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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Abdidas Journal of Community Development Jurnal EduHealth Prosiding Seminar Nasional COSMIC Kedokteran
Titiek Sunaryati, Titiek
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Ilmiah Kedokteran Wijaya Kusuma

 1 
EFFECT OF GARLIC EXTRACT ON SMALL INTESTINE TO INCREASE INTERFERON γ IN WHITE MALE BALB/C MICE Sunaryati, Titiek
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 2 (2012): Edisi Oktober 2012
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

     Common cold is an infectious disease that is caused by viruses. The purpose of this study is to explain how garlic extract can increase body  immunity.     This was experimental study using white male BALB/c strain mice, 10 weeks old with bodyweight of 25-35 grams. Group 1 received placebo (CMC Na) for 14 days. Group 2 received 10mg/kg BW garlic extract for 14 days, and group 3 received 20mg/kg BW garlic extract for 14 days. After 14 days mice were sacrified then  intestines were removed and processed in the paraffin block, then were stained with immunohistochemistry.     There was one  variable such as the amount of cell that produce interferon γ. Data were analyzed by analysis of variance Brown Forsythe, any significant different was further analyzed by using Games Howell in the significant level of 0.05. There were significant difference between groups those received placebo, 10mg/kgBw garlic extract, and 20mg/kgBw garlic extract in each variables.     Garlic extract can increase body immunity via increase in the amount of cell that produce interferon γ. 
THE EFFECT OF Tamarindus indica EXTRACT ON WEIGHT GAIN ON Rattus novergicus RATS WITH OBESE DIET FOOD Putri, Candra Rini Hasanah; Sunaryati, Titiek
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

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Obesity is a health problem whose prevalence tends to increase in Indonesia. Obesity becomes a concern, because it is one of the parameters that often followed by impaired of glucose tolerance in the metabolic syndrome. In Indonesia, Tamarindus indica is believed as a body slimming substance so it has possibility to become an alternative therapy that is easily available and cheap for obesity. The purpose of this study was to determine the ability of Tamarindus indica in inhibiting obesity. This experiment used 28 male Wistar strains in 2-3 months age that were divided into groups: group 1 (negative control, normal diet without Tamarindus indica), group 2 (positive control, obese diet without Tamarindus indica), group 3 (obese diet + Tamarindus indica 2700mg/kg BW), and group 4 (obese diet + Tamarindus indica 3600mg/kg BW). Measurement were performed in the first day after acclimization before treatment (day 8), and repeated weekly afterwards, ie at day 15, 22, 29, 36, and 43. Anova and Tukey Simultaneous statistics test were performed to see the differences in wight gain per week compared with the first week of study, then compared between groups.  Furthermore, a virtual screening that called insilico bioinformatics analyzes was performed to test the binding activity between quercetin and rutin (compounds in Tamarindus indica) with fatty acid synthase, an enzym that plays a role in de novo synthesis of fatty acids. Tamarindus indica was shown to significantly inhibit weight gain in rats with obese diet food (P=0.000), but differences dose of Tamarindus indica did not appear to have significant effect to inhibit obesity (P=0.321). The ability of Tamarindus indica is due to the compounds quercetin and rutin, where these two ingredients estimated to have the ability to inhibit fatty acid synthase with high strength. 
Co-Authors Abadi, Vania Zemima Rahmadya Candra Rini Hasanah Putri HARMAN AGUSAPUTRA Herdiana, Rency Angelika Hilungara, Umbu Reku Djawa Tana Idawati, Ira Inawati Inawati, Inawati Kusumaningtyas, Nisa Priamita Maria Widijanti Sugeng Putu Oky Ari Tania Sugeng, Maria Widjianti