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All Journal JURNAL KIMIA SAINS DAN APLIKASI e-Journal Pustaka Kesehatan Jurnal Pengembangan Pendidikan STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kimia Terapan Indonesia Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Al-Khidmah Jurnal Pengabdian Masyarakat Journal of Pharmacy Science and Technology Borneo Journal of Pharmacy
Ayik Rosita Puspaningtyas1
Faculty Of Pharmacy, University Of Jember, Jember, East Java|University Of Jember|Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences

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PENTINGNYAMATA PELAJARAN BAHASA DAERAH DALAM KURIKULUM SEKOLAH DASAR DALAM EKSISTENSIBUDAYA BANGSA P., Ayik Rosita; Aprila, Fifteen
Jurnal Pengembangan Pendidikan Vol 3, No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

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Abstract

Abstrak. Mata pelajaran bahasa daerahdi tingkat SD sangat penting dalam tingkat awal pengenalan bahasa daerahsebagai budaya bangsa pada pendidikan formal sekaligus dapat menjadi saranadalam kehidupan bermasyarakat yaitu untuk komunikasi dan etika sopan santundalam bermasyarakat. Menurut kurikulum DEPDIKNAS bahasa daerah berfungsi untuk mengembangkankemampuan bernalar, berkomunikasi dan mengungkapkan pikiran atau perasaan sertamelestarikan aset nasional di daerah. Selain itu juga bahasa daerah sebagaibudaya bangsa dapat menjadi identitas diri pada era globalisasi sehingga dapatmenyaring budaya asing yang masuk ke Indonesia. Key word: Bahasa daerah, kurikulum sekolah dasar, budayabangsa.
MOLEKULAR DOCKING DENGAN METODE MOLEGRO VIRTUAL DOCKER TURUNAN KALKON SEBAGAI ANTIMIKROBA Puspaningtyas, Ayik Rosita
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

We have done docking molecule on chalcones derivatives that bind to antibacterial gram-positive (Bacillus subtilis ) and negative (Escherichia coli) compared with chalcones derivatives and chloramphenicol antibiotic. Chalcone derivatives compounds have been synthesized by varying the methoxy groups in chalcone structure. The results showed that chalcone derivatives have antibacterial activity in inhibition of Bacillus subtilis and Escherichia coli that were better than lead compound (chalcone) and chloramphenicol. The results can be viewed from Moldock and Rerank score that has lower energy. The results differ from in vitro study in 1 - (4-Bromo-phenyl) -3 - (4-phenyl-methoxy)-2-propen-1-on and 1-(4-Bromo-phenyl)-3-(3.4-dimethoxy-phenyl)-2-propen-1-on compounds as antibacterial activity in gram-negative bacteria (E. coli) and gram-positive bacteria (Bacillus subtilis) were smaller activity than chloramphenicol. Because of derivatives chalcones was very large lipophylic value (log P>2), these will decrease the activity. In addition, if these were viewed hydrogen bonds on Molegro Virtual Docker between chalcone derivatives and binding of bacterial amino acids, ie Lys 411, Ser 299, Ser 52, and Thr 412 in Bacillus subtilis and Tyr 136 and Tyr 52 in Escherichia coli provide less harmonious interaction within complex binding than that of chloramphenicol.
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA TURUNAN KALKON PADA STRAIN BAKTERI Bacillus subtilis DAN Escherichia coli Puspaningtyas, Ayik Rosita
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 8, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Disease caused by bacteria still have a high prevalence in Indonesia, both in urban and rural areas. Currently the treatment of diseases caused by bacteria carried by many antibiotics, whereas in reality antibacterial drugs like antibiotics are now causing a lot of resistance in some people. Because of this we effort to develop antimicrobial agents, a series of chalcones were 1-(4-Bromo-phenyl) -3-(4-methoxy-phenyl)-2-propen-1-on and 1-(4- Bromo-phenyl)-3-(3,4-dimethoxy-phenyl)-2-propen-1-on compounds.These compounds are synthesized on the basis of QSAR (Quantitative Structure Activity Relationships) using lipophilic, steric, and electronic parameters. Compound 1-(4-Bromo-fenill)-3-(4-methoxy-phenyl)-2-propen-1-on and 1-(4-Bromo-phenyl)-3-(3,4-dimethoxy-phenyl)-2-propen-1-on is made from raw materials 4-bromo-asetophenone and 4-Methoxy benzaldehide/3,4-dimethoxy benzaldehide usual Claisen-Schmidt condensation method of mixing for overnight 24 hours then be recrystallized to obtain a pure crystalline chalcones analog compounds. After the synthesis, compounds were characterized by organoleptic and melting point test. The results showed that a white color, smells aromatic, and needle crystals. The synthesized compounds were characterized by means of their 1H-NMR spectral data. All the compounds were tested for their antibacterial activities by the hole plate method.
PENTINGNYAMATA PELAJARAN BAHASA DAERAH DALAM KURIKULUM SEKOLAH DASAR DALAM EKSISTENSIBUDAYA BANGSA P., Ayik Rosita; Aprila, Fifteen
Jurnal Pengembangan Pendidikan Vol 3 No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak. Mata pelajaran bahasa daerahdi tingkat SD sangat penting dalam tingkat awal pengenalan bahasa daerahsebagai budaya bangsa pada pendidikan formal sekaligus dapat menjadi saranadalam kehidupan bermasyarakat yaitu untuk komunikasi dan etika sopan santundalam bermasyarakat. Menurut kurikulum DEPDIKNAS bahasa daerah berfungsi untuk mengembangkankemampuan bernalar, berkomunikasi dan mengungkapkan pikiran atau perasaan sertamelestarikan aset nasional di daerah. Selain itu juga bahasa daerah sebagaibudaya bangsa dapat menjadi identitas diri pada era globalisasi sehingga dapatmenyaring budaya asing yang masuk ke Indonesia. Key word: Bahasa daerah, kurikulum sekolah dasar, budayabangsa.
Studi Aktivitas Antioksidan Senyawa 1-(p-klorobenzoiloksimetil)-5-fluorourasil dengan Metode Molecular Docking dan Metode DPPH (Antioxidant Activity of 1-(p-chlorobenzoyloxymethyl)-5-Fluorouracyl Using Molecular Docking and DPPH Method) Brahmansyah Diar Rosiarto; Ayik Rosita Puspaningtyas; Diana Holidah
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Cellular damage caused by reactive oxygen species (ROS) free radical and antioxidant activity has an important role as free radical scavenging in body. This study was carried out to evaluate in vitro antioxidant and ligand afinity toward human ROS receptor (PDB code: 3ZBF). In DPPH method, 1-(p-chlorobenzoyloxymethyl)-5-fluorouracil dissolved in etil acetat, while 5-fluorouracil and ascorbic acid as standard dissolved in methanol. The free radical scavenging activity was measured spectrometrically with maximum wavelength at 512 nm. DPPH method show that ascorbic acid have strong antioxidant activity (IC50 = 19.092 ppm), while 1-(p-chlorobenzoyloxymethyl)-5-fluorouracil (IC50 = -2,500,245 ppm) and 5-fluorouracil (IC50 = -4,998 ppm) have not antioxidant activity. Molecular docking (in silico) toward human ROS receptor was indicate 1-(p-chlorobenzoyloxymethyl)-5-fluorouracil (Ki = -6.2 ± 0.04 kkal/mol) has best activity than ascorbic acid (Ki = -4.8 ± 0.19 kkal/mol) and 5-fluorouracil (Ki = -4.6 ± kkal/mol).   Keywords: 1-(p-chlorobenzoyloksimethyl)-5-fluorouracil, 5-Fluorouracyl, antioxidants, DPPH, molecular docking
Analisis HKSA dan Docking Aktivitas Inhibisi Turunan HEPT terhadap Enzim Reverse Transcriptase HIV (QSAR and Docking of Inhibition Activity of HEPT Derivatives Against Enzym Reverse Transcriptase HIV) Ani Riani Hasana; Ayik Rosita; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

This study describes the analysis of QSAR and Docking based on the inhibition activity of the enzyme Reverse Transcriptase HIV by 1-[(2-hydroxyethoxy) metil]-6-(phenylthio) timin (HEPT) derivatives. QSAR modeling using 85 compounds HEPT derivatives have calculated the value of biological activity in vitro inhibition of the value of log1/C, then made a linear regression equation against QSAR parameters like as lipophilic, electronic and steric to obtained maximum results correlation r2 by method Multiple Linear Regression (MLR). Docking used to determine the predictive ability of the inhibitor affinity value when HEPT derivatives interacting with the enzyme Reverse Transcriptase HIV. QSAR study results that play a role in the activity is the refractive index parameter (η), molar volume (MV), Parachor (Pc), I2 (parameter which indicates the presence of Sulphur in position R2) and ISP (parameter which indicates the presence of Sulphur in position X). Best equation obtained with compound 75 has a value of R=0.9135, R2adj=0.8064, RMSE=0.5104, and F=69.4881. Docking study results indicate derivatives with the number 80 has the smallest affinity by -11.3 kcal / mol. Keywords: docking, reverse transcriptase enzyme , HEPT, MLR, QSAR.
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4- Trifluorometilbenzoiloksimetil)-5-Fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Assay of 1-(4- Trifluoromethylbenzoyloxymethyl)-5-Fluorouracil) On MCF-7 Breast Cancer Cell Puspita Arum Wijayanti; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil (TFU) is a derivative compound of anticancer agent, 5-fluorouracil (5-FU). TFU has been synthesized by Ernawati to increase the anticancer activity of 5-FU. However, the cytotoxic and antiproliferative effect of TFU had not been carried out. This study aimed to evaluate the cytotoxic and antiproliferative activity of TFU compared to 5-FU on MCF-7 breast cancer cell line using MTT method. The citotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The cytotoxic effect was determined based on IC50 value while the antiproliferative effect was determine based on the doubling time value. The results showed that TFU had better cytotoxicity on MCF-7 with IC50 value 401.03 ± 0.370 µM compared to 5-FU with IC50 value 4216.32 ± 800.28 µM. The doubling time value of TFU at concentration of ½ IC50, IC50, and 1½ IC50 were 359.66; 364.39; and 448.40 hours respectively, while 5-FU were 184.45; 214.00; and 220.63 hours. The doubling time value indicated that TFU compound was able to prolong the doubling time of MCF-7 cell line compared to 5-FU. Keywords: cancer, cytotoxicity, proliferation,1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil, MCF-7
Sintesis Asam 2-(2-(n-(2,6-diklorofenil)-4 fluorobenzamida)fenil)asetat sebagai Kandidat Obat Penghambat COX (siklooksigenase) Triodora Hutahuruk; Ayik Rosita; Ika Oktavianawati
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Sodium diclofenac is a non selectif NSAID that used as an inflammatory, analgesic, and antipyretic. Several experiment about compound as a derivate sodium diclofenac has been synthesized for reduce side effect. 2-(2-(N-(2,6-dichlorophenyl)-4-fluorobenzamido)phenil)acetat acid (N4FND) is derivate of sodium diclofenac that synthesized for development of drugs. The target compound has been synthesized by benzoylation reaction between sodium diclofenac with 4-fluorobenzoylchloride. And then, the target compound has been purified using Coloumn Chromatography. The isolate was identified using 1HNMR 400 MHz and KBr FTIR. Spectra of of 1HNM 00 MHz and KBr FTIR showed that 2-(2-(N-(2,6-dichlorophenyl)-4-fluorobenzamido)phenil)acetat acid was successfully synthesized. Pure product compound form yellowish white crystals with melting point 165-1670C.
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4-nitrobenzoiloksi- metil)-5-fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Studies of 1-(4-nitrobenzoyloxy- methyl)-5-fluorouracil) on Breast Cancer Cells MCF-7) Eka Mustika Wati; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-nitrobenzoyloxymethyl)-5-fluorouracil (4-NFU) is a derivative of anticancer drug 5-fluorouracil (5-FU) which has been substituted by alkyl, ester, benzene, and nitro groups at N1 position. 4-NFU has been synthesized by Kurnia but anticancer study has not been reported. This research aims to compare the cytotoxicity and antiproliferative activity between 4-NFU and 5-FU on MCF-7 cells. The cytotoxicity and antiproliferative activity were studied by MTT method. The cytotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The result showed that cytotoxicity activity of 4-NFU (IC50 = 134.039 μM) was higher than 5-FU (IC50 = 4211.508 μM) on MCF-7 cells. Based on the unpaired t test, there was a significant difference between IC50 of 4-NFU and 5-FU (α<0.05). The antiproliferative study showed that there was a growth inhibition on MCF-7 cells. The doubling time value of 4-NFU was 290.51 hours at ½ IC50; 350.97 hours at IC50; and 418.2 hours at 1½ IC50. The doubling time value of 5-FU was 185.99 hours at ½ IC50; 214 hours at IC50; and 220.63 hours at 1½ IC50. The doubling time value of 4-NFU was higher than 5-FU so that antiproliferative activity of 4-NFU was higher than 5-FU on MCF-7 cells. Keywords: 1-(4-nitrobenzoyloxymethyl)-5-fluorouracil, cytotoxicity, proliferation, MCF-7
Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase) (Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenil)benzamido)phenil)acetic acid as dic Wahyu Novandari Herdiyanti; Ayik Rosita Puspaningtyas; Ika Oktavianawati
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Sodium diclofenac is an analgetic agent as an antimetabolite that used for treating pain. Several compound as a derivative diclofenac has been synthesis for increase its activity and reduce side effect. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid is a derivate of Sodium diclofenac that synthesized for development new drugs. Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic has benzoylation reaction between Sodium diclofenac and 4-Chlorobenzoil Chloride to give the target compound (2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid).This compound has been purified by Column Chromatography and give yellow color with melting point 143-145oC and then fix identification by H-NMR 400 MHz and KBr FTIR. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid can synthesized and resulted 8.39 % of yield.   Keywords: Sodium diclofenac, 2-(2-(4-Chloro-N-(2,6-dichlorophenyl)benzamido)phenyl)acetic acid, pain.
Co-Authors . Ifada Ari Satia Nugraha Bambang Kuswandi Brahmansyah Diar Rosiarto Carolin Enjelin Rumaikewi Dian Agung Pangaribowo Dian Agung Pangaribowo Diana Holidah Dyah Purwaningtyas Dyan Wigati Eka Mustika Wati Estu Wilujeng Fathunnisa Fathunnisa Fifteen Aprila Fifteen Aprila Fajrin Hadiyatun Nuroniyah Hasana, Ani Riani Ika Oktavianawati Ika Oktavianawati Indah Purnama Sari Indah Purnama Sary Indah Purnama Sary Indah Purnama Sary, Indah Purnama Lindawati Setyaningrum Maasyitoh Sari Latifah Mohammad Rofik Usman Nia Kristiningrum Puspita Arum Wijayanti Tasya Salsabila Multazam Triodora Hutahuruk Wahyu Novandari Herdiyanti Yuni Retnaningtyas