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Profil Pengetahuan tentang Obat Dexamethasone sebagai Terapi Pengobatan Pasien COVID-19 pada Masyarakat di Jawa Timur Fahrul Rozi Saputro; Anisa Cendekia Muslimah; Natalia Vani Kurniawati; Siti Nur Kholisah; Aulia Hanin Fakhira; Ihsan Muhyidin; Fika Hartanti; Nabila Balqish; Aulya Farah Fahreza; Alvina Violita Mulyanto; Syakirah Yasmin Putri; Retha Aulia Rahmah; Tsabitah Virza Novirianingtyas; Aulia Firda Salsabila; Aviatus Solikhah; Yuni Priyandani
Jurnal Farmasi Komunitas Vol. 10 No. 1 (2023): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v10i1.41922

Abstract

Munculnya isu tentang obat dexamethasone sebagai pencegah Coronavirus Disease 2019 (COVID-19) mengakibatkan masyarakat mencari obat dexamethasone tanpa menggali informasi lebih lanjut. Penggunaan obat dexamethasone tidak sesuai indikasi dapat menyebabkan efek samping obat berupa penurunan daya tahan tubuh. Penelitian ini bertujuan untuk mengetahui profil pengetahuan masyarakat di Jawa Timur mengenai fungsi, efek samping, dan penggunaan obat dexamethasone sebagai terapi pengobatan pasien COVID-19. Penelitian ini merupakan penelitian cross sectional dengan pengumpulan data menggunakan teknik non-random sampling (accidental sampling) dan instrumen penelitian berupa kuesioner online. Berdasarkan hasil penelitian diperoleh 237 responden dengan karakteristik jenis kelamin terdiri 78,9% perempuan dan 21,1% laki-laki serta usia 18-23 tahun (88,61%), 24-28 tahun (3,66%), dan >28 tahun (7,79%). Hasil penelitian menunjukkan 1,69% responden dengan pengetahuan rendah, 54,85% responden dengan pengetahuan sedang, dan 43,46% responden dengan pengetahuan tinggi terkait fungsi, efek samping, dan penggunaan obat dexamethasone sebagai terapi pengobatan pasien COVID-19. Berdasarkan hasil penelitian, perlu adanya peningkatan pengetahuan mengenai fungsi, efek samping, dan penggunaan obat dexamethasone sebagai terapi pengobatan pasien Coronavirus Disease 2019 (COVID-19) kepada masyarakat di Jawa Timur untuk mencegah terjadi mispersepsi penggunaan dexamethasone sebagai pengobatan COVID-19
The Effectiveness of Vitamin E Soft Capsules as an Antioxidant Putri, Syakirah Yasmin; Isadiartuti, Dewi; Isnaeni, Isnaeni; Aulya Farah Fahreza; Alvina Violita Mulyanto Putri; Zulfa Diana; Nafa Nazilatul Fatihah; I Gede Rekyadji Arimbawa; Alya Fakhirah; Talitha Nabilla Wijayanata; Muhammad Pramudya Pangestu; Azzalia Firdanthi; Oudrey Addriana; Umi Aida Rohma
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i1.51902

Abstract

Antioxidants inhibited the oxidation of other molecules and played an important role in maintaining a healthy body. Antioxidants were found in fruits, vegetables, all parts of plants, and were present in the body as enzymes or products of metabolism. Vitamin E referred to a large number of natural or synthetic compounds, with alpha-tocopherol being the most active and widely distributed form in nature. Alpha-tocopherol was the most active antioxidant form of vitamin E and served as the primary lipophilic antioxidant in plasma, membranes, and tissues. The most important function of vitamin E was its antioxidant capability, counteracting free radical attacks that could damage cells and cause various degenerative diseases. Additionally, antioxidants helped reduce the effects of photoaging on the skin, potentiated anti-aging and anti-inflammatory activity, increased the rate of wound healing, and helped maintain healthy eyes and the immune system. One form of vitamin E dosage form was a soft capsule, which had several advantages, including the ease of filling the Active Pharmaceutical Ingredient (API) in liquid form, higher production capacity, and formulation uniformity compared to gelatin tablets or hard capsules. Soft capsule preparations also had rapid API release, which could result in achieving therapeutic blood levels more quickly and achieving greater bioavailability. This study aimed to evaluate soft capsule dosage forms in enhancing the effectiveness of vitamin E as an antioxidant. The research utilized review articles sourced from national and international journals, as well as scientific journals. The results showed that vitamin E supplementation in soft capsules could increase its effectiveness as an antioxidant.Keywords:  Soft Capsule, Increase Effectiveness, α-tocopherol, Vitamin E, Antioxidant