E-commerce is a new type of business in which all business processes—such as ordering, payment, and delivery—can be carried out online through applications, whether on websites or mobile platforms. Today, almost all businesses utilize e-commerce as a platform for selling, including those in the medical equipment industry. PT. Wanbass Timur Persada is a company based in Surabaya that specializes in the sale of medical equipment. The main issue faced by the company is the limited reach of its promotional efforts and the dissemination of information to its target consumers, which has resulted in low product sales. Therefore, an e-commerce platform is needed to facilitate broader information dissemination and to streamline the ordering, payment, and delivery processes. In developing e-commerce, besides ensuring functionality, attention must also be paid to several design elements such as layout, images, colour scheme, typesetting, navigation, and content. The method used in this research is User-Centered Design, as it focuses on an iterative approach, usability, user characteristics, environment, tasks, and workflow. The result of this study is an e-commerce prototype featuring a product catalog, ordering process, payment, and delivery. It also applies a simple layout, varied images, a website colour combination, easy-to-read font styles, and comprehensive information.