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All Journal Chemistry Indonesian Journal of Chemical Research Al-Khidmah Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
Indah Purnama Sary, Indah Purnama
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Engineering Environmental Science Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences

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Stability Indicating RP-HPLC for Quantification Mangiferin in Extract of Three Species Mango Leaves Retnaningtyas, Yuni; Kristiningrum, Nia; Renggani, Hidayah Dwi; Sary, Indah Purnama
Indonesian Journal of Chemical Research Vol 8 No 1 (2020): Edisi Bulan Mei (Edition for May)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.8-yun

Abstract

The stability indication of Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was validated for quantitative determination of mangiferin on three species mango leaves (Mangifera odorata Griff, Mangifera foetida Lour, and Mangifera indica L.). The samples were extracted by maseration method using methanol and concentrated using rotary evaporator. The method carried out on stationary phase a purospher RP-18 endcapped (25 cm × 4.6 mm i.d., 5 µm) column with a mobile phase consisting of methanol: phosphoric acid 0.1% (v/v) (31:69); flow rate:0.8 mL/min; solvent methanol, detection was carried out at 258 nm. The analytical performace this measurement is good with the value of linearity (r2=0.998), precision (%RSD=0.649%), and accuration (10.67%). The forced degradation studies were carried out according to the International Conference on Harmonization (ICH) guidelines. The results indicating that the complete separation between degradation products and mangiferin peak occured. The degradation limit of mangiferin 5–20% (according to the guideline of ICH) except in basic condition (100%). The method was succesful applied to determine of the mangiferin in pakel (Mangifera foetida), kweni (Mangifera indica) and kopyor (Mangifera odorata) extract. The mangiferin content was obtained are pakel (9.95%), kopyor (7.40%) and kweni (Mangifera odorata) (2.49%) respectively.
Pelatihan Pemanfaatan Daun Beluntas (Pluchea indica) Sebagai Produk Kesehatan di Sidomekar Semboro Kabupaten Jember Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Al-Khidmah Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): MEI-AGUSTUS
Publisher : Institute for Research and Community Service (LPPM) of the Islamic University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/jak.v5i2.4464

Abstract

The many kinds of health benefits of beluntas (Pluchea indica) are already known, but are still limited for vegetables, even though its essential oil is very high. Essential oils, based on research, can be used as an antibacterial and an inhibitor of viruses. Therefore, we conducted counseling and training on the utilization of Beluntas leaf essential oil through isolation to be developed into health products in the Babatan Sidomekar community, Semboro, Jember. The Covid 19 virus pandemic in Indonesia has had an economic impact on small communities. One way to do this is to provide new knowledge and technology by producing products that can be used to increase income and preventive against COVID-19. Presentation products are more modern, have high selling value, and are more durable, which will be easily accepted by the market. The stages of implementing the activity were socialization in the Babatan Sidomekar community, Semboro, Jember, which was carried out well from August to November 2022, and the community was very enthusiastic about receiving counseling and training in making hand sanitizer and antiseptic soap products from the essential oil of beluntas leaf
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method Pangaribowo, Dian Agung; Fathunnisa, Fathunnisa; Nugraha, Ari Satia; Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6163

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Co-Authors Ari Satia Nugraha Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Fathunnisa, Fathunnisa Nia Kristiningrum Renggani, Hidayah Dwi Yuni Retnaningtyas