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FORMULASI HAND AND BODY LOTION EKSTRAK KULIT BUAH ALPUKAT(PERSEA GRATISSIMA GAERTN) SEBAGAI PELEMBAB yosi darmi rani; Cici Delima; Chandra Pranata
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Alpukat sudah dimanfaatkan masyarakat secara turun temurun sebagai bahan obat tradisional. Alpukat (Persea Americana Mill) merupakan tumbuhan yang banyak mengandung senyawa yang bersifat antioksidan. Flavonoid dan tannin merupakan beberapa senyawa yang memiliki aktivitas antioksidan yang berpotensi sebagai tabir surya (Suryanto, 2012).Tujuan Penelitian Untuk mengetahui ekstrak kulit buah alpukat (Persea Gratissima Gaertn) konsentrasi 3%, 5%, 7% sebagai hand and body lotion.metode penelitian Penelitian ini dengan menggunakan metode penelitian eksperimental Laboratorium.Berdasarkan hasil dari uji anova one way yang di pergunakan untuk menganalisis ektrak kulit buah alpukat sebagai pelembab kulit pada konsentrasi blanko konsentasi 3% konsetrasi 5% dan konsentrasi 7% way menunjukan hasil mean Squaer sebesar 0,333 dengan hasil signifikan 0,052 > 0,05 dapat disimpulkan bahwa dari hasil tabel diatas menunjukkan bahwa kulit buah alpukat dapat digunakan sebagai kelembaban kulit, Kesimpulan Berdasarkan hasil penelitian dan pembahasan ketiga formula hand and body lotion ektrak kulit buah alpukat yang telah di uji selama 28 hari penyimpanan menunjukkan kulit buah alpukat dapat digunakan sebagai kelembaban kulit.

SEMINAR UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TALAS (Colococasia Esculenta L.) TERHADAP BAKTERI Escherichia coli Chandra Pranata; Sartika .; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Salah satu tanaman yang sering dijadikan obat adalah daun Talas (Colocasia esculanta L.). Daun talas memiliki kandungan senyawa flavonoid, alkaloid, saponin dan tannin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Eschericia coli adalah salah satu jenis bakteri yang dapat menyebabkan infeksi pada pencernaan. Salah satu tujuan penelitian ini untuk mengetahui aktivitas antibakteri daun talas dengan konsentrasi yang paling efektif dalam menghambat bakteri Eschericia coli. Penelitian ini adalah penelitian eksperimental murni. Daun talas aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan bahwa ada aktivitas antibakteri pada setiap konsentrasi. Kesimpulan pemberian aktivitas daun talas dengan konsentrasi 15%, 25%, dan 35% memberikan daya hambat pertumbuhan bakteri paling efektif dengan kosentrasi 25%, 35% yang termasuk dalam kategori kuat. Saran diharapkan kepada peneliti selanjutnya dapat melakukan uji terhadap bakteri lain dan membuat formulasi dari ekstrak daun talas

Workload Analysis of Pharmacists at Tanjung Selamat General Hospital, Langkat, 2025 Nemas Adelina Lubis; Rahmad Gurusinga; Chandra Pranata
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 2 (2026): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/r470a461

Pharmaceutical personnel play a crucial role in ensuring the quality of healthcare services in hospitals. A high workload, if not properly managed, can negatively affect performance, patient safety, and service quality. This study aims to analyze the workload of pharmacists at the Pharmacy Installation of Tanjung Selamat General Hospital, Langkat, focusing on four main variables: the type and number of tasks, limitations in human resources, duration and work shift patterns, and work adjustment strategies.This study employed a qualitative approach using a descriptive method. Data were collected through in-depth interviews with one key informant (Head of the Pharmacy Installation) and three triangulation informants (Pharmaceutical Technical Personnel and Pharmacy Assistants). Data analysis was conducted through data reduction, data presentation, and conclusion drawing.The results indicate that pharmacists and pharmaceutical personnel at Tanjung Selamat General Hospital handle various types of tasks, including administrative and non-clinical duties such as medical waste management. The limited number of staff leads to task overlap, uneven shift distribution, and an increased risk of work fatigue. The 24-hour shift system has not been optimally implemented due to the disproportionate distribution of personnel. Work adjustment strategies, such as task prioritization and teamwork, have been applied; however, they remain individual-based and are not yet supported by a structured managerial system.In conclusion, the workload of pharmaceutical personnel is considered high and complex. The hospital needs to increase staffing levels, evaluate the shift system, and strengthen supporting systems such as standard operating procedures (SOPs) and information technology. Adjustments in human resource management policies are essential to maintain work efficiency and the quality of pharmaceutical services

Analysis of the Relationship between Risk Management of Laboratory Test Errors and the Quality of Laboratory Personnel Services at GrandMed Lubuk Pakam Hospital Selda manullang; Barita Aritonang; Chandra Pranata
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 2 (2026): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/753ef675

Risk management is an essential component of a laboratory quality system to prevent errors in examination results and to improve service quality. This study aimed to analyze the relationship between risk management of laboratory result errors and the service quality of laboratory personnel at GrandMed Hospital Lubuk Pakam. This study employed a quantitative method with a cross-sectional design. A total of 30 respondents were recruited using a total sampling technique. Data were collected using questionnaires and analyzed using the Spearman Rank correlation test. The results show that the type of error is significantly associated with service quality (r = 0.389; p = 0.034), risk identification has a very strong and significant association (r = 0.752; p = 0.000), and risk analysis is significantly associated with service quality (r = 0.382; p = 0.037). However, risk control is not significantly associated (r = 0.156; p = 0.410), and user satisfaction is also not significantly associated (r = 0.052; p = 0.784). Overall, risk management of laboratory errors shows a very strong positive correlation with the service quality of laboratory personnel (r = 0.823; p = 0.000). In conclusion, risk identification and risk analysis are the main factors associated with improving the service quality of laboratory personnel. Therefore, strengthening standard

Effect of Green Apple Juice on SOD And IL-6 in Cigarette Smoked Rats Chandra Pranata; Asti Pratiwi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ardvgn81

Cigarette smoke contains oxidants or free radicals and approximately 4,700 hazardous chemicals. Elevated levels of free radicals in the body can trigger the generation of Reactive Oxygen Species (ROS), leading to oxidative stress. This condition arises when there is an imbalance between oxidants and antioxidants. During this process, oxygen (O2) leakage occurs, resulting in the formation of superoxide radicals (*O2), which can subsequently induce the production of pro-inflammatory cytokines such as IL-6. The objective of this study was to evaluate the effect of green apple juice supplementation on superoxide dismutase (SOD) and IL-6 levels in male Wistar rats exposed to cigarette smoke. The study employed a Post-Test Only Control Group Design. A total of 20 male rats that met the inclusion criteria were randomly assigned to four groups: K1, K2, K3, and K4. Group K3 received standard feed supplemented with green apple juice at a dose of 13.5 grams per day, while group K4 received standard feed supplemented with green apple juice at a dose of 27 grams per day. Both groups were exposed to cigarette smoke for 14 consecutive days. On the 15th day, blood samples were collected from the male Wistar rats to measure SOD and IL-6 levels using the ELISA method. Data were analyzed using a One-Way ANOVA test, followed by Tukey's Post Hoc test. The results showed that the highest average SOD level was observed in group K2 (1.76 ng/L), while the highest IL-6 level was recorded in group K1 (4.08 ng/L). The One-Way ANOVA test indicated significant differences in SOD and IL-6 levels among the groups, with a p-value of <0.05.

The Potential of Durian (Durio zibethinus) Fruit Peel Extract on Blood Pressure, SOD, and hsCRP Levels in Male Wistar Rats Hasni Yaturramadhan Harahap; Chandra Pranata
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6fhzjm83

Hypertension remains a major global health problem and is recognized as a leading risk factor for cardiovascular disease. Its pathogenesis involves complex mechanisms, particularly oxidative stress and chronic inflammation. An imbalance between free radical production and endogenous antioxidant defense, especially the enzyme Superoxide Dismutase (SOD), leads to endothelial dysfunction and elevated blood pressure. In parallel, inflammatory mediators such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the progression of hypertension. Although conventional therapies are effective, they are often associated with side effects and long-term costs, prompting interest in alternative treatments derived from natural resources. Durian peel (Durio zibethinus), usually considered waste, is rich in bioactive compounds such as flavonoids, alkaloids, tannins, and saponins with potential antioxidant and anti-inflammatory effects. This study employed a true experimental design with a post-test control group using male Wistar rats induced with hypertension by L-NAME administration. Animals were randomized into five groups: negative control, positive control (captopril), and three treatment groups with different extract doses. Assessments included blood pressure measurement, SOD activity, IL-6, and hs-CRP levels. Results demonstrated that durian peel extract contained an average flavonoid level of 16.27 mg QE/g with moderate antioxidant activity (IC50 88.90 µg/mL). The highest dose (800 mg/kgBW) reduced blood pressure by 14.2 ± 3.90 mmHg, approaching the effect of captopril (15.03 ± 6.30 mmHg). Moreover, SOD activity increased, IL-6 levels declined at medium to high doses, and hs-CRP levels decreased significantly, nearly comparable to the positive control. In conclusion, durian peel extract shows potential as an antihypertensive agent through mechanisms involving enhanced antioxidant defense and reduced systemic inflammation.

Effectiveness Test of a 96% Ethanolic Extract Cream of Sambung Nyawa Leaves (Gynura procumbens L.) on Incision Wounds in Male White Rats Chandra Pranata; Hasni Yaturramadhan Harahap; Herlina Herlina; Anissa Jelita Silitonga
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fh42gn18

Background: A major challenge in wound care is the high risk of infection and the relatively prolonged healing process. Synthetic antiseptics such as povidone iodine remain widely used as first-line therapy; however, prolonged use has been reported to cause adverse effects, including tissue irritation and the potential to delay epithelialization under certain conditions. Therefore, alternative therapies that are safer, more effective, and accessible to the community are needed. One promising approach involves the use of traditional medicinal plants known to possess antiseptic, anti-inflammatory, astringent, and antibacterial properties. Sambung Nyawa leaves (Gynura procumbens L.) have been empirically used in Indonesia to treat various health conditions, including skin wounds. This study aimed to evaluate the wound healing effect of an ethanol extract cream of Sambung Nyawa leaves and to determine the most effective concentration for incision wound healing. Methods: A true experimental method with a post-test only control group design was employed. The study subjects were male white rats (Rattus norvegicus) with standardized incision wounds. The animals were treated with Sambung Nyawa leaf extract cream at concentrations of 5%, 10%, and 20%, along with a positive control group (povidone iodine) and a negative control group. The observed parameter was wound diameter following treatment. Results: The findings indicated that the 20% cream concentration demonstrated the fastest healing time, followed by the 10% and 5% concentrations, the positive control, and the negative control. Differences in wound diameter among treatment groups suggest that Sambung Nyawa leaf extract has the potential to accelerate the wound healing process. Conclusion: Cream formulations containing 5%, 10%, and 20% extract exhibited effectiveness relatively comparable to povidone iodine, indicating their potential for development as a natural alternative therapy for incision wounds.

The Effectiveness of Cupping Therapy in Reducing Blood Pressure in Hypertensive Patients at Citra Medika 3 Limau Manis Clinic Herlina H; Sri Nur Yana; Chandra Pranata
Medistra Medical Journal (MMJ) Vol 2 No 1 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v2i1.2378

Hypertension, a medical condition characterized by chronically elevated blood pressure, is one of the most prevalent cardiovascular diseases. Although asymptomatic in its early stages, hypertension can lead to serious complications in the cardiovascular system and other vital organs. Cupping therapy is a complementary treatment modality that has been used as an alternative approach to manage hypertension. This study aims to evaluate the effectiveness of wet cupping therapy in lowering blood pressure. The method employed involves the application of wet cupping therapy on patients with hypertension. The study results indicate that cupping therapy significantly lowers blood pressure in hypertensive patients, as evidenced by the Wilcoxon test showing a significant difference before and after the intervention. Based on the effectiveness of wet cupping therapy in lowering blood pressure, it shows potential for development as an alternative treatment for hypertension.

Penetapan Kadar Total Fenol dan Total Flavonoid pada Lotion Berbahan Ekstrak Daun Sisrsak (Annona muricata) dan Kulit Buah Naga Merah (Hylocereus polyrhizus) Menggunakan Spektrofotometri UV–VIS Suci Rahmadani Siregar; Suprianto; Chandra Pranata; Intan Coni Caroline Marbun
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.04

Background: Phenolic and flavonoid compounds from soursop (Annona muricata) leaves and red dragon fruit (Hylocereus polyrhizus) peel have potential applications in lotion formulations; therefore, their quantification is important for quality evaluation. Objective: To determine total phenolic content (TPC) and total flavonoid content (TFC) in lotion formulations containing combined plant extracts and to assess the analytical method performance. Method; Four formulations were prepared: F0 (without extract), F1 (0.5% + 0.5%), F2 (1.0% + 1.0%), and F3 (1.5% + 1.5%). TPC was measured using the Folin–Ciocalteu method (mg GAE/g) and TFC using the AlCl₃ colorimetric method (mg QE/g). Method validation included repeatability (%RSD, n = 6) and spike-recovery accuracy at 80–120%. Results: The method showed good precision (%RSD 1.08% for TPC and 1.21% for TFC) and acceptable accuracy with recoveries of 98–102%. F0 showed non-detectable values, while increasing extract concentration resulted in higher TPC (3.82 ± 0.14 to 9.71 ± 0.33 mg GAE/g) and TFC (0.86 ± 0.05 to 2.35 ± 0.10 mg QE/g). Differences among formulations were statistically significant (p < 0.05). Conclusion: The UV–Vis method is suitable for determining TPC and TFC in lotion matrices, and higher levels of combined extracts significantly increase both parameters, supporting their use for quality standardization of herbal lotions.

Healthy and Safe Food Education for Elementary School Students: A Program Implementation at SDN 104242 Lubuk Pakam Hasni Yaturramadhan Harahap; Barita Aritonang; Shofian Syarifuddin; Chandra Pranata; Dicky Yuswardi Wiratma
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/16azg768

Background: Elementary school students' knowledge regarding the selection of healthy and safe food remains low, posing a risk to their nutritional status and health. Schools serve as effective settings for enhancing knowledge through nutrition and food safety education. Therefore, this community service activity aimed to increase the knowledge of students at SDN 104242 Lubuk Pakam regarding the importance of consuming healthy and safe food. Objective: This community service activity aimed to improve the knowledge and awareness of students at SDN 104242 Lubuk Pakam concerning the importance of consuming healthy and safe food. Methods: The program was implemented through a preliminary survey, educational sessions involving interactive lectures, discussions, meaning-making activities, and educational games, followed by an evaluation using pre-tests and post-tests administered to 55 students. Results: The community service activity, attended by 55 students from SDN 104242 Lubuk Pakam, demonstrated an increase in knowledge regarding healthy and safe food following the educational intervention. Pre-test results indicated that the majority of students fell into the "poor" knowledge category (45.45%), followed by the "fair" (36.36%) and "good" (18.18%) categories. Post-test results showed an improvement, with the "good" knowledge category rising to 63.64%, while the "fair" category decreased to 27.27% and the "poor" category dropped to 9.09%. These results indicate that the education provided was effective in enhancing students' knowledge regarding the selection of food that is healthy, nutritious, hygienic, and safe for consumption. Conclusion: The educational program proved effective in increasing students' knowledge and awareness regarding healthy and safe food. This activity is expected to support the development of healthy eating habits from an early age and contribute to improving the health of school-aged children.awareness regarding healthy and safe food. This activity is expected to support the development of healthy eating habits from an early age and contribute to improving the health of school-aged children.

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