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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Lentera Farma
ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL SPONS Stylissa carteri YANG DIKOLEKSI DARI TELUK MANADO Christo Togelang; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 11 No. 2 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.41728

Abstract

ABSTRACTSea sponges have enormous bioactive potential. The research was to identify the antioxidant and ethanol sponge ethanol Stylissa carteri collected from the mando bay. The study is an experimental laboratory that will test the antioxidant activity of collected Stylissa carteri sponge extract from manado bay. The findings suggest the antioxidant activity of the Stylissa carteri sponge obtained from manado bay has antioxidant activity and the higher the concentration of it increases. The most high antioxidant activity found on the Stylissa carteri spong with a concentration of 25 ppm. Keywords: Antioxidant, DPPH, Stylissa carteri, Manado Bay  ABSTRAKSpons laut memliki potensi bioaktif yang sangat besar. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ektrak etanol spons Stylissa carteri yang dikoleksi dari Teluk Mando. Penelitian ini merupakan eksperimental laboratorium yang akan menguji aktivitas antioksidan dari ekstrak spons Stylissa carteri yang dikoleksi dari teluk Manado. Hasil penelitian ini menunjukan aktivitas antioksidan dari spons Stylissa carteri yang diperoleh dari Teluk Manado memiliki aktivitas antioksidan dan semakin tinggi konsentrasi semakin tinggi pula kadar antioksidan yang dihasilkan. Aktivitas antioksidan yang paling tinggi terdapat pada Spons Stylissa carteri dengan konsentrasi 25 ppm. Kata Kunci : Antioksidan, DPPH, Stylissa carteri, Teluk Manado
Non-Specific Standardization Test for Areca Yaki Fruit Extract (Areca Vestiaria) Nadine Natari; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42039

Abstract

The chemical substances contained in the extracts of natural ingredients must be maintained in quality, so standardization is required. This study aims to prove that ethanol extract of Areca yaki Fruit (Areca Vestiaria) meets the non- specific parameters on the standardization of natural ingredients extract. Ethanol extract of Areca Yaki Fruit  is extracted using maceration method. The extracts obtained were tested for several non-specific parameters including desiccant shrinkage, moisture content, total ash content and acid insoluble ash content. The test results are compared with the standard parameters. Areca Yaki Fruit ethanol extract has a drying shrinkage of 0.027%, moisture content of 0.5242%, total ash content of 0.712% and 0.883%, and insoluble acid ash content of 0.048% and 0.056%. Areca Yaki Fruit ethanol extract meets the standard parameters, desiccant shrinkage, moisture content, total ash content, and insoluble acid ash content.
Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria Wiranatika Jhonatan Sangkoy; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42307

Abstract

WIRANATIKA SANGKOY. Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. Under the guidance of HERNY EI SIMBALA as a leader and ERLADYS RUMONDOR as a member.One of the native plants of Indonesia that is widespread in several areas in Indonesia that has the potential to be developed in research testing antibacterial activity is the areca yaki leaf plant. This study aimed to determine the antibacterial activity of areca yaki (Areca vestiaria) leaves against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa at concentrations of 20%, 40%, and 60%. This research was conducted using the Kirby-Bauer method. From the results of this study, the data obtained that concentrations of 20%, 40%, and 60% of Staphylococcus aureus and Escherichia coli bacteria are concentrations that are included in the moderate group, while Pseudomonas aeruginosa at a concentration of 20% is included in the strong group and 40% and 60% are only included in the moderate group.
POTENTIAL OF RED FRUIT (PANDANUS CONOIDEUS CAROTEN LAMK) PAPUA BASED ON LITERATURE REVIEW Hermelina Yosephina Burdam; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42896

Abstract

                              ABSTRACRed fruit plant (Pandanus conoideus Lamk) Papua. is an endemic plant that can grows in almost all areas of Papua, from the lowlands to the highlands. Red Fruit (Pandanus conoideus Lamk,) belongs to the Pandanus family. This plant is widely available Find in Papua, Papua New Guinea, And This Research Aims To know the potential of red fruit (Pandanus conoideus Lamk) Papua based on literature review, research It Uses Qualitative Descriptive Method Aims to Draw, Describe, Explain, Explain, and answer in detail the research results. Based on literature review, red fruit has potential As Socio-Economic Value, As Traditional Medicine, Cure Cancer And tumors, HIV/Aids,High Blood Pressure, Gout, Stroke, Eye Disorders, Osteoporosis, Diabetes Mellitus, Increases Sperm Production in Men, Increases Intelligence, As a Food Source, As Antioxidant, Antidiabetic, Anti-Inflammatory Antibacterial Cardiovascular, Hypertension 
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI ETANOL DARI BATANG TANAMAN GEDI (Abelmoschus manihot L.) Luy Parala; Herni I. E. Simbala; Erladys M. Rumondor
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.48894

Abstract

Tanaman gedi (Abelmoschus manihot L.) adalah tanaman yang memiliki banyak potensi sebagai senyawa aktif. Tanaman gedi memilliki banyak sumber senyawa antioksidan yang terdapat pada daunnya. Penelitian pada batang gedi bertujuan agar mengetahui jika batang tanaman gedi memiliki jumlah antioksidan yang sama dengan daun gedi. Penelitian yang dilakukan menggunakan metode eksperimental dengan metode DPPH (1,1-difenil-2-pikrilhidrazil). Ekstraksi dilakukan dengan metode maserasi untuk mengambil senyawa metabolit sekunder. Pengujian hasil ekstrak dan fraksi dilakukan dengan spektrofotometri UV-Vis pada panjang gelombang 517 nm. Hasil pengujian diperoleh aktivitas ekstrak dari masing-masing fraksi yaitu: ekstrak etanol 82,08%, fraksi metanol 77,65 %,  fraksi kloroform 85,66%, n-heksan 78,26%.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK SPONS Callyspongia aerizusa DARI PERAIRAN DESA POOPOH KABUPATEN MINAHASA Viocindy Riska Nusaly; Defny S.Wewengkang; Erladys Rumondor
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49230

Abstract

Callyspongia aerizusa is one of the sponge species that is spread across the Indonesian marine waters and rich in bioactive compounds such as secondary metabolites that is used in medicine field as antibacterial but still not widely used by the people. The improvement of bacteria resistant has been a serious problem in the medicine field, therefore there should be an improvement of a new antibiotic medicine from natural ingredients for the healt improvement. This research aims to find the activity of extracts of sponge Callyspongia aerizusa from the waters of Poopoh Village, Minahasa Regency against the growth of Pseudomonas aeruginosa and Staphylococcus aureus bacteria. The growth of bacterial is tested by disc diffusion Kirby Bauer method and by observing the value of generated inhibition zone. From the result of the research, the extracts of Callyspongia aerizusa sponge has clear zone against Staphylococcus aureus bacteria of 8 mm in the concentration of 250 µg/disc, and the Pseudomonas aeruginosa bacteria has 9 mm in the concentration of 250 µg/disc which categorized as medium. It can be concluded that the Callyspongia aerizusa sponge has an metabolite compound with wide spectrum activity that can hinder the growth of Gram-negative and Gram-positive bacteria
Uji Kualitatif Kandungan Senyawa Kimia Perasan Jeruk Nipis ( Citrus aurantifolia Swingle ) SELLYANA MAHARANI BAWEKES; Adithya Yudistira; Erladys Melindah Rumondor
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.49269

Abstract

Jeruk Nipis (Citrus aurantifolia Swingle) merupakan salah satu tanaman yang memiliki efek terapeutik untuk mengatasi penyakit yang disebabkan oleh bakteri. Bagian tanaman jeruk nipis (Citrus aurantifolia Swingle) yang banyak dimanfaatkan saat ini adalah buahnya. Buah jeruk nipis (Citrus aurantifolia Swingle.) telah banyak digunakan sebagai obat batuk, peluruh dahak, influenza, obat jerawat, penurun panas (antipireutik), diare, antiinflamasi, antireumatik, antikoagulan, antiinfeksi, dan antibakteri. Penelitian ini merupakan eksperimental laboratorium dengan pengujian terhadap perasan Jeruk Nipis (Citrus aurantifolia Swingle) dengan metode uji kualitatif yang bertujuan untuk mengetahui ada atau tidaknya kandungan senyawa kimia pada perasan Jeruk Nipis (Citrus aurantifolia Swingle) dengan menggunakan metode uji alkaloid, flavonoid,tanin,fenol dan saponin. Hasil pengujian diperoleh kandungan senyawa kimia pada perasan jeruk nipis (Citrus aurantifolia Swingle) positif mengandung senyawa alkaloid, flavonoid, tanin dan fenol. Sedangkan pada saponin hasilnya negatif . Kata Kunci : Jeruk Nipis Citrus aurantifolia Swingle , Kualitatif
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ALGA Halimeda opuntia DARI PERAIRAN DESA POOPOH KABUPATEN MINAHASA Bryan Andrew Tikonuwu; Defny Silvia Wewengkang; Erladys Rumondor
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49364

Abstract

Halimeda opuntia is a genus of seaweed from the Chlorophyta division that contains bioactive compounds that can be utilized in various fields, especially in medicine. This study was conducted with the aim of determining the antibacterial activity of Halimeda opuntia algae extracts obtained from coastal waters of Poopoh Village, Tombariri District, Minahasa Regency against Pseudomonas aeruginosa and Staphylococcus aureus bacteria. Samples were extracted by maceration method using 95% ethanol solvent. Antibacterial activity testing was conducted using the Kirby and Bauer Disc Diffusion method. The results showed that the average diameter of the inhibition zone against Pseudomonas aeruginosa test bacteria was 6.83 mm and for Staphylococcus aureus test bacteria was 8.58 mm, the inhibition zone that arose against these two bacteria was included in the medium inhibition category. Through this study, it can be concluded that ethanol extract has antibacterial activity against test bacteria, especially on Staphylococcus aureus bacteria. Keywords: Algae, Halimeda opuntia, antibacterial activity, Pseudomonas aeruginosa, Staphylococcus aureus
Uji Aktivitas Antioksidan Ekstrak Etanol Spons Aaptos aaptos yang diperoleh dari Pantai Parentek Kabupaten Minahasa Shalomyta Monangin; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55063

Abstract

Spons Aaptos aaptos merupakan biota laut yang memiliki kemampuan menghasilkan senyawa bioaktif yang berpotensi tinggi sebagai sumber antioksidan alami. Antioksidan adalah senyawa yang dapat menetralkan radikal bebas sehingga tidak mengganggu metabolisme tubuh. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan spons Aaptos aaptos. Penelitian ini merupakan eksperimental laboratorium dengan pengujian terhadap ekstrak etanol spons Aaptos aaptos menggunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl). Hasil analisis data nilai % inhibisi adalah 54,04% (2,5 ppm), 56,46% (5 ppm), 59,52% (10 ppm), 76,92 % (15 ppm), dan 78,25% (20 ppm). Aktivitas antioksidan tertinggi dicapai pada konsentrasi 20 ppm dengan nilai % inhibisi sebesar 78,25%. Hal ini menunjukan bahwa sampel spons Aaptos aaptos yang diperoleh dari Pantai Parentek Kabupaten Minahasa memiliki aktivitas antioksidan dan efektif sebagai antioksidan.
Antioxidant Activity Test of Ethanol Extract of Sarcophyton sp. Obtained at Parentek Beach, Minahasa Regency Berlian Tasya Tumundo; Adithya Yudistira; Erladys Melindah Rumondor
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55114

Abstract

Sarcophyton sp. contain bioactive compounds that are efficacious as antioxidants. The purpose of this research is to determine the antioxidant activity of ethanol extract produced by Sarcophyton sp. By extraction using maceration method with 95% ethanol solvent and testing using DPPH (1,1- diphenyl-2-picrylhydrazyl) method. The results of data analysis of % inhibition obtained were 47.09% (20 ppm), 54.8% (40 ppm), 56.7% (60 ppm), 60.6% (80 ppm) and 62.4% (100 ppm). The ethanol extract of Sarcophyton sp. obtained from Parentek Beach, Minahasa Regency has the highest antioxidant activity at a concentration of 100 ppm which is 62.4%..
Co-Authors Adithya Yudistira Agow, Mikhael C. Alfiani Idie Barliana, Melisa I. Berlian Tasya Tumundo Billy Arthur Porajow Brian G. A. Adilan Bryan Andrew Tikonuwu Bunet, Greey C.E. Christo Togelang Datu, Olvie S. Datu, Olvie Syenni Defny Silvia Wewengkang Edi, Hosea Jaya Elly Suoth Fatimawali . Gayatri Citraningtyas Grafland Langkay Henki Rotinsulu, Henki Hermelina Yosephina Burdam Herni I. E. Simbala Herny E.I. Simbala Hosea J. Edy, Hosea J. Idie, Alfiani Ira Handayani Puspita Prins Jabes Wolter Kanter Julianri Sari Lebang, Julianri Sari Karlah L. R. Mansauda Kevin R. Mengko Kinanti, Agata Mega Kindangen, Eunike Elizabeth Kiwol, Hilda Komang Ayu May Widyani Laleno, Ellysa N. Lampongajo, Stela Mahdalena Lontaan, Gloria J. Lumbu, Alisa W. R. Lumentut, Natalia Luntungan, Brigita Michelle Luy Parala Marampung, Wahyuni Melisa I. Barliana Melisa Oktafiani Makalunsenge Miracle Cristia Meyfi Bambulu Moelyono Moektiwardoyo Moelyono Moektiwardoyo, Moelyono Mohtar, Khumairah Nadine Natari Pangemanan, Stephany P. Rolos, Tesalonika N. Rondonuwu, Greifen Triky Sambou, Christel N. SELLYANA MAHARANI BAWEKES Shalomyta Monangin Tawalujan, Wulan P. Trina E. Tallei, Trina E. Tumundo, Berlian Tasya Viocindy Riska Nusaly Viska Fadila Tompunu Widya Astuty Lolo, Widya Astuty Wiranatika Jhonatan Sangkoy Yulien C. Sambode