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All Journal Acta Pharmaceutica Indonesia Biota JURNAL FARMASI GALENIKA Jurnal Insan Farmasi Indonesia Riset Informasi Kesehatan Kartika : Jurnal Ilmiah Farmasi Jurnal Farmasi Galenika
Mira Andam Dewi, Mira Andam
Fakultas Farmasi - Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Penentuan Kadar Selenium dalam Suplemen Kesehatan dengan Metode Spektrofotometri Menggunakan Reagen Kolorimetri 2,3-Diaminonaftalena Gumilar, Anggi; Putri, Adinda Triani; Dewi, Mira Andam; Ibrahim, Slamet
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.24847

Abstract

Health supplements containing selenium are now increasingly used by public . However, so far, a simple analytical method for determining selenium in health supplements are still rare. The latest method for determining selenium is based on  Inductively Coupled Plasma (ICP) spectrometry. The cost of this method is very expensive. This study aims to apply and validate the UV-Vis Spectrophotometry method for determining selenium in health supplements using 2,3 Diaminonaphthalene as  reagent. The study began by testing the specificity of reaction between Selenium with the reagent, that it is showed in specific spectrum with maximum absorbance wavelength at 483 nm. The linearity test using calibration curve, the results obtained were a linear regression equation y = 0.0126x + 0.0736 with the value of r2 = 0.9974 and Vx0 = 0.01%. Limit of detection = 0.00917 mg/mL and limit of quantitation = 0.02777 mg/mL. The accuracy of this method expressed as an average of % Recovery was 97.84% and the precision expressed as % RSD was 0.02%. The final step of this study was the determination of selenium in supplement samples using the standard addition method. The average results obtained based on the determination of selenium levels in supplements were 58.82% (sample A); 111.17% (sample B); and 98.08% (sample C) calculated against the selenium levels listed on the label of each sample, namely 25, 30, and 50 mg Se, with the requirement being in the range of 90 - 110% of the levels listed on the label. Thus, only sample C meets the requirements.
Co-Authors Aditya Ayuning Tyas Agung Subekti Agung Subekti, Agung Athina Mardatillah Fitri Sukmanengsih Fitri Sukmanengsih, Fitri Gumilar, Anggi Julia Ratnawati Julia Ratnawati, Julia Marlia Singgih Wibowo Naomi Oktavia A Naomi Oktavia A, Naomi Oktavia Putranti Adirestuti Putranti Adirestuti Putranti Adirestuti Putranti Adirestuti, Putranti Putri, Adinda Triani Rahmana Emran Kartasasmita Rina Anugrah Rina Anugrah, Rina Ririn Puspadewi, Ririn Salsabila, Nabila Hafna Slamet Ibrahim - Tyas, Aditya Ayuning Wakilatul Hasanah