of herbal formulations.
Antidiabetes Activity of Ethanol Extract of Pandan Leaves (Pandanus amaryllifolius Roxb) in Male White Mice (Mus musculus) Jehan, Nabilah Nauli; Hidayah, Harismayanti; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32378

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. This study aims to evaluate the antidiabetic effect of ethanol extract of fragrant pandan leaves (Pandanus ammarillyfolius Roxb) on aloxane-induced male white mice (Mus musculus). After alloxane induction, all test animals reached hyperglycemic conditions with blood glucose levels of ≥126 mgdL. The method used was the Paired Sample T-Test to analyze the difference in blood glucose levels before and after the treatment. The normality of the data was tested by the Shapiro-Wilk test, while the homogeneity was tested by the Leven test. The results showed that the most effective ethanol extract of fragrant pandan leaves reduced blood glucose levels at a dose of 600mgkgBB by 26%, a dose of 400mgkgBB by 21%, a dose of 200mgkgBB by 18%, a positive control using glibenclamide 0.65mgkgBB as much as 10% and a negative control using CMC-Na by 3%.
Characterization of microencapsulated Saga Leaves Extract (Abrus precatorius L.) and Analgetic Activity Tests in Male Mice (Mus musculus) Jehan, Nabilah Nauli; Titik Sunarni; Dian Marlina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.280-289

Abstract

Background: Saga leaves are one of the plants that have analgesic activity. Saga leaves contain phenol compounds, flavonoids, tannins, alkaloids, and saponins. Phenol has instability with oxygen, light, and high temperatures. Therefore, the microencapsulation process is necessary. Microcapsule characterization in this study included encapsulation efficiency, particle size, distribution value and morphology. Objective: This research was to determine the characterization of microcapsules and the analgesic activity of saga leaf extract microcapsules in male mice. Methods: The microencapsulation process conducted in this study was carried out using the spray drying method. Saga leaf extract was coated with the coating material in the ratio of 1:20. Several ratios of maltodextrin (MD) and soy protein isolate (SPI) (100%:0%); (75%%:25); (50%:50%); (25%:75%) were applied as the coating material. The encapsulation efficiency was determined by comparing the total phenol content of the extract and microcapsule. Particle size and distribution values were tested using a particle size analyzer. Microcapsule morphology was seen using scanning electron microscopy. Analgesic activity test using the tail-flick method with mice as test animals. Data analysis in this study used one-way ANOVA. Results: The encapsulation efficiency obtained was 31.40-80.29%. The particle size obtained in the microcosm was 17.70-30.90 µm. The distribution value obtained was 1.42-2.45. The morphology of the microcapsule obtained was round and had wrinkles. The analgesic activity obtained in this study resulted in significantly different pain inhibition values before and after microencapsulation. Conclusion: The characteristics of microcapsule preparations are well-known, and the analgesic activity of various microcapsules was 42.43-57.15%.
Co-Authors Ayudia Cipta Khairani Dian Marlina Hidayah, Harismayanti Luviriani, Eva Rosellynia Calyptranti Titik Sunarni Veithzal Rivai Zainal