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Formulation and Evaluation of Body Lotion Preparation from Ethanol Extract of Avocado Leaves (Persea americana Mill.) as Antioxidant with DPPH Method Putri Nuraimun Simanjuntak; Herlina Herlina; Barita Aritonang; Hasni Yaturramadhan Harahap
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/hf00qs72

Skin damage is a common problem that can affect appearance and health. Excessive exposure to free radicals from UV rays is one of the main causes of skin damage, the use of body lotions containing natural antioxidant compounds is very important to protect the skin from these effects. Avocado leaves (Persea americana Mill.) have been known to contain antioxidant chemicals that are good for skin protection, one of which is flavonoids. The purpose of this study was to determine whether avocado leaf body lotion preparations can function as antioxidants and to develop body lotion preparations that meet the evaluation test requirements. The research stages included the preparation of simple drugs, the preparation of avocado leaf extract, the test of antioxidant functional groups with UV-Vis and FTIR spectroscopy, the preparation of avocado leaf ethanol extract body lotion, the evaluation of body lotion preparations, and the testing of antioxidant activity of body lotions using the DPPH method. The results of the phytochemical analysis revealed the presence of tannins, alkaloids, saponins, and flavonoids. Avocado leaf extract body lotion was formulated in four concentration variations (0%, 2%, 4%, and 6%). All formulas meet SNI, with a pH of 7 and a spreadability of between 5-7 cm. Antioxidant activity tests showed a decreasing IC50 value with increasing extract concentration: 12.4643 µg/mL (2%), 4.6300 µg/mL (4%), and 1.1065 µg/mL (6%), which are categorized as very strong. The formulation with a concentration of 6% showed stronger activity. The conclusion of this study indicates that lotion made from avocado leaf extract has the potential as a skin care product with very strong antioxidant capabilities.

Evaluation of the Effectiveness of Ethanol Extract of (Acalypha indica L.) Leaves as a Treatment for Gastric Ulcers in Male Rattus norvegicus Rats Suci Wulandari; Hasni Yaturramadhan Harahap; Rinanda Desela Br Tambunan; Basyariah Lubis
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/bvmsms48

Acalypha indica L., commonly known as Indian copperleaf, is a wild medicinal plant typically found along roadsides and in gardens. Its leaves contain various bioactive compounds, including saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for its anti-inflammatory, antibacterial, antifungal, and antioxidant properties, which help combat oxidative stress caused by free radicals. This study aimed to evaluate the effectiveness of ethanol extract of Acalypha indica L. leaves in treating gastric ulcers in male Wistar rats (Rattus norvegicus). This research was a true experimental study involving the extraction of Acalypha indica L. leaves using ethanol, preparation of the extract suspension, and induction of gastric ulcers in rats using aspirin at a dose of 800 mg/kg body weight (BW) administered orally. A total of 30 male Rattus norvegicus rats were divided into six groups. Three control groups is Ulcer control, Negative control, Positive control. Three treatment groups receiving ethanol extract of Acalypha indica leaves (EEAIL) at doses of: EEDAA 50 mg/kgBB, EEDAA100 mg/kg BB, EEDAA 200 mg/kgBB. Ulcer induction was carried out daily until surgical examination was performed on days 4, 9, and 14. Macroscopic observations of the stomach were conducted to assess the number of ulcers and ulcer scores. Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test to determine significant differences between groups. Macroscopic examination showed that the ethanol extract of Acalypha indica leaves (EEAIL) reduced the number of gastric ulcers. Complete healing of ulcers was observed in the positive control group, as well as in the groups receiving EEAIL at 200 mg/kg BW and 100 mg/kg BW, by day 14. In contrast, the 50 mg/kg BW group and the ulcer control group showed no signs of healing by the end of the observation period. The most effective dose was 200 mg/kg BW, demonstrating the highest capacity to reduce the number of gastric ulcers.

The Potential of Durian (Durio zibethinus) Fruit Peel Extract on Blood Pressure, SOD, and hsCRP Levels in Male Wistar Rats Hasni Yaturramadhan Harahap; Chandra Pranata
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6fhzjm83

Hypertension remains a major global health problem and is recognized as a leading risk factor for cardiovascular disease. Its pathogenesis involves complex mechanisms, particularly oxidative stress and chronic inflammation. An imbalance between free radical production and endogenous antioxidant defense, especially the enzyme Superoxide Dismutase (SOD), leads to endothelial dysfunction and elevated blood pressure. In parallel, inflammatory mediators such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the progression of hypertension. Although conventional therapies are effective, they are often associated with side effects and long-term costs, prompting interest in alternative treatments derived from natural resources. Durian peel (Durio zibethinus), usually considered waste, is rich in bioactive compounds such as flavonoids, alkaloids, tannins, and saponins with potential antioxidant and anti-inflammatory effects. This study employed a true experimental design with a post-test control group using male Wistar rats induced with hypertension by L-NAME administration. Animals were randomized into five groups: negative control, positive control (captopril), and three treatment groups with different extract doses. Assessments included blood pressure measurement, SOD activity, IL-6, and hs-CRP levels. Results demonstrated that durian peel extract contained an average flavonoid level of 16.27 mg QE/g with moderate antioxidant activity (IC50 88.90 µg/mL). The highest dose (800 mg/kgBW) reduced blood pressure by 14.2 ± 3.90 mmHg, approaching the effect of captopril (15.03 ± 6.30 mmHg). Moreover, SOD activity increased, IL-6 levels declined at medium to high doses, and hs-CRP levels decreased significantly, nearly comparable to the positive control. In conclusion, durian peel extract shows potential as an antihypertensive agent through mechanisms involving enhanced antioxidant defense and reduced systemic inflammation.

Effectiveness Test of a 96% Ethanolic Extract Cream of Sambung Nyawa Leaves (Gynura procumbens L.) on Incision Wounds in Male White Rats Chandra Pranata; Hasni Yaturramadhan Harahap; Herlina Herlina; Anissa Jelita Silitonga
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fh42gn18

Background: A major challenge in wound care is the high risk of infection and the relatively prolonged healing process. Synthetic antiseptics such as povidone iodine remain widely used as first-line therapy; however, prolonged use has been reported to cause adverse effects, including tissue irritation and the potential to delay epithelialization under certain conditions. Therefore, alternative therapies that are safer, more effective, and accessible to the community are needed. One promising approach involves the use of traditional medicinal plants known to possess antiseptic, anti-inflammatory, astringent, and antibacterial properties. Sambung Nyawa leaves (Gynura procumbens L.) have been empirically used in Indonesia to treat various health conditions, including skin wounds. This study aimed to evaluate the wound healing effect of an ethanol extract cream of Sambung Nyawa leaves and to determine the most effective concentration for incision wound healing. Methods: A true experimental method with a post-test only control group design was employed. The study subjects were male white rats (Rattus norvegicus) with standardized incision wounds. The animals were treated with Sambung Nyawa leaf extract cream at concentrations of 5%, 10%, and 20%, along with a positive control group (povidone iodine) and a negative control group. The observed parameter was wound diameter following treatment. Results: The findings indicated that the 20% cream concentration demonstrated the fastest healing time, followed by the 10% and 5% concentrations, the positive control, and the negative control. Differences in wound diameter among treatment groups suggest that Sambung Nyawa leaf extract has the potential to accelerate the wound healing process. Conclusion: Cream formulations containing 5%, 10%, and 20% extract exhibited effectiveness relatively comparable to povidone iodine, indicating their potential for development as a natural alternative therapy for incision wounds.

Healthy and Safe Food Education for Elementary School Students: A Program Implementation at SDN 104242 Lubuk Pakam Hasni Yaturramadhan Harahap; Barita Aritonang; Shofian Syarifuddin; Chandra Pranata; Dicky Yuswardi Wiratma
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/16azg768

Background: Elementary school students' knowledge regarding the selection of healthy and safe food remains low, posing a risk to their nutritional status and health. Schools serve as effective settings for enhancing knowledge through nutrition and food safety education. Therefore, this community service activity aimed to increase the knowledge of students at SDN 104242 Lubuk Pakam regarding the importance of consuming healthy and safe food. Objective: This community service activity aimed to improve the knowledge and awareness of students at SDN 104242 Lubuk Pakam concerning the importance of consuming healthy and safe food. Methods: The program was implemented through a preliminary survey, educational sessions involving interactive lectures, discussions, meaning-making activities, and educational games, followed by an evaluation using pre-tests and post-tests administered to 55 students. Results: The community service activity, attended by 55 students from SDN 104242 Lubuk Pakam, demonstrated an increase in knowledge regarding healthy and safe food following the educational intervention. Pre-test results indicated that the majority of students fell into the "poor" knowledge category (45.45%), followed by the "fair" (36.36%) and "good" (18.18%) categories. Post-test results showed an improvement, with the "good" knowledge category rising to 63.64%, while the "fair" category decreased to 27.27% and the "poor" category dropped to 9.09%. These results indicate that the education provided was effective in enhancing students' knowledge regarding the selection of food that is healthy, nutritious, hygienic, and safe for consumption. Conclusion: The educational program proved effective in increasing students' knowledge and awareness regarding healthy and safe food. This activity is expected to support the development of healthy eating habits from an early age and contribute to improving the health of school-aged children.awareness regarding healthy and safe food. This activity is expected to support the development of healthy eating habits from an early age and contribute to improving the health of school-aged children.

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