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All Journal Chemistry Indonesian Journal of Chemical Research Borneo Journal of Pharmacy Journal of Agropharmacy
Indah Purnama Sary, Indah Purnama
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Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science Medicine & Pharmacology

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Stability Indicating RP-HPLC for Quantification Mangiferin in Extract of Three Species Mango Leaves Retnaningtyas, Yuni; Kristiningrum, Nia; Renggani, Hidayah Dwi; Sary, Indah Purnama
Indonesian Journal of Chemical Research Vol 8 No 1 (2020): Edisi Bulan Mei (Edition for May)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.8-yun

Abstract

The stability indication of Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was validated for quantitative determination of mangiferin on three species mango leaves (Mangifera odorata Griff, Mangifera foetida Lour, and Mangifera indica L.). The samples were extracted by maseration method using methanol and concentrated using rotary evaporator. The method carried out on stationary phase a purospher RP-18 endcapped (25 cm × 4.6 mm i.d., 5 µm) column with a mobile phase consisting of methanol: phosphoric acid 0.1% (v/v) (31:69); flow rate:0.8 mL/min; solvent methanol, detection was carried out at 258 nm. The analytical performace this measurement is good with the value of linearity (r2=0.998), precision (%RSD=0.649%), and accuration (10.67%). The forced degradation studies were carried out according to the International Conference on Harmonization (ICH) guidelines. The results indicating that the complete separation between degradation products and mangiferin peak occured. The degradation limit of mangiferin 5–20% (according to the guideline of ICH) except in basic condition (100%). The method was succesful applied to determine of the mangiferin in pakel (Mangifera foetida), kweni (Mangifera indica) and kopyor (Mangifera odorata) extract. The mangiferin content was obtained are pakel (9.95%), kopyor (7.40%) and kweni (Mangifera odorata) (2.49%) respectively.
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method Pangaribowo, Dian Agung; Fathunnisa, Fathunnisa; Nugraha, Ari Satia; Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6163

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Kadar Flavonoid Total dan Aktivitas Tabir Surya Ekstrak Kulit Edamame (Glycine max (L.) Merr.) Kristiningrum, Nia; Fadhil, Anfaq Syahriyal; Retnaningtyas, Yuni; Pangaribowo, Dian Agung; Pratoko, Dwi Koko; Sary, Indah Purnama; Wulandari, Lestyo
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Edamame pod waste (Glycine max (L.) Merr.) is often underutilized despite its potential to contain bioactive compounds such as flavonoids, which possess antioxidant and ultraviolet (UV) protective properties. Excessive exposure to UV radiation can cause various skin problems, including premature aging and increased risk of skin cancer, highlighting the need for safe natural sunscreen agents. This study aimed to determine the total flavonoid content and Sun Protection Factor (SPF) value of ethanol extract of edamame pods in vitro. Extraction was performed using the maceration method with 96% ethanol. Total flavonoid content was determined using UV–Vis spectrophotometry with AlCl₃ and CH₃COOK reagents, using quercetin as a standard at a maximum wavelength of 446 nm. The SPF value was evaluated in vitro using a UV–Vis spectrophotometer at wavelengths of 290–320 nm with 5 nm intervals and calculated using the Mansur equation. All measurements were performed in triplicate. The results showed that the ethanol extract of edamame pods contained a total flavonoid content of 5.177 ± 0.432 mg QE/g extract. At a concentration of 1500 µg/mL, the extract exhibited the highest SPF value of 17.22, which is categorized as ultra protection against UVB radiation. These findings indicate that the ethanol extract of edamame pods (Glycine max (L.) Merr.) has potential as a natural source of flavonoids and a photoprotective agent for sunscreen or cosmetic formulations.
Co-Authors Ari Satia Nugraha Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Fadhil, Anfaq Syahriyal Fathunnisa, Fathunnisa Lestyo Wulandari Nia Kristiningrum Renggani, Hidayah Dwi Yuni Retnaningtyas