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All Journal Narra J The Journal of Society Medicine (JSOCMED) Narra X
Olga R. Siregar, Olga R.
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Correlation of Fibrinogen Level with PELOD-2 Score As A Predictive Factor For Mortality in Pediatric Sepsis Susanti, Dia Tri; Yanni, Gema Nazri; Saing, Johannes H.; Mutiara, Erna; Lubis, Aridamuriany D.; Siregar, Olga R.
Journal of Society Medicine Vol. 2 No. 11 (2023): November
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i11.106

Abstract

Introduction: Fibrinogen is a prognostic biomarker in septic children, lower fibrinogen levels are closely related to higher risk of death. Organ dysfunction was diagnosed based on PELOD-2 score. The aim of this study was to determine the corelation between fibrinogen levels and PELOD-2 score as a predictor of mortality in pediatric patient with sepsis treated in the PICU and HCU at H. Adam Malik General Hospital. Method: A cross-sectional study of pediatric patients with sepsis treated in the PICU and HCU H. Adam Malik General Hospital, Medan. Correlation of fibrinogen levels with PELOD-2 scores was seen on day I and day III of treatment in patient aged 1 month to 18 years with a hospital stay of at least 72 hours and were analyzed using the Spearman test and the relationship between fibrinogen and mortality was analyzed using the Mann-Whitney test. Results: 50 subjects were recruited in this study, fibrinogen levels had no correlation with PELOD-2 score day I (p = 0,074, r = -0,225) and with PELOD-2 score days III (p = 0,110, r = -0,229) and with mortality (p = 0,160). Conclusion: Fibrinogen levels were not correlate with PELOD-2 score as a predictive factor for mortality in septic children.
Ivermectin and dexamethasone combination induces apoptosis in SUP-B15 cell line Siregar, Olga R.; Wahyuni, Arlinda S.; Pasaribu, Ayodhia P.; Edianto, Deri; Ugrasena, I DG.; Amelia, Rina; Lubis, Inke ND.; Rusda, Muhammad
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1975

Abstract

The development of glucocorticoid resistance has complicated the management of acute lymphoblastic leukemia (ALL), leading to increased mortality rates. Ivermectin, a low-cost and well-established anthelmintic, exhibits anticancer potential and may enhance glucocorticoid toxicity in ALL, offering a possible strategy to overcome resistance. The aim of this study was to evaluate the apoptotic effect of combining ivermectin with dexamethasone in ALL. ALL SUP-B15 cells were cultured under standard conditions before treatment with dexamethasone (200 nM) alone or combined with ivermectin (5, 10, and 20 µM), with an untreated group serving as the control.  Cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay by measuring cell viability and inhibition. Apoptosis was evaluated through BAX, BCL-2, and CASP3 gene expression analysis using reverse transcription-polymerase chain reaction (RT-PCR). The findings revealed that the combination of ivermectin and dexamethasone was superior in the repression of ALL cell viability compared to control (p<0.001). The combination of dexamethasone 200 nM + ivermectin 20 μM demonstrated the most significant cell inhibition of 38.16±0.04% (p<0.001) and produced the lowest cell viability of 61.84±0.05% (p<0.001). Moreover, the combination of dexamethasone 200 nM + ivermectin 20 μM demonstrated superior upregulations of BAX (p<0.001) and CASP3 (p<0.001). In conclusion, the addition of ivermectin (5 µM) to dexamethasone regimen (200 nM) increases its cytotoxic and apoptotic activities against SUP-B15 cell line as observed by the CASP3 and BAX upregulation. Studies to confirm the enhanced anticancer activity by this combination by observing the protein levels and animal studies are warranted.
Associations between seizure management and sleep disorders in children with epilepsy: A cross-sectional study in Medan, Indonesia Suistaya, Novi A.; Dimyati, Yazid; Siregar, Olga R.; Harahap, Juliandi; Dewi, Ika C.; Lubis, Mahrani; Mukhtar, Fatima AS.; Alharbi, Olayan
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.168

Abstract

Sleep disorders are prevalent in children, particularly those with chronic illnesses such as epilepsy, where they disrupt sleep quantity, quality, or timing. The aim of this study was to analyze factors associated with sleep disorder among epileptic children admitted to Haji Adam Malik General Hospital, Medan, Indonesia. The study employed cross sectional design, recruiting 49 children (4–10 years old) with epilepsy at Haji Adam Malik General Hospital from February to June 2024. Data collection was carried out using the Children's Sleep Habit Questionnaire (CSHQ) questionnaire. Further, data on Anti-Epileptic Drugs (AED) intake and history and type of seizures were collected. Pearson’s Chi-square test was employed to analyze the association of the demographic, seizure characteristics, and AED with sleeping disorder. The findings suggest that sleep disorder in children with epilepsy was prevalent (n=26, 53.1%), mostly occurring in boys (32.7%) and those receiving valproic acid (n=9, 34.6%) and its combination with levetiracetam (n=8, 30.8%). Chi-square test results showed that seizure history intake (p<0.001), AEDs intake (p<0.001), and type of AED (p=0.010) were significantly associated with sleep disorder. In conclusion, seizure management strategies and AED regimens can influence sleep disorders in children with epilepsy. Therefore, revisiting and modifying AED treatments may be required to improve both seizure control and sleep quality in affected patients.
Co-Authors Alharbi, Olayan Ayodhia P. Pasaribu, Ayodhia P. Deri Edianto Dewi, Ika C. Dimyati, Yazid Erna Mutiara Harahap, Juliandi Johannes H. Saing, Johannes H. Lubis, Aridamuriany D. Lubis, Inke ND. Lubis, Mahrani Mukhtar, Fatima AS. Rina Amelia Rusda, Muhammad Suistaya, Novi A. Susanti, Dia Tri Ugrasena, I DG. Wahyuni, Arlinda S. Yanni, Gema Nazri