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All Journal JURNAL KIMIA SAINS DAN APLIKASI

Enny Fachriyah

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University Jl. Prof. Soedarto, SH., Tembalang, Semarang

Author-ID : 6051499

Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Phytochemical Test, Determination of Total Phenol, Total Flavonoids and Antioxidant Activity of Ethanol Extract of Moringa Leaves (Moringa oleifera Lam) Enny Fachriyah; Dewi Kusrini; Ifan Bagus Haryanto; Synta Mutiara Bunga Wulandari; Widyaningrum Islami Lestari; Sumariyah Sumariyah
Jurnal Kimia Sains dan Aplikasi Vol 23, No 8 (2020): Volume 23 Issue 8 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Moringa (Moringa oleifera Lam) is a medicinal plant that is a source of nutrients. It is rich in protein, fatty acids, minerals, relatively high polyphenol compounds, and has antioxidant activity. This study aims to obtain information about secondary metabolites, total phenol content, total flavonoids, and antioxidant activity of the ethanol extract of Moringa leaves. Total phenol was determined by the Folin–Ciocâlteu method, while total flavonoids were determined by the AlCl3 colorimetric method. Whilst the antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method at a wavelength of 517 nm. The results showed that the ethanol extract of Moringa leaves contained flavonoids, phenols, tannins, saponins, alkaloids, and steroids. The total phenol content in the ethanol leaf extract was 63.16 mg GAE/g extract, and the total flavonoid content was 10.477 mg QE/g extract. Moringa leaf ethanol extract has antioxidant activity with an IC50 of 118.6145 mg/L, classified as having moderate antioxidant activity.

Isolasi, Identifikasi dan Uji Sitotoksik Senyawa Alkaloid Daun Ketapang yang Sudah Menguning (Terminalia cattapa Linn) Ferdian Cahya Prima; Dewi Kusrini; Enny Fachriyah
Jurnal Kimia Sains dan Aplikasi Vol 16, No 2 (2013): Volume 16 Issue 2 Year 2013
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan proses isolasi senyawa alkaloid indol daun ketapang yang sudah menguning (Terminalia Cattapa Linn) dengan metode ekstraksi Asam-Basa. Hasil isolasi diperoleh senyawa alkaloid total sebesar 1,423 gram (percent 0,287%). Analisis menggunakan spektrofotometri UV-Vis menunjukkan adanya serapan pada panjang gelombang 206 dan 224 nm, yang mengindikasikan bahwa senyawa alkaloid memiliki kerangka dasar indol. Uji sitotoksik diperoleh harga LC50 sebesar 157,004 ppm.

Improvement of Bioactivity with Nanoparticle Fabrication: Cytotoxic Test of Ethanol, N-Hexane and Ethyl Acetate Extract from Red Galangal Rhizome (Alpinia purpurata (Vieill.) K. Schum) in Bulk and Nanoparticle size using BSLT Method Enny Fachriyah; Dewi Kusrini; Pratama Jujur Wibawa
Jurnal Kimia Sains dan Aplikasi Vol 21, No 1 (2018): Volume 21 Issue 1 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Some of the secondary metabolites present in red algae are terpenoids, quinones, flavonoids, alkaloids, essential oils, diarylheptanoids, steroids, cardioglycosides, oils and fats, tannins, carbohydrates. Activity of rhizomes, leaves and flowers red leaf is as antimicrobial, anti-fungal, anti-oxidants, anti-tumor, anti-cancer and vasodilator. One way to improve the physical, chemical and bioactivity properties of natural compounds was to make them into nanoparticles. In this study, the isolation of bioactive compounds contained in red laos rhizome by maceration method using ethanol solvent was done, then partitioned with n-hexane and ethyl acetate. The extracts thus obtained are fabricated into nanoparticles. Extracts in bulk and nanoparticles were then tested for cytotoxic activity using BSLT method. Results of analysis with PSA showed that ethanol extract had size 410,8 nm, n-hexane extract 220,7 nm and ethyl acetate extract 208,3 nm. The results of cytotoxic tests showed that nanoparticle size increased cytotoxic activity. Ethyl acetate extract was most active compared to ethanol and n-hexane extracts with LC50values of 17.919; 84,956; 166,526 ppm. Whereas the nanoparticle size was respectively 10,491; 74,072 and 84,197 ppm. Cytotoxic activity increases with nanoparticle fabrication.

Synthesis of Nano Chitosan as Carrier Material of Cinnamon’s Active Component Ngadiwiyana Ngadiwiyana; Enny Fachriyah; Purbowatiningrum Ria Sarjono; Nor Basid Adiwibawa Prasetya; Ismiyarto Ismiyarto; Agus Subagio
Jurnal Kimia Sains dan Aplikasi Vol 21, No 2 (2018): Volume 21 Issue 2 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Development and innovation to improve the efficacy of active ingredients of a plant can be done by using nanoparticle encapsulation of chitosan, which has dual function of protecting natural extracts degradation and delivering natural extracts to the target site. Chitosan is a natural polymer that is nontoxic, mucoadhesive, biodegradable, and biocompatible. This polymer also has a low level of immunogenicity and can be prepared into nanoparticles in mild conditions that make it suitable for natural extracts delivery systems. This paper reported synthesis of chitosan nanoparticles for cinnamon’s natural extract delivery. Chitosan synthesis was carried out by chitin deacetylation isolated from shrimp shells. Chitosan characterization was done by measuring deacetylation degree by FTIR. Chitosan nanoparticles were prepared by ionic gelation method using tripolyphosphate as crosslinker. Morphology and particle size of nano chitosan were characterized using a scanning electron microscope (SEM) and a transmission electron microscope (TEM). The result found that the yield of deproteinated chitin was 62.60%. Further process of demineralization resulted a yield of 52.60%, then depigmentation with a yield of 75.56%, and deacetylation with a yield of 79.02%. FTIR analysis showed that deacetylation degree of chitin into chitosan was found of 87.78%. Characterization by SEM found that nano chitosan has a particle size of 87 nm. While TEM images showed that the nano chitosan has a uniform shape and a lower physical aggregation.

Isolation of Flavonoid Compounds from Eceng Gondok (Eichhornia crassipes) and Antioxidant Tests with DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Method Kautsar Elvira; Enny Fachriyah; Dewi Kusrini
Jurnal Kimia Sains dan Aplikasi Vol 21, No 4 (2018): volume 21 Issue 4 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

The research had been conducted of the isolation of flavonoid compounds from water hyacinth plants (Eichhornia crassipes) and antioxidant activity test by DPPH (1,1-diphenyl-2-picrylhydrazyl) method. This research starts from maceration of water hyacinth with ethanol solvent. Ethanol extract was hydrolyzed with HCl. Flavonoid separation is carried out by column chromatography and preparative thin layer chromatography. The obtained isolates were analyzed by UV vis spectrophotometer and FTIR spectrophotometer. Antioxidant activity was carried out by DPPH method. Flavonoid isolates were obtained as heavy as 4.5 mg (0.006%). The results of the analysis of flavonoid isolates A4a with UV vis spectrophotometer appear at a wavelength of 368 nm (band I) and 260 nm (band II). The results of the analysis with FTIR shown that the isolates had functional groups O-H, aliphatic C-H, CH3, C =O, aromatic C = C, and C-O ether, it was suspected that flavonoid isolates had a basic structure of quercetin 7-methyl ether compounds. The results of antioxidant activity test of flavonoid isolates shown IC50 price of 254.66 mg / L

Sintesis Biodiesel dari Minyak Mikroalga Nannochloropsis Sp. Melalui Transesterifikasi Menggunakan Katalis Basa Riza Habibi; Enny Fachriyah; Dewi Kusrini
Jurnal Kimia Sains dan Aplikasi Vol 13, No 1 (2010): Volume 13 Issue 1 Year 2010
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan penelitian tentang sintesis biodiesel dari minyak mikroalga Nannochloropsis sp. melalui transesterifikasi menggunakan katalis basa. Isolasi minyak mikroalga dilakukan dengan metode ekstraksi soxhlet menggunakan pelarut n-heksan, diperoleh ekstrak minyak dalam fraksi lipid sebanyak 23,793 gram dengan rendemen 5,28 %. Sintesis biodiesel/metil ester asam lemak melalui transesterifikasi dengan variasi katalis KOH dan K2CO3. Metil ester yang terbentuk dianalisis menggunakan 1H NMR. Puncak proton metoksi dari metil ester tampak pada δ ± 3,7 ppm. Luas puncaknya menunjukkan kelimpahan proton metoksi dari metil ester pada penggunaan katalis K2CO3 lebih besar dari penggunaan KOH. Hasil analisis GC-MS menunjukkan komposisi asam lemak penyusun minyak mikroalga adalah asam miristat, palmitoleat, palmitat, linolelaidat, elaidat, dan stearat. Biodiesel B5 mikroalga (blending 5% biodiesel dan 95% solar murni) mempunyai sifat viskositas kinematik 40°C sebesar 4,71 mm2.s-1 dan density 15°C sebesar 862 kg.cm-3. Hasil analisis ini menunjukkan bahwa sifat viskositas kinematik dan density biodiesel B5 mikroalga memenuhi syarat dalam batasan standar Dirjen Migas.

Isolasi, Identifikasi Senyawa Alkaloid dari Daun Rivina humilis L. serta Uji Sitotoksik Menggunakan Metode BSLT (Brine Shrimp Lethality Test) Edwin Fadhly; Dewi Kusrini; Enny Fachriyah
Jurnal Kimia Sains dan Aplikasi Vol 18, No 2 (2015): Volume 18 Issue 2 Year 2015
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Penelitian tentang penapisan fitokimia, isolasi, identifikasi alkaloid dari daun getih-getihan (Rivina humilis L.) serta uji sitotoksisitas dengan metode BSLT telah dilakukan. Isolasi alkaloid diawali dengan maserasi daun Rivina humilis L. dengan pelarut etanol 96%, dilanjutkan penghilangan klorofil dengan menggunakan aquades (1:1). Selanjutnya hasil maserasi tersebut dipartisi dengan pelarut n-heksana, diperoleh ekstrak n-heksana dan ekstrak etanol-air. Ekstrak etanol-air dilakukan isolasi alkaloid hingga diperoleh ekstrak alkaloid berwarna coklat kemerahan sebanyak 0,7323 gram. Pemisahan alkaloid dilakukan dengan metode kromatografi lapis tipis preparatif dan uji kemurniannya menggunakan metode KLT dengan berbagai eluen didapatkan 1 noda pada pita A1. Isolat alkaloid A1 berbentuk padatan putih dan mempunyai titik leleh sebesar 290-292°C. Hasil analisis spektrofotometer UV-Vis memperkirakan bahwa senyawa alkaloid A1 mempunyai struktur dasar indol. Analisis dengan spektofotometer FTIR menunjukkan adanya gugus N-H, O-H, =C-H aromatik, CH2, C=N, C=O, C=C aromatik, dan C-O eter. Sedangkan kromatogram LC-MS menunjukkan puncak tertinggi pada waktu retensi 1,8 menit dan memiliki bobot molekul sebesar 267.27 g/mol. Hasil uji sitotoksik menunjukkan bahwa ekstrak alkaloid mempunyai harga LC50 sebesar 25,439 ppm.

Isolation and Testing of Bacteria from Steroid Compounds obtained from Anting-anting Leaf (Acalypha indica L.) Ditya Vega Fauzia; Dewi Kusrini; Enny Fachriyah
Jurnal Kimia Sains dan Aplikasi Vol 21, No 2 (2018): Volume 21 Issue 2 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Isolation of steroid compounds from the leaves of the earrings (Acalypha indica L.) and the antibacterial test has been performed. This study aims to obtain information about secondary metabolite compound leaves of Anting-anting, obtaining and identifying steroid isolates from the leaves of Anting-anting and knowing the antibacterial activity of the positive fraction of steroid compounds. The research stages include sample preparation, phytochemical test, isolation, separation, purification of steroid compounds, identification of steroid isolates using LC-MS/MS, and antibacterial test by paper disc method. The results of phytochemical screening show that the leaves of the earrings contain alkaloid compounds, flavonoids, steroids, saponins, tannins, and quinones. From the results of steroid isolation, we found steroid isolates weighing 0.0065 grams (0.0058%). Identification of steroid isolates using LC-MS/MS at a retention time of 7.49 min with [M+H]+ 399 m/z indicated the presence of a brassicasterol compound. The results of antibacterial test of fraction A from chloroform extract containing steroid compound showed antibacterial activity against Staphylococcus aureus bacteria and Escherichia coli bacteria.

Isolasi dan Identifikasi Senyawa Flavonoid dari Ekstrak Etil Asetat Rimpang Bengle (Zingiber cassumunar Roxb.) Safira Safira; Enny Fachriyah; Dewi Kusrini
Jurnal Kimia Sains dan Aplikasi Vol 15, No 1 (2012): Volume 15 Issue 1 Year 2012
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan isolasi, identifikasi, dan uji toksisitas senyawa flavonoid dari ekstrak etil asetat rimpang bengle (Zingiber cassumunar Roxb.). Dari hasil penelitian, didapatkan rendemen ekstrak metanol sebanyak 5.75% berasal dari maserasi serbuk rimpang bengle menggunakan metanol. Ekstrak metanol yang didapat selanjutnya diekstraksi menggunakan etil asetat dan didapatkan ekstrak etil asetat sebanyak 4.8%. Hasil penapisan fitokimia rimpang bengle dan ekstrak etil asetat menunjukkan bahwa pada keduanya mengandung senyawa flavonoid, saponin, steroid dan triterpenoid. Kemudian dilakukan pemisahan senyawa flavonoid dari ekstrak etil asetat menggunakan kromatografi kolom dan KLT preparatif. Dari hasil kromatografi kolom didapatkan 8 fraksi (FA-FH). Hasil KLT preparatif fraksi D memunjukkan adanya dua senyawa flavonoid. Hasil identifikasi menggunakan UV-Vis dengan penambahan pereaksi geser diperoleh flavonoid golongan flavonol (3-OH bebas) yaitu 3,5,6,4’ tetrahidroksi flavonol flavonoid golongan auron yaitu 6,7,4’ trihidroksi auron. Hasil uji toksisitas terhadap fraksi metanol, fraksi etil asetat dan hasil kolom fraksi D masing-masing memiliki nilai LC50 berturut-turut 41,645 ppm; 56,603 ppm; 143,384 ppm sehingga ketiga hasil tersebut memiliki potensi sebagai anti bakteri.

Isolasi, Identifikasi dan Uji Aktivitas Antibakteri Minyak Atsiri Akar Sidaguri (Sida rhombifolia Linn) Winarti Winarti; Dewi Kusrini; Enny Fachriyah
Jurnal Kimia Sains dan Aplikasi Vol 12, No 2 (2009): Volume 12 Issue 2 Year 2009
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan penelitian tentang isolasi, identifikasi dan uji aktivitas antibakteri minyak atsiri akar sidaguri (Sida rhombifolia Linn). Penelitian ini bertujuan untuk mengisolasi, mengidentifikasi senyawa minyak atsiri dari akar sidaguri serta mengetahui aktivitasnya sebagai antibakteri. Metode yang dilakukan dalam penelitian ini meliputi destilasi uap, brine shrimp lethality test (BSLT), Kromatografi Gas-Spektrometer Massa (GC-MS) dan metode difusi cakram kertas. Dari hasil penelitian diperoleh minyak berwarna kuning muda berbentuk seperti pasta yang berbau khas sidaguri dengan rendemen 0,024 % dan indeks bias sebesar 1,569 pada 25°C. Analisis Kromatografi Gas-Spektrometer Massa (GC-MS) menunjukkan bahwa minyak atsiri akar sidaguri didominasi oleh 2 senyawa: 4-terpineol dan α-terpineol. Hasil uji aktivitas minyak atsiri terhadap bakteri Escherichia coli pada konsentrasi 750 ppm dan 1000 ppm menunjukkan luas daerah hambatan sebesar 0,0176 mm2 dan 0,0197 mm2, sedangkan minyak atsiri pada bakteri Staphylococcus aureus sebesar 0,0123 mm2 dan 0,0158 mm2.

Co-Authors Afrezza Lukman Rosyid Agus Subagio Andriyani Budi Listyo Ayu Ni’mah Azifa Buyung Rukmantara Susena Putra Candra Dewa Pramana Putra Choirulina Maulida Dewi Kusrini Dian Nopitasari Dita Widia Ningrum Ditya Putri Solihati Ditya Vega Fauzia Edwin Fadhly Fajar Budi Laksono Ferdian Cahya Prima Ifan Bagus Haryanto Ika Rissanti Ismiyarto Ismitarto Kautsar Elvira Maulina Dwi Haryani Muhammad Untoro Ngadiwiyana M.Si. S.Si. Nor Basid Adiwibawa Prasetya Pratama Jujur Wibawa Purbowatiningrum Ria Sarjono Riza Habibi Safira Safira Sumariyah Sumariyah Synta Mutiara Bunga Wulandari Vatara Artanta Silalahi Widyaningrum Islami Lestari Wihda Wihdatul Hidayah Winarti Winarti Windi Susmayanti Yuliana Manik

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