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All Journal JURNAL FOKUS KONSELING JOPS (Journal Of Pharmacy and Science) Collaborative Medical Journal (CMJ) International Journal of Applied Guidance and Counseling Indonesia Berdaya Jurnal Abdi Kesehatan dan Kedokteran JFARM (Jurnal Farmasi) Indonesian Journal of Guidance and Counseling: Theory and Application
Santi Widiasari, Santi
Universitas Ahmad Dahlan
Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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KONSELING KARIR RINGKAS BERFOKUS SOLUSI: KONSELING KARIR UNTUK MEMBANTU MENETAPKAN PILIHAN KARIR SISWA SMK MENGHADAPI MEA Saputra, Wahyu Nanda Eka; Widiasari, Santi
JURNAL FOKUS KONSELING Vol 3, No 1 (2017)
Publisher : STKIP Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26638/jfk.286.2099

Abstract

MEA be one challenge for the country of Indonesia. One way to prepare qualified human resources through education. The parties have a role to address the various challenges that arise and thrive in the world of education in Indonesia in the era of MEA is BK teacher/ counselor . Effective counseling interventions need to prepare qualified human resources in the face of the MEA , the Solution Focused Brief Career Counseling . In the counseling intervention , students are required to be able to immediately solve the problem of his career and making career choices that match their interests , talents and expertise so as to compete in the world of work.
MEKANISME INHIBISI ANGIOTENSIN CONVERTING ENZYM OLEH FLAVONOID PADA HIPERTENSI Widiasari, Santi
Collaborative Medical Journal Vol 1 No 2 (2018): Mei
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.777 KB)

Abstract

Sistem renin-angiotensin-aldosteron merupakan faktor utama dalam memelihara tekanan darah arteri. Salah satu sasaran komponennya adalah angiotensin-converting enzyme (ACE), yang merupakan zink terglikolisasi dipeptidil-karboksipeptidase yang fungsi utamanya adalah mengatur tekanan darah arteri dan keseimbangan elektrolit melalui sistem renin-angiotensin-aldosteron ini. Sejumlah ekstrak dan senyawa yang berasal dari tanaman telah terbukti secara in vitro sebagai ACE inhibitor. Efek yang menguntungkan ini secara umum dianggap berasal dari adanya molekul flavonoid, yang turunan senyawa kimia kompleksnya dapat mencapai ke dalam pusat aktif ACE. Flavonoid adalah kelompok senyawa alam dengan variabel struktur fenolik dan dapat ditemukan pada tumbuhan. Pada saat ini terdapat peningkatan minat pada potensi teraputik tanaman obat yang kemungkinan berkaitan dengan gugus phenolnya, khususnya flavonoid. Flavonoid telah dikonsumsi oleh manusia sejak lama. Flavonoid memiliki kemampuan biologi yang luas dalam menjaga kesehatan manusia dan membantu mengurangi resiko berbagai penyakit. Khususnya untuk efek anti hipertensi dari senyawa flovanol telah diteliti secara luas. Senyawa ini menghasilkan kemampuan untuk mengurangi stres oksidatif, menghambat aktifitas angiotensin converting enzim, meningkatkan relaksasi endotel pembuluh darah, mengatur signaling sel dan ekspresi gen. Kemampuan untuk menggunakan flavonoid sebagai ACE inhibitor dalam mengatur tekanan darah telah diteliti sejak beberapa dekade yang lalu dan hampir semua telah terbukti  efektif dalam menekan kerja ACE.
PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) DAN GLIBENKLAMID TERHADAP PENURUNAN KADAR GLUKOSA PADA MENCIT PUTIH (Mus Muscullus) YANG DIINDUKSI ALOKSAN Widiasari, Santi; Rahmi, Aziza; Kesuma, Yuli; Zuhir, Elvina; Ramsky, Dina
Collaborative Medical Journal Vol 7 No 1 (2024): Januari 2024
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v7i1.4466

Abstract

Diabetes merupakan penyakit yang jumlah penderitanya mengalami peningkatan di Indonesia. Menurut data IDF, Indonesia menempati peringkat ke-5 dengan penderita DM terbanyak di dunia. Berdasarkan profil kesehatan riau, pada tahun 2020 terdapat 90.796 orang menderita DM. Dinas Kesehatan Kota Pekanbaru juga melaporkan bahwa DM termasuk dalam tiga penyakit yang banyak di derita di kota Pekanbaru. Penggunaan obat baru dari herbal salah satunya adalah tanaman sirsak (Annona Muricata L). Daun tanaman ini memiliki beragam kandungan aktif diantaranya adalah flavonoid dan tanin. Flavonoid didalam daun sirsak dapat menghambat kerja enzim α-glukosidase sehingga menurunkan kemampuan reabsorpsi glukosa kedalam darah. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian kombinasi ekstrak etanol daun sirsak (Annona muricata L) dan glibenklamid dalam menurunkan kadar glukosa mencit putih jantan (mus muscullus) yang diinduksi aloksan. Metode penelitian yang digunakan adalah eksperimental denga rancangan pretest posttest with control group. Hasil dari penelitian ini didapatkan perbedaan bermakna rata-rata kadar glukosa mencit yang diinduksi aloksan terhadap kelompok yang diberikan kombinasi ekstrak etanol daun sirsak dan glibenklamid, penurunan kadar glukosa dari 227mg/dL menjadi 116,50mg/dL setelah diberikan perlakuan (p-value <0,05). Terdapat pengaruh kombinasi ekstrak daun sirsak (Annona muricata L) dan glibenklamid terhadap penurunan kadar glukosa mencit jantan (mus musculus).
Temuan Baru Ekstrak Kulit Nanas Sebagai Potensi Antidiabetes pada Tikus Putih (Rattus Norvegicus) Diinduksi Streptozotocin Oktariani, Eva; Widiasari, Santi; Faisal, Faisal; Putri, Mega Rahayu; Nurfadhilatusholiha, Nurfadhilatusholiha
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4613

Abstract

Diabetes mellitus is chronic and metabolic disease which occurs because of the increase of blood glucose level or hyperglycemia caused the body which cannot produce or use insulin effectively. Hyperglycemia has a glucotoxic effect resulting in an increase in ROS (reactive oxygen species) thus inducing liver pathogenesis which promotes severe inflammatory and apoptotic responses, as indicated by an increase in the SGPT enzyme. The pineapple peel contains flavonoid. It is known of having a strong antioxidant activity. With the giving of pineapple peel extract, it is expected to decrease the blood glucose level. This research to find out the the effect of pineapple peel extract (Ananas comusus L. Merr) on decreasing blood glucose levels and SGPT levels in male white rats (Rattus norvegicus) induced by streptozotocin. This research is an experimental study with a research design of pretest and posttest control group design. The samples consisted of 18 rats divided into 6 groups consisted of: normal control, negative control, and positive control group given metformin, and pineapple peel extract with dose 200mg/KgBW, 300mg/KgBW and 500mg/KgBW for 28 days and the measurement of the rats blood glucose was conducted by blood glucose test meter at day 1, day 4 (after post inductionof STZ 45mg/KgBW given by intraperitoneal), and day 29. The analysis result of One Way ANOVA showed that pineapple peel extract with dose 200mg/KgBW, 300mg/KgBW, and 500mg/KgBW decrease the blood glucose level significant (p-value<0,05) with negative control group. There was no significant difference between 200mg/KgBW, 300mg/KgBW and 500mg/KgBW compared with positive control (p>0.05). There was an effect of pineapple peel extract administration on the SGPT levels of STZ-induced rats with a dose of 200mg/kg BW, 300mg/kg BW, 500mg/kg BW (p-value <0.05). The administration of 300mg/kg BW pineapple peel extract had the highest decrease in SGPT levels compared to other groups. Pineapple peel extract (Ananas comosus L. Merr) can reduce blood glucose leveland SGPT levels in rats induced by streptozotocin with the greatest reduction at dose 300mg/KgBW.
Pelatihan Pembuatan Susu Kedelai Kurma “SUDEMA” dalam Upaya Meningkatkan Mikroba Baik Saluran Pencernaan di Kelurahan Lembah Sari, Rumbai Timur Mursyida, Eliya; Surya, Alfin; Widiasari, Santi; Oktariani, Eva; Sidoretno, Wahyu Margi; Wedyawatifitri, Riana Adelaide; Suryandhi, Guntur; Al-Basyari, M. Habib Mifta
Indonesia Berdaya Vol 5, No 2 (2024)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2024797

Abstract

Indonesia merupakan salah satu Negara yang memiliki sekitar 71 varietas kedelai. Kedelai diketahui memiliki kandungan protein yang hampir sama dengan susu sapi. Protein pada kedelai dapat mempernagruhi komunitas mikroba usus dan dapat juga digunakan sebagai prebiotik. Selain kedelai, kurma juga memiliki banyak manfaat bagi tubuh. Bahkan susu kedelai dan kurma dikombinasi diketahui memiliki manfaat bagi kesehatan. Masyarakat RT 02 RW 06 Lembah Sari masih minim terhadap kombinasi pengolahan susu kedelai kurma. Pengabdian bertujuan untuk melatih masyarakat dalam membuat susu kedelai kurma yang berstandar secara mandiri. Pengabdian ini dilakukan di RT 02 RW 06 Lembah Sari dengan cara melatih secara langsung pembuatan susu kedelai kurma yang disertai penyebaran leaflet tentang cara pembuatan susu kedelai kurma, dilanjutkan dengan sesi tanya-jawab, dan pengisian kuesioner terkait kepuasan masyarakat terhadap pelaksanaan pengabdian. Hasil pengabdian didapatkan bahwa masyarakat sangat antusias dengan pelatihan ini dan dibuktikan dengan data dari pengisian kuesioner yang didapatkan bahwa masyarakat sangat setuju dan setuju dengan diadakannya kegiatan pelatihan ini.
Integration of Solution-Focused Brief Counseling with Creative Arts: A Literature Review Widiasari, Santi; Ramli, M.; Wahyuni, Fitri
International Journal of Applied Guidance and Counseling Vol. 5 No. 1 (2024)
Publisher : Universitas Mercu Buana Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26486/ijagc.v5i1.3079

Abstract

In face developments of the era that are changing so quickly, counselor creativity be one of the important indicator that needs to be developed in implementation counseling service. This counselor's creativity can encourage achievement counseling service goals that was meaningful and has a significant impact on changes in counselee behavior. The aim of this article is to describe the opportunities of integration solution-focused brief counseling with the creative arts. This article is study literature with a structured and systematic meta-analysis from ideas development and research of solution-focused brief counseling with the creative arts. This article is an analysis of 46 articles published between 2007 and 2022 . In addition, there are 5 scientific articles directly related to the combination of brief counseling focus solution with creative arts. The results of an analysis of these articles found that integration of solution-focused brief counseling with the creative arts is a counseling innovation by integrating principles in creative counseling that seeks to help students realize their abilities and potential so that they can come up with solutions to the problems they have. Integration of the creative arts in solution-focused brief counseling is important to do to increase the effectiveness of the counseling services provided. Creative art that can support the effectiveness of solution-focused brief counseling are drawings, puppets, metaphors, and sand trays. The findings of this study provide recommendations for further research to identify the effectiveness of solution-focused brief counseling with other creative arts empirically in overcoming certain problems in counselees.
Pengaruh Pemberian Susu Kedelai ( Glycine Max) Terhadap Gula Darah Tikus Yang Diinduksi Aloksan widiasari, santi; Rahmadianti Hervani
JFARM - Jurnal Farmasi Vol. 2 No. 1 (2024)
Publisher : Yayasan Rahmatan Fiddunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jfarm.v2i1.487

Abstract

Diabetes mellitus DM adalah suatu penyakit kronis dimana organ pankreas tidak memproduksi cukup insulin atau ketika tubuh tidak efektif dalam menggunakannya. Data dari Riskesdas 2013 menunjukkan angka kejadian DM di Indonesia sebanyak 2,1% mengalami peningkatan dibandingkan dengan tahun 2007.Metformin sebagai obat anti diabetes oral pilihan pertama memiliki efek samping berupa gangguan gastrointestinal seperti diare, mual, muntah, dan perut kembung. Susu kedelai mengandung protein tinggi dan senyawa lesitin, yang mempunya fungsi untuk keseimbangan metabolisme dalam pengendalian glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kedelai terhadap gula darah tikus yang diinduksi aloksan. Penelitian ini merupakan penelitian eksperimental dengan rancangan pre and post test control group. sampel menggunakan 30 ekor tikus wistar berusia 2-3 bulan. Sampel dibagi dalam 5 kelompok secara acak. Hasil dari penelitian ini adalah penurunan kadar glukosa darah terlihat signifikan pada kelompok perlakuan 1 dengan dosis 15 ml/hari, dengan rerata penurunan 112,00 dengan pemberian susu kedelai selama 14 hari.
Social Application of Empathy in Serat Wedharaga to Strengthen the Character of Professional Counselor Candidates Based on Cased Method Learning Indreswari, Henny; Bariyyah, Khairul; Apriani, Rizka; Reidana, Linka Latifany Falasifa; Widiasari, Santi; Costa, Augusto da
Indonesian Journal of Guidance and Counseling: Theory and Application Vol. 14 No. 1 (2025): June 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijgc.v14i1.16086

Abstract

Facts in the field show that the empathy skills that prospective counselors have in understanding their counseling, especially in the aspect of empathy have not been comprehensively internalized. This research has three specific objectives (1) to develop a case method learning model guide based on serat wedharaga  values to increase the empathy of prospective counselors; (2) the developed model is theoretically tested through the validation of material experts, media, and potential users; (3) The model is empirically tested that  the case method learning model  is based on the value of serat wedharagas to increase the empathy of prospective counselors. The implementation of this research uses the development method with ADDIE design. The results of the development are in the form of a learning guide that includes sixteen meetings, containing materials, media, and evaluation tools. The developed learning model proved to be theoretically feasible and practically effective, demonstrated through a paired t-test with a value of Sig. (2-tailed) = 0.000, indicating a significant improvement between pretest and posttest. Thus, serat wedharaga value-based learning  is effective in increasing the empathy of prospective counselors. Suggestions for the next researcher to conduct follow-up studies related to the development of other learning models to strengthen the professional character of prospective counselors.
Efektivitas Terapi Kombinasi Metformin dengan Habbatussauda (nigella sativa) dalam Penurunan Kadar Glukosa Darah pada pasien Diabetes Mellitus: Effectiveness of Combination Therapy of Metformin and Black Seed (Nigella sativa) in Reducing Blood Glucose Levels in Patients with Diabetes Mellitus Widiasari, Santi; Siregar, Teddy Syah
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 1 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i1.94

Abstract

The prevalence of diabetes mellitus is estimated to increase to 111.2 million people aged 65-79 years. This figure will further increase to 578 million in 2030 and 700 million in 2045. Based on region, Southeast Asia is ranked 3rd with a prevalence of diabetes mellitus of 11.3%. Metformin is indicated for treatment in patients with increased blood glucose, but has side effects in the form of lactic acidosis in patients with hypoxemia, alcoholism, cirrhosis, sepsis, shock, and contrast exposure as well as gastrointestinal side effects. The aim to analyze the effect of using combination therapy of metformin with black seed (Nigella sativa) in reducing blood glucose levels in diabetes mellitus patients. Method: This research uses analytical observational research with a cross sectional method. The sampling technique was purposive sampling in diabetes mellitus patients who were using metformin therapy at SIAK Regional Hospital with a sample of 7 patients who were using metformin and 7 patients who were using combination thrapy of metformin with Black Seed. The data will be analyzed using the Independent T test because it meets the parametric requirements with a p-value > 0.05. In this study it was found that the difference in the decrease in blood glucose levels during the metformin therapy group was greater than in the combination therapy group with the normality test results showing a p-value >0.05 which means the data is normally distributed. In the results of the independent t-test, the p value was obtained (0.332), which means there was no effect on reducing blood glucose levels in the metformin therapy group with black seed. Based on the presentation of the research results, it can be concluded that the combination therapy of black seed and metformin does not significantly reduce blood glucose levels in diabetes mellitus patients with a p value >0.332, meaning that there is no significant effect on the use of the combination therapy of black seed and metformin.
Co-Authors Al-Basyari, M. Habib Mifta Alfin Surya Costa, Augusto Da Faisal Faisal Fitri Wahyuni Henny Indreswari Kesuma, Yuli Khairul Bariyyah M. Ramli Misfa, Olvaria Mursyida, Eliya Nurfadhilatusholiha, Nurfadhilatusholiha Oktariani, Eva Putri, Mega Rahayu Rahmadianti Hervani Rahmi, Aziza Ramsky, Dina Reidana, Linka Latifany Falasifa Rizka Apriani Sabrina Hayati Safitri, Bellanera Alifia Sidoretno, Wahyu Margi Siregar, Teddy Syah Suryandhi, Guntur Wahyu Nanda Eka Saputra, Wahyu Nanda Eka Wedyawatifitri, Riana Adelaide Zuhir, Elvina