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All Journal The Indonesian Biomedical Journal Nusantara Medical Science Journal Jurnal Biologi Tropis Jurnal Ilmiah Ecosystem Oto Rhino Laryngologica Indonesiana YARSI Medical Journal International Journal of Nasopharyngeal Carcinoma Jurnal Riset Multidisiplin : Agrisosco

Abdul Qadar Punagi

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Author-ID : 348606

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Maksilektomi medial endoskopik Punagi, Abdul Qadar
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Latar belakang: Penggunaan endoskop memberikan spesifisitas yang tinggi dalam membedakan mukosa yang tidak sehat dengan yang sehat sehingga preservasi mukosa sehat dapat dioptimalkan danfisiologi mukosiliar dapat dipertahankan. Maksilektomi medial endoskopik adalah prosedur penanganantumor jinak untuk mengurangi morbiditas yang ditimbulkan oleh prosedur operasi terbuka. Tujuan:Untuk mengurangi morbiditas dan tingkat kekambuhan pada penanganan tumor jinak sinonasal. Kasus: Dilaporkan 2 kasus tumor jinak sinonasal, yaitu inverted papilloma dan schwannoma yang ditangani secara maksilektomi medial endoskopik dengan mengoptimalkan preservasi mukosa danpatensi duktus nasolakrimal. Teknik marsupialisasi endoskopik dilakukan untuk menjamin patensi duktusnasolakrimal dengan bantuan sonde Bowman. Penatalaksanaan: Maksilektomi medial endoskopik danmarsupialisasi duktus nasolakrimal. Kesimpulan: Maksilektomi medial endoskopik dapat menjadi pilihanpada penatalaksaan tumor jinak sinonasal karena memberikan keuntungan pada pasien yaitu tidak adanyasikatriks pada wajah dan preservasi mukosa sehat lebih optimal. Kata kunci: maksilektomi medial endoskopik, tumor sinonasal, patensi duktus nasolakrimalABSTRACT Background: The use of endoscope provides high specificity in distinguishing healthy and unhealthy mucosa thus the preservation of healthy mucosa could be optimized and physiologic mucocilliarytransport system could be maintained. Endoscopic medial maxillectomy is a procedure for treating benignsinonasal tumor, aimed to reduce the morbidity caused by open surgical procedure. Purpose: To reducethe morbidity and the recurrence rates in the treatment of benign sinonasal tumors. Case report: Twocases of benign sinonasal tumor which were inverted papilloma and schwannoma, treated by endoscopicmedial maxillectomy with optimal mucosal preservation and nasolacrimal duct patency. Marsupializationendoscopic technique was performed to ensure the patency of nasolacrimal duct supporting by Bowmansonde. Management: Endoscopic medial maxillectomy with marsupialization of nasolacrimal duct.Conclusion: Endoscopic medial maxillectomy could be an optional treatment for benign sinonasal tumorbecause the procedure has less facial cicatrix and optimal preservation of healthy mucosa, which areadvantages for the patient. Keywords: endoscopic maxillectomymedial, sinonasal tumor, nasolacrimalduct patency

Deteksi pepsin pada penderita refluks laringofaring yang didiagnosis berdasarkan reflux symptom index dan reflux finding score Andriani, Yunida; Akil, Muhammad Amsyar; Gaffar, Masyita; Punagi, Abdul Qadar
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Background: It is estimated that more than 50% of patients with voice disorders who come fortreatment are caused by laryngopharyngeal reflux (LPR). LPR has been implicated in the etiology ofmany laryngeal disorders including subglottic stenosis, laryngeal carcinoma, laryngeal contact ulcer,laryngospasm and vocal nodule on the vocal cords. Ambulatory 24 hour double-probe (pharyngeal andesophageal) pH monitoring is the gold standard examination for diagnosing LPR, but it is still far fromideal criteria.The assessment of pepsin in airway secretions could be used as a sensitive diagnosticmarker of LPR because pepsin is not synthesized by any type of airway cells. Purpose: The aim ofthis study was to detect the presence of pepsin on laryingopharyngeal reflux patients which diagnosedbased on reflux symptom index (RSI) dan reflux finding score (RFS) at Wahidin Sudirohusodo Hospital,Makassar. Methods: This is a comparative quantitative study. We performed RSI and RFS examinationson 51 samples, followed by saliva pepsin detection using ELISA method on 48 samples, then analyzed withSpearman’s Rho test. Result: RSI score >13 was found in 48 samples (94,12%) and RFS score >7 wasin 51 samples (100%). Pepsin was detected on all sputum samples, however there was no significant relationship betwen RSI and RFS scoring with the level of pepsin in saliva (p>0.01). Conclusion: Pepsin was detected on saliva of patients with laringopharyngeal reflux who was diagnosed based on RSI andRFS. We concluded that RSI and RFS can be used as diagnostic tools for LPR. Keywords: laringopharyngeal reflux, reflux symptom index, reflux finding score, pepsin Abstrak : Latar belakang: Diperkirakan lebih dari 50% pasien dengan gangguan suara yang datang berobatke dokter THT diakibatkan oleh refluks laringofaring (RLF). Diduga RLF berperan pada patogenesissejumlah kelainan pada laring, termasuk stenosis subglotik, karsinoma laring, laryngeal contact ulcers,laringospasme dan vokal nodul pada pita suara. Pemeriksaan ambulatory 24 hour double-probe pHmonitoring merupakan gold standard untuk mendiagnosis RLF, namun pemeriksaan ini masih jauh darikriteria ideal. Menentukan adanya pepsin pada sekret saluran napas merupakan petanda diagnostik yangsensitif untuk RLF karena pepsin tidak dihasilkan oleh sel apapun dalam saluran napas. Tujuan: Penelitianini bertujuan mendeteksi keberadaan pepsin pada penderita refluks laringofaring yang didiagnosisberdasarkan refluks symptom index (RSI) dan reflux finding score (RFS). Metode: Jenis penelitian iniadalah komparatif kuantitatif. Dilakukan pemeriksaan RSI dan RFS pada 51 percontoh dan dilanjutkandengan pemeriksaan pepsin saliva menggunakan metode ELISA pada 48 percontoh lalu dilakukan ujiSpearman’s Rho. Hasil: Skor RSI >13 sebanyak 48 percontoh (94,12%) dan skor RFS >7 sebanyak 51percontoh (100%). Pepsin terdeteksi pada saliva semua percontoh. Tidak ada hubungan yang bermaknaantara skoring RSI dan RFS dengan kadar pepsin pada saliva (p>0,01). Kesimpulan: RSI dan RFS dapatdigunakan dalam menegakkan diagnosis RLF. Kata kunci: refluks laringofaring, reflux symptom index, reflux finding score, pepsin

EFEKTIFITAS LARUTAN CUCI HIDUNG AIR LAUT STERIL PADA PENDERITA RINOSINUSITIS KRONIS BERDASARKAN PATENSI HIDUNG DAN KUALITAS HIDUP Qadar Punagi, Abdul; Rahmy Sujuthi, Ade
Jurnal Kedokteran YARSI Vol 17, No 3 (2009): SEPTEMBER - DESEMBER 2009
Publisher : Lembaga Penelitian Universitas YARSI

Penatalaksanaan standar rinosinutis kronis pada orang dewasa saat ini yang direkomendasikan oleh kelompok Studi Rinologi PERHATI-KL meliputipemberian antibiotika, dekongestan oral, kortikosteroid dan mukolitik disertaiterapi tambahan irigasi hidung. Penilaian patensi hidung dan kualitas hiduppenderita dapat dijadikan acuan penilaian efektifitas terapi rinosinusitis.Sampai saat ini belum ada laporan hasil penelitian yang konsisten tentangprioritas pilihan cairan cuci hidung yang digunakan. Penelitian yangberkaitan dengan efektifitas hasil terapi cuci hidung larutan air laut sterilsebagai terapi tambahan pada terapi standar rinusinusitis kronis perludilakukan. Telah dilakukan penelitian uji klinis terbuka (open trial) menggunakanterapi standard atau terapi standard disertai larutan cuci hidung air lautsteril pada penderita rinosinusitis kronis yang berobat di poliklinik THT RSWahidin Sudirohusodo Makassar. Hasil penelitian menunjukkan bahwaterdapat perbedaan bermakna nilai NIPF sebelum dan setelah intervensiantara kelompok air laut steril (P 0,05) dengan kelompok terapi standar(P 0,05) juga terdapat perbaikan nilai SNOT-20 secara bermakna (P 0,05)pada kelompok air laut steril setelah intervensi. Kemaknaan klinik padapenelitian ini adalah pemberian larutan cuci hidung air laut steril sebagaiterapi tambahan akan memperbaiki patensi hidung dan kualitas hiduppenderita rinitis kronis dibandingkan dengan hanya terapi standar saja.

Comparison of The Means of Argyrophilic Nucleolar Organizer Region (mAgNOR) Pre- and Post-Therapy in Nasopharyngeal Carcinoma Patients at Wahidin Sudirohusodo General Hospital Makassar Freddy George Kuhuwael; Muhammad Fadjar Perkasa; Upik Anderiani Miskad; Abdul Qadar Punagi; Fatmawati Arsyad Said
The Indonesian Biomedical Journal Vol 8, No 2 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i2.213

BACKGROUND: Nasopharyngeal carcinoma (NPC) is malignant tumor growing in nasopharynx with a predilection in fossa Rossenmuller and nasopharyngeal roof. This research aimed to prove whether the means of argyrophilic nucleolar organizer region (mAgNOR) can predict the success of treatment in nasopharyngeal carcinoma patients.METHODS: We used diagnostic test method with longitudinal design and purposive sampling technique. Endoscopic biopsy examination was performed on 15 nasopharyngeal carcinoma patients before and after therapy, 13 patients underwent chemotherapy and other two underwent chemoradiotherapy. Tumor tissues were stained and AgNOR was calculated.RESULTS: Based on the tumor stage, sample characteristic showed 3 patients (20%) were in stage II, 3 patients (20%) in stage III, and 9 patients (60%) in stage IV, with pre- and post-therapy mAgNOR were 1.610±0.988 and 1.000±0.000, respectively in stage II, 1.100±0.092 and 1.000±0.000, respectively in stage III, 1.226±0.265 and 1.107±0.164, respectively in stage IV patients. Based on histopathology type, 4 patients (26.7%) had non keratinizing squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.117±0.134 and 1.060±0.120, respectively, while 11 patients (73.3%) had undifferentiated squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.335±0.528 and 1.065±0.146, respectively. Overall the pre-therapy were significantly higher than post-therapy mAgNOR. In subgroups there are significant differences in stage IV and type 3.CONCLUSION: The values of AgNOR were decreased in all NPC stages and significantly decreased in undifferentiated squamous cell carcinoma. AgNOR can be used to predict the successfulness of therapy in NPC.KEYWORDS: nasopharyngeal carcinoma, therapy, proliferation, mAgNOR

Dynamics of Interleukin-10 Levels in Chronic Rhinosinusitis with/without Allergy Abdul Qadar Punagi; Sutji Pratiwi Rahardjo
The Indonesian Biomedical Journal Vol 7, No 3 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v7i3.182

BACKGROUND: Rhinosinusitis occurs when the lining of the nasal and sinuses gets inflamed, infected or irritated, become swollen, and create extra mucus, the swollen lining may also interfere with drainage of mucus. Chronic rhinosinusitis (CRS) is a more persistent problem that requires a specific treatment approach. Aim of this study was to determine changes in interleukin (IL)-10 as an anti-inflammatory cytokines in allergic and non-allergic CRS at Makassar. METHODS: A prospective cohort study was designed to assess the level of IL-10 for three times during two weeks of therapy. Medication of Cefadroxil 500 mg 2x1, Pseudoephedrine 30 mg 2x1, Terfenadine 40 mg 2x1 and Methylprednisolone 4 mg 3x1, was conducted during two weeks for 13 subjects in allergic CRS group and 12 subjects in non-allergic CRS group. Results were statistically analyzed with student t-test and paired t-test.RESULTS: The changes in levels of IL-10 in allergic CRS group were increased, but not significant (5.293 to 5.769, p=0.058), and in non-allergic CRS group were decreased, but not significant (6.125 to 5.475, p=0.103). CONCLUSION: The serum levels of IL-10 were not significant increased in allergic CRS group and not significant decreased in non-allergic CRS group. KEYWORDS: interleukin-10, chronic rhinosinusitis, allergy, cefadroxil, pseudoephedrine, terfenadine, methylprednisolone

NPC-Exosome Carry Wild and Mutant-type p53 among Nasopharyngeal Cancer Patients Hamsu Kadriyan; Eka Sunarwidhi Prasedya; Nova Audrey Luetta Pieter; Masyita Gaffar; Amsyar Akil; Agusalim Bukhari; Budu Budu; Andi Alfian Zainuddin; Rina Masadah; Achmad Chusnu Romdhoni; Abdul Qadar Punagi
The Indonesian Biomedical Journal Vol 13, No 4 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i4.1718

BACKGROUND: Nasopharyngeal cancer (NPC) is known to release a specific exosome. NPC-derived exosome (NPC-Exo) could carry p53. However, information regarding the type of p53 carrier on NPC-Exo remains limited. This study aims to introduce our important findings regarding the type of p53 NPC-Exo cargo.METHODS: Serum from patients with NPC were prepared for exosome isolation with Seramir Exoquick by following the manual instructions. RT-PCR was conducted to determine the expression levels of latent membrane protein 1 (LMP-1) and p53 in the exosome isolate. Partial sequencing of p53 amplicon was conducted to determine mutation type of p53.RESULTS: There were 8 patients enrolled in this study. According to RT-PCR results, the expression levels of LMP-1 and p53 varied in the NPC-Exo isolate. Based on sequencing analysis, 1 case of p53 mutation was noticeable.CONCLUSION: According to current results, the NPC-derived exosome potentially carries not only wild type but also mutant type p53. Further research is needed to explore deeper the effect of the mutant type p53 as an exosome carrier in the clinical application.KEYWORDS: Nasopharyngeal cancer, exosome, p53, mutation

Nasofrontal Complex Variation Frontal Sinus Drainage System Increases Frontal Rhinosinusitis Incident Abdul Qadar Punagi
The Indonesian Biomedical Journal Vol 8, No 1 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i1.197

BACKGROUND: This research was conducted to find out the relation of anatomy variation of nasofrontal complex on the frontal sinus drainage system with frontal rhinosinusitis incident. METHODS: This research was using cross-sectional design involving 75 patients with chronic rhinosinusitis. Coronal paranasal sinus CT scan with sagittal plane reformat was carried out to examine. The CT scan figures were analyzed from every side and there were 150 samples found as the result. Data was analyzed using chi square test. RESULTS: The research indicates that there is no significant relation between frontal cell types, agger nasi cell, chonca media bullosa with incident of frontal rhinosinusitis (p>0.05). Prevalence of superior attachment of uncinate process (UP), type 1 (UP superior attachment on lamina papiracea) was found on 43 sides (28.6%), type 6 (UP superior attachment to medial turbinate) was found in 29 sides (19.3%). Prevalence of frontal rhinosinusitis was found in 42 (28%) from 150 sides. Group 1 drainage (medial side drainage; drainage to meatus medius [type 1-3]) was found in 32 sides (76.2%) and group 2 drainage (lateral side drainage; drainage to infundibulum ethmoid [type 4-6]) was found in 10 sides (23.8%). CONCLUSION: There is significant relation between frontal rhinosinusitis incident with variation of frontal sinus drainage (p<0.05) and drainage on group 1 has significant existence statistically on frontal rhinosinusitis incident. KEYWORDS: frontal rhinosinusitis, anatomy variation, nasofrontal complex, frontal sinus drainage

IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score Lidya Turupadang; Muhammad Fadjar Perkasa; Abdul Qadar Punagi; Azmi Mi'rah Zakiah; Burhanuddin Bahar
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18765

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP

Correlation of Rhinomanometry Measurement and True Lateral Radiography towards the Degree of Upper Airway Obstruction in Patients with Adenoid Hypertrophy Nanda Mayasari; Sutji Pratiwi Rahardjo; Abdul Kadir; Muhammad Fajar Perkasa; Abdul Qadar Punagi
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18869

Background: Adenoid hypertrophy is one of the most common disorders in children which may lead to upper airway obstruction. Various modalities to measure airway obstruction in patients with adenoid hypertrophy, including true lateral radiographs, nasoendoscopy, and rhinomanometry are available; however, the results from different studies are still controversial. This study aimed to determine the relationship between the results of rhinomanometry and the true lateral radiographs to the degree of upper airway obstruction in patients with adenoid hypertrophy. Methods: This cross-sectional study included a total of 33 patients with adenoid hypertrophy aged 5-18 years using a purposive sampling technique. Patients diagnosed with adenoid hypertrophy were subjected to a true lateral examination using lateral neck radiographs to measure the degree of airway obstruction. Subsequently, an active anterior rhinomanometry was performed by measuring resistance and nasal airflow and then measuring the degree of airway obstruction. Data analysis was done using Chi-Square test. Results: The rhinomanometric nasal resistance in the inspiratory phase was 0.4159 ± 0.15201 Pa/cm3/s and 0.3694 ± 0.13717 Pa/cm3/s in the expiration phase. The results showed a significant relationship between the true lateral radiographs and both nasal inspiratory (p=0.005) and expiratory resistance (p=0.004). Similarly, the relationship between the true lateral radiographs and nasal airflow on both inspiratory and expiratory rhinomanometry was significant (p<0.05). Conclusion: Rhinomanometric measurements can be used as an additional objective examination in assessing the degree of upper airway obstruction in patients with adenoid hypertrophy prior to surgery.

The Relationship between Neutrophil on Lymphocyte Ratio with Clinical Stage of Nasopharyngeal Carcinoma Patients Nur Fadhila Kurnia; Abdul Qadar Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19121

Introduction: The general objective of this study was to determine the relationship between the ratio of neutrophils to lymphocytes and the clinical stage in patients with nasopharyngeal carcinoma. While the specific goal is to know the characteristics of patients with nasopharyngeal carcinoma. Knowing the description of peripheral neutrophil levels in patients with nasopharyngeal carcinoma. Knowing the description of peripheral lymphocyte levels in patients with nasopharyngeal carcinoma. Knowing the picture of NLR at the clinical stage of patients with nasopharyngeal carcinoma. Methods:The target population in this study were all patients with nasopharyngeal carcinoma. The affordable population is all patients with nasopharyngeal carcinoma who are undergoing treatment at. RSUP. Dr Wahidin Sudirohusodo for the period July 2018 to July 2019.. Results: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex. Statistical tests were used to see whether or not there was a relationship. between these two variables is the Kruskal-Wallis test, which was chosen because it is a non-parametric comparative test for variables with more than two categories. Conclusions: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex.

Co-Authors Abdul Kadir Abdul Kadir Agri, Hardianti Agusalim Bukhari Alimah, Yarni Aminuddin Aminuddin Anak Agung Ayu Niti Wedayani Andi Alfian Zainuddin Andi Baso Sulaiman Andriani, Yunida Azmi Mi'rah Zakiah Budu Budu Burhanuddin Bahar Cangara, Husni Dewi Kurniawati Eka Savitri Eka Sunarwidhi Prasedya Emanuel Quadarusman Ervina Mariani Evans, Gunterus Fadjar Perkasa Fatmawati Arsyad Said Freddy George Kuhuwael Frederik George Kuhuwael Gaffar, Masyita Hamid, Firdaus Hamsu Kadriyan Hasbullah, Ayu Ameliyah Ima Arum Lestarini Irawan Yusuf Khaeruddin K Lidya Turupadang Mahmuddin, Ihsan Makbul, Hidayat Mochammad Hatta Muhammad Amsyar Akil Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Fajar Perkasa Nanda Mayasari Nani Iriani Djufri Nani Iriani Djufri Nova Audrey Luetta Pieter Nur Fadhila Kurnia Pandiangan, Marojahan Pieter, Nova Audrey Luetta Pratiwi Rahardjo, Sutji Rachmawati Djalal Rahardjo, Sutji P Rahmy Sujuthi, Ade Ramadhita, Nova Izza Salsa Restuningdyah, Novia Andansari Putri Rina Masadah Riskiana Djamin Rita Talango Romdhoni, Achmad Chusnu Sutji P. Rahardjo Syahrijuita, Syahrijuita Tanty Tanagi Toluhula Tobo, Gadis Sabrina UPIK ANDERIANI MISKAD, UPIK ANDERIANI

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