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All Journal Global Medical and Health Communication The Indonesian Biomedical Journal Health Notions Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Indonesian Applied Physics Letters Cermin Dunia Kedokteran Cermin Dunia Kedokteran Folia Medica Indonesiana
Yudi Her Oktaviono, Yudi Her
Department Of Cardiology & Vascular Medicine, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Case report: stent dislodgedment Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Male 61 years old who presented with stable angina since 1 month ago, with Risk factor of CAD: hypertension, Dyslipidemia and heavy smoker. The ECG showed inferior old myocardial infarction. Diagnostic coronary angiography found: bifurcatio lesion at distal LMCA with significant stenosis 60% at the distal LM and 85% at the osteal LCx (Medina score 1-1-0), high D1 and diffuse disease with maximal stenosis 85% at the distal LAD after D2, Significant stenosis 85% at the osteal LCx and CTO at the distal after OM1, diffuse disease with maximal stenosis 85% at the mid RCA. A 6-Fr JR 4.0 guiding catheter (Launcher, Medtronic) was engaged into the right coronary artery ostium via the femoral artery. GW pilot 50 (Hi-Torque Pilot 50) inserted to distal RCA. Perform Balloon support by Saphire II inserted to mid RCA and dilated, after that perform balloon to proximal RCA and dilated. Stent DES Firebird II (Rapamycin) to mid RCA and dilated. Stent BMS Apollo 3.0x36 mm inserted to proximal-mid RCA, overlapping with previous stent, but was loss or dislodged and insert to the guiding catheter. BMS stent was pulled out with small balloon ex stent. GC 6F 4.0 inserted to ascending Aorta and engaged at ostium RCA. BMS stent Arthos PICO 3.0x 34 mm inserted to proximal-mid RCA, overlapping with previous stent and dilated. Final angiography confirmed successful pull out of loss stent and dilation of the RCA.
Pci in patient with heavy calcified lesion. Management and balloon rupture complication Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 51, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Balloon angioplasty in calcified coronary lesions may have a decreased success rate and an increased incidence of complications. This lesion remain a technical challenge in interventional cardiology despite novel approaches and devices. We describe a case with heavy calcified coronary lesion in LAD that was not only resistant to high-pressure inflation of conventional, non-compliant balloons and cutting balloon but the inflations also results in balloon rupture. Even, the first balloon became fracture and entrapment in LAD. The fractured balloon could be removed using second baloon inflation in LCX. The angioplasty balloon was successfully performed after rotational atherectomy by rotablator and succesfully continued by implantation stent DES.
Case report: use of intra-aortic balloon pump (iabp) in high-risk percutaneous coronary intervention procedure Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 51, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Intra-aortic balloon pump (IABP) is often used in patients who undergo high risk percutaneous coronary intervention (PCI) procedures, particularly if associated with hemodynamic impairment. However, this device is still underused in this center. In this case report, a 65-year old male patient with triple vessel disease (chronic total occluded left anterior descending artery-LAD, and significant stenoses of left circumflex and right coronary arteries), low ejection fraction and preprocedure blood pressure, was reported to have IABP support applied before PCI. The intervention to penetrate the occluded LAD was not success. After procedure, the patient was observed in intensive care unit. Weaning of IABP was performed after about 30 hours usage, without complication.
Hybrid Procedure in Aortoiliac Bifurcation and Femoral Lesion Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 58, No. 4
Publisher : Folia Medica Indonesiana

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Highlights: • A patient had a long segment of total occlusion to the proximal right common iliac and anterior tibial artery. • The treatment is a combination of percutaneous transluminal angioplasty (PTA) using vascular stent and the Fogarty thrombectomy. • Hybrid procedure can treat multilevel artery occlusive diseases, with shorter hospitalization, less perioperative morbidity, and similar early- and long-term efficacy. Abstract: Critical limb ischemia is a condition that threatens the viability of lower extremities and must be treated promptly to avoid major amputation. Revascularization is the most effective treatment method for critical limb ischemia. Revascularization using a hybrid of endovascular and open surgery is a minimally invasive procedure that performs well as the treatment for medically high-risk patients. A hybrid procedure should be considered for patients with high surgical risk. However, there are factors that could compromise its long-term patency, such as critical limb ischemia and diabetes. This study reported a case of a 53-year-old Asian male with history of insulin-dependent diabetes mellitus and long-standing tobacco use, presented with pain in the right leg at rest approximately 30 days prior to admission. Physical examination revealed a low temperature and remarkable non-palpable pulses in the right femoral, posterior tibial, and dorsalis pedis segments. Arteriography with run-offs revealed a long segment of total occlusion from the proximal right common iliac and anterior tibial artery. There was non-significant stenosis in the right popliteal artery. The patient was treated using a combination of percutaneous transluminal angioplasty (PTA) of the right common iliac artery using vascular stent and the Fogarty thrombectomy of the common femoral artery, equipped with an X-ray system and a moveable radiolucent surgical table. The anticoagulant used on the patient during the procedure was heparin. There was no residual stenosis after the procedure on the occlusion along the right common iliac artery to the common femoral artery. In conclusion, multilevel artery occlusive diseases could be treated by hybrid procedure, with shorter hospitalization, less perioperative morbidity, and similar early- and long-term efficacy compared with open revascularization.
A NETWORK META-ANALYSIS: EFFICACY AND SAFETY OF ROTATIONAL ATHERECTOMY, ORBITAL ATHERECTOMY, AND INTRAVASCULAR LITHOTRIPSY COMPARISONS FOR NODULAR CORONARY LESIONS IN PERCUTANEOUS CORONARY INTERVENTION Handayani, Riana; Oktaviono, Yudi Her; Suryawan, I Gde Rurus; Susilo, Hendri; Aziz, Karimah Khitami; Erwan, Nabila Erina
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Percutaneous Coronary Intervention (PCI) has continued to evolve since its introduction in 1977. Currently, 12% of all PCI procedures for coronary artery stenosis involve Calcified Nodules (CN). CN is defined as nodular calcification that protrudes into the lumen of the coronary artery. In this era, improving the feasibility and success of PCI is essential through the use of advanced techniques, innovative approaches, and specialized devices in coronary interventions. These techniques include Rotational Atherectomy (RA), Orbital Atherectomy (OA), and Intravascular Lithotripsy (IVL). Comparisons of RA, OA, and IVL are still being extensively studied in terms of their effectiveness and safety in treating complex lesions such as CN. Given the high costs of these devices, this Network Meta-Analysis (NMA) was conducted to evaluate and compare the efficacy and safety of RA, OA, and IVL based on recent studies. The primary analysis in this study was performed using MetaInsight V6.1.1, presenting odds ratios (OR) based on a Bayesian Network Meta-Analysis and ranking the interventions according to the Surface Under the Cumulative Ranking Curve (SUCRA). The primary outcomes assessed were efficacy and safety. Efficacy was defined as the procedural success rate, and safety as the overall safety rate of each procedure. Secondary outcomes included periprocedural complications (dissection, perforation, slow flow/no-reflow, cardiac tamponade, and device failure), as well as the incidence of major adverse cardiovascular events (MACE) within 30 days. The analysis revealed a statistically significant difference in efficacy between IVL and RA, favoring IVL (OR 2.66, 95% CrI: 1.27, 6.16). However, no statistically significant differences were observed in other primary or secondary outcomes among RA, OA, and IVL. Based on SUCRA rankings, OA was the most effective in preventing MACE, while RA showed the lowest risk of periprocedural complications. Nevertheless, this network meta-analysis has several limitations due to the uncertainty of the available data. Further research, including randomized controlled trials (RCTs) or larger cohort studies with direct comparisons of all three techniques (closed-loop designs), is warranted to validate these findings.
Technology Acceptance Model (TAM) of TELE-ECG to Screen Cardiovascular Disease in Jayapura Regency, Papua Oktaviono, Yudi Her; Isfandiari, Muhammad Atoillah; Dharmadjati, Budi Baktijasa; Ramadhan, Muhammad; Prabowo, Emil; Ludfy Avianto, Achmad Tri; Muhammad, Raditya Rizki; Tri Saputra, Pandit Bagus
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 6 No. SI (2025): Cardiovascular and Cardiometabolic Journal Special Issue (ACSA 2024)-In Press
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v6iSI.2025.13-22

Abstract

Background: The cardiovascular mortality rate in Papua is still relatively high. This study aims to assess the readiness and benefits of telescreens with tele-ECG on high-risk population based on the Technology Acceptance Model (TAM) theory in Jayapura Regency, Papua. Material and Methods: This cross-sectional study was made based on the Technology Acceptance Model (TAM) questionnaire which was distributed to health workers using a validated Likert scale and analyzed using the Structural Equation Model with LISREL. Result: The results show that the total internet connection is 71% good or very good. Around 77% of respondents felt that telescreening for high-risk cardiovascular disease would be beneficial, with 76% of respondents having the intention to commit to using the telescreening. Conclusion: Internet access in the Jayapura Regency area is quite good and is not an obstacle to providing telescreening with with tele-ECG services. This TAM can be the basis for the development of telescreening for the early detection of high-risk populations so that cardiovascular death can be prevented. - Highlights: This study demonstrates high readiness among healthcare workers in Jayapura Regency to adopt tele-ECG–based cardiovascular screening, with adequate internet connectivity reported in most primary health centers. A majority of respondents perceived tele-ECG as useful, easy to use, and relevant to their clinical practice. Technology Acceptance Model analysis indicates strong intention to use tele-ECG for screening high-risk cardiovascular populations. These findings support tele-ECG telescreening as a feasible and scalable approach for early cardiovascular disease detection in geographically remote and underserved regions
Quercetin Stabilizes Atherosclerotic Plaques by Reducing Matrix Metalloproteinase-9 Expression and Enhancing M2 Macrophage Activity in Wistar Rats Romi Ermawan; Budi Susetyo Pikir; Mulyanto Mulyanto; Budi Utomo; Widjiati Widjiati; Yudi Her Oktaviono
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3790

Abstract

BACKGROUND: Quercetin has been shown to alleviate and prevent atherosclerosis. However, its role in stabilizing atherosclerotic plaques to prevent plaque rupture remains unclear. Therefore, this study was conducted to investigate the effects of quercetin on stabilizing atherosclerotic plaques.METHODS: Thirty-two Wistar rats were objected to a high-fat diet, along with an endothelial injury procedure conducted during the second week to create atherosclerotic plaque models. After six weeks, the subjects were randomly assigned to five groups consist of two control groups and three treatment groups treated with different quercetin dosages. Following the treatment, all subjects were euthanized to collect the left common carotid artery. The stability of the atherosclerotic plaques was evaluated by measuring the expression of matrix metalloproteinase-9 (MMP-9) using real-time polymerase chain reaction, assessing the activity of M1 and M2 macrophages along with the M1/M2 ratio using an enzyme-linked immunosorbent assay, and determining the maximum intima thickness through histopathological examination.RESULTS: Quercetin significantly reduced the expression of MMP-9, increased the activity of M2 macrophages, and lowered the M1/M2 ratio at doses of 10 and 50 mg/kg. However, there was no effect on M1 macrophage activity or maximum intima thickness. Path analysis indicated that quercetin primarily enhanced atherosclerotic plaque stability by reducing MMP-9 expression (p<0.001) and subsequently enhancing M2 macrophage activity (p=0.002).CONCLUSION: Quercetin administration significantly decreased the expression of MMP-9, enhanced the activity of M2 macrophages, and lowered the M1/M2 ratio at specific doses. These findings emphasize the significance of quercetin in stabilizing atherosclerotic plaques.KEYWORDS: atherosclerotic plaque, quercetin, stability, Wistar rats
The endothelial injury technique using intravenous catheters: a new alternative method for developing atherosclerotic plaque models in Wistar rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto; Utomo, Budi; Widjiati , Widjiati; Oktaviono, Yudi Her
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.14

Abstract

Background: Developing an atherosclerotic plaque model is crucial in atherosclerosis research, as creating such a model remains a significant challenge. Objective: This study evaluates the endothelial injury technique using intravenous catheters as an alternative method for developing atherosclerotic plaque models in Wistar rats. Methods: This true experimental study employs a post-test-only control group design. Twenty-two adult male Wistar rats were randomly allocated into three groups: a control group, a treatment group that underwent a 6-week intervention, and another treatment group that underwent an 8-week intervention. The control group was fed a standard diet of 320 kcal per 100 grams, while both treatment groups received a high-fat diet of 414 kcal per 100 grams. In the second week, endothelial injury was induced in the left common carotid artery of both treatment groups using a 26G intravenous catheter. The parameters assessed in the atherosclerotic plaque model included matrix metalloprotease-9 expression, M1 macrophage activity, M2 macrophage activity, maximal intima thickness, and the degree of arterial stenosis. Result: The endothelial injury technique using intravenous catheters significantly impacted matrix metalloprotease-9 expression (p<0.001) in both the 6-week and 8-week treatment groups compared to the control group. In contrast, the treatment's effects on maximal intima thickness (p=0.003) and the degree of arterial stenosis (p=0.002) were statistically significant only after 8 weeks of intervention compared to the control group. Conclusion: The endothelial injury techniques using intravenous catheters can be considered an alternative method for developing atherosclerotic plaque models in Wistar rats. Although this new technique has several limitations, it holds promise for further development in future studies.
Android Application for Initial Screening of Atrial Fibrillation Using The Dempster Shafer Method Oktaviono, Yudi Her; Yatijan, Marcella Aurelia; Purwanti, Endah; Rachmawati, Rizky Widya; Bustomi, M. Arief
Indonesian Applied Physics Letters Vol. 4 No. 1 (2023): Indonesian Applied Physics Letters - June 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iapl.v4i1.48159

Abstract

Atrial Fibrillation (FA) is one of the most common types of heart rhythm abnormalities found in clinical practice in Indonesia. Atrial fibrillation can cause a stroke risk 5 times. Meanwhile, stroke cases themselves tend to rise and become one of the main causes of death every year. The cause of the high number of FA cases is the lack of public knowledge and awareness/sensitivity to the early symptoms of the disease. The purpose of this study was to design an android device for early screening of suspected FA through examination of pulse, complaints/symptoms and disease risk factors. The dempster shafer method is used as a decision making tool for suspected FA or not FA. The results of the detection system performance test, obtained a sensitivity of 93.5%, a specificity of 89.7%, and an accuracy of 91.7%. The test results of the android application design, namely Visual Design and User Interaction, Functionality, Stability and Performance and Overall Satisfaction, show a "good" response in all aspects.
Co-Authors Abdurachman Abdurachman Angliana Chouw Angliana Chouw Ariikah Dyah Lamara Astrid Aulia Artiono Puteri Aziz, Karimah Khitami Budi Susetyo Pikir Budi Utomo Budi Utomo Chorisma Permata Putri Nurazizah Dharmadjati, Budi Baktijasa Djanggan Sargowo Djanggan Sargowo Endah Purwanti Erwan, Nabila Erina Febryanti Hartono Feranti Meuthia Ferry Sandra Hanang Anugrawan Achmad Handayani, Riana Irien Eko Hermawati Kevin Luke Lefi, Achmad Ludfy Avianto, Achmad Tri Luqman Hakim Andira M. Arief Bustomi Mahendra Eko Saputra Mahrus A Rahman, Mahrus A Marshel Tendean Marshel Tendean Meuthia, Feranti Meuthia, Feranti Mohammad Aris Widodo Mohammad Aris Widodo Muhammad Atoillah Isfandiari Muhammad Fachriyan Romadhona Muhammad Ramadhan Muhammad, Raditya Rizki Mulyanto Mulyanto Mulyanto Mulyanto Pandit Bagus Tri Saputra Prabowo, Emil Prasmono, Agung Putri, Alisia Yuana Rachmat Ageng Prastowo Rachmawati, Rizky Widya Rakha Achmad Maulana Romi Ermawan Romi Ermawan, Romi Rosi Amrilla Fagi Saskia Ratna Desita Soemantri, Djoko SOETJIPTO . Sundari Indah Wiyasihati Suryawan, I Gde Rurus Suryo Ardi Hutomo Susilo, Hendri Tri Saputra, Pandit Bagus tyagita rani savitri Widjiati Widjiati, Widjiati Yanni Dirgantara Yanni Dirgantara Yatijan, Marcella Aurelia