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Bintari Tri Sukoharjanti
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ANALISIS EFEKTIVITAS BIAYA PERAWATAN TERAPI GASTRITIS PADA PASIEN UNIT RAWAT INAP DI RSI SUNAN KUDUS TAHUN 2018-2020 Kharisma Aprilita Rosyidah; Arina Zulfah Primananda; Wahid Sabaan; Bintari Tri Sukoharjanti
IJF (Indonesia Jurnal Farmasi) Vol 7, No 2 (2022): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v7i2.1390

Abstract

Persentase dari angka kejadian gastritis di Indonesia menurut WHO adalah 40,8% dan angka kejadian gastritis di beberapa daerah di Indonesia cukup tinggi dengan angka kejadian 274.396 kasus dari 238.452.952 jiwa penduduk (WHO, 2013). Berdasarkan profil kesehatan Indonesia tahun 2009, gastritis merupakan salah satu penyakit dalam sepuluh penyakit terbanyak pada pasien rawat inap di Rumah Sakit di Inonesia dengan jumlah 30.154 kasus (4,9%). Di provinsi Jawa Tengah tahun 2009 angka kejadian penderita penyakit gastritis mencapai 31,2% (Depkes RI, 2009). Dalam pengambilan keputusan pengobatan, termasuk gastritis, tidak hanya mempertimbangkan keamanan, khasiat dan mutu saja, tetapi juga harus mempertimbangkan nilai ekonominya. Faktor ekonomi yang penting adalah pemilihan obat yang cost effective, yaitu biaya pengobatan lebih terjangkau oleh masyarakat dan efektif untuk mendapatkan hasil klinik yang baik (Rustiani, dkk., 2014). Analisis Efektivitas Biaya merupakan suatu metode farmakoekonomi untuk memilih dan menilai program atau obat yang terbaik pada beberapa pilihan terapi dengan tujuan yang sama (Andayani, 2013). Dalam pemilihan prioritas strategi pengobatan mana yang memberikan outcome pengobatan yang baik, perlu dilakukan analisis yang mengkaitkan antara biaya yang dibutuhkan dengan outcome yang dihasilkan. Penelitian ini bertujuan untuk mengetahui apakah terdapat efektivitas biaya perawatan terapi gastritis pada pasien rawat inap di salah satu rumah sakit di Kudus yaitu RSI Sunan Kudus, tahun 2018 sampai 2020. Penelitian ini merupakan penelitian observasional dengan analisis deskriptif dan pengambilan data secara retrospektif, sedangkan untuk pengambilan data sekunder meliputi rekam medis dan biaya rawat inap pasien RSI Sunan Kudus. Berdasarkan hasil penelitian menunjukkan pasien terbanyak merupakan pasien dewasa (19-55 tahun) sebanyak 41%, mayoritas perempuan (62%), dengan rata-rata LOS (Length Of Stay) 4 hari.  Total rata-rata biaya pengobatan terendah terdapat pada kombinasi obat omeprazol dan pantoprazol. Terapi pengobatan yang memiliki efektivitas terapi paling baik (100%) yaitu omeprazol, pantoprazol, ranitidin + lansoprazol, omeprazol + esomeprazol, dan  omeprazol + pantoprazol. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat efektivitas biaya pada  kombinasi omeprazol dan pantoprazol yang memiliki nilai REB paling rendah yaitu Rp.18.986,76/ 1% efektivitas dan berada di posisi dominan pada perbandingan efektivitas dan biaya terapi.
UJI KARAKTERISTIK FISIK FORMULASI CLAY MASK EKSTRAK ETANOL DAUN UNGU (Graptophyllum pictum L.Griff) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus Choirun Nisak; Hasriyani, Hasriyani; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1534

Abstract

Skin problems caused by hormones, dead skin cells, clogged pores due to excess oil, and bacterial infections such as Staphylococcus aureus are known as acne. Antibiotics can cause side effects, so natural alternatives such as purple leaf masks are used because of their content of flavonoids, saponins, and tannins with antibacterial properties. Clay masks work by absorbing oil and cleaning pores. This study aims to determine the effectiveness of purple leaf extract clay mask in inhibiting Staphylococcus aureus and its physical characteristics. Formulations include F0 (0%), F1 (20%), F2 (23%), and F3 (26%) with antibacterial testing using disc diffusion methods and physical characteristics. The best physical results are shown by F2 (23%) because the physical quality of the formula is the best. Antibacterial results showed that F3 (26%) had the largest inhibition zone (9.16 mm), followed by F2 (5.76 mm), and F1 (3.9 mm). Purple leaf clay mask shows potential as an antibacterial against Staphylococcus aureus with F2 (23%) considered the best formulation due to its good inhibitory effect and standard-compliant physical properties.
FORMULASI DAN UJI ANTIBAKTERI EKSTRAK BIJI KETUMBAR (Coriandrum sativum L.) PADA SEDIAAN SPRAY GEL ANTIJERAWAT DENGAN VARIASI CARBOPOL 940 Muhammad Zielal Askari; Muhammad Nurul Fadel; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1559

Abstract

Acne is a skin problem or infection that generally appears on the face, neck, chest, and back. Acne is caused by the bacteria Propionibacterium acnes. Acne treatments that are often used are topical medications containing synthetic antibiotics. However, the use of these drugs can cause adverse resistance. Another alternative for acne therapy is using natural ingredients. This study aims to determine the antibacterial activity of coriander seed extract in a spray gel preparation. Flavonoid, terpenoid, saponin and tannin compounds contained in seeds This study is an experimental laboratory study using the disc diffusion method with 5 treatments, namely coriander seed extract with a concentration of carbopol F1 0.1%, F2 0.2%, F3 0.3%, a positive control spray gel brand "X" and a negative control only base without extract. The process of making coriander seed extract is carried out through the maceration method for 3x24 hours with 70% ethanol solvent. The filtrate obtained is then evaporated using a water bath to become a thick extract and continued for making spray gel preparations and antibacterial testing. The results of the research on the spray gel formulation from coriander seed extract showed the organoleptic physical characteristics of F1, F2, F3 were yellowish brown, liquid, and had a distinctive coriander odor. The pH test was 6.46; 6.32; 6.04, the viscosity test was 93.43 cP; 81.10 cP; 78.67 cP, the adhesiveness test of all formulas was stated not to drip for 10 seconds, and the spreadability was 6.01 cm; 5.48 cm; 4.42 cm. In the antibacterial test of the spray gel preparation, the inhibition zone value was obtained, namely F1 5.97 mm, F2 6.05 mm, F3 6.08 mm, and the positive control 10.10 mm. Based on the research of the three formulations, the most optimal spray gel preparation was F2 because it met the requirements of the physical test and antibacterial test.
PENGARUH VARIASI FORMULASI TEH CELUP DAUN TEH HIJAU (Camellia sinensis) KOMBINASI SERAI (Cymbopogon nardus) DAN JAHE (Zingiber officinale) TERHADAP KADAR FLAVONOID Haq, Athifa Afra Aulia; Endang Setyowati; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1642

Abstract

Excess free radicals can trigger oxidative stress and contribute to degenerative diseases. Flavonoids, as natural antioxidants, neutralize free radicals and are therefore important in the development of functional beverages. This study aimed to evaluate sensory characteristics, panelist preference, and flavonoid content, and to determine the optimal formulation of tea bags containing green tea leaves (Camellia sinensis), lemongrass (Cymbopogon nardus), and ginger (Zingiber officinale). Four formulations were prepared: F1 (100% green tea), F2 (70:15:15), F3 (50:25:25), and F4 (30:35:35). Flavonoid content was determined by UV-Vis spectrophotometry, while sensory properties were assessed through organoleptic and hedonic tests. Panelists were aged 18–59 years, regular tea drinkers, with normal sensory ability, while exclusion criteria included pregnancy, breastfeeding, allergies, medication use. Results showed that F4 had the highest flavonoid content (49.397 ± 3.258 mg QE/L), followed by F3 (32.677 ± 3.703 mg QE/L), F2 (13.877 ± 1.960 mg QE/L), and F1 (11.117 ± 1.502 mg QE/L). Statistical analysis confirmed significant effects of formulation on flavonoid content and sensory attributes of color, aroma, and taste (p < 0.05). F4 was identified as the optimal formulation with superior flavonoid content and panelist acceptance.
Co-Authors Arina Zulfah Primananda Choirun Nisak Endang Setyowati Haq, Athifa Afra Aulia Hasriyani Hasriyani, Hasriyani Kharisma Aprilita Rosyidah Muhammad Nurul Fadel Muhammad Zielal Askari Wahid Sabaan