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All Journal Chimica et Natura Acta Jurnal Kartika Kimia Jurnal Abdimas Kartika Wijayakusuma Journal of Applied Agricultural Science and Technology Kartika : Jurnal Ilmiah Farmasi
Yenni Karlina, Yenni
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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PENGUJIAN POTENSI ANTIJAMUR EKSTRAK AIR KAYU SECANG TERHADAP Aspergillus niger DAN Candida albicans Karlina, Yenni; Adirestuti, Putranti; Agustini, Dewi Meliati; Fadhillah, Nurul Laily; Fauziyyah, Nida; Malita, Desi
Chimica et Natura Acta Vol 4, No 2 (2016)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (55.615 KB) | DOI: 10.24198/cna.v4.n2.10676

Abstract

Khasiat kayu secang sebagai minuman sudah banyak dikenal. Beberapa contoh penggunaan secara empiris adalah untuk mengatasi nyeri akibat gangguan sirkulasi darah, penawar racun bagi tubuh, antiseptik, antibakteri dan antikoagulan. Semua khasiat tersebut terkait dengan metabolit sekundernya, antara lain flavonoid, polifenol, terpenoid dan tanin yang membuat kayu secang memiliki aktivitas antibakteri. Pada penelitian sebelumnya diketahui fraksi metanol, ekstrak dan fraksi etanol dari kayu secang, menunjukan aktivitas antibakteri. Berdasarkan alasan tersebut, telah dilakukan penelitian tentang uji potensi kayu secang terhadap pertumbuhan Aspergillus niger dan Candida albicans. Ekstraksi dilakukan dalam pelarut air (mineral kemasan, pH 3,0 dan pH 7,0); pada suhu 60°C selama 30 menit. Mikroorganisme uji adalah Aspergillus niger dan Candida albicans. Potensi antimikroba diukur berdasarkan daya hambat pada kedua mikroba uji dengan metode difusi perforasi. Hasil penelitian menunjukkan ekstrak air pH 3,0 dengan konsentrasi 20% mampu menghambat kapang dan khamir dengan diameter 9,69 dan 9,42 mm. Metabolit berupa flavonoid dan terpenoid diduga yang berperan dalam hal ini.
Edukasi Mengenai Sindrom Metabolik dan Pemanfaatan Herba Seledri sebagai Tanaman Obat Penurun Tekanan Darah Kepada Masyarakat Riyanti, Soraya; Karlina, Yenni; Damayanty, Alfina Chairunnisa; Lisningpuri, Dede Dwi; Maulana, Faza; Zahra, Natasya Shafira; Ahmad, Tasya Maulidiyyah; Putri, Tria Rhobiatul Esa
Jurnal Abdimas Kartika Wijayakusuma Vol 5 No 2 (2024): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v5i2.351

Abstract

Sindrom metabolik merupakan kumpulan faktor risiko kelainan metabolik yang memiliki korelasi dengan penyakit tidak menular seperti kolesterol, hipertensi, diabetes mellitus, dan obesitas. Sindrom metabolik ini dapat dicegah melalui penanganan secara farmakologis maupun non farmakologis. Pada penanganan non farmakologis dapat dilakukan dengan pemberian jamu yang mengandung komposisi dari beberapa tumbuhan berkhasiat. Herba seledri (Apium graveolens) dikenal masyarakat di Indonesia sebagai sayur mayur yang biasa ditemukan dalam beberapa jenis masakan dan memiliki aroma yang khas. Herba seledri mengandung minyak atsiri dan flavonoid yang berkhasiat dalam mencegah penyakit kardiovaskular, kadar glukosa darah tinggi, dan masalah pada kelebihan berat badan. Kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan untuk memberikan penyuluhan mengenai manfaat herba seledri dalam mencegah terjadinya penyakit sindrom metabolik seperti diabetes melitus, hipertensi, obesitas dan penyakit jantung koroner. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan pemahaman masyarakat mengenai sindrom metabolik dan cara pengolahan jamu di wilayah Posyandu Anggrek 21 Cipageran. Jenis kegiatan menggunakan metode pemberian pretest, materi penyuluhan, dan post-test. Hasil persentase mengenai pemahaman responden terhadap sindrom metabolik meningkat dari 88% menjadi 96% sedangkan pada pemahaman mengenai tanaman seledri sebagai penurun sindrom metabolik terdapat peningkatan persentase dari 75% menjadi 92%, sehingga pada pelaksanaan penyuluhan ini berhasil memberikan pengaruh pemahaman dan pengetahuan pada responden.
POTENSI EKSTRAK JAHE MERAH (Zingiber officinale Roscoe var. sunti), PEGAGAN (Centella asiatica (L.) Urb.) DAN KAYU MANIS (Cinnamomum Burmanni (C.Ness & T.Ness)) SEBAGAI HERBAL PENUNDA KEPIKUNAN Emeralda, Gerardine; Riyanti, Soraya; Karlina, Yenni
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.650

Abstract

Demensia atau kepikunan merupakan sindrom yang disebabkan oleh gangguan di otak. Sebanyak 60-70% demensia disebabkan oleh penyakit alzheimer. Penyakit alzheimer disebabkan oleh adanya penurunan asetilkolin (ACh) karena dihidrolisis oleh enzim asetilkolinesterase (AChE). Penghambatan aktivitas enzim AChE digunakan sebagai terapi penyakit alzheimer. Tanaman herbal memiliki potensi untuk menghambat enzim asetilkolinesterase karena memiliki banyak kandungan kimia. Tujuan dari penelitian ini adalah menentukan aktivitas peghambatan enzim AChE dari 3 jenis tumbuhan yang ada di Indonesia yaitu jahe merah (Zingiber officinale Roscoe var. sunti), pegagan (Centella asiatica (L.) Urb.), dan kayu manis (Cinnamomum burmanni (C.Ness & T.Ness)) serta kombinasi masing-masing ekstrak. Proses ekstraksi simplisia menggunakan metode maserasi dalam etanol 96%. Pengujian aktivitas penghambat  asetilkolinesterase (AChE) menggunakan metode Ellman. Hasil penelitian menunjukkan ekstrak etanol herba pegagan, dan kulit kayu manis berturut-turut sebesar 818,011 ug/mL dan 186,737 ug/mL, sedangkan ekstrak etanol jahe merah memiliki nilai IC50 > 1000 ug/mL. Nilai IC50 zat aktif donepezil adalah 0,277 ug/mL. Ekstrak etanol kulit kayu manis menunjukkan aktivitas penghambatan enzim AChE paling baik. Kombinasi ekstrak rimpang jahe merah dan kulit kayu manis dengan nilai IC50 293,166 ug/mL lebih lemah dari ekstrak tunggalnya, diduga sifat kombinasi kedua ekstrak tersebut antagonis. Ekstrak etanol kulit kayu manis paling berpotensi untuk dikembangkan lebih lanjut sebagai herbal penunda kepikunan. Kata kunci : Kepikunan, jahe merah, pegagan, kayu manis.   Abstract Dementia is a syndrome caused by a variety of brain disorder. About 60-70% dementia is caused by alzheimer disease. Decrease in acetylcholine level led by the hydrolysis of acetylcholinesterase enzym (AChE) has been the common cause of Alzheimer disease. Inhibitory activity of AChE enzyme is used in the alzheimer disease therapy. Herbal plants have the potential as the AChE inhibitor because it contains a lot of chemical compounds. This study aims at studying the inhibitory activity of acetylcholinesterase enzyme of three plants existing in Indonesia, namely Red Ginger (Zingiber officinale Roscoe var. sunti), Gotu Kola (Centella asiatica (L.) Urb.) and Cinnamon (Cinnamomum burmanni (C.Ness & T.Ness)) as well as the combination of their respective extracts. Simplicia was extracted with maceration method using ethanol 96%. AChE inhibitory activity was tested using Ellman method. The results show that IC50 value of ethanolic extracts of Gotu Kola and Cinnamon herbs are 818.011 ug/mL and 186.737 ug/mL respectively, while for red ginger is > 1000 ug/mL. The IC50 value of donepezil active substance is 0.277 ug/mL. Ethanolic extract of Cinnamon was found to have the best inhibitory activity of AChE enzyme. Combined extracts of red ginger and cinnamon with the IC50 value of 293.166 ug/mL has been the most effective inhibitor of AChE enzyme. Cinnamon ethanolic extract has the greatest potential for further development in the herbal extracts for dementia prevention. Keywords : dementia, red ginger, gotu kola, cinnamon.
Pengaruh Variasi Pelarut Etanol-Air Terhadap Aktivitas Antioksidan Ekstrak Tempe Karlina, Yenni; Sukrasno, Sukrasno; Riyanti, Soraya; Hairunnisa, Hairunnisa; Hilda, Hilda; Marselyun, Marselyun
Jurnal Kartika Kimia Vol 7 No 2 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i2.865

Abstract

Indonesia has a variety of processed food products made from beans, one of which is tempeh. A traditional Indonesian dish, tempeh is made from soybeans (Glycine max). The bioactive isoflavones contained in tempeh possess phenolic groups that contribute to its antioxidant properties. In addition to isoflavones, compounds such as superoxide dismutase and tocopherol also exhibit antioxidant activity. This study aimed to evaluate the antioxidant activity of tempeh extracts by varying the concentrations of ethanol in the solvent: 96% ethanol, 70% ethanol, 50% ethanol, 30% ethanol, and water. Extraction was performed using ultrasonic-assisted extraction, and antioxidant activity was assessed using the DPPH method, both qualitatively (via dynamolysis and TLC) and quantitatively (using UV-Visible spectrophotometry). The results from the qualitative antioxidant tests using dynamolysis and TLC showed potential antioxidant activity, evidenced by a yellow color change after the sample was sprayed with 0.2% DPPH reagent. Quantitative UV-Visible spectrophotometric testing with quercetin as a standard yielded an IC50 value of 2.86 µg/mL. The IC50results for the extracts in decreasing order of ethanol concentration were as follows: 96% ethanol extract (2638.49 µg/mL), 70% ethanol extract (2559.49 µg/mL), 50% ethanol extract (2288.65 µg/mL), 30% ethanol extract (1945.54 µg/mL), and water extract (2946.45 µg/mL). The highest antioxidant activity was observed in the 30% ethanol tempeh extract, while the lowest antioxidant activity was found in the water extract. These findings indicate that tempeh extracts exhibit antioxidant activity, which varies depending on the ethanol-water solvent composition.
Comparative Assessment of Antioxidant Properties Between In-Vitro Cultured Cat's Whiskers Leaves (Orthosiphon stamineus) and Quercetin Faramayuda, Fahrauk; Choirunnisa, Dinda; Karlina, Yenni
Journal of Applied Agricultural Science and Technology Vol. 9 No. 4 (2025): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55043/jaast.v9i4.479

Abstract

The present study investigates the antioxidant properties of in-vitro cultured leaves of cat's whiskers (Orthosiphon stamineus) compared to the well-known antioxidant quercetin. Antioxidants are crucial for neutralizing free radicals and play a significant role in protecting cells from oxidative stress, a contributing factor to various diseases and aging processes. The research aims to quantify and compare the radical scavenging activity of extracts from the in vitro cultured leaves and quercetin, using the DPPH method, a widely recognized assay in antioxidant research. Extraction involved macerating in-vitro cultured cat's whiskers leaves with 96% ethanol, which facilitates the dissolution of active phytochemicals. Antioxidant activity was subsequently assessed through the DPPH assay, where colorimetric change indicates the extract’s scavenging ability towards free radicals. The findings revealed that the in vitro cultured leaves extract exhibited a potent antioxidant activity, with an IC50 value of 0.74 μg/mL, significantly lower than quercetin’s IC50 value of 7.51 μg/mL. These results highlight the potential of in-vitro cultured cat's whiskers as a natural antioxidant source, suggesting possible applications in the food and pharmaceutical industries, where combating oxidative stress is essential for health maintenance and disease prevention. Further research is necessary to elucidate the specific biochemical pathways and mechanisms underpinning the antioxidant capacity of the in vitro cultured leaves extracts.
Co-Authors Agustini, Dewi Meliati Ahmad, Tasya Maulidiyyah Choirunnisa, Dinda Damayanty, Alfina Chairunnisa Emeralda, Gerardine Fadhillah, Nurul Laily Fahrauk Faramayuda, Fahrauk Fauziyyah, Nida Hairunnisa Hairunnisa Hilda Hilda I Nyoman Puge, I Nyoman Lisningpuri, Dede Dwi Malita, Desi Marselyun, Marselyun Maulana, Faza Putranti Adirestuti, Putranti Putri, Tria Rhobiatul Esa Soraya Riyanti, Soraya Sukrasno ., Sukrasno Sukrasno Sukrasno Zahra, Natasya Shafira