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All Journal Sebatik HERBAPHARMA : Journal of Herb Farmacological Pharmaceutical And Biomedical Sciences Journal (PBSJ) Borobudur Pharmacy Review
Rosellynia Calyptranti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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KONSENTRASI HAMBAT DAN BUNUH MINIMUM EKSTRAK ETANOL DAN METANOL KULIT DURIAN (Durio zibethinus Murr) TERHADAP SALMONELLA THYPI Rosellynia Calyptranti; Eva Luviriani; Linda Safitri
HERBAPHARMA : Journal of Herb Farmacological Vol 4 No 1 (2022): Volume 4 Nomor 1 Juni 2022
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v4i1.285

Abstract

Durian (Durio zibethinus Murr) is a type of fruit that is very popular by everyone and is classified as a very abundant fruit. Compound content active in durian skin (Durio zibethinus Murr) such as alkaloids, phenols, flavonoids, tannins, and saponins can inhibit and kill bacteria that function as the antibacterial. The active compound can be obtained through the extraction process with a suitable solvent. This study aims to determine the value and difference between Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Durian Skin ((Durio zibethinus Murr.) Ethanol and Methanol Extract against Salmonella typhi. Salmonella typhi is a pathogenic bacterium that causes a large number of infections in humans in the form of typhoid fever. This study uses a completely randomized design (CDR). A factorial pattern consisting of 2 factors, namely the solvent factor and the concentration factor. Data analysis used Two Way ANOVA test to find out the comparison of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Durian Skin (Durio zibethinus Murr.) Ethanol and Methanol Extract against Salmonella typhi. If the data is not normally distributed then followed by a nonparametric statistical test, namely the Kruskal-Wallis test. The result of this study showed that at multilevel dilutions of Salmonella typhi which shows the number of colonies 30-300 CFU/ml at a dilution of 10-7. Durian peel ethanol extract can inhibit Salmonella typhi bacteria in the concentration of 25% and durian peel methanol extract can inhibit bacteria Salmonella typhi at a concentration of 10%. Statistical test results show that there is no difference in the Minimum Inhibitory Concentration (MIC) of Durian Skin ((Durio zibethinus Murr.) Ethanol and Methanol Extract against Salmonella typhi. (Asymp sig. >0,05).
FORMULASI GEL EKSTRAK ETANOL SERAI WANGI (Cymbopongon nardus L.) SEBAGAI SEDIAAN ANTISEPTIK TANGAN TERHADAP BAKTERI Staphylococcus epidermis Triani Kurniawati; Rosellynia Calyptranti; Febyayu Anggraeni
HERBAPHARMA : Journal of Herb Farmacological Vol 4 No 1 (2022): Volume 4 Nomor 1 Juni 2022
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v4i1.287

Abstract

Kesehatan merupakan investasi yang bertujuan untuk meningkatkan efisiensi kerja dan meningkatkan kesejahteraan keluarga. Serai Wangi (Cymbopogon nardus L.) memiliki senyawa aktif yang dapat digunakan untuk pengobatan seperti antibakteri dan antiseptik. Penelitian ini bertujuan untuk mengetahui karakteristik mutu formulasi gel ekstrak etanol serai wangi (Cymbopogon nardus L.) sebagai gel antiseptik tangan dan untuk mengetahui pengaruh variasi formulasi gel terhadap aktivitas antibakteri sediaan gel ekstrak etanol serai wangi (Cymbopogon nardus L.). Penelitian ini merupakan penelitian eksperimental, dengan Rancangan Acak Lengkap (RAL). Berdasarkan hasil penelitian, uji karakteristik mutu gel antiseptik semua variasi konsentrasi formulasi gel antiseptik tangan ekstrak etanol serai wangi (Cymbopogon nardus L.), pada uji organoleptis dengan mengamati bentuk, warna dan bau, uji homogenitas, uji daya sebar dan uji pH memberikan karakteristik mutu gel antiseptik yang baik kecuali pada uji viskositas tidak ada formulasi yang memenuhi syarat pada uji viskositas tersebut. Pada variasi konsentrasi ekstrak etanol serai wangi (Cymbopogon nardus L.) dengan konsentrasi 5%, 10% dan 15%, menghasilkan rata - rata diameter zona hambat masing - masing sebesar 3,4 mm, 3,5 mm dan 4,1 mm kemampuan penghambatan pada ketiga formulasi gel ekstrak etanol serai wangi (Cymbopogon nardus L.) sebagai sediaan gel antiseptik menunjukkan kategori penghambatan yang tidak peka. Hasil uji one way ANOVA diperoleh nilai signifikasi yaitu (0,676>0,05) tidak terdapat pengaruh variasi formulasi gel ekstrak etanol serai wangi (Cymbopogon nardus L.) sebagai sediaan antiseptik terhadap aktivitas antibateri pada bakteri Staphylococcus epidermidis.
Mangiferin Content in N-Hexane and Diethyl Ether Fractions of Mango (Mangifera indica L.) Leaves Var. Gedong Gincu : Luviriani, Eva; Calyptranti, Rosellynia; Jehan, Nabilah Nauli
Sebatik Vol. 28 No. 2 (2024): December 2024
Publisher : STMIK Widya Cipta Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46984/sebatik.v28i2.2513

Abstract

Mango (Mangifera indica L.) is a tropical fruit plant with high economic value and potential as a source of phytopharmaceuticals. One notable mango variety is Gedong Gincu, originating from Majalengka Regency, West Java, which contains active compounds such as mangiferin, flavonoids, saponins, and tannins with various therapeutic effects. This study aims to compare the mangiferin content in the n-hexane and diethyl ether fractions of Gedong Gincu mango leaf extract using the Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method. Mango leaves were extracted with ethanol, followed by fractionation using n-hexane and diethyl ether. The resulting fractions were then analyzed for mangiferin content using RP-HPLC. The weights of the n-hexane and diethyl ether fractions were 13.418 g and 8.21 g, respectively. Phytochemical screening revealed the presence of flavonoids, alkaloids, phenols, tannins, and saponins. RP-HPLC analysis showed differences in mangiferin content between the two fractions, with retention times (RT) of 1.430 minutes for the n-hexane fraction and 1.473 minutes for the diethyl ether fraction, indicating variations in solubility and interaction with the mobile phase. The RP-HPLC quantification revealed that the n-hexane fraction contained 339.5 mg/L of mangiferin, while the diethyl ether fraction contained 547.3 mg/L. This study provides valuable insights into the comparison of extraction solvents for mangiferin, which can be further utilized in the development of herbal formulations.
Kualitas mikrobiologi basis pelembab dari lemak daging Sapi metode low temperature dan bouble boiling berdasarkan angka lempeng total (ALT) Kurniawati, Triani; Luviriani, Eva; Rahasasti, Indri Dwi; Calyptranti, Rosellynia; Shafly, Alman
Borobudur Pharmacy Review Vol 5 No 1 (2025): January- June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v5i1.13560

Abstract

Dry skin is a problem that bothers many people. One of the causes of dry skin is skin dehydration, which can be overcome by using moisturizing cosmetics. Vaseline is a moisturizer commonly used by the public because it does not cause allergies and has good moisturizing capabilities. However, it is derived from non-renewable petroleum, necessitating alternatives. Animal fats can be used as cosmetic moisturizers and are considered safer than chemical substances like zinc oxide. According to BPOM, cosmetic products must pass safety tests such as microbial contamination, heavy metal contamination, and chemical contamination tests. Beef fat contains water and fatty acids that can create a suitable medium for microbial growth. However, temperature and water content affect microbial growth, necessitating further research on the microbiological quality of beef fat using low temperature and double boiling methods. This study aims to determine the microbiological quality of beef fat moisturizer bases using low temperature and double boiling methods through Total Plate Count (TPC) testing. This research is a pre-experimental study with a one-shot case study design. The results show that the TPC values of beef fat using low temperature and double boiling methods are each 1 x 10^4 CFU/g. This indicates that the TPC values of beef fat using low temperature and double boiling methods do not meet BPOM criteria, which is < 500 CFU/g. Keywords: Moisturizer; Beef Tallow; Low Temperature; Double Boiling; Total Plate Count.
Aktivitas Antibakteri Sediaan Masker Gel Peel Off Ekstrak Mentimun (Cucumis Sativus) Dan Tomat (Solanum Lycopersicum) Terhadap Staphylococcus Epidermidis Rahasasti, Indri Dwi; Luviriani, Eva; Calyptranti, Rosellynia; Kurniawati, Triani; Rahayu, Lia Handayani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.35117

Abstract

Acne is a disease that can be caused by bacteria, one of which is Staphylococcus epidermidis. Acne can be treated with active compounds derived from natural ingredients such as cucumbers and tomatoes. Gel masks peel off. This study aims to determine the average diameter of the inhibition zone, the difference in the average diameter of the inhibition zone, and the antibacterial activity of the peel-off from a mixture of cucumber (Cucumis sativus) and tomato  (Solanum lycopersicum) with a concentration of 5%, 10 %, 15%, 20% against  Staphylococcus epidermidis. This experimental study uses a Completely Randomized Design (CRD) consisting of one factor and 6 levels. The results showed that the average diameter of the inhibition zone of the anti-acne peel-off gel mask preparation of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10%, 15% and 20% were 16.38 mm, respectively. ; 24.88 mm; 29.88 mm and 34.88 mm. There was a significant difference in the average diameter of the inhibition zone of the peel off mixture of cucumber and tomato extracts with a concentration of 5%, 10%, 15%, and 20%; against Staphylococcus epidermidis. gel mask preparation peels off from a mixture of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10% concentration, 15% concentration and 20% concentration, namely strong, very strong, very strong and very strong.  
Co-Authors Febyayu Anggraeni Indri Dwi Rahasasti Linda Safitri Luviriani, Eva Nabilah Nauli Jehan Rahayu, Lia Handayani Shafly, Alman Triani Kurniawati Triani Kurniawati, Triani