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All Journal Jurnal Kedokteran Brawijaya The Indonesian Biomedical Journal Nusantara Medical Science Journal Oto Rhino Laryngologica Indonesiana Majalah Sainstekes
Muhammad Fadjar Perkasa, Muhammad Fadjar
Departemen THT-KL Fakultas Fakultas Kedokteran Universitas Hasanuddin, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : nusantara medical science journal

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IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score Lidya Turupadang; Muhammad Fadjar Perkasa; Abdul Qadar Punagi; Azmi Mi'rah Zakiah; Burhanuddin Bahar
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18765

Abstract

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP
The Examination of Olfactory Function and Mucocilliary Transport in Gas Station Officers in Makassar, Indonesia Rahmat Hidayat; Eka Savitri; Muhammad Fadjar Perkasa; Abdul Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19233

Abstract

Introduction: Chronic exposure to fuel oil can cause chemical burns to the olfactory epithelium, which can cause anosmia. This study aimed to compare mucociliary transport time and olfactory function between operator and non-operator officers at gas stations. Methods: This cross-sectional study was conducted from September to November 2020 and involved 40 subjects divided into two equal groups each consisting of 20 gas station operators and non-operators, respectively. The examination of mucociliary transport time was carried out by saccharin test, while the olfactory function was examined by assessing e olfactory threshold, discrimination, and identification (TDI) score using the Sniffin sticks test. Results: There was a significant difference in the mean mucociliary transport time and olfactory function between gas station operators and non-operators (P<0.001). In addition, there was also a significant correlation between the mucociliary transit time and olfactory function (p<0.05), with a strong negative correlation coefficient (r=-0.620). Therefore, the longer the mucociliary transit time, the gas station attendant's olfactory function will decrease. Conclusion: mucociliary transport time and olfactory function in non-operator public gas station officers were better than operators, probably because inhalation of chemical pollutants induces the release of proinflammatory cytokines, chronic inflammation of the nasal mucosa results in impaired olfactory cells and mucin glands.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Punagi Abdul Qadar Punagi Andi Alfian Zainuddin Azmi Mi'rah Zakiah Burhanuddin Bahar Dewi Kurniawati Eka Savitri Fatmawati Arsyad Said Freddy George Kuhuwael Idris, Nurlaily Khaeruddin K Latief, Nikmatia Lidya Turupadang Muhammad Ilyas Muhammad Ilyas Muhammad Ridha Maulana Muis, Mirna Nurlaily Idris Rahmat Hidayat Tanty Tanagi Toluhula UPIK ANDERIANI MISKAD, UPIK ANDERIANI