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All Journal Cakrawala Pendidikan Jurnal Berita Ilmu Keperawatan Syntax Literate: Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Gizi Klinik Indonesia Majalah Farmaseutik Academic Hospital Journal
Probosuseno Probosuseno
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan, Universitas Gadjah Mada
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Kualitas hidup lansia hipertensi dengan overweight dan tidak overweight Tri Mei Khasana; Nyoman Kertia; Probosuseno Probosuseno
Jurnal Gizi Klinik Indonesia Vol 17, No 1 (2020): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.38913

Abstract

The quality of life in elderly hypertension with overweight and non-overweightBackground: Indonesia will enter the period of aging and an increase in several elderlies with chronic diseases. The biggest health problems of the elderly are degenerative diseases, namely hypertension which significantly disrupts the quality of life both in terms of physical and mental health. One of the causal conditions associated with hypertension is overweight and obesity, which is known at this time the prevalence of obesity is growing progressively in old age. However, the results of research related to the influence of obesity on quality of life are still controversial.Objective: To determine differences in quality of life between hypertensive elderly who are overweight and non-overweight.Method: Cross-sectional study conducted in Yogyakarta City in Januari-April 2017 with a subject of 200 elderly people aged 60-74 years. Overweight was determined based on BMI measurements (>23 kg/m2) with an estimation of elderly height using depa length, quality of life of the elderly was measured using WHOQOL-BREF questionnaire, and compared the quality of life by age, gender, education, occupation, income, marital status, comorbidity, and disease history. Data analysis used independent t-test and linear regression.Results: Mean of environmental domain score was significantly higher (p=0,012) in elderly hypertension with overweight (26,69±3,28) compared to elderly hypertension non-overweight (25,44±3,58). Overweight protective effect on the low quality of life of the environment domain because it is influenced by other factors such as marital status, income, and education. Multivariate analysis shows that income and marital status are external factors that consistently influence the quality of life of the elderly both in total scores and per domain. High-income elderly people with married status have a better quality of life score.Conclusions: The mean score of the environmental domain is higher in elderly hypertension with overweight. Quality of life scores will be better in high income elderly and married.
Innovative education training program of hajj healthcare workers improves the outcomes of Indonesian elderly hajj pilgrims Probosuseno Probosuseno; Fidiansjah Fidiansjah; Wasilah Rochmah; Ali Ghufron Mukti
Jurnal Cakrawala Pendidikan Vol 41, No 2 (2022): Cakrawala Pendidikan (June 2022)
Publisher : LPMPP Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/cp.v41i2.47490

Abstract

The ability of the Muslim community in Indonesia to perform the hajj pilgrimage, which fulfills Islam’s fifth pillar, is increasing. With the rise in life expectancy, the number of Indonesian elderly hajj pilgrims (EHP) is consequently growing. However, chronic conditions such as impairments, illnesses, and diseases cause an increase in morbidity and mortality among EHP. Thus, an innovative training program with practical tips for a healthy hajj experience is needed to improve the healthcare service to the EHP. This study aims to investigate the effects of an innovative training on the performance of Hajj Healthcare Workers of Indonesia (HHWI) and on the clinical outcomes of EHP. It was a quasi-experimental study. The population was all HHWI from the Surakarta embarkation in 2014. Meanwhile, the sample of this study was all 21 HHWI from Yogyakarta who received innovative training consisting of EHP special care training (theory and practice) in addition to basic national training. Twenty-one HHWI from Surakarta were randomly chosen as a control group and only received basic national training. Pre and post tests were used to assess knowledge of HHWI after training. The average pretest scores of the intervention and control groups were 48.50 and 48.07, respectively (p= 0.337), while the posttest score of the intervention group was 86.83 (p = 0.033). The measured parameters were the performance of HHWI, which is reflected by the EHP mortality rate, the number of outpatients, and the number of patients referred to the outpatients. We included the EHP under the supervision of HHWI, which has acquired training. EHP morbidity was evaluated as the number of outpatients and referred patients. There were 2216 outpatients from the intervention group as compared with 2144 in the control group, with most of them being 60-70 years old (p= 0,075). The number of referred EHP in the intervention and control groups was 10 and 30 patients, respectively (OR 2.94; p= 0.002). As for the mortality cases, we observed 7 EPH deaths during the hajj period (2 EPH from the intervention group vs 5 EPH from the control group; OR 0.263; p=0.207). Innovative training could reduce referral morbidity and mortality among elderly hajj pilgrims
The Voice of the Qur'an's Potential in Pain Management : Review Study Iwan Purnawan; Yunita Widyastuti; Sri Setiyarini; Probosuseno Probosuseno
Jurnal Berita Ilmu Keperawatan Vol 15, No 2 (2022): July 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bik.v15i2.16990

Abstract

Pain is multidimensional. Pharmacological therapy is still not optimal and has unwanted side effects. Therefore, a safe, effective, and comprehensive non-pharmacological therapy is needed to compensate for the lack of pharmacological therapy. Listening to the recitation of the Quran in several studies has been shown to have a relaxing effect in various situations. The study aims to see whether listening to the Quran as a type of non-pharmacological therapy will help people overcome pain. Method used is comprehensive search on multiple databases (Clinical Key, Cochrane Lab, Medline, Host EBSCO, ProQuest, Science Direct, and Springer Link) using the term "Quran, Holy Quran, Koran, Quran, Pain, Pain Management, and endorphins.". There were 209 articles found, and after several screening stages, 9 articles met the inclusion and exclusion criteria. The level of evidence and the Cochrane Collaboration's tool for assessing the risk of bias was used to assess the article's quality.  The result is listening to The Qur'an has been shown to reduce pain in post-surgery, blood sampling, wound care, dysmenorrhea, and childbirth. Some studies are still lacking evidence and are biased. Listening to the Quran is highly recommended for use as a health service.
Potentially Inappropriate Medication (PIM) pada Pasien Geriatri Rawat Inap di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin Amanda Wulansari; Chairun Wiedyaningsih; Probosuseno Probosuseno
Majalah Farmaseutik Vol 19, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i1.70420

Abstract

Perubahan fisiologi terkait proses penuaan yang secara alami terjadi pada usia lanjut menyebabkan perubahan farmakokinetik dan farmakodinamika obat pada pasien geriatri. Pemilihan obat pada populasi geriatri merupakan proses yang kompleks karena penggunaan obat yang tidak tepat (Potentially Inappropriate Medication) pada populasi ini berasosiasi pada peningkatan risiko morbiditas, bahkan mortalitas. Tujuan penelitian ini adalah untuk mengidentifikasi PIM pada pasien geriatri rawat inap di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin berdasarkan Kriteria Beer’s 2019 serta mengetahui hubungan jumlah obat dan lama rawat inap dengan kejadian PIM. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Data diambil secara retrospektif menggunakan 141 rekam medik pasien geriatri rawat inap di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin tahun 2019. Identifikasi kejadian PIM dilakukan dengan cara membandingkan data pengobatan yang diperoleh menggunakan kriteria Beer’s 2019. Analisis data secara univariat dilakukan untuk melihat prevalensi kejadian PIM pada pasien geriatri rawat inap. Analisis bivariat dilakukan untuk mengetahui hubungan kejadian PIM ditinjau dari jumlah obat dan lama rawat inap dengan menggunakan uji nonparametrik chi square. Hasil penelitian menunjukkan berdasarkan analisis uji univariat persentase prevalensi kejadian PIM dengan kriteria Beer’s 2019 sebesar 63,1 %. Hasil analisis bivariat menunjukkan ada hubungan bermakna antara kejadian PIM dengan jumlah obat dan lama rawat inap di Instalasi Rawat Inap RSUD Dr. H. Moch. Ansari Saleh Banjarmasin dengan nilai p sebesar 0,03 dan 0,00. Penelitian ini diharapkan menjadi sarana bagi praktisi dan referensi dalam penelitian yang lebih lanjut mengenai PIM pada geriatri yang secara tidak langsung juga akan mengoptimalkan terapi.
Perbandingan Luaran Klinik Penggunaan Sacubitril-Valsartan dengan ARB pada Pasien Gagal Jantung Febriana Trisnaputri Rahajeng; Fita Rahmawati; Probosuseno Probosuseno
Majalah Farmaseutik Vol 19, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i2.67051

Abstract

Sacubitril-valsartan merupakan kelas pertama golongan angiotensin receptor-neprilysin inhibitor (ARNI) yang direkomendasikan sebagai pengganti angiotensin-converting enzyme inhibitors (ACEI) untuk menurunkan resiko kejadian hospitalisasi akibat penyakit kardiovaskuler dan kematian pada pasien gagal jantung dengan penurunan fraksi ejeksi yang masih bergejala walaupun sudah mendapatkan terapi optimal. Penelitian ini bertujuan membandingkan luaran klinik penggunaan terapi sacubitril-valsartan dengan ARB pada pasien gagal jantung.Penelitian ini menggunakan rancangan kohort retrospektif melibatkan 105 pasien dengan diagnosis gagal jantung dengan  LVEF ≤ 40% yang terbagi menjadi dua kelompok yaitu kelompok terapi sacubitril-valsartan (26 orang) dan ARB (79 pasien) di RSUP Dr. Sardjito Yogyakarta. Data penelitian diperoleh dari rekam medik pasien tahun 2018-2019. Luaran klinik berupa kejadian hospitalisasi akibat penyakit kardiovaskuler dan adverse  event  yang diamati dalam waktu enam bulan sejak pertama kali diresepkan. Hubungan antara jenis terapi dengan luaran klinik dianalisis menggunakan Chi-square, analisis Kaplan-Meier dan cox regression.Hasil penelitian menunjukkan hospitalisasi akibat penyakit kardiovaskuler terjadi pada 80,7% kelompok sacubitril-valsartan dan 69,6% kelompok ARB (p=0,383). Pada analisis Kaplan-Meier didapatkan mean survival time kejadian hospitalisasi akibat penyakit kardiovaskuler kelompok sacubitril-valsartan 12,7 minggu dan ARB 15 minggu, dimana kelompok sacubitril-valsartan lebih cepat mengalami kejadian hospitalisasi namun tidak bermakna secara statistik (p=0,178; HR(95% CI): 0,717[0,433-1,186]). Adverse events yang timbul dari penggunaan sacubitril-valsartan berupa peningkatan serum kreatinin (satu kejadian), sedangkan pada ARB ditemukan peningkatan serum kreatinin (tujuh kejadian) dan hiperkalemi (lima kejadian). Luaran klinik kedua regimen memberikan hasil yang sama, pertimbangan biaya dan kondisi klinik pasien diperlukan sebagai dasar dalam pemilihan regimen   
Pengaruh Insulin Sliding Scale terhadap Episode Hipoglikemia dan Hiperglikemia Pasien DM Tipe 2 RSA UGM Anna Maria Manullang; Chairun Wiiedyaningsih; Probosuseno Probosuseno
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.309 KB) | DOI: 10.36418/syntax-literate.v7i9.9058

Abstract

Diabetes mellitus tipe 2 adalah penyakit metabolik akibat terjadinya resistensi insulin disertai defisiensi insulin relatif sehingga memerlukan insulin yang dapat menurunkan glukosa darah dengan kerja cepat. Insulin sliding scale merupakan metode untuk mendapatkan dosis insulin yang sesuai di mana memiliki risiko fluktuasi kadar glukosa darah sehingga terjadinya hipoglikemia (<70 mg/dl). Penelitian ini bertujuan untuk mengetahui pengaruh terhadap pengendalian kadar glukosa darah dan resiko hipoglikemia pada pasien diabetes mellitus tipe 2 di RSA UGM. Penelitian ini merupakan penelitian cross sectional dan data penelitian ini diambil secara retrospektif. Subjek penelitian adalah pasien diabetes mellitus tipe 2 yang masuk rawat inap periode Maret 2021 - Oktober 2021 yang teridentifikasi menggunakan insulin sliding scale. Jumlah pasien pada penelitian adalah 97. Selanjutnya di lakukan evaluasi episode kejadian hipoglikemia dan hiperglikemia. Kadar glukosa darah sewaktu pasien menentukan episode hipoglikemia dan hiperglikemia. Uji statistik regresi logistik berganda digunakan untuk hubungan pengaruh variabel jenis obat. Hasil penelitian menyatakan insulin sliding scale yang digunakan terdiri dari 3 kelompok, yaitu insulin sliding scale tunggal (41.2%), kombinasi insulin sliding scale dengan long acting insulin (55.7%), dan kombinasi insulin sliding scale dengan premixed insulin (3.1%). Hasil analisis didapatkan tidak terdapat jenis terapi insulin sliding scale yang signifikan memengaruhi pengendalian kadar glukosa darah (p>0,05). Tingkat episode hipoglikemia dan hiperglikemia masing-masing adalah 1,21 dan 54,46 per 100 pengukuran kadar glukosa darah. Episode hiperglikemia lebih sering terjadi pada pasien diabetes mellitus tipe 2 yang mendapatkan terapi insulin sliding scale.
Hypertension as Risk Factor of Poor Functional Outcome in Primary Ischemic Stroke Patients Siti Aisyah Affiati; Astuti Prodjohardjono; Abdul Gofir; Probosuseno Probosuseno; Noor Alia Susanti; Sri Sutarni; Ismail Setyopranoto
Academic Hospital Journal Vol 4, No 1 (2022)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v4i1.62783

Abstract

Survival rate of ischemic stroke has been improving which increases long-term disability in consequences.  GBD 2017 shows stroke as the third most common cause of morbidity. Hypertension is the most common risk factor for ischemic stroke incidence and affecting long-term functional outcome. Therefore, hypertension control in ischemic stroke is expected to improve functional outcome and quality of life. Therefore, this study was conducted to know the role of hypertension as risk factor of poor functional outcome in primary ischemic stroke patients. Study was conducted by observational retrospective cohort from May 2018 until April 2019 in 7 hospitals in D.I. Yogyakarta. Functional outcome of primary ischemic stroke patients was assessed by physician at day 30 by using Barthel Index. Bivariate analysis was analyzed by using Chi-Square with 95% CI and p-value <0.05 indicated statistical significance. Based on the study, there were increased risk for having dependent functional outcome in hypertension (RR=1.12, 95% CI=0.74-1.69), diabetes mellitus (RR=1.041, 95% CI=0.71-1.53) but these results were not statistically significant (p>0.05). From the study it can be concluded that hypertension is one of the most common risk factors of stroke but hypertension has no role in predicting functional outcome.  However, hypertension increases risk for having poor functional outcome in ischemic stroke patients.
Rasionalitas Terapi Antibiotik Empiris pada Pasien Geriatri dengan Community-Acquired Pneumonia di RS Mardi Rahayu Kristi Noviana Aryadi; Zullies Ikawati; Probosuseno Probosuseno
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.86071

Abstract

Community-acquired Pneumonia (CAP) is an acute infectious disease that affects the tissues (lungs) precisely in the alveoli acquired outside the hospital. The incidence of pneumonia increases with age due to changes in physiologic and immunological status associated with aging and the presence of comorbidities in old age. Pneumonia is the biggest infectious disease in Mardi Rahayu Hospital from 2020 to 2022. Inappropriate selection of empiric antibiotics causes antibiotic resistance and their prolonged use can increase the length of stay so that the cost of treatment increases. Rationale analysis of the use of specific empiric antibiotics in geriatric patients with CAP at Mardi Rahayu Hospital has never been carried out. This study aims to determine the rationality of empirical antibiotic therapy in geriatric patients with CAP. This study used a descriptive and analytic observational design with a cross-sectional method. Analysis of the rationality of empirical antibiotic therapy using the Gyssens method. The results showed that the number of geriatric patients diagnosed with CAP who were hospitalized at Mardi Rahayu Hospital from January to December 2022 who met the inclusion criteria was 139 patients with a total of 158 antibiotic regimens. The results of the rationality analysis showed that as many as 95 antibiotic regimens (60.1%) were included in the 0 (zero) category, which means rational use of antibiotics. Irrational use of antibiotics occurred in 63 regimens in category IV-A as 40 cases (25.3%), IV-B as 9 cases (5.7%), IV-C as 2 cases (1.2%), III- A as 9 cases (5.7%), III-B as 20 cases (12.6%) and II-A as 2 cases (1.2%).
Co-Authors Abdul Gofir Ali Ghufron Mukti Amanda Wulansari Anna Maria Manullang Astuti Prodjohardjono Chairun Wiedyaningsih Chairun Wiiedyaningsih Febriana Trisnaputri Rahajeng Fidiansjah Fidiansjah Ismail Setyopranoto Iwan Purnawan Kristi Noviana Aryadi Noor Alia Susanti Nyoman Kertia Rahmawati, Fita Siti Aisyah Affiati Sri Setiyarini Sri Sutarni Tri Mei Khasana Wasilah Rochmah Yunita Widyastuti Zullies Ikawati