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All Journal Sport and Fitness Journal Jurnal Biologi Tropis Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Bioscientist : Jurnal Ilmiah Biologi Jurnal Sehat Indonesia (JUSINDO)
Made Ayu Mirah Wulandari
Universitas Islam Al-Azhar Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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EFFECT OF CYCLING ON CARDIOVASCULAR HEALTH ASSOCIATED WITH AGING PROCESS Rynda Rynda; Vidya M. Dewi Tanaka; Inaroh Qudsiyah; Ni Ketut Ayu Maharani; Demak Vera Rachelia; Nadia Carolina Notoprawiro; Kenny Augusto; Made Ayu Mirah Wulandari; Indira Vidiari Juhanna
Sport and Fitness Journal Vol 10 No 1 (2022): Volume 10, No. 1, January 2022
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/spj.2022.v10.i01.p09

Abstract

ABSTRACTCycling is a healthy exercise that can be enjoyed by people of all ages, from young children to older adults. Cycling have great attention from the health sector because of aiming to increase levels of physical activity. The main pathways between cycling and health under two perspectives generalizable evidence for health effects and specific impact modeling to quantify health impacts in concrete settings. Risks from air pollution can be assumed to be small, with limited evidence for cycling specific mechanisms. Physical activity, particularly cycling, is known to reduce the risk of cardiovascular diseases, slow down aging, and help in reducing weight and even stress. Keywords: cardiovascular, aging, stress, exercise, cycling
Peppermint Leaf Extract Cream Increased Transforming Growth Factor β (TGF-β) Expression and Collagen Amount In The Male Wistar Rat's Skin Exposed to UVB Made Ayu Mirah Wulandari; Anak Agung Gede Putra Wiraguna; Wimpie Pangkahila
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 13 No 3 (2023): Jurnal Ilmiah Permas: jurnal Ilmiah STIKES Kendal: Juli 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v13i3.1044

Abstract

Peppermint leaves contain flavonoids, menthofuran, and other phenolic compounds that have antioxidant activity and are believed to inhibit collagen degradation in the skin. This study investigated the efficacy of a 5% peppermint leaf extract cream in increasing the transforming growth factor β (TGF-β) expression and collagen amount as indicators of collagen maintenance in male Wistar rats' skin exposed to UVB. Method A randomized post-test-only control group design was performed on male Wistar rats, local strains, aged 2-3 months, with body weights ranging from 180 to 200 grams. According to the sample calculation, 21 rats were randomly divided into three groups. The first group is the control group (without any treatment). The second group was treated with UVB without cream (UVB-only group), and the third group was treated with UVB + 5% peppermint leaf extract cream on exposed skin. After four weeks of treatment, the tissue samples were examined. The expression of TGF-β was evaluated by immunohistochemical examination, and the amount of collagen was examined by Picro-Sirius red staining. Comparative tests were performed on the measurement results of the three groups. The results showed a significant difference in the mean TGF-β expression and collagen amount among the three groups (p<0.001). The group exposed to UVB + 5% peppermint leaf extract cream had the highest mean TGF-β expression and collagen amount (77.41±5.79% and 82.57±2.18%, respectively), followed by the control group (63.17±12.22% and 74.05±7.15%) and the UVB-only group (50.54±11.10% and 65.65±5.56%). Administration of 5% peppermint leaf extract cream effectively increased TGF-β expression and collagen amount in the skin of male Wistar rats exposed to UVB compared to the control and the UVB-only groups.  
Association Between Hypertension and Diabetic Ulcers in Diabetes Mellitus Patients Evada, Alung Abhan; Pramana, Kadek Dwi; Wulandari, Made Ayu Mirah; Azhar, Mutiara Budi
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8259

Abstract

One of the most common diseases in the world, including in Indonesia, is diabetes mellitus, which can lead to complications such diabetic ulcers, which can raise the risk of death and amputation. It is believed that hypertension, as a risk factor in and of itself, contributes to the development of diabetic ulcers by causing both macrovascular and microvascular damage. This study aims to analyze the association between hypertension and diabetic ulcers in diabetes mellitus patients at the Mataram City Regional General Hospital (RSUD). This research is an analytical observational study with a case-control design. Sampling used purposive sampling technique. A total of 105 samples were selected with a 1:2 ratio between the case and control groups who met the inclusion and exclusion criteria. Data analysis was carried out using the Chi-Square test. There is a significant association between hypertension and diabetic ulcers (p-value = 0.028; OR = 2.771; 95% CI = 1.198–6.411). Subjects with uncontrolled hypertension were 3 times more at risk of developing diabetic ulcers.
Relationship Between Age, Coffee Consumption and Smoking with The Incidence of Gastro Esophageal Reflex Disease (GERD) Putri, Annisa Zahara; Pramana, Kadek Dwi; Wulandari, Made Ayu Mirah; Khairunnisai, Khairunnisai
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8324

Abstract

One of the most prevalent illnesses in the world is gastroesophageal reflux disease, or GERD. In addition to sleep patterns, eating habits, such as the amount and timing of meals, as well as the acidity of food, can also lead to GERD. The purpose of this study is to investigate how smoking, coffee intake, and age relate to the prevalence of GERD in the province of NTB, particularly in West Lombok Regency. This study used a quantitative approach and a cross-sectional study design. The Chi Square test was employed for statistical analysis after univariate and bivariate data analysis. The results showed that 52% of respondents were women and 48% of respondents were men. 67% of respondents claimed not to have GERD, while 33% reported having it. There is a substantial correlation between age, coffee consumption, and smoking and the occurrence of GERD at Patut Patuh Patju Hospital in West Lombok. The Patut Patuh Patju Hospital in West Lombok has concluded that smoking, coffee use, and age are associated with GERD.
Hubungan Paritas, Riwayat Hipertensi, dan Indeks Massa Tubuh dengan Kejadian Preeklampsia Pramesti, Made Ardhia Santhi; Wulandari, Made Ayu Mirah; Yumna, Nadira; Santosa, Hilda
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.95

Abstract

Di Indonesia Angka Kematian Ibu (AKI) merupakan masalah kesehatan utama dan masih tertinggal dibandingkan Tujuan Pembangunan Berkelanjutan global. Tiga penyebab utama kematian ibu diam di Indonesia adalah preeklamsia (27,1%), infeksi, dan pendarahan (30,3%). Salah satu dari tiga penyebab utama AKI adalah preeklampsia. Ada beberapa faktor risiko terjadinya preeklamsia, antara lain obesitas, hipertensi, paritas, dan usia ibu. Tujuan penelitian ini adalah untuk mengetahui hubungan paritas, hipertensi, dan indeks massa tubuh dengan preeklamsia di RSUD Kota Mataram. Metodologi yang digunakan dalam penelitian ini adalah desain observasional analitik kuantitatif dengan besar sampel sebanyak 107 responden. Analisis data menggunakan Chi-Square dengan ambang signifikansi (p-value) kurang dari 0,05. Hasil penelitian univariat menunjukkan responden mayoritas berusia 25-29 (40,2%), mengalami preeklampsia 45 (42,1), paritas berisiko 41 (38,3%), memiliki riwayat hipertensi 25 (23,4%), dan IMT kategori berisiko 26 (24,3%). Analisis bivariat menunjukkan terdapat hubungan paritas dengan preeklampsia (p=0,000), riwayat hipertensi dengan preeklampsia (p=0,000), dan indeks massa tubuh dengan preeklampsia (p=0,034) di RSUD Kota Mataram. Kesimpulan dari penelitian ini menunjukkan bahwa paritas, riwayat hipertensi, dan indeks massa tubuh memiliki korelasi dengan kejadian preeklampsia di RSUD Kota Mataram. Implikasi dari hasil temuan ini adalah urgensi meningkatkan pemantauan terhadap ibu hamil yang memiliki faktor risiko preeklampsia, memperluas pengetahuan serta kesadaran mengenai faktor-faktor risiko tersebut, dan meningkatkan efektivitas strategi pencegahan.
In Silico Evaluation of the Antibacterial Potential of Methanolic Lo’i-Keta Extract Against DNA Gyrase in Staphylococcus aureus and Pseudomonas aeruginosa M. Agung Wisnu Pratama; Rozikin; Made Ayu Mirah Wulandari; Resna Hermawati
Bioscientist : Jurnal Ilmiah Biologi Vol. 14 No. 3 (2026): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v14i3.19511

Abstract

This study aimed to evaluate the antibacterial potential of bioactive compounds identified in the methanolic extract of lo’i-keta against DNA gyrase from Staphylococcus aureus (PDB ID: 3G75) and Pseudomonas aeruginosa (PDB ID: 6M1S) using an in silico approach. Bioactive compounds were identified by gas chromatography–mass spectrometry (GC–MS). Ligand preparation and molecular docking were subsequently performed using PyRx 0.8, while ligand–protein interactions were visualized using Discovery Studio. Ciprofloxacin was used as the positive control. GC–MS analysis detected 20 compound peaks, of which 13 compounds were validated and included in the docking analysis. Molecular docking results showed that cyclooctacosane exhibited the strongest binding affinity toward the DNA gyrase of S. aureus and P. aeruginosa, with binding energies of −8.3 and −8.2 kcal/mol, respectively. These values were more favorable than those of ciprofloxacin, which showed binding affinities of −7.7 and −7.4 kcal/mol, respectively. In addition, dioctyl benzene-1,2-dicarboxylate displayed a residue interaction pattern similar to that of ciprofloxacin within the active site of DNA gyrase. Hexadecanoic acid (palmitic acid) exhibited a more moderate binding affinity but was present at a relatively high abundance in the extract. These findings indicate that several bioactive compounds in lo’i-keta may form stable interactions with DNA gyrase, supporting its potential as a molecular target for antibacterial activity. Based on the in silico results, cyclooctacosane was identified as the leading candidate DNA gyrase inhibitor, while dioctyl benzene-1,2-dicarboxylate and hexadecanoic acid may serve as supporting candidates for the development of lo’i-keta-based antibacterial agents. This study provides a scientific basis for the traditional use of lo’i-keta; however, further in vitro and in vivo investigations are required to validate these findings.
Co-Authors Anak Agung Gede Putra Wiraguna Demak Vera Rachelia Evada, Alung Abhan Hilda Santosa Inaroh Qudsiyah Indira Vidiari Juhanna Kenny Augusto Khairunnisai, Khairunnisai M. Agung Wisnu Pratama Mutiara Budi Azhar, Mutiara Budi Nadia Carolina Notoprawiro Ni Ketut Ayu Maharani Pramana, Kadek Dwi Pramesti, Made Ardhia Santhi Putri, Annisa Zahara Resna Hermawati Rozikin Rynda Rynda Vidya M. Dewi Tanaka Wimpie I Pangkahila Yumna, Nadira